7-hydroxyflavan - Compound Card

7-hydroxyflavan

Select a section from the left sidebar

7-hydroxyflavan

Structure
Zoomed Structure
  • Family: Plantae - Dracaenaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavan
Canonical Smiles Oc1ccc2c(c1)O[C@@H](CC2)c1ccccc1
InChI InChI=1S/C15H14O2/c16-13-8-6-12-7-9-14(17-15(12)10-13)11-4-2-1-3-5-11/h1-6,8,10,14,16H,7,9H2/t14-/m0/s1
InChIKey KFUMHIDDQQILEL-AWEZNQCLSA-N
Formula C15H14O2
HBA 2
HBD 1
MW 226.27
Rotatable Bonds 1
TPSA 29.46
LogP 3.46
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 17
Formal Charge 0
Fraction CSP3 0.2
Exact Mass 226.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Dracaena cinnabari Dracaenaceae Plantae 1142948

Showing of synonyms

  • Helal I.E, Elsbaey M, et al. (2022). A new homoisoflavan from Dracaena cinnabari Balf. f. resin: a-glucosidase and COX-II inhibitory activity. Natural product research, 2022, 36(5), 1224-1229. [View] [PubMed]
Pubchem: 442413
Kegg Ligand: C09757
Chebi: 2267
Nmrshiftdb2: 60072449

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2)c3ccccc3

Level: 1

Mol. Weight: 226.27 g/mol

Structure

SMILES: C1CCOc(c12)cccc2

Level: 0

Mol. Weight: 226.27 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 226.27 g/mol

Anti-alpha-glucosidase

Absorption

Caco-2 (logPapp)
-4.91
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.390
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.29

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.240
Plasma Protein Binding
94.39
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.060
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.630
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.800
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
5.520
Micronucleos
Safe
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.460
Rat (Acute)
1.730
Rat (Chronic Oral)
1.780
Fathead Minnow
4.360
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
360.620
Hydration Free Energy
-8.430
Log(D) at pH=7.4
3.980
Log(P)
3.73
Log S
-3.22
Log(Vapor Pressure)
-6.08
Melting Point
90.24
pKa Acid
10.73
pKa Basic
4.92
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9833
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9801
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9538
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9538
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9535
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9493
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.9417
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.9270
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9216
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9194
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9185
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.9175
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9160
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9156
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.9151
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.9141
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9136
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9096
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9033
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9015
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8998
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8996
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8976
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8956
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8951
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8925
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.8893
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8869
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8832
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8820
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8800
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8767
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.8761
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8753
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8735
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8723
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8715
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8685
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8675
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8632
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8625
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.8578
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8576
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8574
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8569
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8560
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8537
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8530
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.8518
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8459
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8446
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8436
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8432
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8424
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8421
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8384
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8371
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8354
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8350
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8324
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8312
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8306
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8302
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8301
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8284
Bromodomain testis-specific protein Q58F21 BRDT_HUMAN Homo sapiens 3 0.8276
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8255
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8243
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8240
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8233
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.8223
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8192
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.8179
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.8175
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8148
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8118
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8105
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.8103
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8088
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8082
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8071
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8064
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.8062
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8053
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.8053
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8044
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8042
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8025
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8023
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8020
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8005
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7999
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7994
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7994
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7977
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7975
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7959
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7947
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.7922
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7921
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7904
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7894
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7873
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7869
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7869
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7863
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7855
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7847
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.7844
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7837
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7836
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7831
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7829
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.7818
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7814
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 4 0.7806
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 3 0.7792
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7769
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7765
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7765
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7763
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 3 0.7761
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7737
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7723
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7721
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7719
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7719
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7718
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7715
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7714
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7694
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7687
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7684
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7684
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7680
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7674
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7672
Retinoic acid receptor RXR-alpha P28700 RXRA_MOUSE Mus musculus 3 0.7669
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7665
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7664
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7651
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7650
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7642
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7641
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7640
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7636
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7633
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7632
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7629
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7629
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7616
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7613
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7609
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7601
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7597
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7590
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7588
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7586
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7584
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7564
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7563
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7563
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7563
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7558
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7550
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7546
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7545
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7542
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7541
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7535
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7519
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7518
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7517
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7509
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7507
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7505
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7503
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7503
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 4 0.7498
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7494
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7493
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7487
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7487
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7483
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7479
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7474
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7470
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7469
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7465
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7461
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7461
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7460
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7460
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7453
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7451
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7448
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7444
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7433
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 2 0.7431
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7430
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7429
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7426
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7413
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7413
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7412
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7411
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7406
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7395
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7389
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7387
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 2 0.7384
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7382
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7375
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 2 0.7375
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7374
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7374
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7372
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7372
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 2 0.7372
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7370
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7369
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7363
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7363
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7356
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7356
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7354
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7354
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7348
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7348
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7344
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7337
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7332
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7331
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7326
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7323
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 3 0.7319
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7317
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7316
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7312
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7311
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7310
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7308
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7298
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7297
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7286
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7284
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7283
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7278
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7277
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7276
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7275
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7274
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7272
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7271
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7267
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7260
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7257
Dihydrofolate reductase Q6FPH0 Q6FPH0_CANGA Candida glabrata 3 0.7256
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7254
Retinoic acid receptor beta P10826 RARB_HUMAN Homo sapiens 3 0.7249
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7249
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7245
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7243
Aldo-keto reductase family 1 member C21 Q91WR5 AK1CL_MOUSE Mus musculus 3 0.7232
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7226
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7219
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7219
Thyroid hormone receptor alpha P04625 THA_CHICK Gallus gallus 3 0.7217
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7212
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7207
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7206
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7204
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7202
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7201
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7196
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7195
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7194
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8RQP5 ISPF_THET8 Thermus thermophilus 3 0.7186
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7183
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7183
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7183
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 2 0.7182
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7176
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 4 0.7175
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7174
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7174
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7173
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7173
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7170
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7167
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7163
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7161
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7160
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7159
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7159
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 2 0.7148
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7146
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7145
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7144
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7143
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 2 0.7142
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 2 0.7141
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7140
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7140
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7139
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7139
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7137
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7137
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7136
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7123
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7122
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7121
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7119
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7117
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7112
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7110
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7109
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7108
Carbonic anhydrase 13 Q8N1Q1 CAH13_HUMAN Homo sapiens 3 0.7105
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7104
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7103
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7103
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 3 0.7097
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7097
Adenosine kinase P55263 ADK_HUMAN Homo sapiens 3 0.7089
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7089
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7082
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7077
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7076
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7076
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7073
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7068
Transthyretin P02766 TTHY_HUMAN Homo sapiens 3 0.7067
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7067
Thymidylate synthase P07607 TYSY_MOUSE Mus musculus 3 0.7055
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7055
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7054
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7053
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7053
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7051
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 4 0.7049
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7048
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7044
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7041
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7039
Thymidylate synthase ThyA P9WFR9 TYSY_MYCTU Mycobacterium tuberculosis 3 0.7039
Epothilone C/D epoxidase Q9KIZ4 C167_SORCE Sorangium cellulosum 2 0.7039
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7038
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7037
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7034
Troponin C, slow skeletal and cardiac muscles P09860 TNNC1_CHICK Gallus gallus 2 0.7034
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 2 0.7030
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7030
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7027
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7021
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7019
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7019
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7015
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7015
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7014
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7013
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7007
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7006
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7004
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 2 0.7003
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7002

Download SDF