3-hydroxy-6,7,4'-trimethoxyflavone - Compound Card

3-hydroxy-6,7,4'-trimethoxyflavone

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3-hydroxy-6,7,4'-trimethoxyflavone

Structure
Zoomed Structure
  • Family: Apiaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone
Canonical Smiles COc1ccc(cc1)c1oc2cc(OC)c(cc2c(=O)c1O)OC
InChI InChI=1S/C18H16O6/c1-21-11-6-4-10(5-7-11)18-17(20)16(19)12-8-14(22-2)15(23-3)9-13(12)24-18/h4-9,20H,1-3H3
InChIKey IOZLPDWMWQMTRB-UHFFFAOYSA-N
Formula C18H16O6
HBA 6
HBD 1
MW 328.32
Rotatable Bonds 4
TPSA 78.13
LogP 3.19
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 328.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Ammoides atlantica Apiaceae Plantae 386050

Showing of synonyms

  • Benteldjoune M, Boudiar T, et al. (2021). Antioxidant activity and characterization of flavonoids and phenolic acids of Ammoides atlantica by RP–UHPLC– ESI–QTOF–MS. Nat Prod Res, 2021, 35(10), 1639-1643.. [View] [PubMed]
Pubchem: 12657886

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 222.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 146.14 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.52
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.560
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.58

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.490
Plasma Protein Binding
84.68
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.970
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.120
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.270
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.660
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.780
Rat (Acute)
2.310
Rat (Chronic Oral)
2.170
Fathead Minnow
4.900
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
436.980
Hydration Free Energy
-10.160
Log(D) at pH=7.4
1.940
Log(P)
2.16
Log S
-3.95
Log(Vapor Pressure)
-6.98
Melting Point
182.61
pKa Acid
7.64
pKa Basic
0.4
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9800
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9660
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9554
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9509
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9427
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 5 0.9367
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9223
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9204
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9170
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9167
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9151
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9145
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9144
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.9135
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9130
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9126
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.9125
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9122
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9062
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9043
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9018
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8959
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8937
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8929
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8923
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8920
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8917
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.8915
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8910
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8893
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8888
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8824
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8764
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8764
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8714
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8709
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8686
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.8685
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8678
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8676
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8675
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8662
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 5 0.8661
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8632
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8629
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8607
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8606
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 5 0.8583
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8557
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8555
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8546
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8538
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8536
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8526
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8507
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8430
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.8426
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 5 0.8416
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8414
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8388
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8373
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 5 0.8360
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8355
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8337
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8330
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8308
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8257
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8227
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8187
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8174
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8131
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.8122
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.8099
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8096
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8083
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8066
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8061
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8038
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7973
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7960
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7952
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7947
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7942
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7940
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7939
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 4 0.7936
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7936
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 4 0.7924
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7922
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7888
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7883
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.7882
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7865
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7858
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7857
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7854
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7838
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7837
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.7804
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7797
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7787
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7781
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7776
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7774
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7773
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7754
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7753
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7749
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7744
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7739
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7727
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7720
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7691
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7682
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7678
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7671
Putative secreted protein C9Z6T8 C9Z6T8_STRSW Streptomyces scabiei 4 0.7670
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7669
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7641
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7631
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7631
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7617
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7613
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7607
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7589
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7588
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7585
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7580
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7575
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7566
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7565
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7562
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7547
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7535
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7517
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7511
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7502
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7488
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7486
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7471
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7469
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7465
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7464
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7462
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7461
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7456
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7454
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7453
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7452
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7447
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7442
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7440
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7428
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7414
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7410
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7408
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7398
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.7397
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 3 0.7396
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7388
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7388
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7374
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7372
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7366
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7357
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7357
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7354
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.7354
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7351
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7350
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7339
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7338
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7335
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7331
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7331
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7331
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7329
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7319
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7319
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7318
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7317
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7312
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7311
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7308
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7307
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7301
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7293
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7287
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7286
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7284
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7282
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7276
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7275
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7273
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7267
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7263
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7257
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7251
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7248
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7247
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7245
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7235
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7227
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7226
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7224
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7214
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7214
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7208
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7199
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7194
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7189
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7187
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7184
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7179
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7171
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7165
DNA topoisomerase 1 P06612 TOP1_ECOLI Escherichia coli 3 0.7153
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7151
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7140
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7136
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7134
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7127
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7125
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 3 0.7118
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7114
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7104
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7095
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7095
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7090
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7085
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7083
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 4 0.7082
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7082
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7079
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7055
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7038
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7032
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7026
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7016
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7010
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7007
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7006
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7006
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7004
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7003
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7000

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