(3R)-7-hydroxy-3',4'-methylenedioxyhomoisoflavan - Compound Card

(3R)-7-hydroxy-3',4'-methylenedioxyhomoisoflavan

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(3R)-7-hydroxy-3',4'-methylenedioxyhomoisoflavan

Structure
Zoomed Structure
  • Family: Plantae - Dracaenaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavan
Canonical Smiles Oc1ccc2c(c1)OC[C@@H](C2)Cc1ccc2c(c1)OCO2
InChI InChI=1S/C17H16O4/c18-14-3-2-13-6-12(9-19-16(13)8-14)5-11-1-4-15-17(7-11)21-10-20-15/h1-4,7-8,12,18H,5-6,9-10H2/t12-/m1/s1
InChIKey FCAZVAZHPLNPBB-GFCCVEGCSA-N
Formula C17H16O4
HBA 4
HBD 1
MW 284.31
Rotatable Bonds 2
TPSA 47.92
LogP 2.91
Number Rings 4
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.29
Exact Mass 284.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Dracaena cinnabari Dracaenaceae Plantae 1142948

Showing of synonyms

  • Helal I.E, Elsbaey M, et al. (2022). A new homoisoflavan from Dracaena cinnabari Balf. f. resin: a-glucosidase and COX-II inhibitory activity. Natural product research, 2022, 36(5), 1224-1229. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: O1COc(c12)ccc(c2)CC(C3)COc(c34)cccc4

Level: 1

Mol. Weight: 284.31 g/mol

Structure

SMILES: C1CCOc(c12)cccc2

Level: 0

Mol. Weight: 284.31 g/mol

Structure

SMILES: O1COc(c12)cccc2

Level: 0

Mol. Weight: 284.31 g/mol

Anti-alpha-glucosidase

Absorption

Caco-2 (logPapp)
-4.93
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.660
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.32

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.220
Plasma Protein Binding
84.42
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
12.220
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.610
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.050
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
6.080
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.630
Rat (Acute)
1.820
Rat (Chronic Oral)
1.340
Fathead Minnow
4.510
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
413.230
Hydration Free Energy
-8.400
Log(D) at pH=7.4
3.790
Log(P)
3.8
Log S
-3.88
Log(Vapor Pressure)
-8.13
Melting Point
125.97
pKa Acid
10.01
pKa Basic
4.93
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9780
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9762
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9653
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9634
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9584
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.9566
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.9556
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9531
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9498
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.9466
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.9446
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9428
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9364
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9342
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9320
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9314
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.9310
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9296
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9256
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9247
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9244
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9244
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 4 0.9237
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9196
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9194
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9181
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9170
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 3 0.9151
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9124
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9118
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9117
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.9083
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9074
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9058
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.9057
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9034
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.9017
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9016
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8997
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8995
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.8992
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8982
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8972
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8970
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8964
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8961
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8957
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8954
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.8928
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.8918
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8915
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8905
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8890
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8885
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.8872
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8865
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8863
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8863
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8859
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8854
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8851
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8830
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8827
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.8818
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8801
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8789
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8776
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8775
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8772
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.8771
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8771
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8769
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8769
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8755
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8751
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8747
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 4 0.8704
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8692
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8691
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8691
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8679
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8675
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8673
Endochitinase B1 Q873X9 CHIB1_ASPFM Aspergillus fumigatus 4 0.8660
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8652
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.8649
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8644
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8615
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8615
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8610
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8599
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8597
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8583
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8574
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8567
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 4 0.8565
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8550
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8550
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8547
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8546
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8537
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8536
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.8533
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8519
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.8503
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8494
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8492
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8488
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8464
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8462
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.8445
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8441
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8441
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8438
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8432
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 4 0.8428
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.8424
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8409
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8401
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8401
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8397
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8391
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.8373
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8372
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.8353
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8327
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8326
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 3 0.8324
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8317
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.8295
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8281
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8279
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8277
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8272
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8271
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8258
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.8249
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8239
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8227
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8211
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8209
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.8193
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.8176
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8129
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 3 0.8129
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 5 0.8126
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.8121
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8118
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8117
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 4 0.8110
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8106
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8101
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8098
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8098
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8098
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.8093
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8092
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.8087
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.8085
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8084
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8072
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.8060
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8054
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8041
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8035
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 4 0.8033
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8014
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.8004
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7993
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7992
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7991
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7986
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7983
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7980
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7964
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7954
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7943
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7939
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7938
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7938
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7937
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7936
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7935
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7927
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7919
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7919
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7916
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7913
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7906
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7895
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7891
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7872
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7851
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7849
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7843
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7841
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7834
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7825
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7821
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7819
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7812
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7806
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 4 0.7798
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7796
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7785
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7785
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7769
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.7767
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7756
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7753
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7752
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7739
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7735
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7735
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7728
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7717
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7714
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7702
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7695
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7695
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7688
Bilin-binding protein P09464 BBP_PIEBR Pieris brassicae 4 0.7677
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7677
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7673
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7664
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7661
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7661
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7659
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7651
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7651
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7651
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7646
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7644
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7641
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7640
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7635
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7631
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7629
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7628
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7625
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7623
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7622
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7622
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7621
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7620
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7615
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7610
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7596
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7591
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7587
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7582
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7582
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7574
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7567
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7565
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7564
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7563
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7562
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7558
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7553
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7552
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7542
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7536
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7535
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7531
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7526
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7522
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7522
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7513
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7512
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7511
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7509
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7508
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7508
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7504
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7504
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7499
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7495
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7492
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7491
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7489
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7487
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7482
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7482
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8ZMF7 ISPF_SALTY Salmonella typhimurium 3 0.7481
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7480
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7475
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7474
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7472
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7469
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7462
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7462
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.7457
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7454
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7451
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7449
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7448
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7447
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7447
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7444
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7443
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7442
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7442
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7440
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7440
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7433
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7433
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7425
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7420
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7418
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7416
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7416
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7414
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7411
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7405
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7402
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7401
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7398
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7398
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7397
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7397
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7393
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7391
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7390
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7390
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7388
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7388
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7385
Estrogen receptor beta Q62986 ESR2_RAT Rattus norvegicus 4 0.7380
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7380
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7377
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7377
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7372
Bifunctional dihydrofolate reductase-thymidylate synthase Q07422 DRTS_TOXGO Toxoplasma gondii 3 0.7371
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 3 0.7366
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7364
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7361
Rac-like GTP-binding protein ARAC7 O82480 RAC7_ARATH Arabidopsis thaliana 3 0.7355
Aldo-keto reductase family 1 member C21 Q91WR5 AK1CL_MOUSE Mus musculus 4 0.7353
Putative N-acetyl glucosaminyl transferase Q6U8B0 Q6U8B0_RAOTE Raoultella terrigena 3 0.7351
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7349
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7347
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7342
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7342
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7333
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7331
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7329
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7326
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7326
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7325
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7323
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7322
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7320
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7319
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7317
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7316
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 4 0.7315
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7315
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7315
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7313
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7310
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7310
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7307
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7302
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7300
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7300
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7296
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7294
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7282
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7281
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7279
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7275
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7274
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7271
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7270
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7269
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7267
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.7266
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7265
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7261
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7261
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7256
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7254
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7252
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7250
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7250
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7248
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7247
Thyroid hormone receptor alpha P04625 THA_CHICK Gallus gallus 3 0.7244
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7244
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7243
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7241
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7239
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7236
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8RQP5 ISPF_THET8 Thermus thermophilus 3 0.7229
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7226
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7223
HAP protein Q8IM15 Q8IM15_PLAF7 Plasmodium falciparum 3 0.7222
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7222
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7218
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7214
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7213
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7210
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7207
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7206
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7201
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7200
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7199
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7199
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7196
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7196
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7194
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7192
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7189
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7185
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7183
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7183
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7166
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7166
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7166
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7163
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7162
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7162
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7158
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7152
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7149
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7148
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7147
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7137
Putative pteridine reductase 2 Q8I814 Q8I814_TRYCR Trypanosoma cruzi 4 0.7132
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7130
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7126
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7124
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7121
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7120
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7120
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7119
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7119
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7116
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7113
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7111
Phytohormone-binding protein G7J032 PHBP_MEDTR Medicago truncatula 4 0.7109
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7109
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7107
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7105
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7104
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7102
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7097
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7094
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7091
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7089
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7088
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7088
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7085
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7084
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7084
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7083
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7078
Transthyretin P02766 TTHY_HUMAN Homo sapiens 3 0.7076
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7076
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7076
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7075
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7074
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7074
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7073
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7065
Estrogen receptor beta Q62986 ESR2_RAT Rattus norvegicus 3 0.7064
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 2 0.7062
Cytidylate kinase Q5SL35 KCY_THET8 Thermus thermophilus 3 0.7061
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7060
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7059
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7058
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7053
Poly [ADP-ribose] polymerase 1 P26446 PARP1_CHICK Gallus gallus 3 0.7049
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7046
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7046
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7044
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7043
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.7042
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7041
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7041
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7040
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7040
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7040
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7037
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7036
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7036
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7035
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7035
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7033
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7033
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7032
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7032
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7030
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7025
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7025
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7023
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7023
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7021
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7020
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7018
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7013
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7011
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7009
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7007
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7007
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7004
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7004
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7003
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7002

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