N-acetylphenylalanyl-L-phenylalanine - Compound Card

N-acetylphenylalanyl-L-phenylalanine

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N-acetylphenylalanyl-L-phenylalanine

Structure
Zoomed Structure
  • Family: Plantae - Combretaceae
  • Kingdom: Plantae
  • Class: Peptide
    • Subclass: Peptide
Canonical Smiles C(=O)([C@@H](NC(=O)[C@@H](NC(=O)C)Cc1ccccc1)Cc1ccccc1)O
InChI InChI=1S/C20H22N2O4/c1-14(23)21-17(12-15-8-4-2-5-9-15)19(24)22-18(20(25)26)13-16-10-6-3-7-11-16/h2-11,17-18H,12-13H2,1H3,(H,21,23)(H,22,24)(H,25,26)/t17-,18-/m0/s1
InChIKey RXVJYWBNKIQSSP-ROUUACIJSA-N
Formula C20H22N2O4
HBA 3
HBD 3
MW 354.41
Rotatable Bonds 8
TPSA 95.5
LogP 1.55
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 354.16
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Terminalia laxiflora Combretaceae Plantae 39992

Showing of synonyms

  • Tawfike A.F, Abbott G, et al. (2018). Metabolomic-Guided Isolation of Bioactive Natural Products from Curvularia sp., an Endophytic Fungus of Terminalia laxiflora. Planta medica, 2018, 84(3), 182-190. [View] [PubMed]
Pubchem: 1549486

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CCC(=O)NCCc2ccccc2

Level: 1

Mol. Weight: 354.41 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 354.41 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.45
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.180
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-3.02

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.740
Plasma Protein Binding
106.73
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
1.020
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.790
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.340
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.090
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-1.630
Rat (Acute)
1.880
Rat (Chronic Oral)
2.100
Fathead Minnow
3.990
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
432.060
Hydration Free Energy
-9.620
Log(D) at pH=7.4
-1.120
Log(P)
1.06
Log S
-2.31
Log(Vapor Pressure)
-10.15
Melting Point
180.62
pKa Acid
6.96
pKa Basic
4.71
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 3 0.9628
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.9598
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 3 0.9569
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.9424
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9348
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9280
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.9238
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9232
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.9184
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9157
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.9117
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.9090
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9027
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9015
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 3 0.9014
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9008
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8949
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8918
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8895
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8893
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8864
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8832
Phenylpyruvate C(3)-methyltransferase Q643C8 MPPJ_STRHY Streptomyces hygroscopicus 3 0.8817
Prothrombin P00734 THRB_HUMAN Homo sapiens 4 0.8779
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8777
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8768
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8733
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 4 0.8732
Prothrombin P00734 THRB_HUMAN Homo sapiens 4 0.8722
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.8708
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 3 0.8685
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8640
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 3 0.8548
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8545
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8511
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 3 0.8475
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8468
Snake venom metalloproteinase atrolysin-D P15167 VM1AD_CROAT Crotalus atrox 3 0.8460
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 3 0.8451
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8425
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8365
VioE domain-containing protein Q7NSZ5 Q7NSZ5_CHRVO Chromobacterium violaceum 3 0.8357
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8341
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8333
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8263
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8255
TGF-beta receptor type-1 P36897 TGFR1_HUMAN Homo sapiens 3 0.8238
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8236
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8208
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 3 0.8199
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 3 0.8159
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8156
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8126
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.8109
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.8108
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.8097
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8096
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8091
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8047
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8038
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8030
Pol protein Q000H7 Q000H7_9HIV1 Human immunodeficiency virus 1 3 0.7989
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 3 0.7988
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7970
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7968
Orf1ab polyprotein Q6T1E9 Q6T1E9_CVHSA SARS coronavirus CUHK-L2 3 0.7966
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7954
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7950
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7950
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7904
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7902
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7877
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7862
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7862
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7858
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7855
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7819
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 3 0.7810
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7803
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7792
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 3 0.7787
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 3 0.7784
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7767
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7752
Carboxypeptidase A1 P00730 CBPA1_BOVIN Bos taurus 3 0.7747
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7742
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7738
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7728
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7717
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7710
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7686
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7676
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7675
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7674
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.7673
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7672
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7666
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7665
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7660
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7655
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 3 0.7654
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.7652
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7648
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7645
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7644
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7640
1-deoxy-D-xylulose 5-phosphate reductoisomerase Q9X5F2 DXR_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7625
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7624
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7624
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7622
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7622
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7616
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7615
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7615
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7614
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7603
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7595
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7587
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7586
Ribosomal protein S6 kinase beta-1 P23443 KS6B1_HUMAN Homo sapiens 3 0.7582
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7581
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 2 0.7571
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 3 0.7564
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7561
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7561
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.7559
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7556
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7556
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7548
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7547
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7535
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7534
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7533
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7532
Heat shock 70 kDa protein 1B P0DMV9 HS71B_HUMAN Homo sapiens 3 0.7525
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7518
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7514
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7511
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7501
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7499
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7494
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7485
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7484
Metallophosphoesterase MPPED2 B1WBP0 MPPD2_RAT Rattus norvegicus 3 0.7469
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7466
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7466
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7462
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7460
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7457
Kelch-like ECH-associated protein 1 Q14145 KEAP1_HUMAN Homo sapiens 3 0.7456
Phospholipase A2, membrane associated P14555 PA2GA_HUMAN Homo sapiens 2 0.7453
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7444
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7439
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 5 0.7428
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 4 0.7427
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7427
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7405
Hydroxymethylglutaryl-CoA synthase Q9FD71 HMGCS_ENTFL Enterococcus faecalis 2 0.7393
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 2 0.7387
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7383
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7382
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7377
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7376
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7367
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7366
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7359
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7343
5-formyltetrahydrofolate cyclo-ligase P75430 MTHFS_MYCPN Mycoplasma pneumoniae 2 0.7331
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7326
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7322
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7321
Glutamate receptor ionotropic, kainate 1 P22756 GRIK1_RAT Rattus norvegicus 2 0.7314
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7307
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7304
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 2 0.7302
Cytochrome P450 2C9 P11712 CP2C9_HUMAN Homo sapiens 3 0.7300
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7291
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7288
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 2 0.7288
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7287
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7279
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7279
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7276
Protease O38708 O38708_9HIV1 Human immunodeficiency virus 1 3 0.7275
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7274
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 2 0.7270
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7268
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 2 0.7267
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7258
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7257
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7254
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 2 0.7253
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7248
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7247
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7247
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 2 0.7245
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 3 0.7245
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7243
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7242
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7238
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7237
Cytosol aminopeptidase P00727 AMPL_BOVIN Bos taurus 2 0.7236
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7233
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 2 0.7231
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7222
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7222
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 5 0.7214
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7213
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7208
Signaling protein P83820 P83820_THETH Thermus thermophilus 3 0.7205
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 3 0.7195
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7195
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7193
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7192
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7189
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 3 0.7188
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7187
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7187
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7185
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7183
Serine protease 1 P00760 TRY1_BOVIN Bos taurus 4 0.7182
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7179
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7174
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7171
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7165
Mitogen-activated protein kinase 14 P47811 MK14_MOUSE Mus musculus 3 0.7163
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7160
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7157
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7155
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7150
Ribonucleoside-diphosphate reductase 1 subunit beta P69924 RIR2_ECOLI Escherichia coli 3 0.7149
Tissue factor P13726 TF_HUMAN Homo sapiens 4 0.7145
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7145
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7145
MutT/nudix family protein Q5SJY9 Q5SJY9_THET8 Thermus thermophilus 2 0.7145
Shikimate dehydrogenase (NADP(+)) P56119 AROE_HELPY Helicobacter pylori 3 0.7145
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7144
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7139
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7135
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7134
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7132
Putative snRNP Sm-like protein Q8ZYG5 Q8ZYG5_PYRAE Pyrobaculum aerophilum 2 0.7131
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7127
RNA 2',3'-cyclic phosphodiesterase P37025 THPR_ECOLI Escherichia coli 3 0.7126
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7126
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7123
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7122
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7122
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7120
Interstitial collagenase P03956 MMP1_HUMAN Homo sapiens 3 0.7117
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7115
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.7107
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7103
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 3 0.7099
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7091
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7086
L-lactate dehydrogenase Q27743 LDH_PLAFD Plasmodium falciparum 2 0.7080
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7071
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7071
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7067
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7067
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7065
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7065
ATP-dependent Clp protease ATP-binding subunit ClpX O25926 CLPX_HELPY Helicobacter pylori 3 0.7062
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7060
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.7060
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 4 0.7052
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7052
Ribonucleoside-diphosphate reductase large chain 1 P21524 RIR1_YEAST Saccharomyces cerevisiae 2 0.7048
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7044
ADP-ribosyl-[dinitrogen reductase] hydrolase A7XNI2 A7XNI2_AZOBR Azospirillum brasilense 2 0.7043
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7040
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7038
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7033
Actin, alpha skeletal muscle P68135 ACTS_RABIT Oryctolagus cuniculus 3 0.7030
Uncharacterized protein Q55S71 Q55S71_CRYNB Cryptococcus neoformans var. neoformans serotype D 3 0.7026
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7022
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.7021
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7021
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7021
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7020
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 2 0.7011
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7010
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7009
2'-5'-oligoadenylate synthase 1 P00973 OAS1_HUMAN Homo sapiens 2 0.7006
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7004
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7001

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