Chrysotoxene - Compound Card

Chrysotoxene

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Chrysotoxene

Structure
Zoomed Structure
  • Family: Plantae - Dioscoreaceae
  • Kingdom: Plantae
  • Class: Phenanthrene
Canonical Smiles COc1cc2ccc3c(c2c(c1OC)OC)ccc(c3OC)O
InChI InChI=1S/C18H18O5/c1-20-14-9-10-5-6-12-11(7-8-13(19)16(12)21-2)15(10)18(23-4)17(14)22-3/h5-9,19H,1-4H3
InChIKey JILKBZSAOHQOQD-UHFFFAOYSA-N
Formula C18H18O5
HBA 5
HBD 1
MW 314.34
Rotatable Bonds 4
TPSA 57.15
LogP 3.73
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.22
Exact Mass 314.12
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Dioscorea communis Dioscoreaceae Plantae 55634

Showing of synonyms

  • Boudjada A, Touil A, et al. (2019). Phenanthrene and dihydrophenanthrene derivatives from Dioscorea communis with anticholinesterase, and antioxidant activities. Natural product research, 2019, 33(22), 3278-3282. [View] [PubMed]
Pubchem: 5315859
Nmrshiftdb2: 60080361
CPRiL: 418836
Structure

SMILES: c1cccc(c1c23)ccc2cccc3

Level: 0

Mol. Weight: 314.34 g/mol

Antibutyrylcholinesterase

Absorption

Caco-2 (logPapp)
-4.68
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.580
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.17

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.560
Plasma Protein Binding
71.09
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.710
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.060
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.410
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.490
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.430
Rat (Acute)
2.650
Rat (Chronic Oral)
2.250
Fathead Minnow
5.080
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
433.370
Hydration Free Energy
-8.400
Log(D) at pH=7.4
2.690
Log(P)
3.2
Log S
-4.22
Log(Vapor Pressure)
-6.46
Melting Point
142.69
pKa Acid
9.07
pKa Basic
2.17
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9691
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9568
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9563
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9512
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9432
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9310
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.9247
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9226
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.9142
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9098
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9057
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9055
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9027
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.9004
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8920
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8906
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8894
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8889
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8882
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8864
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8835
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8813
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8786
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8716
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8662
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8652
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 4 0.8648
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8637
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.8624
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8620
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.8615
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8611
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8606
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8594
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8593
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8583
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8567
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8553
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8545
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8528
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8522
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8485
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8477
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8462
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8454
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8441
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8400
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8398
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8380
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8334
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8328
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8299
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8294
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8275
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8222
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8218
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8218
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8197
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.8175
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8138
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8130
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8101
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8091
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8085
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8066
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.8063
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8048
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8012
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7983
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7928
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7926
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 3 0.7890
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7886
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7884
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7884
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7833
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7812
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7807
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7793
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7785
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7777
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7762
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7760
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7757
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7749
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7745
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7726
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7724
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7718
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7707
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7705
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7699
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7689
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7687
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.7680
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7675
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7667
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7647
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7646
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7644
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7621
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7603
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.7576
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.7573
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7569
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7566
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7551
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7546
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7545
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7537
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7523
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7521
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7507
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7498
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7481
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7478
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7475
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7465
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7463
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7457
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7454
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7454
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7452
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7442
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7413
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7410
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7407
Cyclic nucleotide-binding protein B8FW11 B8FW11_DESHD Desulfitobacterium hafniense 3 0.7401
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7399
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7399
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7387
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 3 0.7376
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7375
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7371
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7353
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7351
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7349
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7346
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7345
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7334
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7330
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7326
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7324
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7316
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7315
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7314
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7312
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7307
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7306
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7300
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7299
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7298
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7289
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7287
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7278
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7261
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7259
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7258
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7240
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7233
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7233
Bifunctional protein GAL10 P04397 GAL10_YEAST Saccharomyces cerevisiae 4 0.7224
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7224
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7222
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7218
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7209
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7202
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7200
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7198
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7193
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7186
mitogen-activated protein kinase kinase Q7YTF7 Q7YTF7_PLAF7 Plasmodium falciparum 4 0.7182
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7182
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7172
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7172
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7168
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7161
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7159
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7149
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7145
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7143
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7141
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7131
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7130
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7128
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7122
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7116
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7112
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7108
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7103
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7093
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7085
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7085
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7079
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7079
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7073
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7072
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7061
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7054
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7049
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7049
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7045
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7045
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7037
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7029
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7025
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7023
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7019
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7018
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7014
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7012
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7010
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7008
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7004

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