Xanthenone - Compound Card

Xanthenone

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Xanthenone

Structure
Zoomed Structure
  • Family: Fungi - Chaetomiaceae
  • Kingdom: Fungi
  • Class: Alkaloid
Canonical Smiles O=c1c2ccccc2oc2c1cccc2
InChI InChI=1S/C13H8O2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H
InChIKey JNELGWHKGNBSMD-UHFFFAOYSA-N
Formula C13H8O2
HBA 2
HBD 0
MW 196.2
Rotatable Bonds 0
TPSA 30.21
LogP 2.95
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 15
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 196.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Chaetomium sp. NF00768 Chaetomiaceae Fungi 5149

Showing of synonyms

  • Xu Q.L, Xiao Y.S, et al. (2018). Novel chaetospirolactone and orsellide F from an endophytic fungus Chaetomium sp.. Journal of Asian natural products research, 2018, 20(3), 234-241. [View] [PubMed]
Pubchem: 7020
Chebi: 37647
Nmrshiftdb2: 10016201
Bindingdb: 50155411
CPRiL: 52288
Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 196.2 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.65
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-3.670
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.63

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.310
Plasma Protein Binding
72.97
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.360
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.430
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.760
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.470
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.580
Rat (Acute)
1.860
Rat (Chronic Oral)
1.770
Fathead Minnow
4.650
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
359.480
Hydration Free Energy
-7.690
Log(D) at pH=7.4
2.990
Log(P)
3.24
Log S
-4.22
Log(Vapor Pressure)
-6.01
Melting Point
181.06
pKa Acid
6.61
pKa Basic
2.39
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9753
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.9284
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.9271
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.9176
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.9169
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9145
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.9125
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9078
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8947
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8891
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8583
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8554
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8506
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8467
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8366
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8356
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.8353
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8352
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8173
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.8106
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8087
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8049
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8037
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8016
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8015
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8000
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 3 0.7972
Albumin P02769 ALBU_BOVIN Bos taurus 3 0.7916
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7905
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 3 0.7897
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7897
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7871
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7870
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7857
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7856
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7797
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7789
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7770
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7752
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7740
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7738
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7734
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7731
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 2 0.7714
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7700
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7689
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 2 0.7673
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7662
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7657
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7654
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7643
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 3 0.7620
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7618
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7615
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7611
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7609
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7603
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7599
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7593
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7590
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7587
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7582
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7581
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7578
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7575
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7574
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7571
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7570
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7565
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7563
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7540
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7529
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7528
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7526
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7522
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7516
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 2 0.7511
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 2 0.7511
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7511
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7503
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7502
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7498
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7496
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 2 0.7494
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7492
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 2 0.7483
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 2 0.7473
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 2 0.7464
Aldehyde dehydrogenase, dimeric NADP-preferring P30838 AL3A1_HUMAN Homo sapiens 2 0.7463
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7458
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7447
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 2 0.7445
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7444
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7441
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 2 0.7435
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 2 0.7434
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7430
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7427
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 2 0.7425
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7420
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7417
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7414
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7411
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7405
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7405
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7403
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7403
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7402
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7401
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7400
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 2 0.7400
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7395
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7390
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 2 0.7390
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7386
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 4 0.7382
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 2 0.7370
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7365
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7363
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 2 0.7357
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 2 0.7356
Phospholipase A2, membrane associated P14555 PA2GA_HUMAN Homo sapiens 2 0.7355
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 2 0.7355
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7352
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7350
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7350
Stimulator of interferon genes protein Q3TBT3 STING_MOUSE Mus musculus 2 0.7348
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7346
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7339
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7338
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 2 0.7329
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7328
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7322
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7322
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 2 0.7317
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7307
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 2 0.7305
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7305
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7305
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7302
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 2 0.7301
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7297
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7292
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7287
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.7286
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7285
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7283
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7274
Farnesyl pyrophosphate synthase P14324 FPPS_HUMAN Homo sapiens 2 0.7274
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7270
Thiosulfate reductase Q72LA4 Q72LA4_THET2 Thermus thermophilus 3 0.7261
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7258
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7248
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 2 0.7248
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7230
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 2 0.7228
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7226
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7225
Neutrophil collagenase P22894 MMP8_HUMAN Homo sapiens 2 0.7224
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7218
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7210
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7209
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7206
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 2 0.7205
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7186
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7185
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7176
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7171
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7171
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7165
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 2 0.7162
Biphenyl-2,3-diol 1,2-dioxygenase P47228 BPHC_PARXL Paraburkholderia xenovorans 2 0.7159
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7158
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7152
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7152
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7146
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 2 0.7144
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7140
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7132
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7131
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.7127
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7125
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 2 0.7121
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7117
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7113
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7113
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7107
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7103
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 2 0.7100
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7082
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 2 0.7076
Protoporphyrinogen oxidase, mitochondrial O24164 PPOM_TOBAC Nicotiana tabacum 2 0.7074
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7072
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7072
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 2 0.7070
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 2 0.7067
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7064
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7063
Prostatic acid phosphatase P15309 PPAP_HUMAN Homo sapiens 2 0.7063
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7060
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7059
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 2 0.7055
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7051
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7046
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7044
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.7043
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7041
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7031
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7024
Prostaglandin reductase 3 Q8N4Q0 PTGR3_HUMAN Homo sapiens 2 0.7019
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 2 0.7018
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 2 0.7018
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 2 0.7016
2'-hydroxybiphenyl-2-sulfinate desulfinase P54997 SOXB_RHOSG Rhodococcus sp 2 0.7013
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7013
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7005

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