Chaetocochin C - Compound Card

Chaetocochin C

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Chaetocochin C

Structure
Zoomed Structure
  • Family: Fungi - Chaetomiaceae
  • Kingdom: Fungi
  • Class: Alkaloid
Canonical Smiles Clc1c(cccc1Cl)C=C1COc2c(C1=O)cccc2
InChI InChI=1S/C16H10Cl2O2/c17-13-6-3-4-10(15(13)18)8-11-9-20-14-7-2-1-5-12(14)16(11)19/h1-8H,9H2
InChIKey ULJCHPBDDVYXLG-UHFFFAOYSA-N
Formula C16H10Cl2O2
HBA 2
HBD 0
MW 305.16
Rotatable Bonds 1
TPSA 26.3
LogP 4.65
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.06
Exact Mass 304.01
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Chaetomium sp. Chaetomiaceae Fungi 1769349

Showing of synonyms

  • Kabbaj FZ, Lu S, et al. (2015). Bioactive metabolites from Chaetomium aureum: Structure elucidation and inhibition of the Hsp90 machine chaperoning activity. Bioorganic and Medicinal Chemistry,2015,23(1),126-131. [View] [PubMed]
Pubchem: 4559109

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C=C(C2=O)COc(c23)cccc3

Level: 1

Mol. Weight: 305.16 g/mol

Structure

SMILES: O=C1C(=C)COc(c12)cccc2

Level: 0

Mol. Weight: 305.16 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 305.16 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.75
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.79
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.03

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
2.2
Plasma Protein Binding
76.67
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.24
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
2.13
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.77
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.42
Micronucleos
Safe
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
5.36
Rat (Acute)
2.62
Rat (Chronic Oral)
1.65
Fathead Minnow
5.04
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
402.28
Hydration Free Energy
-6.67
Log(D) at pH=7.4
3.97
Log(P)
4.51
Log S
-5.8
Log(Vapor Pressure)
-7.33
Melting Point
112.51
pKa Acid
9.59
pKa Basic
2.85
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9819
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9804
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9764
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9740
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9712
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.9586
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9571
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9439
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9356
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.9348
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9339
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.9321
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.9187
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9133
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9076
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9034
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.9025
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.9010
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8996
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8986
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8974
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8971
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8940
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.8937
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8914
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8893
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8885
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8858
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8855
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8854
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8834
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8822
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8799
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8740
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8728
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8506
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8479
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8411
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8383
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.8340
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8326
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8299
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.8297
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8214
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.8149
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8132
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8131
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8077
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8070
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.8062
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7974
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7969
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7961
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7960
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7957
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 2 0.7944
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7939
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7938
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7935
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7934
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7897
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7868
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7859
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 2 0.7843
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7825
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7814
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7814
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7810
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7801
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7789
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7789
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7787
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7783
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7783
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7775
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7774
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7773
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7767
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7762
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7757
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7750
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7746
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7743
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7736
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7731
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7730
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 2 0.7729
Acyl-homoserine-lactone synthase Q4VSJ8 Q4VSJ8_BURGL Burkholderia glumae 4 0.7725
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7717
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 2 0.7714
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7704
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7698
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7696
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7689
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7684
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7680
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7673
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7665
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7657
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7656
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7654
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7638
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7632
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7630
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7620
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7617
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7615
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7611
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7611
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7606
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7602
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7600
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7598
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 2 0.7598
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7597
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7595
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7595
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.7591
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7591
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7585
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7572
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7566
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7565
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7564
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7556
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7554
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7554
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7550
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7549
Interleukin-1 receptor-associated kinase 4 Q9NWZ3 IRAK4_HUMAN Homo sapiens 3 0.7535
Epoxide hydrolase B P95276 EPHB_MYCTO Mycobacterium tuberculosis 3 0.7533
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7530
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7527
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7527
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7522
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7519
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7513
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7507
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7505
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7505
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7503
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7496
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7493
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7492
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7489
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7487
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7483
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7483
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7482
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7482
Beta-ketoacyl-[acyl-carrier-protein] synthase III Q820T1 FABH_ENTFA Enterococcus faecalis 2 0.7476
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7473
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7470
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7469
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7465
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 3 0.7461
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7458
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7453
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 2 0.7447
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 2 0.7446
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7445
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7445
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 2 0.7441
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7435
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7429
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7428
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 2 0.7428
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7416
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7415
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7415
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 2 0.7412
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7408
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7400
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7399
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7399
Probable flavin-dependent thymidylate synthase O41156 THYX_PBCV1 Paramecium bursaria Chlorella virus 1 3 0.7398
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7397
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7368
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7365
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 3 0.7364
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7364
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7359
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 3 0.7358
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7354
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7348
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 2 0.7347
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7342
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 2 0.7336
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7335
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7335
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7334
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7333
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 2 0.7325
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7320
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7307
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7306
Alanine racemase Q65YW7 Q65YW7_STRLA Streptomyces lavendulae subsp. lavendulae 3 0.7301
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7297
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7296
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7296
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7294
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7292
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7289
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7289
Serine protease 1 P00760 TRY1_BOVIN Bos taurus 3 0.7285
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7284
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7284
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7282
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7279
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7273
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 2 0.7273
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7273
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7272
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7271
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7269
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 2 0.7266
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7265
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 2 0.7262
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7259
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7255
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7244
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7237
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.7236
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7233
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7226
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7226
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7226
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7224
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7223
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7222
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7221
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.7220
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7219
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 2 0.7218
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7217
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7217
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7216
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.7198
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7192
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7190
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7188
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 2 0.7187
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7186
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7182
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 2 0.7179
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.7171
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7166
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7164
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7163
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 2 0.7160
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7159
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7152
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7151
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7149
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 2 0.7149
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7146
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7144
Botulinum neurotoxin type A P0DPI0 BXA1_CLOBO Clostridium botulinum 2 0.7141
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7140
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7137
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7131
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 2 0.7126
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7120
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7118
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7116
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7102
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.7101
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7099
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 2 0.7097
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 2 0.7094
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 2 0.7091
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7080
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7079
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7065
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7065
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7064
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7061
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7055
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7049
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7048
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 2 0.7043
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7036
Cytochrome P450 2C9 P11712 CP2C9_HUMAN Homo sapiens 2 0.7027
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.7023
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 2 0.7023
Hut operon positive regulatory protein P10943 HUTP_BACSU Bacillus subtilis 2 0.7017
Peroxisome proliferator-activated receptor delta Q03181 PPARD_HUMAN Homo sapiens 2 0.7014
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7008
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7003
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7001

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