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Prestragol

Family: Plantae - Asteraceae
Kingdom: Plantae
Class: Monoaromatic

Canonical Smiles	OCC(Cc1ccc(cc1)OC)O
InChI	InChI=1S/C10H14O3/c1-13-10-4-2-8(3-5-10)6-9(12)7-11/h2-5,9,11-12H,6-7H2,1H3
InChIKey	FTVDGXRTMDRADG-UHFFFAOYSA-N
Formula	C₁₀H₁₄O₃
HBA	3
HBD	2
MW	182.22
Rotatable Bonds	4
TPSA	49.69
LogP	0.59
Number Rings	1
Number Aromatic Rings	1
Heavy Atom Count	13
Formal Charge	0
Fraction CSP3	0.4
Exact Mass	182.09
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Artemisia dracunculus	Asteraceae	Plantae	72341

Showing of synonyms

Talbi M, Saadali B, et al. (2016). Two natural compounds – a benzofuran and a phenylpropane – from Artemisia dracunculus. Journal of Asian natural products research, 2016, 18(8), 724-9. [View] [PubMed]

Pubchem: 176896

Cas: 17131-20-3

No compound-protein relationship available.

SMILES: c1ccccc1

Level: 0

Mol. Weight: 182.22 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.55
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -3.33
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -3.25

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.46
Plasma Protein Binding: 7.0
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 5.79
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.24
Biodegradation: Toxic
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.29
Liver Injury II: Safe
hERG Blockers: Safe
Daphnia Maga: 3.6
Micronucleos: Safe
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 2.29
Rat (Acute): 1.97
Rat (Chronic Oral): 2.51
Fathead Minnow: 3.55
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 306.98
Hydration Free Energy: -13.02
Log(D) at pH=7.4: 0.43
Log(P): 0.69
Log S: -1.27
Log(Vapor Pressure): -4.63
Melting Point: 80.24
pKa Acid: 12.21
pKa Basic: 1.77

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.9704
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9582
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9544
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9522
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9495
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9423
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9406
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9405
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.9373
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.9286
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9238
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	3	0.9168
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9166
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.9143
cAMP-dependent protein kinase catalytic subunit alpha	P05132	KAPCA_MOUSE	Mus musculus	3	0.9077
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.9009
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8893
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.8873
Transcriptional activator, LuxR/UhpA family of regulators	Q7NQP7	Q7NQP7_CHRVO	Chromobacterium violaceum	3	0.8872
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8833
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.8831
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8819
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8815
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.8805
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8688
Amine oxidase [flavin-containing] B	P27338	AOFB_HUMAN	Homo sapiens	3	0.8675
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.8646
Catalase-peroxidase	Q3JNW6	KATG_BURP1	Burkholderia pseudomallei	3	0.8587
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.8546
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8527
Cytochrome P450 2A6	P11509	CP2A6_HUMAN	Homo sapiens	3	0.8436
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	3	0.8422
Alpha/beta hydrolase fold protein	D2J2T6	D2J2T6_9RHIZ	Ochrobactrum sp. T63	3	0.8407
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8379
Mitogen-activated protein kinase kinase kinase 5	Q99683	M3K5_HUMAN	Homo sapiens	3	0.8324
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8319
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8313
Transcriptional activator, LuxR/UhpA family of regulators	Q7NQP7	Q7NQP7_CHRVO	Chromobacterium violaceum	3	0.8261
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.8260
Matrix metalloproteinase-20	O60882	MMP20_HUMAN	Homo sapiens	3	0.8171
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.8167
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8062
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8028
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.8008
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7992
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7941
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	3	0.7939
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7938
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7899
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7898
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7889
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	3	0.7877
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7875
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7873
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7852
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	3	0.7847
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7799
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7780
Cyclin-dependent kinase 8	P49336	CDK8_HUMAN	Homo sapiens	3	0.7766
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7754
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7731
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7716
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7711
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7707
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	4	0.7706
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7702
Amine oxidase [flavin-containing] B	P27338	AOFB_HUMAN	Homo sapiens	3	0.7687
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7667
Peroxidase C1A	P00433	PER1A_ARMRU	Armoracia rusticana	3	0.7658
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7640
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	3	0.7624
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7618
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7617
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7611
Biotin carboxylase	P43873	ACCC_HAEIN	Haemophilus influenzae	3	0.7605
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7603
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7587
Phosphotriesterase	Q5KZU5	Q5KZU5_GEOKA	Geobacillus kaustophilus	3	0.7586
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7579
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7576
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	3	0.7561
Protein kinase C iota type	Q62074	KPCI_MOUSE	Mus musculus	3	0.7547
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7545
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7543
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7537
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7520
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.7511
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7509
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	4	0.7506
rRNA methylase	Q8DSS3	Q8DSS3_STRMU	Streptococcus mutans serotype c	2	0.7495
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7493
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7491
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7490
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	3	0.7472
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7471
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7466
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7465
Chymotrypsinogen A	P00766	CTRA_BOVIN	Bos taurus	3	0.7464
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7463
Bifunctional purine biosynthesis protein ATIC	P31335	PUR9_CHICK	Gallus gallus	3	0.7448
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7447
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7446
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.7444
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	Q9Y3Z3	SAMH1_HUMAN	Homo sapiens	3	0.7431
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7425
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7418
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7407
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7399
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	3	0.7399
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7395
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7389
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	3	0.7372
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7371
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7366
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7363
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7363
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7353
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7353
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7351
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7350
Caffeic acid O-methyltransferase	Q9ZTU2	Q9ZTU2_LOLPR	Lolium perenne	3	0.7349
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7344
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	2	0.7334
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7332
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	2	0.7313
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7311
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7311
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7310
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7306
Lipoyl synthase 2	Q8DLC2	LIPA2_THEEB	Thermosynechococcus vestitus	4	0.7302
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7296
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7294
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7291
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7290
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7289
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	3	0.7284
Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	RET_HUMAN	Homo sapiens	3	0.7283
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7283
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7280
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.7279
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7279
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7277
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7274
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7269
16S rRNA (guanine(1405)-N(7))-methyltransferase	Q763K9	Q763K9_ECOLX	Escherichia coli	3	0.7267
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7267
Tryptophan synthase alpha chain	P00929	TRPA_SALTY	Salmonella typhimurium	3	0.7261
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7261
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7259
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7255
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7254
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	2	0.7251
GMP reductase	Q81JJ9	GUAC_BACAN	Bacillus anthracis	2	0.7250
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7247
GMP reductase 2	Q9P2T1	GMPR2_HUMAN	Homo sapiens	3	0.7244
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	2	0.7244
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7243
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7242
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7240
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	2	0.7230
RIO-type serine/threonine-protein kinase Rio1	O28471	RIO1_ARCFU	Archaeoglobus fulgidus	3	0.7229
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	Q9Y3Z3	SAMH1_HUMAN	Homo sapiens	2	0.7224
Orotidine 5'-phosphate decarboxylase	O26232	PYRF_METTH	Methanothermobacter thermautotrophicus	3	0.7223
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	2	0.7223
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7221
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7215
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7213
Protein mono-ADP-ribosyltransferase PARP14	Q460N5	PAR14_HUMAN	Homo sapiens	3	0.7211
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7208
Receptor-interacting serine/threonine-protein kinase 1	Q13546	RIPK1_HUMAN	Homo sapiens	3	0.7203
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7186
N-terminal acetyltransferase A complex subunit NAT1	P12945	NAT1_YEAST	Saccharomyces cerevisiae	2	0.7185
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7175
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7174
Flavin reductase like domain-containing protein	Q4UKE8	Q4UKE8_RICFE	Rickettsia felis	3	0.7170
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7168
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7168
Inosine-5'-monophosphate dehydrogenase	Q756Z6	Q756Z6_ASHGO	Ashbya gossypii	3	0.7166
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	3	0.7165
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7165
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7164
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7159
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7157
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	2	0.7154
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7150
Nucleoside permease	Q9KPL5	Q9KPL5_VIBCH	Vibrio cholerae serotype O1	3	0.7149
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7140
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	2	0.7139
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7135
Cyclic nucleotide-binding domain-containing protein	E0RR11	E0RR11_SPITD	Spirochaeta thermophila	2	0.7132
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	4	0.7127
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7127
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7122
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7119
3-hydroxybenzoate 4-monooxygenase	Q6SSJ6	MOBA_COMTE	Comamonas testosteroni	2	0.7117
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7115
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	2	0.7114
Regulatory protein SdiA	P07026	SDIA_ECOLI	Escherichia coli	3	0.7113
Cytosine-specific methyltransferase	Q8EVR5	Q8EVR5_MYCPE	Mycoplasma penetrans	3	0.7109
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	2	0.7109
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7107
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7105
Metallo-beta-lactamase type 2	P26918	BLAB_AERHY	Aeromonas hydrophila	2	0.7104
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.7101
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7097
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7096
Nicotinamide riboside kinase 1	Q9NWW6	NRK1_HUMAN	Homo sapiens	3	0.7095
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7095
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	2	0.7093
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7090
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic	Q9FYS3	HGGL_SECCE	Secale cereale	3	0.7088
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7086
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7085
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7082
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7082
Geranyl diphosphate 2-C-methyltransferase	D3KYU3	GPPMT_STRLS	Streptomyces lasalocidi	3	0.7079
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7079
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7078
Metallophosphoesterase	A3DJ38	A3DJ38_HUNT2	Clostridium thermocellum	2	0.7076
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	2	0.7076
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7076
DNA (cytosine-5)-methyltransferase 1	Q9AXT8	H32_ARATH	Zea mays	3	0.7075
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7074
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7072
Archaeal actin homolog	Q9HKL4	ACTH_THEAC	Thermoplasma acidophilum	2	0.7071
Tryptophan synthase alpha chain	P00929	TRPA_SALTY	Salmonella typhimurium	2	0.7070
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7070
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7067
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7064
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7062
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7062
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase	P47229	BPHD_PARXL	Paraburkholderia xenovorans	2	0.7060
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7059
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7051
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7046
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7045
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	2	0.7040
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	2	0.7037
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7029
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7022
Nitric oxide synthase 3	P29474	NOS3_HUMAN	Homo sapiens	3	0.7022
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	2	0.7020
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	2	0.7019
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7018
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7016
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7015
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	2	0.7014
CMP/hydroxymethyl CMP hydrolase	B4Y381	B4Y381_9ACTN	Streptomyces rimofaciens	3	0.7008
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7003
Nucleoside diphosphate kinase	A5J299	A5J299_PENVA	Penaeus vannamei	2	0.7002

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