2-propanoic acid-3-(4-methoxyphenyl)-2-ethylhexyl ester - Compound Card

2-propanoic acid-3-(4-methoxyphenyl)-2-ethylhexyl ester

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2-propanoic acid-3-(4-methoxyphenyl)-2-ethylhexyl ester

Structure
Zoomed Structure
  • Family: Plantae - Chenopodiaceae
  • Kingdom: Plantae
  • Class: Fatty Acid
Canonical Smiles CCCCC(COC(=O)/C=C/c1ccc(cc1)OC)CC
InChI InChI=1S/C18H26O3/c1-4-6-7-15(5-2)14-21-18(19)13-10-16-8-11-17(20-3)12-9-16/h8-13,15H,4-7,14H2,1-3H3/b13-10+
InChIKey YBGZDTIWKVFICR-JLHYYAGUSA-N
Formula C18H26O3
HBA 3
HBD 0
MW 290.4
Rotatable Bonds 9
TPSA 35.53
LogP 4.47
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.5
Exact Mass 290.19
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Haloxylon scoparium Chenopodiaceae Plantae 1665493

Showing of synonyms

  • Lachkar N, Lamchouri F, et al. (2021). Chemical composition, phenolic content and antioxidant capacity of Haloxylon scoparium extracts. Evidence-based complementary and alternative medicine : eCAM, 2021, 2021, 9011168. [View] [PubMed]
Pubchem: 5355130
Chebi: 88667
Drugbank: DB09496
CPRiL: 10529
Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 290.4 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.63
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.2
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-3.03

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.69
Plasma Protein Binding
42.79
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.84
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.83
Biodegradation
Toxic
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.92
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.61
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
5.48
Rat (Acute)
1.68
Rat (Chronic Oral)
2.22
Fathead Minnow
4.52
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
339.01
Hydration Free Energy
-5.11
Log(D) at pH=7.4
5.53
Log(P)
6.15
Log S
-5.79
Log(Vapor Pressure)
-4.78
Melting Point
23.03
pKa Acid
11.79
pKa Basic
5.56
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9923
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9618
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.9547
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9479
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9448
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9421
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9291
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9259
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.9251
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9249
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9042
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8991
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8874
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8762
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8675
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8598
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8507
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8480
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.8319
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.8318
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.8097
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.8061
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8056
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8038
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.8007
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7994
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7977
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7970
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7951
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7950
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.7949
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7945
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7934
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.7932
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7920
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7911
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7909
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 2 0.7885
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7870
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7866
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7849
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7844
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7842
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7829
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7825
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 3 0.7812
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7803
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7800
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7780
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7780
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7779
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7770
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7767
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 3 0.7750
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7748
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7728
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7727
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7727
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7720
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7716
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7700
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7671
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7665
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7665
Cartilage oligomeric matrix protein Q9R0G6 COMP_MOUSE Mus musculus 3 0.7654
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7641
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7639
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7631
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7626
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7623
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7622
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7620
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7599
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7588
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7576
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7574
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7558
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7540
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7536
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7519
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7510
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7506
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7504
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.7500
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7493
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7488
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7474
Beta-elicitin cinnamomin P15569 ELIB_PHYCI Phytophthora cinnamomi 3 0.7472
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7466
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7456
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7454
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7453
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7442
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 2 0.7435
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7435
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7430
Methyl-branched lipid omega-hydroxylase P9WPP3 CP124_MYCTU Mycobacterium tuberculosis 3 0.7428
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7427
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 2 0.7426
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7426
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7420
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7409
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7407
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7402
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7401
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7394
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7389
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7385
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7384
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7383
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7383
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7378
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7376
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7375
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7370
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7364
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7363
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7362
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7361
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7358
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7356
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7353
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7352
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7343
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7337
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7335
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7332
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7328
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7325
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7324
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7323
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7313
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7311
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7310
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7310
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7307
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7306
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7301
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7301
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7296
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7292
Sodium/potassium-transporting ATPase subunit alpha Q4H132 Q4H132_SQUAC Squalus acanthias 2 0.7284
Trichodiene synthase P13513 TRI5_FUSSP Fusarium sporotrichioides 2 0.7281
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7275
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7273
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7267
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7266
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7260
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7253
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 2 0.7248
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7248
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7243
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7241
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7240
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.7240
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7239
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7236
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7236
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7234
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7233
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 2 0.7230
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7228
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7223
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7220
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7213
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7210
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7210
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7209
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7205
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7204
Lanosterol 14-alpha demethylase CYP51 P10614 CP51_YEAST Saccharomyces cerevisiae 3 0.7200
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7196
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.7196
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 2 0.7196
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7194
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7190
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7188
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7181
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7181
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7179
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7177
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7174
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7170
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7166
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7163
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7162
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7157
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7155
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7155
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7154
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7154
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7153
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7153
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7150
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 2 0.7145
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7144
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7136
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7135
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7134
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7132
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7129
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7127
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7126
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7123
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 3 0.7122
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7118
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7117
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7116
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7115
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7114
Nuclear receptor ROR-alpha P35398 RORA_HUMAN Homo sapiens 3 0.7106
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 2 0.7104
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7102
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7101
Delta-type opioid receptor P41143 OPRD_HUMAN Homo sapiens 3 0.7097
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7097
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7093
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7087
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7085
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7078
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7076
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7075
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7074
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7066
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7066
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7063
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 2 0.7062
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7059
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7054
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7045
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7032
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7025
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 2 0.7023
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7023
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 2 0.7018
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.7015
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7015
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.7011
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7007
Fatty acid-binding protein, intestinal P02693 FABPI_RAT Rattus norvegicus 3 0.7006
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7005

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