7,4'-dihydroxy-3'-methoxyhomoisoflavan - Compound Card

7,4'-dihydroxy-3'-methoxyhomoisoflavan

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7,4'-dihydroxy-3'-methoxyhomoisoflavan

Structure
Zoomed Structure
  • Family: Plantae - Dracaenaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavan
Canonical Smiles COc1cc(ccc1O)C[C@H]1COc2c(C1)ccc(c2)O
InChI InChI=1S/C17H18O4/c1-20-17-8-11(2-5-15(17)19)6-12-7-13-3-4-14(18)9-16(13)21-10-12/h2-5,8-9,12,18-19H,6-7,10H2,1H3/t12-/m1/s1
InChIKey VPBUFBPXQYLUKE-GFCCVEGCSA-N
Formula C17H18O4
HBA 4
HBD 2
MW 286.33
Rotatable Bonds 3
TPSA 58.92
LogP 2.9
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.29
Exact Mass 286.12
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Dracaena cinnabari Dracaenaceae Plantae 1142948

Showing of synonyms

  • Helal I.E, Elsbaey M, et al. (2022). A new homoisoflavan from Dracaena cinnabari Balf. f. resin: a-glucosidase and COX-II inhibitory activity. Natural product research, 2022, 36(5), 1224-1229. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CC(C2)COc(c23)cccc3

Level: 1

Mol. Weight: 286.33 g/mol

Structure

SMILES: C1CCOc(c12)cccc2

Level: 0

Mol. Weight: 286.33 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 286.33 g/mol

Anti-alpha-glucosidase

Absorption

Caco-2 (logPapp)
-4.82
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.600
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.52

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.000
Plasma Protein Binding
76.65
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.720
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.730
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.880
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
4.940
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.420
Rat (Acute)
1.750
Rat (Chronic Oral)
2.290
Fathead Minnow
4.330
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
394.980
Hydration Free Energy
-8.450
Log(D) at pH=7.4
3.420
Log(P)
2.75
Log S
-3.85
Log(Vapor Pressure)
-7.17
Melting Point
148.67
pKa Acid
9.77
pKa Basic
5.71
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9777
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9769
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9580
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9566
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9507
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9422
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9396
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9369
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9364
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.9355
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9331
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9328
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.9325
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9299
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.9291
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.9283
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.9256
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9252
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9240
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.9235
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9233
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9218
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9216
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9172
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9156
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 4 0.9148
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9144
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.9133
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9107
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9098
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.9096
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.9068
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9062
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9057
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.9010
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.9007
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8995
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.8981
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8977
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8937
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8932
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.8931
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8927
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8924
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8912
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8904
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.8898
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8897
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8873
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 3 0.8870
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8867
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8861
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8854
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8851
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8836
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.8821
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8802
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.8799
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8798
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8797
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.8796
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8784
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8782
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8781
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8779
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8778
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8776
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8772
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8772
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8771
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8766
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8763
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8753
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8733
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8726
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8715
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8687
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8685
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8680
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8679
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8673
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8664
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8653
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8651
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8646
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8635
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8621
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.8610
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8610
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8609
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8606
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8604
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8602
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8598
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8584
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8574
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8574
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8572
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8561
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8551
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8548
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8548
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8537
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.8534
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8528
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8527
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8525
Endochitinase B1 Q873X9 CHIB1_ASPFM Aspergillus fumigatus 4 0.8516
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8516
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8512
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.8503
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8503
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8501
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8497
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8491
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.8473
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8471
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8461
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8456
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8454
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 4 0.8452
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8452
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8450
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8449
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8449
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8440
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 3 0.8437
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8428
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8419
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8408
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8402
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 4 0.8399
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 4 0.8392
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8390
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 4 0.8381
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8379
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8369
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.8366
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8365
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8361
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8351
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8350
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8347
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8342
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8338
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8337
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8332
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8330
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8330
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8327
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.8326
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8325
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8317
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8308
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8306
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8299
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8288
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 3 0.8274
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8266
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8263
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8262
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8262
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8260
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.8255
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8254
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8244
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.8241
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8240
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8240
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8239
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8219
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.8205
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8202
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8200
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8197
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8194
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8192
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8178
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8172
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.8168
Androgen receptor P19091 ANDR_MOUSE Mus musculus 4 0.8163
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8161
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8152
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8146
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.8144
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8141
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8123
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.8121
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.8116
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 4 0.8109
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8108
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8105
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8099
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.8088
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8085
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.8078
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8074
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.8071
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.8070
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8065
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8058
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8055
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 4 0.8052
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 5 0.8048
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 4 0.8040
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8038
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8038
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 5 0.8031
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8015
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8008
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8006
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7999
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7996
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7991
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7989
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.7984
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7980
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7971
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7967
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7966
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7957
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7956
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7948
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7947
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7943
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7940
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7934
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7934
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7933
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7932
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7932
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7931
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7929
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7924
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7919
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.7919
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7915
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7908
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7882
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7879
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7878
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7876
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7876
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7875
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7874
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7868
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7868
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7867
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7864
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7863
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7853
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7844
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7843
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7839
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7835
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7831
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7814
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7810
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7806
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7801
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7797
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7796
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7795
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7792
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 3 0.7791
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7790
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7779
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7776
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7773
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7772
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7771
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 4 0.7764
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7758
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 4 0.7752
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7751
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7750
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7749
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7747
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 4 0.7745
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7742
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7742
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7739
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7738
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7736
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7733
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7723
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7722
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7720
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7716
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7716
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 5 0.7708
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7702
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7701
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7699
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7697
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7697
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7696
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.7696
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7692
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7676
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7675
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7675
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7674
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7673
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7672
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 4 0.7669
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7664
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.7653
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7650
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Q9UL51 HCN2_HUMAN Homo sapiens 4 0.7649
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7648
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7644
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7639
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7638
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7633
Bilin-binding protein P09464 BBP_PIEBR Pieris brassicae 4 0.7632
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7625
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7611
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7607
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7605
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7604
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7598
Aldo-keto reductase family 1 member C21 Q91WR5 AK1CL_MOUSE Mus musculus 4 0.7597
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.7595
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7594
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7584
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7579
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7578
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7576
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.7575
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7572
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7555
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7555
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7554
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7554
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7551
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7550
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7543
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7540
Transthyretin P02766 TTHY_HUMAN Homo sapiens 3 0.7539
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7539
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7535
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7527
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7527
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 4 0.7526
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7522
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7521
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7514
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7513
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7511
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7504
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7502
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7497
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7496
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7491
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 5 0.7488
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7484
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7483
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7481
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 4 0.7480
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8ZMF7 ISPF_SALTY Salmonella typhimurium 3 0.7480
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7479
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7478
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7478
Sulfotransferase 1E1 P49891 ST1E1_MOUSE Mus musculus 4 0.7477
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7477
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7472
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7466
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7459
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7452
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7442
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7442
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7432
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7430
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7420
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7420
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7420
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7417
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7416
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7416
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7413
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7411
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7410
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7410
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7409
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7406
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7406
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7404
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7401
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7400
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7398
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7394
Estrogen receptor beta Q62986 ESR2_RAT Rattus norvegicus 4 0.7392
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7387
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7382
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7378
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7378
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7377
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7371
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7369
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7363
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7363
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7354
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7352
Putative N-acetyl glucosaminyl transferase Q6U8B0 Q6U8B0_RAOTE Raoultella terrigena 3 0.7352
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7349
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7347
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7344
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7343
Rac-like GTP-binding protein ARAC7 O82480 RAC7_ARATH Arabidopsis thaliana 3 0.7343
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7342
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7340
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7338
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7333
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7331
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7330
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7330
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7327
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7325
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7322
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7318
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7316
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7315
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7314
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7311
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7311
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7308
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7306
Dihydrofolate reductase Q6FPH0 Q6FPH0_CANGA Candida glabrata 4 0.7305
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.7304
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7302
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 5 0.7301
Estrogen-related receptor gamma P62509 ERR3_MOUSE Mus musculus 4 0.7299
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7296
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7296
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7295
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7294
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7290
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 5 0.7288
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7286
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7284
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7279
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7278
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7278
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7277
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7275
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7272
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7272
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7272
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7272
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7269
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7267
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7264
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7258
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7257
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7256
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7254
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7252
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7252
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7249
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7249
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7248
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7247
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7244
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7240
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.7240
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7238
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.7237
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8RQP5 ISPF_THET8 Thermus thermophilus 3 0.7231
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7226
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7226
HAP protein Q8IM15 Q8IM15_PLAF7 Plasmodium falciparum 3 0.7224
Clathrin heavy chain 1 Q00610 CLH1_HUMAN Homo sapiens 3 0.7224
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7222
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7220
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7219
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 2 0.7219
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7217
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7210
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7207
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7207
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7203
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7203
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7203
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7202
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.7195
Gibberellin receptor GID1A Q9MAA7 GID1A_ARATH Arabidopsis thaliana 3 0.7192
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.7191
Estrogen receptor beta Q62986 ESR2_RAT Rattus norvegicus 5 0.7187
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 5 0.7184
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7183
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7180
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7177
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7177
Calmodulin-1 P0DP29 CALM1_RAT Rattus norvegicus 3 0.7173
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7170
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7169
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7168
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7168
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7166
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7163
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7162
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7159
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7158
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7158
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7152
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7152
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7151
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7149
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7149
Bifunctional dihydrofolate reductase-thymidylate synthase Q07422 DRTS_TOXGO Toxoplasma gondii 3 0.7142
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7141
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7140
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7140
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7138
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7138
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7138
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7136
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7134
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7133
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7132
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7130
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7130
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7128
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7127
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7126
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7124
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7124
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7120
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7116
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7115
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7115
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7114
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7111
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7111
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7109
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7108
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7108
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7106
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7106
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7097
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7096
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7096
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7095
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7089
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7079
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7076
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7074
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7073
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7073
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7070
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.7070
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7066
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7065
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7065
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7062
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7061
Poly [ADP-ribose] polymerase 1 P26446 PARP1_CHICK Gallus gallus 3 0.7059
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7058
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7056
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7054
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7053
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7052
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7048
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7047
Beta-ketoacyl-[acyl-carrier-protein] synthase III Q820T1 FABH_ENTFA Enterococcus faecalis 2 0.7043
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7043
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7040
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7039
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7035
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7033
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7031
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7029
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7029
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7027
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7027
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7026
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7025
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7025
Xanthine dehydrogenase/oxidase P22985 XDH_RAT Rattus norvegicus 3 0.7024
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7023
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7022
Cytidylate kinase Q5SL35 KCY_THET8 Thermus thermophilus 3 0.7021
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7020
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7019
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7018
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7016
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7016
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7015
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7013
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7012
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.7006
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7004

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