N-(p‐hydroxy phenethyl)-acetate acetamide - Compound Card

N-(p‐hydroxy phenethyl)-acetate acetamide

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N-(p‐hydroxy phenethyl)-acetate acetamide

Structure
Zoomed Structure
  • Family: Plantae - Chenopodiaceae
  • Kingdom: Plantae
  • Class: Alkaloid
Canonical Smiles CC(=O)NCCc1ccc(cc1)OC(=O)C
InChI InChI=1S/C12H15NO3/c1-9(14)13-8-7-11-3-5-12(6-4-11)16-10(2)15/h3-6H,7-8H2,1-2H3,(H,13,14)
InChIKey RNDRBPVTMKQIBA-UHFFFAOYSA-N
Formula C12H15NO3
HBA 3
HBD 1
MW 221.26
Rotatable Bonds 4
TPSA 55.4
LogP 1.29
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 16
Formal Charge 0
Fraction CSP3 0.33
Exact Mass 221.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Haloxylon scoparium Chenopodiaceae Plantae 1665493

Showing of synonyms

  • Lachkar N, Lamchouri F, et al. (2021). Chemical composition, phenolic content and antioxidant capacity of Haloxylon scoparium extracts. Evidence-based complementary and alternative medicine : eCAM, 2021, 2021, 9011168. [View] [PubMed]
Pubchem: 577423

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 221.26 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.45
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.09
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.82

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.28
Plasma Protein Binding
23.63
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.6
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.28
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.4
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.18
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.18
Rat (Acute)
1.94
Rat (Chronic Oral)
1.81
Fathead Minnow
3.84
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
316.67
Hydration Free Energy
-11.93
Log(D) at pH=7.4
0.79
Log(P)
0.86
Log S
-1.54
Log(Vapor Pressure)
-5.12
Melting Point
105.29
pKa Acid
11.52
pKa Basic
6.29
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.9910
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.9718
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9690
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.9640
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9615
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.9610
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9597
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.9588
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.9491
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9478
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.9435
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9423
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9414
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.9377
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.9344
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.9322
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.9311
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9303
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.9300
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.9280
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9272
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.9249
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9223
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9217
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9199
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9161
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9063
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9053
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9046
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9032
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9024
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8905
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8895
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8865
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8862
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.8847
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8828
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.8770
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8643
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8584
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8523
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8439
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.8412
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8411
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8353
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8313
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8306
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 3 0.8237
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8234
Ascorbate-specific PTS system EIIC component P39301 ULAA_ECOLI Escherichia coli 3 0.8187
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8166
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8140
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 3 0.8138
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.8109
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8066
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8063
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8037
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7966
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7958
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7951
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7947
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7898
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7836
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7799
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7794
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7787
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7784
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7776
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7770
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 3 0.7769
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7762
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7754
Adenine DNA glycosylase P83847 MUTY_GEOSE Geobacillus stearothermophilus 3 0.7743
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7733
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7714
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7712
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7712
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7708
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7697
Chromosomal replication initiator protein DnaA P46798 DNAA_THEMA Thermotoga maritima 3 0.7693
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7686
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7679
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7673
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7671
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7666
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7657
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7649
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7647
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7644
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7637
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7632
Vanillyl-alcohol oxidase P56216 VAOX_PENSI Penicillium simplicissimum 3 0.7630
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7624
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7617
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7614
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7606
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7604
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7602
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7601
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7600
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7596
ATP-dependent Clp protease ATP-binding subunit ClpX O25926 CLPX_HELPY Helicobacter pylori 3 0.7587
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7579
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7575
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7562
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7560
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7558
Dihydroneopterin aldolase P9WNC5 FOLB_MYCTU Mycobacterium tuberculosis 4 0.7556
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7546
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7543
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7539
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7533
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7532
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7523
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7522
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7520
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7514
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.7514
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7513
Mismatch repair endonuclease PMS2 P54278 PMS2_HUMAN Homo sapiens 3 0.7508
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7505
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7498
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7497
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7495
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 4 0.7482
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7480
Plasmid partition protein A P07620 PARA_ECOLX Escherichia coli 3 0.7480
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7479
ATP-dependent protease ATPase subunit HslU P43773 HSLU_HAEIN Haemophilus influenzae 3 0.7476
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 3 0.7475
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7473
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7467
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7461
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 2 0.7456
eIF-2-alpha kinase GCN2 P15442 GCN2_YEAST Saccharomyces cerevisiae 3 0.7453
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7453
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7449
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7447
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7445
Eukaryotic translation initiation factor 2 subunit alpha P20459 IF2A_YEAST Saccharomyces cerevisiae 3 0.7440
Mitogen-activated protein kinase kinase kinase 7 O43318 M3K7_HUMAN Homo sapiens 3 0.7431
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.7429
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7428
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7426
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7423
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7417
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7416
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase Q8U0R7 PURP_PYRFU Pyrococcus furiosus 3 0.7414
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7414
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7413
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7412
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7412
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7408
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7408
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7407
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7407
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7405
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7404
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7403
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7403
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7402
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7402
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7401
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7399
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7398
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7397
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.7394
Chaperone protein ClpB Q9RA63 CLPB_THET8 Thermus thermophilus 3 0.7392
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7390
Psp operon transcriptional activator P37344 PSPF_ECOLI Escherichia coli 3 0.7387
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7385
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7382
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7382
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7377
Serine/threonine-protein kinase PLK Q4KMI8 Q4KMI8_DANRE Danio rerio 3 0.7377
Mitogen-activated protein kinase kinase kinase 21 Q5TCX8 M3K21_HUMAN Homo sapiens 3 0.7376
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7373
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7372
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7368
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7364
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7363
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7363
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7362
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7362
Ribosomal protein S6 kinase alpha-1 Q15418 KS6A1_HUMAN Homo sapiens 3 0.7358
Malate synthase G P9WK17 MASZ_MYCTU Mycobacterium tuberculosis 3 0.7357
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7351
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7346
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic Q9FYS3 HGGL_SECCE Secale cereale 3 0.7344
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7344
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7339
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7338
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 3 0.7338
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7334
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7333
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7333
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7333
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7332
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7331
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7329
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7326
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7324
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7323
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7319
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7318
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7318
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7317
Putative aminoglycoside phosphotransferase P9WI99 Y3168_MYCTU Mycobacterium tuberculosis 3 0.7315
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7314
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7313
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7306
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7304
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7303
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7302
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7298
Indole-3-glycerol phosphate synthase P9WFX7 TRPC_MYCTU Mycobacterium tuberculosis 2 0.7297
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7295
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7293
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7291
Serine/threonine-protein kinase RIO1 Q9BRS2 RIOK1_HUMAN Homo sapiens 3 0.7291
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7290
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7289
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7289
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7287
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7283
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7282
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7280
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7278
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7277
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7276
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7276
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7274
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 2 0.7273
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7270
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7270
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7269
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7267
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7266
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7260
Serine/threonine-protein kinase CtkA Q9ZKJ5 CTKA_HELPJ Helicobacter pylori 3 0.7259
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7259
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7258
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7258
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7257
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7256
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7252
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7250
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7249
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7248
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7243
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7241
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7240
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7238
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7237
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7235
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7235
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7232
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7229
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7229
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7228
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7227
Activated CDC42 kinase 1 Q07912 ACK1_HUMAN Homo sapiens 3 0.7223
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7223
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7220
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 2 0.7220
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7216
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7215
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7215
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7209
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7207
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7207
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 2 0.7206
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7201
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 2 0.7195
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7194
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7186
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7186
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7185
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7185
Lethal factor P15917 LEF_BACAN Bacillus anthracis 2 0.7182
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7180
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7178
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic Q1XH05 HGL1B_WHEAT Triticum aestivum 3 0.7174
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7173
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7169
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7169
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7167
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7161
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7158
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7154
Bifunctional purine biosynthesis protein ATIC P31335 PUR9_CHICK Gallus gallus 3 0.7154
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7152
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7150
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7147
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7146
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7146
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7146
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 3 0.7145
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7143
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7142
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7142
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7141
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7140
Uncharacterized protein Q46E79 Q46E79_METBF Methanosarcina barkeri 3 0.7138
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7136
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7136
Three-prime repair exonuclease 1 Q91XB0 TREX1_MOUSE Mus musculus 2 0.7132
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 2 0.7132
Release factor glutamine methyltransferase Q9WYV8 PRMC_THEMA Thermotoga maritima 3 0.7130
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7130
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7125
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7121
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 2 0.7114
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7109
GMP reductase 2 Q9P2T1 GMPR2_HUMAN Homo sapiens 3 0.7107
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.7104
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7098
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7097
Metallophosphoesterase MPPED2 B1WBP0 MPPD2_RAT Rattus norvegicus 3 0.7096
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7095
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7094
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7090
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7089
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7086
Probable enoyl-CoA hydratase EchA8 P9WNN9 ECHA8_MYCTU Mycobacterium tuberculosis 3 0.7085
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7085
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7084
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 2 0.7084
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7082
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7076
Ferrichrome outer membrane transporter/phage receptor P06971 FHUA_ECOLI Escherichia coli 3 0.7074
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7073
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7072
Arginine kinase O15992 KARG_ANTJA Anthopleura japonica 2 0.7072
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7063
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7061
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7056
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7055
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7054
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7051
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7051
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 3 0.7047
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7047
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7042
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7035
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7034
5'-methylthioadenosine nucleosidase Q9T0I8 MTN1_ARATH Arabidopsis thaliana 3 0.7032
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7032
Cytosolic heat shock protein 90 Q7XJ80 Q7XJ80_HORVU Hordeum vulgare 3 0.7030
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 2 0.7029
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 3 0.7025
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7022
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7019
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7012
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7012
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7005
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7004
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7003
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 2 0.7003
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 2 0.7002
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7001

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