Herorensol - Compound Card

Herorensol

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Herorensol

Structure
Zoomed Structure
  • Family: Dioscoreaceae
  • Kingdom: Plantae
  • Class: Phenanthrene
Canonical Smiles COc1cc(OC)c2c(c1)ccc1c2cc(O)c(c1O)O
InChI InChI=1S/C16H14O5/c1-20-9-5-8-3-4-10-11(14(8)13(6-9)21-2)7-12(17)16(19)15(10)18/h3-7,17-19H,1-2H3
InChIKey XBRWZGJRPNVSKC-UHFFFAOYSA-N
Formula C16H14O5
HBA 5
HBD 3
MW 286.28
Rotatable Bonds 2
TPSA 79.15
LogP 3.13
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 286.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Dioscorea communis Dioscoreaceae Plantae 55634

Showing of synonyms

  • Boudjada A, Touil A, et al. (2019). Phenanthrene and dihydrophenanthrene derivatives from Dioscorea communis with anticholinesterase, and antioxidant activities. Natural product research, 2019, 33(22), 3278-3282. [View] [PubMed]
Pubchem: 71597149

No compound-protein relationship available.

Structure

SMILES: c1cccc(c1c23)ccc2cccc3

Level: 0

Mol. Weight: 178.23 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.0
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.910
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.12

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.430
Plasma Protein Binding
76.12
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.210
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.390
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.030
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.740
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.730
Rat (Acute)
2.340
Rat (Chronic Oral)
3.320
Fathead Minnow
4.590
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
445.690
Hydration Free Energy
-11.990
Log(D) at pH=7.4
2.090
Log(P)
3.02
Log S
-4.58
Log(Vapor Pressure)
-6.51
Melting Point
197.5
pKa Acid
7.5
pKa Basic
5.62
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9516
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9475
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9453
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.9414
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9371
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9353
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9342
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9333
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.9282
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9153
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.9140
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9108
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9107
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9101
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.9090
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9053
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9022
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9022
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8970
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8952
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8936
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8935
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8848
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 5 0.8837
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8819
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 5 0.8808
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 4 0.8769
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8767
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8759
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8758
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.8686
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8638
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8627
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.8614
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8501
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8500
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 4 0.8490
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8490
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8490
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.8469
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8465
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8458
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8448
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.8434
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.8434
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8417
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8385
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8315
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8314
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8308
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8289
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8269
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8263
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8254
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8224
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8218
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8206
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8195
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.8188
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8174
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8163
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 4 0.8135
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8066
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8038
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.8007
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8001
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7977
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7970
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7943
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7939
Thymidine phosphorylase P07650 TYPH_ECOLI Escherichia coli 5 0.7938
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7938
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7935
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7934
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7929
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7925
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7909
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7908
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7904
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7900
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7899
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7894
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7871
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7859
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7850
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7849
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7843
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7837
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7831
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7819
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7815
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7775
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7759
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7744
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7736
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7724
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7701
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7696
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7682
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7673
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7659
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 3 0.7642
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7638
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7635
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7607
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7595
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7590
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7590
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7584
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7582
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7578
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7567
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7564
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7559
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7551
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7548
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7524
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7524
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7515
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7513
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7513
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7500
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7485
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7482
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7479
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7475
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7457
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7456
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7426
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7425
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7423
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7410
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7406
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7401
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7397
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7387
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7383
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7370
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7359
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7358
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7357
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7356
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7341
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7339
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7333
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7328
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7325
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7292
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7289
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7283
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7283
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7276
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7260
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7247
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7240
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7232
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7226
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7226
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7216
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7200
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7190
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7183
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7182
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7181
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7176
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7173
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7171
Peptide deformylase 1B, chloroplastic/mitochondrial Q9FUZ2 DEF1B_ARATH Arabidopsis thaliana 3 0.7166
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7156
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7147
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7140
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7134
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7127
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7124
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7115
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7107
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 4 0.7092
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 4 0.7092
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7090
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7085
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7085
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7080
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7070
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7067
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7054
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7053
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7051
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7049
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7049
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7047
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7043
Diguanylate phosphodiesterase A6T8V8 A6T8V8_KLEP7 Klebsiella pneumoniae subsp. pneumoniae 4 0.7041
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7035
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7032
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7029
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7029
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7024
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7022
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 4 0.7008
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7007
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7006
Rho family GTPase C4M4W4 C4M4W4_ENTHI Entamoeba histolytica 4 0.7001

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