4,4'-dihydroxy-2-methoxydihydrochalcone - Compound Card

4,4'-dihydroxy-2-methoxydihydrochalcone

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4,4'-dihydroxy-2-methoxydihydrochalcone

Structure
Zoomed Structure
  • Family: Plantae - Dracaenaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Polyhydroxlated Chalcone
Canonical Smiles COC1C=C(O)C=CC1C=CC(=O)c1ccc(cc1)O
InChI InChI=1S/C16H16O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,12,16-18H,1H3
InChIKey VISVGNWNVQSXIJ-UHFFFAOYSA-N
Formula C16H16O4
HBA 4
HBD 2
MW 272.3
Rotatable Bonds 4
TPSA 66.76
LogP 2.77
Number Rings 2
Number Aromatic Rings 1
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 272.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Dracaena cinnabari Dracaenaceae Plantae 1142948

Showing of synonyms

  • Helal I.E, Elsbaey M, et al. (2022). A new homoisoflavan from Dracaena cinnabari Balf. f. resin: a-glucosidase and COX-II inhibitory activity. Natural product research, 2022, 36(5), 1224-1229. [View] [PubMed]
Pubchem: 129824109

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)C=CC2C=CC=CC2

Level: 1

Mol. Weight: 272.3 g/mol

Structure

SMILES: C1=CCCC=C1

Level: 0

Mol. Weight: 272.3 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 272.3 g/mol

Anti-alpha-glucosidase

Absorption

Caco-2 (logPapp)
-4.76
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.140
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.43

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.710
Plasma Protein Binding
11.72
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.020
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.460
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.330
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
5.120
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
0.680
Rat (Acute)
2.360
Rat (Chronic Oral)
2.600
Fathead Minnow
4.210
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
382.940
Hydration Free Energy
-10.430
Log(D) at pH=7.4
1.960
Log(P)
1.99
Log S
-3.25
Log(Vapor Pressure)
-6.45
Melting Point
153.38
pKa Acid
8.31
pKa Basic
3.21
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9624
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9573
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.9492
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.9399
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9373
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9330
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9324
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9299
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.9245
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9235
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9185
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.9182
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9158
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.9096
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.9042
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8968
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8956
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.8908
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8882
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8876
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8868
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.8854
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8850
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8834
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8801
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8788
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8750
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.8723
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.8683
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8658
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8646
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8644
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8627
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8618
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.8586
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.8583
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8583
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 4 0.8582
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8575
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8561
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8516
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8502
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8463
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8461
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8448
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.8388
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8336
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8271
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8270
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8253
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8236
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8201
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8195
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 3 0.8172
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8133
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8131
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8074
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8074
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8062
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8015
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8005
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7994
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7986
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7978
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7977
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7969
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7957
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7957
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7948
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 3 0.7927
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7923
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7896
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7846
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7841
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7826
Putative FAD-dependent oxygenase EncM Q9KHK2 Q9KHK2_9ACTN Streptomyces maritimus 3 0.7811
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7789
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7779
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7779
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7770
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7756
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7721
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7717
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7707
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7695
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7688
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7681
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7677
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7667
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7660
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7654
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7638
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7618
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7609
AcsD Q93AT8 Q93AT8_DICCH Dickeya chrysanthemi 4 0.7606
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7577
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7573
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.7573
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7568
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7553
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7540
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7536
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7531
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7512
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7510
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7501
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.7479
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7470
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7467
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7466
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7463
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7460
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7457
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 3 0.7438
Probable bifunctional SAT/APS kinase O67174 SATC_AQUAE Aquifex aeolicus 3 0.7437
dTDP-fucosamine acetyltransferase Q8FBQ3 WECD_ECOL6 Escherichia coli O6:H1 3 0.7433
Probable nicotinate-nucleotide adenylyltransferase Q9HX21 NADD_PSEAE Pseudomonas aeruginosa 3 0.7429
Glucose-1-phosphate thymidylyltransferase P26393 RMLA_SALTY Salmonella typhimurium 3 0.7421
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7420
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7404
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7400
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7399
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7399
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7398
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7396
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7386
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7383
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7375
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7375
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7369
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7366
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7350
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7336
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7331
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7328
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7327
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7316
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7314
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7306
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7305
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7281
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7279
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7278
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7275
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7269
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7268
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7267
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7267
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7255
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7250
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7248
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7239
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7236
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7231
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7226
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7218
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7218
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7203
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7195
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7194
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7192
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7189
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7181
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7176
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7176
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 3 0.7171
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7171
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7169
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7168
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7166
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7165
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7164
Mannosylglycerate synthase D0MI02 D0MI02_RHOM4 Rhodothermus marinus 3 0.7160
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7156
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7143
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7140
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7139
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7133
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7130
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7130
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7125
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7123
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7117
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7106
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7105
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7105
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7092
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7088
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7087
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7081
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7080
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7075
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7074
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7073
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7069
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7067
Guanylate kinase P15454 KGUA_YEAST Saccharomyces cerevisiae 3 0.7063
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7063
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7057
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7057
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7056
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7056
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7053
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7047
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7046
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7043
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7043
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7042
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7036
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7035
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7034
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7034
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7033
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.7032
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7029
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7028
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7027
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7026
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7023
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7023
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7022
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7022
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 SIR3_HUMAN Homo sapiens 4 0.7021
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7017
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7016
LD-carboxypeptidase A0A6L8PVW7 A0A1Q4LWC0_BACAN Bacillus anthracis 3 0.7012
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7004
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7002
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7000

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