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2,4,8-trimethoxy-3,7-phenanthrenediol

Family: Plantae - Dioscoreaceae
Kingdom: Plantae
Class: Phenanthrene

Canonical Smiles	COc1cc2ccc3c(c2c(c1O)OC)ccc(c3OC)O
InChI	InChI=1S/C17H16O5/c1-20-13-8-9-4-5-11-10(6-7-12(18)16(11)21-2)14(9)17(22-3)15(13)19/h4-8,18-19H,1-3H3
InChIKey	LLRLPRUFUGWYOL-UHFFFAOYSA-N
Formula	C₁₇H₁₆O₅
HBA	5
HBD	2
MW	300.31
Rotatable Bonds	3
TPSA	68.15
LogP	3.43
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	22
Formal Charge	0
Fraction CSP3	0.18
Exact Mass	300.1
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Dioscorea communis	Dioscoreaceae	Plantae	55634

Showing of synonyms

Boudjada A, Touil A, et al. (2019). Phenanthrene and dihydrophenanthrene derivatives from Dioscorea communis with anticholinesterase, and antioxidant activities. Natural product research, 2019, 33(22), 3278-3282. [View] [PubMed]

Pubchem: 11779542

Cas: 118169-17-8

Nmrshiftdb2: 60076403

Chembl: CHEMBL469491

Comptox: DTXSID70472452

No compound-protein relationship available.

SMILES: c1cccc(c1c23)ccc2cccc3

Level: 0

Mol. Weight: 300.31 g/mol

Anti-acetylcholinesterase

Antibutyrylcholinesterase

Antioxidant

Absorption

Caco-2 (logPapp): -4.55
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.790
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.73

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.480
Plasma Protein Binding: 74.82
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 7.450
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 2.070
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.410
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.140
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 4.120
Rat (Acute): 2.380
Rat (Chronic Oral): 2.730
Fathead Minnow: 4.890
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 428.360
Hydration Free Energy: -9.990
Log(D) at pH=7.4: 2.510
Log(P): 2.81
Log S: -4.43
Log(Vapor Pressure): -6.39
Melting Point: 174.41
pKa Acid: 8.19
pKa Basic: 3.71

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9607
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9492
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9446
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9431
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.9351
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.9309
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.9272
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.9243
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.9187
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.9140
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	4	0.9073
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.9038
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9022
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8976
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8948
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	3	0.8932
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	4	0.8903
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8879
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	4	0.8859
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8844
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	3	0.8809
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.8764
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8716
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8712
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	5	0.8687
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8676
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.8668
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8668
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8662
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8646
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.8645
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.8629
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8622
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	4	0.8612
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	4	0.8609
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	4	0.8609
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8603
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	4	0.8585
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8585
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8583
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8548
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8547
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8533
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.8498
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8498
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8489
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8484
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8470
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.8442
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8438
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8429
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.8419
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.8416
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.8410
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	Q46381	BPHB_COMTE	Comamonas testosteroni	3	0.8403
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8399
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8399
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8340
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8315
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8303
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8287
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8268
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.8262
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.8233
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8215
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8193
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.8191
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8188
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.8187
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8177
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.8175
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8152
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.8148
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8143
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.8134
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.8125
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.8120
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8103
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.8098
Mitogen-activated protein kinase kinase kinase 5	Q99683	M3K5_HUMAN	Homo sapiens	3	0.8084
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.8063
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8058
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.8033
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8017
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8007
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	3	0.7989
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7963
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	4	0.7952
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	3	0.7905
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7889
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7882
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7815
Polymerase acidic protein	Q5EP34	Q5EP34_9INFA	Influenza A virus	4	0.7814
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7814
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7809
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7808
Aldo-keto reductase family 1 member C1	Q04828	AK1C1_HUMAN	Homo sapiens	2	0.7803
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7797
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7765
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	3	0.7764
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7753
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7726
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7721
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.7718
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7714
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7710
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7709
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7706
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.7684
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7683
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7671
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7670
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7654
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7643
Thymidylate kinase	Q9KQI2	KTHY_VIBCH	Vibrio cholerae serotype O1	4	0.7633
Riboflavin biosynthesis protein	Q9WZW1	Q9WZW1_THEMA	Thermotoga maritima	4	0.7632
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.7619
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7617
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7608
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7601
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7598
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7584
Sepiapterin reductase	Q64105	SPRE_MOUSE	Mus musculus	4	0.7577
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	4	0.7574
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7571
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	4	0.7560
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7536
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7531
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7509
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7508
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7508
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	5	0.7486
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7485
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7471
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7450
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7449
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7437
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.7434
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7434
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7433
Eukaryotic translation initiation factor 4E-1	P29557	IF4E1_WHEAT	Triticum aestivum	4	0.7422
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7403
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7395
Tyrosine 3-monooxygenase	P04177	TY3H_RAT	Rattus norvegicus	3	0.7389
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7384
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	2	0.7383
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7375
Cyclic nucleotide-binding protein	B8FW11	B8FW11_DESHD	Desulfitobacterium hafniense	3	0.7372
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7367
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7356
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7351
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7350
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7343
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7343
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	3	0.7341
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7336
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7334
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	4	0.7333
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7327
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7324
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7315
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7313
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7310
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7306
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7304
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7298
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7297
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7297
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	3	0.7295
6,7-dimethyl-8-ribityllumazine synthase	P9WHE9	RISB_MYCTU	Mycobacterium tuberculosis	5	0.7291
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7284
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7272
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7270
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7269
Orotidine 5'-phosphate decarboxylase	O58462	PYRF_PYRHO	Pyrococcus horikoshii	3	0.7262
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	4	0.7258
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7258
Nucleoside phosphorylase, putative	Q57VZ2	Q57VZ2_TRYB2	Trypanosoma brucei brucei	4	0.7253
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7251
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7250
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7248
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7244
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	3	0.7236
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7235
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7229
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7228
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7223
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7212
Diguanylate phosphodiesterase	A6T8V8	A6T8V8_KLEP7	Klebsiella pneumoniae subsp. pneumoniae	4	0.7205
3',5'-cyclic-AMP phosphodiesterase 4A	P27815	PDE4A_HUMAN	Homo sapiens	3	0.7196
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7189
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.7188
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7176
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	3	0.7175
mitogen-activated protein kinase kinase	Q7YTF7	Q7YTF7_PLAF7	Plasmodium falciparum	4	0.7162
Bifunctional protein GAL10	P04397	GAL10_YEAST	Saccharomyces cerevisiae	4	0.7158
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7152
Endoplasmin	P14625	ENPL_HUMAN	Homo sapiens	3	0.7144
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7135
Renin	P00797	RENI_HUMAN	Homo sapiens	2	0.7135
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7121
Histone-lysine N-methyltransferase EHMT2	Q96KQ7	EHMT2_HUMAN	Homo sapiens	3	0.7120
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7117
Putative protease I	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron	2	0.7106
N-acetylhexosamine 1-kinase	E8MF12	NAHK_BIFL2	Bifidobacterium longum subsp. longum	3	0.7098
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7097
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	4	0.7096
Hematopoietic prostaglandin D synthase	O60760	HPGDS_HUMAN	Homo sapiens	3	0.7092
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7088
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	4	0.7085
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7073
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7071
Cyclin-dependent kinase 5	Q00535	CDK5_HUMAN	Homo sapiens	4	0.7065
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	3	0.7065
Catalase-peroxidase	Q3JNW6	KATG_BURP1	Burkholderia pseudomallei	3	0.7065
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7060
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7060
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	4	0.7059
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7059
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7054
Ceramide transfer protein	Q9Y5P4	CERT_HUMAN	Homo sapiens	2	0.7053
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	3	0.7051
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7050
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7049
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7047
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7045
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7044
dTDP-4-dehydrorhamnose 3,5-epimerase	A0A6L7H6N0	A0A1S0QLH9_BACAN	Bacillus anthracis	3	0.7030
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	3	0.7029
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7021
Nucleoprotein	P33469	NCAP_CVHOC	Human coronavirus OC43	3	0.7017
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7011
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7008
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	4	0.7008
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7002

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