3-(2-N-acetyl-N-methylaminoethyl)indole - Compound Card

3-(2-N-acetyl-N-methylaminoethyl)indole

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3-(2-N-acetyl-N-methylaminoethyl)indole

Structure
Zoomed Structure
  • Family: Plantae - Chenopodiaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Indole Alkaloid
Canonical Smiles CC(=O)N(CCc1c[nH]c2c1cccc2)C
InChI InChI=1S/C13H16N2O/c1-10(16)15(2)8-7-11-9-14-13-6-4-3-5-12(11)13/h3-6,9,14H,7-8H2,1-2H3
InChIKey QXARHNVPFNXOJM-UHFFFAOYSA-N
Formula C13H16N2O
HBA 1
HBD 1
MW 216.28
Rotatable Bonds 3
TPSA 36.1
LogP 2.19
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 16
Formal Charge 0
Fraction CSP3 0.31
Exact Mass 216.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Haloxylon scoparium Chenopodiaceae Plantae 1665493

Showing of synonyms

  • Lachkar N, Lamchouri F, et al. (2021). Chemical composition, phenolic content and antioxidant capacity of Haloxylon scoparium extracts. Evidence-based complementary and alternative medicine : eCAM, 2021, 2021, 9011168. [View] [PubMed]
Pubchem: 383154
Chebi: 169440
Nmrshiftdb2: 70092935

No compound-protein relationship available.

Structure

SMILES: c1c[nH]c(c12)cccc2

Level: 0

Mol. Weight: 216.28 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.46
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.32
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.14

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.32
Plasma Protein Binding
21.05
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
12.36
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.35
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.77
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.34
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.37
Rat (Acute)
1.97
Rat (Chronic Oral)
1.84
Fathead Minnow
3.64
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
322.18
Hydration Free Energy
-14.56
Log(D) at pH=7.4
1.53
Log(P)
1.88
Log S
-2.55
Log(Vapor Pressure)
-6.83
Melting Point
121.03
pKa Acid
9.96
pKa Basic
7.58
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9896
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9888
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9868
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9668
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9658
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9645
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9592
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.9588
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.9581
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.9535
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9424
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.9317
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9276
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.9230
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.9209
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9190
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9177
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.9159
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9077
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 3 0.9067
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9035
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.9027
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 3 0.8972
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8943
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8914
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 3 0.8900
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8864
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 3 0.8862
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8679
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8678
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8612
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.8587
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8475
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8444
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8405
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.8360
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.8339
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8311
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.8289
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8247
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8244
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8221
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.8151
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8147
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8138
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8123
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.8100
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8096
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8050
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8035
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8018
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7998
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7970
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7940
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7928
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7923
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 2 0.7880
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7873
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7871
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7869
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7851
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7816
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7813
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7812
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7806
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7792
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7791
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7790
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7788
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7785
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7779
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 2 0.7773
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 2 0.7762
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 2 0.7755
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7738
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7722
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7711
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7710
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7708
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7705
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 2 0.7700
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7699
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 2 0.7684
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7678
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7676
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7670
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 2 0.7670
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7669
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7665
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7661
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7658
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 2 0.7658
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7653
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7646
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7646
Aromatase P11511 CP19A_HUMAN Homo sapiens 2 0.7642
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7641
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7638
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 2 0.7629
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7623
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7621
Envelope glycoprotein gp160 C6G099 C6G099_9HIV1 Human immunodeficiency virus 1 2 0.7618
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7615
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7614
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7610
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7607
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7604
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7602
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7599
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7598
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7596
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7596
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 2 0.7594
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7593
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7581
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7575
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7573
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7573
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7567
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7564
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7560
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7558
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7556
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7555
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7550
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7548
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7543
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7538
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.7537
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7534
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7533
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7533
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7531
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7531
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7523
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7518
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7516
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7511
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7510
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7507
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7499
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7498
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7498
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7493
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7491
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7480
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7478
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7474
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7474
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 2 0.7474
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.7469
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7469
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 2 0.7467
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7467
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7466
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7465
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7464
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7461
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7458
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 2 0.7454
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7449
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7448
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7447
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7447
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7447
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7443
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 2 0.7442
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7440
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7439
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7436
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 2 0.7431
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7430
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 2 0.7429
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7429
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7427
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7421
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7420
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7419
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7419
Albumin P14639 ALBU_SHEEP Ovis aries 2 0.7419
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.7419
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7418
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7413
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7410
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7407
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7407
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7406
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7401
S-methyl-5'-thioadenosine phosphorylase Q97W94 MTAP_SACS2 Saccharolobus solfataricus 3 0.7401
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7401
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7399
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7394
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7394
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7391
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7386
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7380
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7379
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7376
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7375
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7373
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7372
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7369
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7367
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7365
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 2 0.7364
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7364
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7360
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7360
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7360
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7360
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7357
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7356
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7356
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7352
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 2 0.7351
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7351
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7348
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 2 0.7347
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7341
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7341
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7337
Receptor-interacting serine/threonine-protein kinase 1 Q13546 RIPK1_HUMAN Homo sapiens 3 0.7337
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7337
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7336
Poly [ADP-ribose] polymerase 1 P26446 PARP1_CHICK Gallus gallus 3 0.7335
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7330
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 2 0.7327
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7327
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7325
Purine nucleoside phosphorylase DeoD-type 1 Q9KPM0 DEOD1_VIBCH Vibrio cholerae serotype O1 3 0.7324
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7323
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7322
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7319
D-alanine--D-alanine ligase Q5HEB7 DDL_STAAC Staphylococcus aureus 2 0.7312
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7312
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7310
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7310
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7301
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7301
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7299
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7299
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7297
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7295
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7293
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7292
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7292
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7285
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7282
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7279
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 2 0.7275
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7275
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7273
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7272
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7272
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7271
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7268
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7264
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7249
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7247
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7247
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7245
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7245
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7245
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7243
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7242
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 2 0.7242
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7231
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7231
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 2 0.7228
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7224
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 2 0.7224
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7223
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7222
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7220
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7220
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7219
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7219
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7218
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7216
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 2 0.7212
Envelope glycoprotein gp160 Q0ED31 Q0ED31_9HIV1 Human immunodeficiency virus 1 2 0.7210
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7210
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7210
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7209
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7209
Trichodiene synthase P13513 TRI5_FUSSP Fusarium sporotrichioides 2 0.7208
Aromatase P11511 CP19A_HUMAN Homo sapiens 2 0.7206
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7206
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7204
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7204
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7202
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7201
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7197
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7197
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7196
5'-methylthioadenosine nucleosidase / s-adenosylhomocysteine nucleosidase Q8YBL1 Q8YBL1_BRUME Brucella melitensis biotype 1 3 0.7195
Death-associated protein kinase 3 O43293 DAPK3_HUMAN Homo sapiens 2 0.7195
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7194
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7189
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7185
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7184
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7183
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7180
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7180
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7176
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7176
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7175
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7172
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7171
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 2 0.7171
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7171
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7169
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7165
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 2 0.7162
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7158
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7156
Catabolite activator protein C3SQJ7 C3SQJ7_ECOLX Escherichia coli 3 0.7154
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7153
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 2 0.7152
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 3 0.7150
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7146
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7144
Lethal factor P15917 LEF_BACAN Bacillus anthracis 2 0.7141
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7133
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7133
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7131
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 2 0.7129
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 2 0.7127
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic O96693 DXR_PLAFX Plasmodium falciparum 2 0.7127
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7126
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7125
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7122
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7122
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7120
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7116
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7115
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7115
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7112
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7112
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7112
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7108
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7102
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7100
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7099
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7095
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7090
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7084
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7081
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7080
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7079
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7077
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 2 0.7074
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7072
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7070
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7069
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7066
Protein UshA P07024 USHA_ECOLI Escherichia coli 2 0.7062
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 2 0.7060
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7059
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7055
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7048
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7048
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7047
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7045
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7044
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7044
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 2 0.7043
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7041
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 2 0.7034
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7023
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 2 0.7023
Phenylpyruvate C(3)-methyltransferase Q643C8 MPPJ_STRHY Streptomyces hygroscopicus 2 0.7023
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7022
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7021
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7018
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7018
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7017
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7013
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7011
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7007
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7002
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7001
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7001

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