5,7-dihydroxy-2-(4-hydroxyphenyl)-3,8-dimethoxy-4H-chromen-4-one - Compound Card

5,7-dihydroxy-2-(4-hydroxyphenyl)-3,8-dimethoxy-4H-chromen-4-one

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5,7-dihydroxy-2-(4-hydroxyphenyl)-3,8-dimethoxy-4H-chromen-4-one

Structure
Zoomed Structure
  • Family: Capparaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonol
Canonical Smiles COc1c(oc2c(c1=O)c(O)cc(c2OC)O)c1ccc(cc1)O
InChI InChI=1S/C17H14O7/c1-22-15-11(20)7-10(19)12-13(21)17(23-2)14(24-16(12)15)8-3-5-9(18)6-4-8/h3-7,18-20H,1-2H3
InChIKey QEXFTGWTWYZALN-UHFFFAOYSA-N
Formula C17H14O7
HBA 7
HBD 3
MW 330.29
Rotatable Bonds 3
TPSA 109.36
LogP 2.59
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 330.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Cleome arabica Capparaceae Plantae 511509

Showing of synonyms

  • Ladhari A, Tufano I, et al. (2020). Influence of new effective allelochemicals on the distribution of Cleome arabica L. community in nature. Natural product research, 2020, 34(6), 773-781. [View] [PubMed]
Pubchem: 13983738
Nmrshiftdb2: 60026838

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 222.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 146.14 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.1
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.020
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.82

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.250
Plasma Protein Binding
87.27
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.750
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.500
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.420
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.680
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.010
Rat (Acute)
2.310
Rat (Chronic Oral)
2.720
Fathead Minnow
4.590
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
476.120
Hydration Free Energy
-10.660
Log(D) at pH=7.4
2.910
Log(P)
3.27
Log S
-5.43
Log(Vapor Pressure)
-7.75
Melting Point
239.31
pKa Acid
7.32
pKa Basic
3.11
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9802
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9747
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9403
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9364
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9300
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9241
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.9190
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9157
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9108
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9030
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9009
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8989
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8930
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8918
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8913
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.8898
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8892
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8892
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8889
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8880
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8835
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8830
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8822
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8801
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8778
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8768
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8766
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8741
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8733
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8732
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8730
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8719
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8715
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8685
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8681
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8662
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8662
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8616
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8595
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8563
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8533
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8504
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8481
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8480
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8467
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8460
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8451
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8447
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8445
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8426
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8403
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8395
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8385
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8383
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8361
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8359
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.8342
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8325
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8315
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8293
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8277
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8276
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8253
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8246
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8230
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8225
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8219
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8182
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.8145
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8132
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8127
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.8126
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8108
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8105
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8100
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8088
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8088
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8085
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8079
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8066
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8045
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8041
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8031
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8024
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8011
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7968
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7961
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7959
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7932
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7924
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7917
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7910
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7877
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7848
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7836
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7822
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7811
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7807
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7803
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7797
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7796
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7793
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7761
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7756
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7742
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7729
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7723
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7716
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7707
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7702
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7702
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7684
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7667
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7662
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7659
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7644
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7607
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7601
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7595
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7590
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7581
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7565
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7556
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7535
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7526
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7525
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7510
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7506
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7488
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7475
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7474
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7459
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7452
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7451
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7442
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7424
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7423
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7418
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7401
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7393
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7385
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7376
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7361
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7356
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7353
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7353
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7352
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7350
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7343
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7337
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7334
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7314
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7314
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7311
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7309
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7306
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7303
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7292
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7290
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7286
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7286
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7284
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7280
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7275
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7271
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7271
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7264
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7245
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7241
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7213
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7206
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7205
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7205
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7179
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7146
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7141
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7140
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7138
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7120
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7119
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.7113
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7112
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7112
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7102
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7087
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7087
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7075
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7068
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7067
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7043
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7042
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7036
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7030
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7016
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7015
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7009

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