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Trilobatin

Family: Plantae - Euphorbiaceae
Kingdom: Plantae
Class: Phenolic
- Subclass: Polyphenol

Canonical Smiles	OC[C@H]1O[C@@H](Oc2cc(O)c(c(c2)O)C(=O)CCc2ccc(cc2)O)[C@@H]([C@H]([C@@H]1O)O)O
InChI	InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-12-7-14(25)17(15(26)8-12)13(24)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-23,25-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
InChIKey	GSTCPEBQYSOEHV-QNDFHXLGSA-N
Formula	C₂₁H₂₄O₁₀
HBA	10
HBD	7
MW	436.41
Rotatable Bonds	7
TPSA	177.14
LogP	-0.2
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	31
Formal Charge	0
Fraction CSP3	0.38
Exact Mass	436.14
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Euphorbia gaditana	Euphorbiaceae	Plantae	3990

Showing of synonyms

Badaoui M, Magid A, et al. (2020). Antioxidant activity-guided isolation of constituents from Euphorbia gaditana Coss. and their antioxidant and tyrosinase inhibitory activities. Phytochemistry Letters, 2020, 39, 99-104. [View]

Pubchem: 6451798

Cas: 4192-90-9

Gnps: CCMSLIB00006523964

Zinc: ZINC000031166407

Chebi: 145829

Nmrshiftdb2: 60021300

Metabolights: MTBLC145829

Chembl: CHEMBL514177

Comptox: DTXSID10194681

Bindingdb: 50256748

CPRiL: 62362

SMILES: c1ccccc1CCC(=O)c2ccc(cc2)OC3CCCCO3

Level: 2

Mol. Weight: 436.41 g/mol

SMILES: c1ccccc1C(=O)CCc2ccccc2

Level: 1

Mol. Weight: 436.41 g/mol

SMILES: c1ccccc1OC2CCCCO2

Level: 1

Mol. Weight: 436.41 g/mol

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 436.41 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 436.41 g/mol

Antioxidant

Absorption

Caco-2 (logPapp): -6.95
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Non-Absorbed
Madin-Darby Canine Kidney: -5.510
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: -0.7

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.770
Plasma Protein Binding: 76.17
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 12.630
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: -2.100
Biodegradation: Toxic
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.620
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 4.950
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -35.580
Rat (Acute): 2.310
Rat (Chronic Oral): 3.960
Fathead Minnow: 4.030
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 579.170
Hydration Free Energy: -8.220
Log(D) at pH=7.4: 0.680
Log(P): 0.26
Log S: -3.54
Log(Vapor Pressure): -12.41
Melting Point: 167.02
pKa Acid: 4.84
pKa Basic: 7.36

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.9502
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.9449
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.9446
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9408
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.9407
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.9390
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.9325
Thiazole tautomerase	P25053	TENI_BACSU	Bacillus subtilis	3	0.9286
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.9247
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9128
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9116
Anthranilate phosphoribosyltransferase	P9WFX5	TRPD_MYCTU	Mycobacterium tuberculosis	3	0.9095
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.9010
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8999
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8975
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8930
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.8855
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8827
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8822
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.8804
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.8758
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8712
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8701
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.8655
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8647
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	3	0.8572
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	3	0.8564
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8528
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8479
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8456
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8445
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8405
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	3	0.8389
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	3	0.8384
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8359
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8349
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8302
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8299
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	4	0.8215
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	3	0.8205
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.8189
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.8168
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8167
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8159
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.8157
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.8149
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8148
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.8099
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.8071
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.8036
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8031
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8002
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.7998
Mexicain	P84346	MEX1_JACME	Jacaratia mexicana	3	0.7984
Disks large homolog 1	Q12959	DLG1_HUMAN	Homo sapiens	4	0.7975
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7965
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	4	0.7934
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.7930
beta-glucosidase	Q92AS9	Q92AS9_LISIN	Listeria innocua serovar 6a	3	0.7870
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7818
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7815
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.7813
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7804
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7787
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7741
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7737
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7720
Succinyl-CoA:acetate CoA-transferase	B3EY95	SCACT_ACEAC	Acetobacter aceti	3	0.7713
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	3	0.7712
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7693
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7693
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7691
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7662
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	3	0.7649
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7641
Anthranilate phosphoribosyltransferase	P9WFX5	TRPD_MYCTU	Mycobacterium tuberculosis	3	0.7635
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.7628
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7626
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7622
Seed lectin subunit I	P05045	LEC1_VIGUC	Vigna unguiculata subsp. cylindrica	3	0.7622
Shikimate dehydrogenase (NADP(+))	O67049	AROE_AQUAE	Aquifex aeolicus	3	0.7620
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7620
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7618
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7617
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7610
Oxygenase	Q194P4	Q194P4_STRAA	Streptomyces argillaceus	3	0.7607
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7583
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	4	0.7569
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	3	0.7558
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7553
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	P12995	BIOA_ECOLI	Escherichia coli	3	0.7546
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7542
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.7534
Isoflavone 4'-O-methyltransferase	Q29U70	I4OMT_MEDTR	Medicago truncatula	3	0.7532
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7512
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7512
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7504
Serine/threonine-protein kinase VRK1	Q99986	VRK1_HUMAN	Homo sapiens	3	0.7491
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	3	0.7489
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7483
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7472
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7464
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7450
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7448
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.7445
Type 4 fimbrial biogenesis protein PilM	G3XD28	G3XD28_PSEAE	Pseudomonas aeruginosa	3	0.7442
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7435
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7425
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7420
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7416
Subunit alpha of sarocosine oxidase	Q50LF0	Q50LF0_9CORY	Corynebacterium sp. U-96	4	0.7404
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	3	0.7400
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7399
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7397
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7396
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7394
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7386
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.7379
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7371
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	3	0.7370
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7360
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7360
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.7353
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7344
Elongation factor Tu 1	P0CE47	EFTU1_ECOLI	Escherichia coli	3	0.7344
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.7342
C-1-tetrahydrofolate synthase, cytoplasmic	P11586	C1TC_HUMAN	Homo sapiens	4	0.7341
5-formyltetrahydrofolate cyclo-ligase	P75430	MTHFS_MYCPN	Mycoplasma pneumoniae	2	0.7338
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7323
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7305
Acyl-CoA:acyl-CoA alkyltransferase	Q8PDX2	OLEA_XANCP	Xanthomonas campestris pv. campestris	3	0.7300
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	4	0.7297
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7293
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7285
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7281
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7281
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.7267
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7251
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7249
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.7247
Biotin carboxylase	P43873	ACCC_HAEIN	Haemophilus influenzae	3	0.7246
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7245
Orotidine 5'-phosphate decarboxylase	O26232	PYRF_METTH	Methanothermobacter thermautotrophicus	3	0.7231
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7230
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7230
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7228
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7226
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7225
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7221
NOP5/NOP56 related protein	Q8U4M1	Q8U4M1_PYRFU	Pyrococcus furiosus	4	0.7220
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7215
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	2	0.7208
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7204
Lipoprotein E	P26093	HEL_HAEIN	Haemophilus influenzae	3	0.7199
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7194
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7183
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7181
MutT/nudix family protein	O33199	O33199_MYCTO	Mycobacterium tuberculosis	3	0.7177
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7173
2-aminohexano-6-lactam racemase	Q7M181	ACLR_ACHOB	Achromobacter obae	2	0.7173
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7172
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	3	0.7168
7-methylguanosine phosphate-specific 5'-nucleotidase	Q9W197	5NT3B_DROME	Drosophila melanogaster	3	0.7166
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7162
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	3	0.7156
Ribosome-inactivating protein alpha-trichosanthin	P09989	RIPT_TRIKI	Trichosanthes kirilowii	4	0.7126
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7123
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	3	0.7120
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7115
2'-5'-oligoadenylate synthase 1	P00973	OAS1_HUMAN	Homo sapiens	2	0.7109
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein	Q5SHN1	Q5SHN1_THET8	Thermus thermophilus	3	0.7108
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7107
Heat shock protein 90	Q18688	HSP90_CAEEL	Caenorhabditis elegans	3	0.7107
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7105
adenine phosphoribosyltransferase	Q967M2	Q967M2_GIAIN	Giardia intestinalis	2	0.7102
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7096
Adenosine 5'-monophosphoramidase HINT1	P80912	HINT1_RABIT	Oryctolagus cuniculus	3	0.7094
Phosphoglycerate kinase	Q83AU6	PGK_COXBU	Coxiella burnetii	3	0.7087
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7082
Poly(A) polymerase, putative	Q381M1	Q381M1_TRYB2	Trypanosoma brucei brucei	4	0.7077
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.7077
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7076
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7066
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7063
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7053
Beta-lactamase	P00811	AMPC_ECOLI	Escherichia coli	3	0.7047
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	3	0.7047
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7030
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	4	0.7026
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7023
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7021
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7018
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	3	0.7018
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2	O95340	PAPS2_HUMAN	Homo sapiens	2	0.7010
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7007
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7006
Genome polyprotein	Q9WLZ5	Q9WLZ5_9FLAV	dengue virus type 2	3	0.7004
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7004

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