ANPDB

Select a section from the left sidebar

Silyhermin

Family: Plantae - Asteraceae
Kingdom: Plantae
Class: Lignan
- Subclass: Flavonolignan

Canonical Smiles	OCC1c2cc(cc(c2OC1c1ccc(c(c1)OC)O)O)[C@@H]1CC(=O)c2c(O1)cc(cc2O)O
InChI	InChI=1S/C25H22O9/c1-32-21-6-11(2-3-16(21)28)24-15(10-26)14-4-12(5-19(31)25(14)34-24)20-9-18(30)23-17(29)7-13(27)8-22(23)33-20/h2-8,15,20,24,26-29,31H,9-10H2,1H3/t15?,20-,24?/m0/s1
InChIKey	AQRHXQBZDLTXPO-QOTJCZOLSA-N
Formula	C₂₅H₂₂O₉
HBA	9
HBD	5
MW	466.44
Rotatable Bonds	4
TPSA	145.91
LogP	3.43
Number Rings	5
Number Aromatic Rings	3
Heavy Atom Count	34
Formal Charge	0
Fraction CSP3	0.24
Exact Mass	466.13
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Silybum marianum	Asteraceae	Plantae	92921

Showing of synonyms

AbouZid S.F, Ahmed H.S, et al. (2017). Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations. Fitoterapia, 2017, 119, 175-184. [View] [PubMed]

Pubchem: 10389806

Chebi: 169173

No compound-protein relationship available.

SMILES: c1ccccc1C(C2)Oc(c23)ccc(c3)C(CC4=O)Oc(c45)cccc5

Level: 2

Mol. Weight: 466.44 g/mol

SMILES: C1COc(c12)ccc(c2)C(CC3=O)Oc(c34)cccc4

Level: 1

Mol. Weight: 466.44 g/mol

SMILES: c1cccc(c12)OC(C2)c3ccccc3

Level: 1

Mol. Weight: 466.44 g/mol

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 466.44 g/mol

SMILES: C1COc(c12)cccc2

Level: 0

Mol. Weight: 466.44 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 466.44 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -6.2
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.1
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.26

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.14
Plasma Protein Binding: 77.26
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 12.39
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.6
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 0.81
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.01
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -315.5
Rat (Acute): 2.33
Rat (Chronic Oral): 3.49
Fathead Minnow: 5.22
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 560.82
Hydration Free Energy: -3.24
Log(D) at pH=7.4: 3.1
Log(P): 2.43
Log S: -6.79
Log(Vapor Pressure): -9.94
Melting Point: 235.08
pKa Acid: 7.54
pKa Basic: 3.64

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.9381
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.9053
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8997
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8962
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8899
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.8847
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8826
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8811
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8790
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8786
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8749
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8743
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8687
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8672
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8636
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8606
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.8586
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	3	0.8527
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8504
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	4	0.8497
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8436
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.8430
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8379
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8364
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8299
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8279
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.8270
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	4	0.8261
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	3	0.8246
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8239
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.8236
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	4	0.8235
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8232
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8226
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8197
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.8193
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8167
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.8164
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8156
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8127
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.8078
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8053
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8033
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8021
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	4	0.7999
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7974
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7971
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7962
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7931
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7881
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7876
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7869
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7866
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7866
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7863
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	4	0.7823
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7822
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.7808
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.7765
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7718
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7704
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.7703
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7703
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.7690
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7684
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7681
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.7681
Ribosomal protein S6 kinase alpha-3	P18654	KS6A3_MOUSE	Mus musculus	5	0.7678
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7673
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7665
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7637
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	4	0.7626
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7622
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7613
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	4	0.7609
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7608
Dihydrofolate reductase	O30463	O30463_MYCAV	Mycobacterium avium	4	0.7603
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7602
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.7600
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7587
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7587
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7582
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7548
Cytochrome P450 130	P9WPN5	CP130_MYCTU	Mycobacterium tuberculosis	3	0.7548
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7540
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.7501
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	4	0.7483
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7470
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7462
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.7461
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7461
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7459
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	3	0.7458
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7453
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.7453
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7452
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	6	0.7449
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7426
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	4	0.7423
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.7417
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7416
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	6	0.7414
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.7399
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7363
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7352
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7351
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	2	0.7343
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7323
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7305
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7304
F420-dependent NADP reductase	O29370	FNO_ARCFU	Archaeoglobus fulgidus	4	0.7304
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7295
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7293
16S rRNA (adenine(1408)-N(1))-methyltransferase	A8C927	NPMA_ECOLX	Escherichia coli	4	0.7285
Single-strand selective monofunctional uracil DNA glycosylase	Q9YGN6	SMUG1_XENLA	Xenopus laevis	4	0.7284
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	6	0.7283
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	4	0.7280
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7279
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7277
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7256
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7246
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7240
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7233
Serine/threonine-protein kinase VRK1	Q99986	VRK1_HUMAN	Homo sapiens	3	0.7231
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.7229
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	Q6NVY1	HIBCH_HUMAN	Homo sapiens	3	0.7213
M17 leucyl aminopeptidase	Q8IL11	Q8IL11_PLAF7	Plasmodium falciparum	3	0.7211
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7204
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	3	0.7200
Dihydrofolate reductase	Q83AB2	Q83AB2_COXBU	Coxiella burnetii	4	0.7186
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.7186
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7180
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7178
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.7176
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	4	0.7172
Dihydrofolate reductase	P00381	DYR_LACCA	Lacticaseibacillus casei	4	0.7168
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7136
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7132
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.7130
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7121
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7117
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7109
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7101
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7097
Uncharacterized protein	Q55S71	Q55S71_CRYNB	Cryptococcus neoformans var. neoformans serotype D	3	0.7096
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7095
RNA-directed RNA polymerase	P11124	RDRP_BPPH6	Pseudomonas phage phi6	4	0.7092
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7090
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	5	0.7071
tRNA-guanine(15) transglycosylase	O58843	ATGT_PYRHO	Pyrococcus horikoshii	3	0.7059
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	4	0.7042
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein	Q5SHN1	Q5SHN1_THET8	Thermus thermophilus	3	0.7036
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	3	0.7034
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.7029
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7028
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.7028
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7023
Capsid protein VP1	O56137	O56137_9VIRU	Adeno-associated virus - 6	3	0.7020
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7019
O-methyltransferase family 2	D5STZ7	D5STZ7_PLAL2	Planctopirus limnophila	4	0.7014
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7011
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7010

Download SDF