2-chloro-N-Z-feruloyltyramine - Compound Card

2-chloro-N-Z-feruloyltyramine

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2-chloro-N-Z-feruloyltyramine

Structure
Zoomed Structure
  • Family: Amaranthaceae, Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Alkaloid
Canonical Smiles COc1cc(ccc1O)/C=C(/C(=O)NCCc1ccc(cc1)O)\Cl
InChI InChI=1S/C18H18ClNO4/c1-24-17-11-13(4-7-16(17)22)10-15(19)18(23)20-9-8-12-2-5-14(21)6-3-12/h2-7,10-11,21-22H,8-9H2,1H3,(H,20,23)/b15-10-
InChIKey NNCWTGJESCJYKH-GDNBJRDFSA-N
Formula C18H18ClNO4
HBA 4
HBD 3
MW 347.8
Rotatable Bonds 6
TPSA 78.79
LogP 3.05
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 347.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Seidlitzia rosmarinus Amaranthaceae Plantae 454547
2 Seidlitzia rosmarinus Leguminosae/Fabaceae Plantae 454547

Showing of synonyms

  • Hassan A.R, El-Kousy S.M, et al. (2017). Metformin, an anthropogenic contaminant of Seidlitzia rosmarinus collected in a desert region near the Gulf of Aqaba, Sinai Peninsula. J. Nat. Prod. 2017, 80, 2830−2834.. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C=CC(=O)NCCc2ccccc2

Level: 1

Mol. Weight: 251.33 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.09
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.880
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.87

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.000
Plasma Protein Binding
45.52
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.830
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.070
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.040
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.850
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
2.960
Rat (Acute)
1.740
Rat (Chronic Oral)
2.440
Fathead Minnow
4.530
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
431.150
Hydration Free Energy
-12.240
Log(D) at pH=7.4
3.180
Log(P)
2.33
Log S
-4.23
Log(Vapor Pressure)
-8.48
Melting Point
160.11
pKa Acid
9.3
pKa Basic
5.4
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9747
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.9598
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9568
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.9540
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9532
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9530
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9498
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9464
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9459
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.9431
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9427
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.9396
Coniferyl alcohol 9-O-methyltransferase A6XNE6 A6XNE6_9ROSI Linum nodiflorum 3 0.9353
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9344
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9339
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9312
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.9274
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9245
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9208
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9184
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 3 0.9174
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9143
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.9108
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9107
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.9092
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9092
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9062
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9025
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8997
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8985
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.8984
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8973
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8971
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8951
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8939
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8910
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8894
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8893
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8865
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8864
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.8859
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 4 0.8853
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.8853
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8836
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8834
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8830
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8812
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8801
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8776
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.8765
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8752
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8743
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8720
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8718
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8705
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.8705
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8688
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8688
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8681
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8666
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8638
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.8621
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8613
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.8606
Laminarinase Q9WXN1 Q9WXN1_THEMA Thermotoga maritima 3 0.8600
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8580
Matrilysin P09237 MMP7_HUMAN Homo sapiens 4 0.8570
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8555
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8544
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8542
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.8534
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8534
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8533
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8523
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8509
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8503
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8469
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.8449
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8437
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8434
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8422
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8373
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8365
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.8357
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8353
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8329
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8319
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.8311
Repressor protein Q7X0D9 Q7X0D9_ACIAD Acinetobacter baylyi 3 0.8310
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8308
Purine nucleoside phosphorylase Q9BMI9 Q9BMI9_SCHMA Schistosoma mansoni 3 0.8248
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8247
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8233
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8211
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8193
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8179
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8175
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8174
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8124
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8115
Tubulin--tyrosine ligase F6Z895 A9ULH4_XENTR Xenopus tropicalis 4 0.8114
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8110
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.8102
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8101
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8071
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8051
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.8041
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.8034
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.8031
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.8021
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8005
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.7990
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7988
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7987
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7987
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7980
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7970
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7960
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7936
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7933
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7931
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7920
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 4 0.7915
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 3 0.7902
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7902
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 3 0.7893
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7891
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7890
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7886
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7885
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7880
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7867
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7860
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7854
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7848
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7843
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7835
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7821
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7814
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7809
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7809
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7805
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7794
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7790
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7775
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.7771
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7768
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7767
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7765
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7744
Neprilysin P08473 NEP_HUMAN Homo sapiens 4 0.7743
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7730
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7718
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7714
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7706
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7705
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7702
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7698
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7692
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7691
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7691
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7681
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7680
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7675
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.7675
S-methyl-5'-thioadenosine phosphorylase Q97W94 MTAP_SACS2 Saccharolobus solfataricus 3 0.7669
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7656
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7653
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7652
Genome polyprotein C0LMU0 C0LMU0_9FLAV dengue virus type 3 3 0.7651
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7650
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7636
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7633
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7632
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7627
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7625
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7611
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7611
Precorrin-3 methylase O68097 O68097_RHOCA Rhodobacter capsulatus 3 0.7607
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7606
N-acetylhexosamine 1-kinase E8MF12 NAHK_BIFL2 Bifidobacterium longum subsp. longum 3 0.7604
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7593
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7590
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7585
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7584
Chaperone protein ClpB Q9RA63 CLPB_THET8 Thermus thermophilus 3 0.7584
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7580
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7578
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7578
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 3 0.7577
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7576
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7573
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7572
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7571
Pol protein Q000H7 Q000H7_9HIV1 Human immunodeficiency virus 1 3 0.7558
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.7553
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7545
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7544
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7540
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7539
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7538
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7537
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7530
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7529
Vanillyl-alcohol oxidase P56216 VAOX_PENSI Penicillium simplicissimum 3 0.7529
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7529
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7526
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7521
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7518
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7502
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7502
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7498
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 4 0.7491
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.7485
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 4 0.7483
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7482
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7481
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7479
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7478
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7475
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7475
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7474
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7471
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7471
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7469
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7468
7-methylguanosine phosphate-specific 5'-nucleotidase Q9W197 5NT3B_DROME Drosophila melanogaster 3 0.7466
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7460
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7456
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 3 0.7456
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7456
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7451
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7451
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7449
Genome polyprotein P29991 POLG_DEN27 Dengue virus type 2 3 0.7445
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7440
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7439
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7438
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 2 0.7438
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7436
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7434
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 3 0.7433
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7432
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7427
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7427
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein Q5SHN1 Q5SHN1_THET8 Thermus thermophilus 3 0.7422
Genome polyprotein A9LIE0 A9LIE0_9FLAV dengue virus type 3 3 0.7422
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7417
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7412
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7411
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7411
Signaling protein P83820 P83820_THETH Thermus thermophilus 3 0.7405
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7402
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7398
Genome polyprotein Q8QL64 Q8QL64_9FLAV Modoc virus 3 0.7395
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7393
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7392
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7389
Mitogen-activated protein kinase kinase kinase 7 O43318 M3K7_HUMAN Homo sapiens 3 0.7383
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7381
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 3 0.7381
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7380
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7374
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7373
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 3 0.7369
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 2 0.7360
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7359
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7353
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7352
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7349
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7347
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7344
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7344
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7340
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7337
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7337
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7336
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7335
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 3 0.7334
Cystathionine beta-lyase MetC P06721 METC_ECOLI Escherichia coli 3 0.7332
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 4 0.7331
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7331
LD-carboxypeptidase A0A6L8PVW7 A0A1Q4LWC0_BACAN Bacillus anthracis 3 0.7327
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7326
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7320
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7313
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7309
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7306
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7304
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7304
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7302
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7299
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7299
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7299
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7297
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7297
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7296
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7293
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7289
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7286
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7282
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7279
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7278
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7273
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7268
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7268
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7267
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7266
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7265
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7263
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7262
Methyltransferase Q81E32 Q81E32_BACCR Bacillus cereus 3 0.7261
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7260
Probable enoyl-CoA hydratase EchA8 P9WNN9 ECHA8_MYCTU Mycobacterium tuberculosis 3 0.7260
Homoserine kinase Q58504 KHSE_METJA Methanocaldococcus jannaschii 4 0.7259
Serine/threonine-protein kinase CtkA Q9ZKJ5 CTKA_HELPJ Helicobacter pylori 3 0.7258
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7257
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7256
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7250
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7249
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7244
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7244
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7244
Petrobactin biosynthesis protein AsbB Q81RQ8 Q81RQ8_BACAN Bacillus anthracis 3 0.7244
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7240
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7233
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7233
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7232
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7229
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7229
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7228
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7227
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 2 0.7225
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7220
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7217
eIF-2-alpha kinase GCN2 P15442 GCN2_YEAST Saccharomyces cerevisiae 3 0.7216
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7214
Nuclear receptor subfamily 5 group A member 2 O00482 NR5A2_HUMAN Homo sapiens 3 0.7213
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7212
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7209
Ras-related protein Rap-1b P61224 RAP1B_HUMAN Homo sapiens 3 0.7209
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7206
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 2 0.7206
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7204
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7203
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7203
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7203
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7199
Casein kinase II subunit alpha P15790 CSK21_YEAST Saccharomyces cerevisiae 4 0.7198
Mismatch repair endonuclease PMS2 P54278 PMS2_HUMAN Homo sapiens 3 0.7196
Adenosine 5'-monophosphoramidase HINT1 P80912 HINT1_RABIT Oryctolagus cuniculus 2 0.7193
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7188
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7186
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7186
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7185
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7184
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7184
Histone-lysine N-methyltransferase KMT5C Q6Q783 KMT5C_MOUSE Mus musculus 4 0.7183
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7183
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7183
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7181
Indole-3-glycerol phosphate synthase P9WFX7 TRPC_MYCTU Mycobacterium tuberculosis 2 0.7180
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7179
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7179
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7178
Bifunctional purine biosynthesis protein ATIC P31335 PUR9_CHICK Gallus gallus 3 0.7177
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7177
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7172
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7172
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7172
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7171
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7163
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7163
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7163
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7161
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7159
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7158
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7156
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7156
L-methionine gamma-lyase Q84AR1 Q84AR1_CITFR Citrobacter freundii 3 0.7156
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.7156
ATP-dependent protease ATPase subunit HslU P43773 HSLU_HAEIN Haemophilus influenzae 3 0.7155
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7155
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7155
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7153
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 4 0.7150
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7150
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7149
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7149
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7148
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7145
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7144
Chaperone protein ClpB Q9RA63 CLPB_THET8 Thermus thermophilus 3 0.7141
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7141
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7138
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7138
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 3 0.7136
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7134
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7133
Bifunctional protein GAL10 P04397 GAL10_YEAST Saccharomyces cerevisiae 4 0.7132
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7126
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7123
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7122
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7118
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7115
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 3 0.7114
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7114
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7112
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7111
Genome polyprotein Q6YMS4 POLG_DEN3S Dengue virus type 3 3 0.7111
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7110
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7109
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7109
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7108
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 2 0.7108
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7107
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7107
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7103
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7102
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7101
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7100
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7099
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7098
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7091
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7091
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7087
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7086
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7083
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7080
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7079
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7077
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7075
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7074
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7074
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7073
Gag-Pol polyprotein P04587 POL_HV1B5 Human immunodeficiency virus type 1 group M subtype B 3 0.7073
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7073
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 4 0.7071
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7071
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7069
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7062
5'-methylthioadenosine nucleosidase / s-adenosylhomocysteine nucleosidase Q8YBL1 Q8YBL1_BRUME Brucella melitensis biotype 1 3 0.7060
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7060
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7058
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 3 0.7056
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7055
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7054
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7054
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7052
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7052
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7050
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7049
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7048
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7048
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7048
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7047
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7047
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7045
Ribonuclease TTHA0252 Q5SLP1 RNSE_THET8 Thermus thermophilus 3 0.7044
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7044
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7042
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7041
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 2 0.7039
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 4 0.7037
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7036
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7035
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 3 0.7035
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7034
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7034
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 2 0.7033
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7033
Cell division control protein 42 homolog P60953 CDC42_HUMAN Homo sapiens 2 0.7031
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 4 0.7029
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 4 0.7027
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7027
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7019
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7017
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7016
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7012
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7012
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7011
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7010
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7009
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7009
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7008
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7007
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7005
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7005
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 2 0.7005
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7004
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7003
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7001
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7001

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