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Orchinol

Family: Plantae - Dioscoreaceae
Kingdom: Plantae
Class: Dihydrophenanthrene

Canonical Smiles	COc1cc(OC)c2c(c1)CCc1c2ccc(c1)O
InChI	InChI=1S/C16H16O3/c1-18-13-8-11-4-3-10-7-12(17)5-6-14(10)16(11)15(9-13)19-2/h5-9,17H,3-4H2,1-2H3
InChIKey	HOVUVTNDNLNINP-UHFFFAOYSA-N
Formula	C₁₆H₁₆O₃
HBA	3
HBD	1
MW	256.3
Rotatable Bonds	2
TPSA	38.69
LogP	3.18
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	19
Formal Charge	0
Fraction CSP3	0.25
Exact Mass	256.11
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Dioscorea communis	Dioscoreaceae	Plantae	55634

Showing of synonyms

Boudjada A, Touil A, et al. (2019). Phenanthrene and dihydrophenanthrene derivatives from Dioscorea communis with anticholinesterase, and antioxidant activities. Natural product research, 2019, 33(22), 3278-3282. [View] [PubMed]

Pubchem: 181686

Cas: 41060-20-2

Kegg Ligand: C10272

Chebi: 7779

Nmrshiftdb2: 70008247

CPRiL: 128993

SMILES: c1cccc(c1c23)CCc2cccc3

Level: 0

Mol. Weight: 256.3 g/mol

Antioxidant

Absorption

Caco-2 (logPapp): -4.9
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.440
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.54

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.250
Plasma Protein Binding: 60.98
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.320
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 2.180
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 0.590
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.410
Micronucleos: Safe
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Toxic
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: 4.460
Rat (Acute): 1.870
Rat (Chronic Oral): 2.430
Fathead Minnow: 4.740
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 382.050
Hydration Free Energy: -8.200
Log(D) at pH=7.4: 2.950
Log(P): 3.63
Log S: -4.61
Log(Vapor Pressure): -6.03
Melting Point: 139.42
pKa Acid: 10.85
pKa Basic: 2.96

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9692
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.9681
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.9525
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.9469
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9387
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.9354
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.9318
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.9280
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9277
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.9259
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.9234
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9225
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9167
17-beta-hydroxysteroid dehydrogenase 14	Q9BPX1	DHB14_HUMAN	Homo sapiens	3	0.9161
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	4	0.9134
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.9134
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9111
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9102
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.9092
Fatty acid-binding protein, intestinal	P12104	FABPI_HUMAN	Homo sapiens	3	0.9088
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.9071
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	3	0.9049
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.8998
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8973
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.8943
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	4	0.8880
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.8873
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	Q46381	BPHB_COMTE	Comamonas testosteroni	3	0.8851
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	3	0.8837
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8814
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8803
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8764
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	3	0.8761
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.8751
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8736
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.8724
Catalase-peroxidase 2	O59651	KATG2_HALMA	Haloarcula marismortui	3	0.8722
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.8719
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.8707
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.8698
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8665
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.8649
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.8644
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	3	0.8641
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8603
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8567
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.8553
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.8532
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.8516
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8510
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.8506
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.8481
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8481
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8442
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.8414
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8395
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.8367
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.8253
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8169
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8151
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.8146
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.8135
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.8081
EbrA repressor	Q79SH7	Q79SH7_STRLI	Streptomyces lividans	3	0.8080
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	3	0.8026
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.8012
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8010
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.7967
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7956
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	3	0.7955
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7935
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.7930
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.7903
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7890
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7873
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7871
Alcohol dehydrogenase 1C	P00326	ADH1G_HUMAN	Homo sapiens	3	0.7865
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7854
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7854
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7834
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7827
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7808
Bifunctional dihydrofolate reductase-thymidylate synthase	A7UD81	A7UD81_PLAFA	Plasmodium falciparum	3	0.7797
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7794
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7792
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7780
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7768
Bifunctional dihydrofolate reductase-thymidylate synthase	D9N170	D9N170_PLAFA	Plasmodium falciparum	3	0.7766
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	3	0.7760
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.7759
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7754
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7753
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7745
Beta-2 adrenergic receptor	P07550	ADRB2_HUMAN	Homo sapiens	2	0.7736
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7718
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	3	0.7715
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7707
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7706
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	3	0.7698
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.7697
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7695
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7694
Aldo-keto reductase family 1 member C1	Q04828	AK1C1_HUMAN	Homo sapiens	2	0.7680
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	2	0.7669
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	4	0.7652
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7650
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7641
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7624
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7623
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7619
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7616
Renin	P00797	RENI_HUMAN	Homo sapiens	2	0.7616
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7613
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.7608
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.7608
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7594
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7582
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7580
Thymidylate kinase	Q9HZN8	KTHY_PSEAE	Pseudomonas aeruginosa	3	0.7571
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7565
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	3	0.7539
Putative protease I	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron	2	0.7538
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7530
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7527
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	3	0.7527
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7524
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	3	0.7522
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	3	0.7515
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7494
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7492
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7485
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7472
Protoporphyrinogen oxidase, mitochondrial	O24164	PPOM_TOBAC	Nicotiana tabacum	2	0.7469
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7459
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	Q46381	BPHB_COMTE	Comamonas testosteroni	3	0.7458
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	2	0.7447
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	2	0.7444
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.7442
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	2	0.7436
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.7435
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7430
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	3	0.7424
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7424
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7422
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7421
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7420
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7416
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7414
Probable esterase KAI2	Q9SZU7	KAI2_ARATH	Arabidopsis thaliana	3	0.7414
Endoplasmin	P14625	ENPL_HUMAN	Homo sapiens	3	0.7408
Estrogen receptor beta	Q62986	ESR2_RAT	Rattus norvegicus	3	0.7406
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7405
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7403
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7403
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7403
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7395
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	3	0.7390
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7386
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	3	0.7382
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.7382
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	2	0.7364
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7363
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7357
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	3	0.7355
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7343
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7340
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7337
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7337
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7336
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7327
Biphenyl-2,3-diol 1,2-dioxygenase	P47228	BPHC_PARXL	Paraburkholderia xenovorans	3	0.7322
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7318
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7315
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7315
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7309
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7308
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	3	0.7303
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7303
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7301
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7292
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7292
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7290
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	3	0.7287
Enoyl-ACP reductase	Q9BJJ9	Q9BJJ9_PLAFA	Plasmodium falciparum	3	0.7280
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7277
Ketimine reductase mu-crystallin	O54983	CRYM_MOUSE	Mus musculus	2	0.7274
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	4	0.7270
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	2	0.7268
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7264
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7261
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7260
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7248
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	2	0.7247
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7246
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7244
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7243
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7242
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7238
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7234
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7232
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	2	0.7231
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	3	0.7229
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7220
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7218
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7218
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7215
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7193
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7192
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7190
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7189
Farnesyl pyrophosphate synthase	P14324	FPPS_HUMAN	Homo sapiens	2	0.7188
Nucleoprotein	P33469	NCAP_CVHOC	Human coronavirus OC43	3	0.7187
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7172
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7171
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7169
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7164
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7159
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7158
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7153
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7153
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7153
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	2	0.7149
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7144
IAG-nucleoside hydrolase	Q9GPQ4	Q9GPQ4_TRYVI	Trypanosoma vivax	3	0.7143
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7134
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7131
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	2	0.7127
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7125
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7121
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7118
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	2	0.7116
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7116
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7108
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7104
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7098
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7094
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.7090
Enoyl-ACP reductase	Q9BJJ9	Q9BJJ9_PLAFA	Plasmodium falciparum	2	0.7086
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7083
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	2	0.7081
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7075
Tryptophan synthase alpha chain	P00929	TRPA_SALTY	Salmonella typhimurium	3	0.7070
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7068
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	3	0.7060
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7059
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.7056
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7055
Oxygen-insensitive NAD(P)H nitroreductase	P38489	NFSB_ECOLI	Escherichia coli	3	0.7037
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7035
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7032
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7028
Thymidine phosphorylase	P07650	TYPH_ECOLI	Escherichia coli	4	0.7027
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7025
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7023
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	2	0.7021
Cytochrome P450 130	P9WPN5	CP130_MYCTU	Mycobacterium tuberculosis	2	0.7020
Hematopoietic prostaglandin D synthase	O60760	HPGDS_HUMAN	Homo sapiens	2	0.7018
Exotoxin A	P11439	TOXA_PSEAE	Pseudomonas aeruginosa	3	0.7016
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7006
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7001
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7001

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