7-hydroxy-labda8(17),13(16),14-trien-19-yl-7’-O-methyl-(Z)-coumarate - Compound Card

7-hydroxy-labda8(17),13(16),14-trien-19-yl-7’-O-methyl-(Z)-coumarate

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7-hydroxy-labda8(17),13(16),14-trien-19-yl-7’-O-methyl-(Z)-coumarate

Structure
Zoomed Structure
  • Family: Araucariaceae
  • Kingdom: Plantae
  • Class: Terpenoid
    • Subclass: Diterpene
Canonical Smiles C=CC(=C)CC[C@H]1C(=C)[C@@H](O)CC2[C@]1(C)CCC[C@]2(C)COC(=O)/C=C\c1ccc(cc1)OC
InChI InChI=1S/C30H40O4/c1-7-21(2)9-15-25-22(3)26(31)19-27-29(4,17-8-18-30(25,27)5)20-34-28(32)16-12-23-10-13-24(33-6)14-11-23/h7,10-14,16,25-27,31H,1-3,8-9,15,17-20H2,4-6H3/b16-12-/t25-,26-,27?,29+,30+/m0/s1
InChIKey SCNSPEWZQZSSIK-MEUNRVCQSA-N
Formula C30H40O4
HBA 4
HBD 1
MW 464.65
Rotatable Bonds 9
TPSA 55.76
LogP 6.52
Number Rings 3
Number Aromatic Rings 1
Heavy Atom Count 34
Formal Charge 0
Fraction CSP3 0.5
Exact Mass 464.29
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Araucaria bidwillii Araucariaceae Plantae 56993

Showing of synonyms

  • Ebada S, Talaat A, et al. (2017). Cytotoxic labdane diterpenes and bisflavonoid atropisomers from leaves of Araucaria bidwillii. Tetrahedron, 2017, 73(21), 3048-3055. [View]

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C=CC(=O)OCC2CCCC(C23)CC(=C)CC3

Level: 1

Mol. Weight: 310.44 g/mol

Structure

SMILES: C=C(C1)CCC(C12)CCCC2

Level: 0

Mol. Weight: 150.26 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.78
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.58
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.84

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.39
Plasma Protein Binding
96.98
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.54
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.9
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-1.0
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
7.17
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-145.38
Rat (Acute)
3.8
Rat (Chronic Oral)
2.63
Fathead Minnow
4.61
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
473.84
Hydration Free Energy
-2.79
Log(D) at pH=7.4
5.67
Log(P)
6.56
Log S
-6.56
Log(Vapor Pressure)
-8.45
Melting Point
107.34
pKa Acid
10.79
pKa Basic
5.23
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9684
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9492
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.9099
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9088
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8904
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8782
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8634
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8610
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8431
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8353
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8258
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.8250
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8117
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8108
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8092
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7989
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7967
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7954
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7915
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7891
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7861
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7837
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7812
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7791
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7763
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7748
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7705
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7670
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7662
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7647
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7645
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.7620
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7620
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7615
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7614
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7611
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7592
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7579
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7571
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7565
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7564
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7544
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7540
Lipoprotein E P26093 HEL_HAEIN Haemophilus influenzae 3 0.7529
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7502
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7501
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7493
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7491
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7475
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7474
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 2 0.7459
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7448
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7448
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7432
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7421
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7406
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7401
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7401
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7401
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7394
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 3 0.7393
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7391
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7389
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7388
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7386
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7386
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7384
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7384
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7381
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7379
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7378
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7375
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7374
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7370
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7367
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7362
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7362
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 3 0.7361
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7358
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7357
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7351
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7347
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7341
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7335
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7335
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 3 0.7333
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7333
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7325
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7323
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7320
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7319
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7315
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7315
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7311
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7307
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 3 0.7306
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7299
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7298
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7295
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7292
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7290
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7288
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7279
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7276
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7271
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 2 0.7267
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7265
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 2 0.7260
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 2 0.7249
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7248
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7243
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7241
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7239
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7229
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7223
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7220
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7216
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7211
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7203
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7203
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7198
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7197
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7196
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7194
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7193
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7178
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7168
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7165
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7159
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7158
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7154
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7153
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7150
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7148
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7136
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7135
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7130
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7128
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.7127
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 2 0.7125
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7120
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7118
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7117
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7115
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7114
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7108
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 2 0.7108
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7105
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7096
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7093
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7075
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7074
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7069
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7069
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7066
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 2 0.7063
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7061
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7060
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7050
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7046
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7045
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7043
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7042
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7039
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7034
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7031
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7024
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7020
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7018
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7018
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 2 0.7015
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7014
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 2 0.7014
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7012
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7012
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7007

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