N-[2-(acetoxy)-2-phenylethyl]-acetamide - Compound Card

N-[2-(acetoxy)-2-phenylethyl]-acetamide

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N-[2-(acetoxy)-2-phenylethyl]-acetamide

Structure
Zoomed Structure
  • Family: Plantae - Chenopodiaceae
  • Kingdom: Plantae
  • Class: Alkaloid
Canonical Smiles CC(=O)OC(c1ccccc1)CNC(=O)C
InChI InChI=1S/C12H15NO3/c1-9(14)13-8-12(16-10(2)15)11-6-4-3-5-7-11/h3-7,12H,8H2,1-2H3,(H,13,14)
InChIKey IRBXSZWDAQBYFF-UHFFFAOYSA-N
Formula C12H15NO3
HBA 3
HBD 1
MW 221.26
Rotatable Bonds 4
TPSA 55.4
LogP 1.43
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 16
Formal Charge 0
Fraction CSP3 0.33
Exact Mass 221.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Haloxylon scoparium Chenopodiaceae Plantae 1665493

Showing of synonyms

  • Lachkar N, Lamchouri F, et al. (2021). Chemical composition, phenolic content and antioxidant capacity of Haloxylon scoparium extracts. Evidence-based complementary and alternative medicine : eCAM, 2021, 2021, 9011168. [View] [PubMed]
Pubchem: 537888

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 221.26 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.38
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-3.96
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.76

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.12
Plasma Protein Binding
24.07
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.37
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.35
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.4
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
4.22
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.93
Rat (Acute)
1.89
Rat (Chronic Oral)
1.99
Fathead Minnow
3.87
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
297.1
Hydration Free Energy
-11.97
Log(D) at pH=7.4
1.1
Log(P)
1.17
Log S
-1.57
Log(Vapor Pressure)
-5.06
Melting Point
100.74
pKa Acid
12.38
pKa Basic
3.97
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.9831
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.9624
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9580
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.9577
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.9499
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.9497
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.9486
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9457
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.9456
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.9419
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.9407
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9385
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9343
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.9338
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9328
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9318
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9318
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.9305
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.9293
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9276
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9275
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9273
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9269
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.9242
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9223
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.9196
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.9192
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.9177
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.9144
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.9127
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9113
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9099
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.9098
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.9097
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.9090
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.9060
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.9050
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.9049
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.9049
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 3 0.9002
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.9001
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8938
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8937
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8924
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8920
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8900
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8895
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8847
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8845
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8842
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8814
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.8777
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8775
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.8768
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8767
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8742
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8721
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8641
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8608
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8520
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8500
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8494
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8459
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8443
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8438
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 3 0.8434
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8423
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.8421
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.8404
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8291
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8288
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8120
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8023
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7961
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7918
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.7910
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7903
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7891
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7876
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7869
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7836
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7814
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 2 0.7805
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7794
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7786
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7760
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7747
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7723
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7710
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7697
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7697
Methionine--tRNA ligase P00959 SYM_ECOLI Escherichia coli 3 0.7695
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7689
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7688
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7683
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7671
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 3 0.7669
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7668
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7667
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7637
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7633
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7621
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7617
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7608
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7602
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7599
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7595
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7583
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7579
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7567
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7550
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7532
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7532
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 3 0.7531
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7525
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7524
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7523
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 2 0.7503
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7493
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7484
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7476
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7469
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7464
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7463
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7460
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7459
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7457
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7456
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7454
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7452
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7450
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7449
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7437
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7435
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7432
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7427
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7427
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7418
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7402
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7401
Genome polyprotein P29991 POLG_DEN27 Dengue virus type 2 3 0.7400
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7391
Mannosylglycerate synthase D0MI02 D0MI02_RHOM4 Rhodothermus marinus 3 0.7388
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7375
Pyruvate:ferredoxin oxidoreductase P94692 PFOR_DESAF Desulfocurvibacter africanus 3 0.7371
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7369
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7366
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 2 0.7366
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7357
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7355
Aminopeptidase A2V759 A2V759_9BACL Aneurinibacillus sp. AM-1 3 0.7351
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 2 0.7351
3-oxoacyl-[acyl-carrier-protein] synthase 1 Q2YQQ9 Q2YQQ9_BRUA2 Brucella abortus 3 0.7342
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7331
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7326
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7323
Receptor-interacting serine/threonine-protein kinase 1 Q13546 RIPK1_HUMAN Homo sapiens 3 0.7322
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7314
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7308
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 2 0.7300
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7295
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7295
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7282
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7279
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7274
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7271
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 3 0.7271
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7269
Uncharacterized protein MJ0489 Q57913 Y489_METJA Methanocaldococcus jannaschii 3 0.7261
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7256
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.7256
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 3 0.7253
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7253
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7247
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7242
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7240
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 2 0.7240
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7239
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7237
Plasmid segregation protein ParM P11904 PARM_ECOLX Escherichia coli 3 0.7226
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7226
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 2 0.7224
DNA adenine methylase P0AEE8 DMA_ECOLI Escherichia coli 3 0.7221
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7219
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7216
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7216
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7212
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7211
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7211
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7211
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7209
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7205
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 2 0.7197
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7194
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7193
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7191
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7190
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7183
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7182
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7182
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7176
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7174
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7164
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7164
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7163
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 2 0.7159
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7157
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7156
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 3 0.7155
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7155
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 2 0.7155
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7152
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7139
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7138
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 3 0.7136
Karilysin D0EM77 KLY_TANFA Tannerella forsythia 2 0.7136
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7133
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7127
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7127
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7121
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7120
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7119
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7118
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7112
Phospholipase A2 P00593 PA21B_BOVIN Bos taurus 2 0.7109
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7103
3-oxoacyl-[acyl-carrier-protein] synthase 2 P0AAI5 FABF_ECOLI Escherichia coli 3 0.7101
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7099
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7093
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7093
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7093
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7090
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7090
Three-prime repair exonuclease 1 Q91XB0 TREX1_MOUSE Mus musculus 2 0.7090
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7089
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7084
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7084
Transitional endoplasmic reticulum ATPase Q01853 TERA_MOUSE Mus musculus 3 0.7075
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7075
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7074
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7071
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 2 0.7071
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7068
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7067
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7066
Mismatch repair endonuclease PMS2 P54278 PMS2_HUMAN Homo sapiens 3 0.7062
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7062
Ribosomal protein S6 kinase alpha-1 Q15418 KS6A1_HUMAN Homo sapiens 3 0.7059
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7056
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7056
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7055
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 2 0.7055
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7041
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7041
Type II methyltransferase M1.MboII P23192 MTM2_MORBO Moraxella bovis 3 0.7040
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7038
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7036
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 3 0.7034
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7019
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7018
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7017
Cytochrome P450 monooxygenase PikC O87605 PIKC_STRVZ Streptomyces venezuelae 2 0.7017
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7015
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7013
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7010
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7006

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