Lusianthridin - Compound Card

Lusianthridin

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Lusianthridin

Structure
Zoomed Structure
  • Family: Plantae - Dioscoreaceae
  • Kingdom: Plantae
  • Class: Dihydrophenanthrene
Canonical Smiles COc1cc(O)c2c(c1)CCc1c2ccc(c1)O
InChI InChI=1S/C15H14O3/c1-18-12-7-10-3-2-9-6-11(16)4-5-13(9)15(10)14(17)8-12/h4-8,16-17H,2-3H2,1H3
InChIKey RDKDIPDDUFMMMT-UHFFFAOYSA-N
Formula C15H14O3
HBA 3
HBD 2
MW 242.27
Rotatable Bonds 1
TPSA 49.69
LogP 2.87
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 18
Formal Charge 0
Fraction CSP3 0.2
Exact Mass 242.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Dioscorea communis Dioscoreaceae Plantae 55634

Showing of synonyms

  • Boudjada A, Touil A, et al. (2019). Phenanthrene and dihydrophenanthrene derivatives from Dioscorea communis with anticholinesterase, and antioxidant activities. Natural product research, 2019, 33(22), 3278-3282. [View] [PubMed]
Pubchem: 442702
Kegg Ligand: C10257
Chebi: 28678
Nmrshiftdb2: 60021906
Bindingdb: 246496
CPRiL: 447212
Structure

SMILES: c1cccc(c1c23)CCc2cccc3

Level: 0

Mol. Weight: 242.27 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.84
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.480
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.47

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.060
Plasma Protein Binding
57.58
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.830
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.770
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.380
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.640
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.400
Rat (Acute)
1.910
Rat (Chronic Oral)
2.710
Fathead Minnow
4.500
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
373.420
Hydration Free Energy
-8.480
Log(D) at pH=7.4
2.820
Log(P)
2.87
Log S
-4.32
Log(Vapor Pressure)
-6.15
Melting Point
196.07
pKa Acid
9.8
pKa Basic
5.35
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9575
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.9463
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9455
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9423
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9405
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9301
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9298
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.9227
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9198
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9194
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9186
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9174
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9152
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.9075
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.9071
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9068
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.9066
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.9065
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9061
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9009
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.9002
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8986
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8984
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8950
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8942
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8939
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8934
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8918
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8909
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.8907
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.8902
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8890
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8884
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8874
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.8874
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.8856
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8850
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8823
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8792
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8760
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.8752
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.8747
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8721
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8720
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8708
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 4 0.8688
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8685
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8621
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8611
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8587
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.8584
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8578
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8570
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8519
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8490
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8454
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.8443
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8439
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8437
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8405
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8388
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8348
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8343
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8337
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8327
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8318
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8302
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8302
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8264
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8199
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8191
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.8122
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8118
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8080
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.8044
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8006
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7966
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7916
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7894
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7887
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7882
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7874
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7863
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7839
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7823
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7820
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7818
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7775
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7769
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7761
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7755
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7750
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7744
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7741
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7738
Renin P00797 RENI_HUMAN Homo sapiens 3 0.7736
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7724
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7701
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7694
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7681
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7670
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7667
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7659
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7655
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7649
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7638
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7636
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7635
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7623
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7622
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.7621
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7619
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7618
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7605
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7595
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7588
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 4 0.7586
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 3 0.7581
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7580
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7576
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7565
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7555
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 3 0.7543
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 3 0.7540
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7540
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7534
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7531
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7527
Bifunctional dihydrofolate reductase-thymidylate synthase D9N170 D9N170_PLAFA Plasmodium falciparum 3 0.7523
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7518
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7516
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7509
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7494
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7492
Protoporphyrinogen oxidase, mitochondrial O24164 PPOM_TOBAC Nicotiana tabacum 2 0.7492
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 3 0.7492
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7483
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7481
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7477
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7473
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.7461
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.7455
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7454
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7452
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7450
Pyruvate dehydrogenase [ubiquinone] P07003 POXB_ECOLI Escherichia coli 3 0.7447
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7447
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7442
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7440
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7439
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7434
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7424
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.7423
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7421
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7419
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7410
Calmodulin-1 P0DP29 CALM1_RAT Rattus norvegicus 3 0.7407
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7405
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7394
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7392
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7390
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7389
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7385
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 2 0.7382
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7381
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7380
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7377
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7368
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7367
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7365
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7357
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7356
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7349
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7345
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7340
Biphenyl-2,3-diol 1,2-dioxygenase P47228 BPHC_PARXL Paraburkholderia xenovorans 3 0.7338
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7336
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7336
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7327
Thymidylate kinase Q9HZN8 KTHY_PSEAE Pseudomonas aeruginosa 3 0.7321
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7318
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7313
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7305
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7297
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7297
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7291
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7281
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7279
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7279
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7279
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7277
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7274
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7274
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7272
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7272
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7262
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7257
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 4 0.7253
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7250
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.7250
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7249
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7246
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7236
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7211
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7210
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7209
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7207
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7202
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7199
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7183
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7183
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7178
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7171
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7168
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7164
Thiamine-binding periplasmic protein P31550 THIB_ECOLI Escherichia coli 3 0.7159
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7157
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7156
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7156
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7147
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7140
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7132
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7131
Estrogen receptor beta Q62986 ESR2_RAT Rattus norvegicus 3 0.7125
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7117
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7113
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7110
Calmodulin-like domain protein kinase Q3HNM4 Q3HNM4_EIMTE Eimeria tenella 3 0.7097
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7096
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7096
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7087
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7086
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 2 0.7084
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7080
GTPase IMAP family member 2 Q9UG22 GIMA2_HUMAN Homo sapiens 3 0.7064
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7056
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7053
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7043
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7038
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7038
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7037
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7036
Renin P00797 RENI_HUMAN Homo sapiens 4 0.7033
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.7027
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7027
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7014
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7011
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7003

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