4,4′-dihydroxy-3,3′-dimethoxy-2′-prenylstilbene - Compound Card

4,4′-dihydroxy-3,3′-dimethoxy-2′-prenylstilbene

Select a section from the left sidebar

4,4′-dihydroxy-3,3′-dimethoxy-2′-prenylstilbene

Structure
Zoomed Structure
  • Family: Plantae - Cyperaceae
  • Kingdom: Plantae
  • Class: Stilbene
    • Subclass: Prenylated Stilbene
Canonical Smiles COc1cc(O)cc(c1CC=C(C)C)/C=C/c1ccc(c(c1)OC)O
InChI InChI=1S/C21H24O4/c1-14(2)5-9-18-16(12-17(22)13-20(18)24-3)8-6-15-7-10-19(23)21(11-15)25-4/h5-8,10-13,22-23H,9H2,1-4H3/b8-6+
InChIKey GXPDXFORUFTUSZ-SOFGYWHQSA-N
Formula C21H24O4
HBA 4
HBD 2
MW 340.42
Rotatable Bonds 6
TPSA 58.92
LogP 4.79
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 25
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 340.17
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Cyperus conglomeratus Cyperaceae Plantae 1423382

Showing of synonyms

  • Zaki A, Ross S, et al. (2018). New flavans and stilbenes from Cyperus conglomeratus. Phytochemistry Letters, 2018, 26, 159-163. [View]
Pubchem: 66575864

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C=Cc2ccccc2

Level: 1

Mol. Weight: 340.42 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 340.42 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.76
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.660
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.04

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.070
Plasma Protein Binding
50.07
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.820
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.990
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.210
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.460
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.900
Rat (Acute)
1.830
Rat (Chronic Oral)
2.710
Fathead Minnow
5.200
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
423.460
Hydration Free Energy
-9.070
Log(D) at pH=7.4
3.980
Log(P)
5.16
Log S
-5.85
Log(Vapor Pressure)
-7.09
Melting Point
141.16
pKa Acid
10.45
pKa Basic
7.38
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9777
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9539
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9484
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9464
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9454
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9451
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9388
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9287
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9281
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9276
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9175
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9150
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9106
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.9049
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.9034
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9033
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9007
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.9004
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9001
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8938
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8937
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8931
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8929
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8862
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8848
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8831
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8811
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8691
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8661
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8634
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8613
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8576
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8553
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8551
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8528
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8515
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8498
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8494
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.8489
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8461
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.8457
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8412
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.8397
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8358
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8332
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8325
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8318
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.8313
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.8300
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.8293
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8274
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8274
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8271
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 4 0.8262
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8247
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8239
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8232
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8165
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8151
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8134
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8115
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.8109
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8101
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8082
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8070
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8045
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8038
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8034
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.8020
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8020
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7998
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7996
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7983
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7979
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7967
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7932
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7927
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7922
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7905
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7901
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7896
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7896
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7872
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.7862
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7827
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7824
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7795
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7782
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7780
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7763
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7757
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7754
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7753
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7709
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7699
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7695
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7663
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7659
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7657
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7634
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7622
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7616
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7615
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7614
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7610
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7609
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7598
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7582
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7569
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7560
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7557
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7539
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7537
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7536
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7534
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7534
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7532
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7530
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7517
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7512
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7510
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 3 0.7505
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7504
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7497
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7483
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7480
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7480
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7469
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7464
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7459
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7459
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7450
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7449
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 2 0.7444
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7440
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7427
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7427
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7416
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7415
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7413
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7411
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7397
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7378
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7377
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7376
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7372
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7369
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7359
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7350
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7347
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7346
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7341
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7337
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7336
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7331
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7328
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7323
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7323
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7320
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7319
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7317
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7312
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 4 0.7309
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7307
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7298
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7294
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7293
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7291
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7290
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7289
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7279
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7279
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7275
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7245
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7241
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7239
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7237
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7237
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7234
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7232
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7230
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7227
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7227
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7224
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7223
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7217
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7217
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7209
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7201
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7194
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7193
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7193
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7187
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7182
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7179
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7178
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7176
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7166
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7166
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7160
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.7154
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7151
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7149
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7145
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7144
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7143
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7139
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7127
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7109
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7108
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 4 0.7107
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7106
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7101
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7093
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7089
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7085
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7080
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7070
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7069
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7061
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7059
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7056
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7049
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7041
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7038
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7037
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7034
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7028
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7026
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7025
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7021
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7020
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7015
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7011
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7010
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7007
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7004
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7001

Download SDF