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7-hydroxy-3',5'-dimethoxyisoflavone

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Isoflavone

Canonical Smiles	COc1cc(OC)cc(c1)c1coc2c(c1=O)ccc(c2)O
InChI	InChI=1S/C17H14O5/c1-20-12-5-10(6-13(8-12)21-2)15-9-22-16-7-11(18)3-4-14(16)17(15)19/h3-9,18H,1-2H3
InChIKey	WSSNVJXVWRIBQI-UHFFFAOYSA-N
Formula	C₁₇H₁₄O₅
HBA	5
HBD	1
MW	298.29
Rotatable Bonds	3
TPSA	68.9
LogP	3.18
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	22
Formal Charge	0
Fraction CSP3	0.12
Exact Mass	298.08
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Astragalus peregrinus	Leguminosae/Fabaceae	Plantae	2014710

Showing of synonyms

Can Sakarya H, Ketrez A. (2023). A New Isoflavone from Astragalus peregrinus. Acta chimica Slovenica, 2023, 70(4), 628-633. [View] [PubMed]

Pubchem: 11208735

Zinc: ZINC000014811756

Nmrshiftdb2: 70090943

Chembl: CHEMBL575075

Bindingdb: 50299413

No compound-protein relationship available.

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 298.29 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 298.29 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 298.29 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.7
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.520
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.38

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.380
Plasma Protein Binding: 75.6
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 5.770
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 2.140
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 0.980
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.190
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 4.070
Rat (Acute): 1.820
Rat (Chronic Oral): 1.970
Fathead Minnow: 4.960
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Toxic
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 437.090
Hydration Free Energy: -11.220
Log(D) at pH=7.4: 2.620
Log(P): 3.78
Log S: -5.23
Log(Vapor Pressure): -7.39
Melting Point: 213.02
pKa Acid: 8.44
pKa Basic: 2.62

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9577
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9523
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	4	0.9497
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.9466
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9365
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9309
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.9300
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9272
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.9261
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.9241
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.9221
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9218
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.9206
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9200
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9188
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9146
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.9110
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9100
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.9087
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9017
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.8903
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.8899
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8854
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8820
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8813
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.8811
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8796
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.8792
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8764
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8760
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.8741
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8730
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8704
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8634
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.8634
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8622
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8564
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8525
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8510
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8488
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8425
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8405
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8367
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.8327
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.8303
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8295
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.8271
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8231
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.8216
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8187
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8176
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.8162
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.8155
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8150
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8113
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8057
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.8055
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7971
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7955
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7953
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7933
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7901
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7888
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7878
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7872
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7868
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7832
Acetolactate synthase catalytic subunit, mitochondrial	P07342	ILVB_YEAST	Saccharomyces cerevisiae	3	0.7825
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7823
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7798
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7785
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7765
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7757
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7749
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7740
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7715
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7706
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7695
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7695
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7685
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.7681
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7669
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	3	0.7669
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7660
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7631
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7620
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.7614
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7603
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7601
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7599
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7586
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	3	0.7574
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7573
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7562
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7549
3',5'-cyclic-AMP phosphodiesterase 4A	P27815	PDE4A_HUMAN	Homo sapiens	3	0.7532
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7532
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7528
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7528
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7524
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	3	0.7523
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7515
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7513
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7496
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7495
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7479
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7478
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.7464
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7440
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	3	0.7437
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	4	0.7429
Protein S100-A4	P26447	S10A4_HUMAN	Homo sapiens	3	0.7414
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7388
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7384
Isoflavone-7-O-methyltransferase 8	O24529	7OMT8_MEDSA	Medicago sativa	4	0.7373
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7366
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7364
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	2	0.7363
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7359
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7356
Uncharacterized protein	Q3F0V8	Q3F0V8_BACTI	Bacillus thuringiensis serovar israelensis ATCC 35646	3	0.7356
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7347
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	3	0.7346
Bromodomain protein, putative	Q8I240	Q8I240_PLAF7	Plasmodium falciparum	4	0.7343
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7336
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7336
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7327
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7322
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7319
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7307
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7298
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7290
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	3	0.7290
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7289
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7288
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7286
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7283
Transthyretin	P02766	TTHY_HUMAN	Homo sapiens	3	0.7274
Putative N-acetyl glucosaminyl transferase	Q6U8B0	Q6U8B0_RAOTE	Raoultella terrigena	3	0.7273
Aspartokinase 1, chloroplastic	Q9LYU8	AK1_ARATH	Arabidopsis thaliana	3	0.7271
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7263
Putative protease I	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron	2	0.7259
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7244
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	4	0.7227
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7226
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7220
Farnesyl pyrophosphate synthase	P14324	FPPS_HUMAN	Homo sapiens	2	0.7218
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7211
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7206
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7200
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	3	0.7197
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7196
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	4	0.7195
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	3	0.7191
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7187
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	3	0.7169
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase	Q6T1W8	FDTA_ANETH	Aneurinibacillus thermoaerophilus	3	0.7165
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	3	0.7154
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7153
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7151
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	3	0.7147
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7143
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	4	0.7142
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7138
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7122
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7121
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7118
DNA ligase	P43813	DNLJ_HAEIN	Haemophilus influenzae	2	0.7118
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7117
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7115
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7112
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	4	0.7107
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7100
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7093
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7086
Orotidine 5'-phosphate decarboxylase	Q5L0U0	PYRF_GEOKA	Geobacillus kaustophilus	3	0.7086
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7085
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	3	0.7081
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7075
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.7074
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7072
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7062
Nucleoprotein	P33469	NCAP_CVHOC	Human coronavirus OC43	3	0.7062
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7059
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7050
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7047
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.7047
NTPase P4	Q94M05	Q94M05_9VIRU	Pseudomonas phage phi12	2	0.7042
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7039
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7038
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7036
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	3	0.7036
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7029
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7029
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7015
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7009
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7007
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7002
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7002
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7002

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