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Amorfrutin B

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Phenolic

Canonical Smiles	COc1cc(CCc2ccccc2)c(c(c1C/C=C(/CCC=C(C)C)\C)O)C(=O)O
InChI	InChI=1S/C26H32O4/c1-18(2)9-8-10-19(3)13-16-22-23(30-4)17-21(24(25(22)27)26(28)29)15-14-20-11-6-5-7-12-20/h5-7,9,11-13,17,27H,8,10,14-16H2,1-4H3,(H,28,29)/b19-13+
InChIKey	DKNIJLWIVUCTHW-CPNJWEJPSA-N
Formula	C₂₆H₃₂O₄
HBA	3
HBD	2
MW	408.54
Rotatable Bonds	10
TPSA	66.76
LogP	6.12
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	30
Formal Charge	0
Fraction CSP3	0.35
Exact Mass	408.23
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Glycyrrhiza foetida	Leguminosae/Fabaceae	Plantae	512625

Showing of synonyms

Weidner C, Rousseau M, et al. (2016). Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. Journal of natural products, 2016, 79(1), 2-12. [View] [PubMed]

Pubchem: 24739090

Cas: 78916-42-4

Zinc: ZINC000013358271

Chembl: CHEMBL2337127

Pdb Ligand: YFB

Bindingdb: 50428826

CPRiL: 200832

SMILES: c1ccccc1CCc2ccccc2

Level: 1

Mol. Weight: 408.54 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 408.54 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.95
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.990
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -3.41

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 2.110
Plasma Protein Binding: 85.16
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 1.870
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.330
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.690
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 4.810
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -16.090
Rat (Acute): 2.040
Rat (Chronic Oral): 2.800
Fathead Minnow: 5.270
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 409.410
Hydration Free Energy: -3.280
Log(D) at pH=7.4: 2.780
Log(P): 8.0
Log S: -5.51
Log(Vapor Pressure): -8.43
Melting Point: 138.38
pKa Acid: 7.53
pKa Basic: 4.53

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.9606
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9579
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	3	0.9539
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	3	0.9516
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.9466
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.9437
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9410
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9390
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9326
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	P33038	MURA_ENTCC	Enterobacter cloacae subsp. cloacae	3	0.9262
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.9257
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.9208
L-lactate dehydrogenase (cytochrome)	P00175	CYB2_YEAST	Saccharomyces cerevisiae	3	0.9199
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.9194
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	3	0.9148
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9075
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.9056
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9051
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9040
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.9029
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.9024
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9020
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.9016
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.9006
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.9002
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8947
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8927
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.8925
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	4	0.8921
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8921
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8919
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8897
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8861
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8836
Pentalenic acid synthase	Q825I8	CYP28_STRAW	Streptomyces avermitilis	3	0.8814
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.8807
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8805
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8801
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8789
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8765
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8755
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8733
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8731
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.8712
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.8712
Catalase-peroxidase 2	O59651	KATG2_HALMA	Haloarcula marismortui	3	0.8705
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8705
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.8677
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8667
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8666
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8630
Beta-ketoacyl-[acyl-carrier-protein] synthase III	Q820T1	FABH_ENTFA	Enterococcus faecalis	3	0.8584
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.8579
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.8570
Apoptosis regulator Bcl-2	P10415	BCL2_HUMAN	Homo sapiens	3	0.8565
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8551
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8546
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8544
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8539
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	3	0.8535
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8534
Enoyl-ACP reductase	Q9BJJ9	Q9BJJ9_PLAFA	Plasmodium falciparum	3	0.8508
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8496
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8458
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	3	0.8451
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.8445
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	3	0.8435
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8410
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8370
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8359
Cytokinin dehydrogenase 1	Q9T0N8	CKX1_MAIZE	Zea mays	3	0.8354
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8353
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8342
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.8336
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.8335
NmrA-like family domain-containing protein 1	Q9HBL8	NMRL1_HUMAN	Homo sapiens	3	0.8297
Anthranilate phosphoribosyltransferase	P00500	TRPD_ACIAD	Acinetobacter baylyi	3	0.8293
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	4	0.8289
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.8271
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.8260
Albumin	P35747	ALBU_HORSE	Equus caballus	3	0.8252
Prostaglandin reductase 3	Q8N4Q0	PTGR3_HUMAN	Homo sapiens	3	0.8237
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8230
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.8203
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.8199
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.8197
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8189
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.8183
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8177
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.8172
Albumin	P35747	ALBU_HORSE	Equus caballus	3	0.8166
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8166
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8164
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.8163
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	3	0.8131
Quorum-sensing transcriptional activator	Q8XBD0	Q8XBD0_ECO57	Escherichia coli O157:H7	3	0.8129
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.8125
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8116
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.8108
NmrA-like family domain-containing protein 1	Q9HBL8	NMRL1_HUMAN	Homo sapiens	3	0.8107
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	4	0.8093
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.8075
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8072
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8061
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.8058
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8055
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.8043
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	3	0.8041
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.8028
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	4	0.8019
4-substituted benzoates-glutamate ligase GH3.12	Q9LYU4	GH312_ARATH	Arabidopsis thaliana	3	0.8019
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.8016
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.8014
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.8014
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8007
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7993
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7984
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7981
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	3	0.7981
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7980
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	2	0.7978
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7977
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7965
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7963
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7959
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.7956
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7954
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7953
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7951
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.7949
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7947
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7939
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7925
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7921
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7917
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7917
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7913
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.7909
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7894
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7888
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7888
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	3	0.7882
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.7876
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	3	0.7872
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7870
AcsD	Q93AT8	Q93AT8_DICCH	Dickeya chrysanthemi	3	0.7869
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7865
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7860
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	2	0.7858
Mandelate racemase	P11444	MANR_PSEPU	Pseudomonas putida	3	0.7858
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7851
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7846
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7844
Integrin alpha-L	P20701	ITAL_HUMAN	Homo sapiens	3	0.7844
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7835
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7832
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.7815
Anthranilate phosphoribosyltransferase	P9WFX5	TRPD_MYCTU	Mycobacterium tuberculosis	3	0.7806
Xanthine dehydrogenase/oxidase	P22985	XDH_RAT	Rattus norvegicus	3	0.7806
Aldo-keto reductase family 1 member C1	Q04828	AK1C1_HUMAN	Homo sapiens	2	0.7801
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.7800
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7780
Biphenyl dioxygenase subunit alpha	P37333	BPHA_PARXL	Paraburkholderia xenovorans	3	0.7778
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7775
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	2	0.7774
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7771
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7769
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7765
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7757
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	2	0.7749
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7745
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7743
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7741
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.7738
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.7730
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.7723
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7721
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7716
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7711
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7708
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7697
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7696
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7694
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7686
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7683
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.7681
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	4	0.7672
Thiazole tautomerase	P25053	TENI_BACSU	Bacillus subtilis	3	0.7671
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7669
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.7668
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7667
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.7665
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7663
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	2	0.7661
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.7660
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7659
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7647
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	4	0.7646
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7629
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	3	0.7624
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7621
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	3	0.7620
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7619
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7609
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	2	0.7604
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7603
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7602
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7589
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.7584
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7573
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	3	0.7573
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7562
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7554
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7551
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7541
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7536
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7535
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7524
Cytochrome b6	P83791	CYB6_MASLA	Mastigocladus laminosus	3	0.7523
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7518
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7518
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7508
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7508
Hydroxymethylglutaryl-CoA synthase	Q9FD71	HMGCS_ENTFL	Enterococcus faecalis	2	0.7502
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7498
Stimulator of interferon genes protein	Q3TBT3	STING_MOUSE	Mus musculus	3	0.7494
Acetylcholine-binding protein	P58154	ACHP_LYMST	Lymnaea stagnalis	3	0.7492
Glutamate dehydrogenase 1, mitochondrial	P00366	DHE3_BOVIN	Bos taurus	3	0.7490
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7488
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7484
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7478
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7473
Histamine N-methyltransferase	P50135	HNMT_HUMAN	Homo sapiens	3	0.7472
Putative protease I	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron	2	0.7463
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7449
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7447
5-formyltetrahydrofolate cyclo-ligase	P75430	MTHFS_MYCPN	Mycoplasma pneumoniae	2	0.7444
Glutamate receptor ionotropic, kainate 1	P22756	GRIK1_RAT	Rattus norvegicus	3	0.7442
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7438
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7436
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7436
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7433
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7431
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.7423
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.7422
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7419
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7411
Chymotrypsinogen A	P00766	CTRA_BOVIN	Bos taurus	3	0.7408
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7405
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7404
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7404
Angiopoietin-1 receptor	Q02763	TIE2_HUMAN	Homo sapiens	3	0.7402
Adenosine kinase	Q9TVW2	ADK_TOXGO	Toxoplasma gondii	3	0.7402
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7399
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	2	0.7394
Polymerase acidic protein	Q5EP34	Q5EP34_9INFA	Influenza A virus	2	0.7390
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7385
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.7384
Putative HMP/thiamine-binding protein YkoF	O34911	YKOF_BACSU	Bacillus subtilis	3	0.7384
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	3	0.7382
Mandelate racemase	P11444	MANR_PSEPU	Pseudomonas putida	3	0.7382
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7381
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7378
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7374
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7373
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7372
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7368
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7368
Acyl-CoA:acyl-CoA alkyltransferase	Q8PDX2	OLEA_XANCP	Xanthomonas campestris pv. campestris	3	0.7365
Cytosol aminopeptidase	P00727	AMPL_BOVIN	Bos taurus	2	0.7363
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	3	0.7362
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7360
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7359
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7355
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7354
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7353
Acetyl-CoA carboxylase	Q00955	ACAC_YEAST	Saccharomyces cerevisiae	3	0.7352
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7352
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7349
Lipoprotein E	P26093	HEL_HAEIN	Haemophilus influenzae	3	0.7347
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7343
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7342
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7341
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7340
Single-stranded-DNA-specific exonuclease RecJ	D0EM60	D0EM60_DEIRD	Deinococcus radiodurans	3	0.7340
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7339
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7338
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7337
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7334
Delta-type opioid receptor	P41143	OPRD_HUMAN	Homo sapiens	5	0.7333
Caffeic acid 3-O-methyltransferase	P28002	COMT1_MEDSA	Medicago sativa	2	0.7331
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7328
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7327
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7326
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	3	0.7326
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7321
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7319
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	3	0.7315
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7313
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7312
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7305
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7304
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7304
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7282
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	2	0.7280
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7274
Nucleoprotein	P33469	NCAP_CVHOC	Human coronavirus OC43	3	0.7273
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.7272
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7272
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7268
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.7268
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.7265
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7262
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7260
Riboflavin biosynthesis protein	Q9WZW1	Q9WZW1_THEMA	Thermotoga maritima	3	0.7259
Heat shock protein 75 kDa, mitochondrial	Q12931	TRAP1_HUMAN	Homo sapiens	3	0.7258
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7256
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7256
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7255
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7249
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7249
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7248
Anthranilate phosphoribosyltransferase	P9WFX5	TRPD_MYCTU	Mycobacterium tuberculosis	3	0.7247
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	Q6NVY1	HIBCH_HUMAN	Homo sapiens	3	0.7244
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P9WNS1	DXR_MYCTU	Mycobacterium tuberculosis	3	0.7243
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	3	0.7242
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	2	0.7242
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7239
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7238
orotidine-5'-phosphate decarboxylase	Q8T6J6	Q8T6J6_PLAFA	Plasmodium falciparum	4	0.7237
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7234
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7234
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7232
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7231
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.7231
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	2	0.7231
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.7229
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7226
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7222
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7218
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	3	0.7218
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7216
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7215
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7214
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7211
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7210
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7206
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7204
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7203
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7202
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7201
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7200
Beta-glucuronidase	P05804	BGLR_ECOLI	Escherichia coli	3	0.7199
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7194
Pyridoxal kinase	O00764	PDXK_HUMAN	Homo sapiens	3	0.7194
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	2	0.7193
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7192
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7185
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7181
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.7178
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7178
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7177
cGMP-dependent protein kinase, putative	A5K0N4	A5K0N4_PLAVS	Plasmodium vivax	3	0.7176
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7176
Nitric oxide synthase, inducible	P35228	NOS2_HUMAN	Homo sapiens	2	0.7174
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7173
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	2	0.7172
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7171
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7167
Botulinum neurotoxin type A	P0DPI0	BXA1_CLOBO	Clostridium botulinum	2	0.7167
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7166
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7165
Neutrophil gelatinase-associated lipocalin	P80188	NGAL_HUMAN	Homo sapiens	3	0.7164
Tyrosine 3-monooxygenase	P04177	TY3H_RAT	Rattus norvegicus	3	0.7162
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7157
DNA double-strand break repair protein Mre11	Q9X1X0	Q9X1X0_THEMA	Thermotoga maritima MSB8	3	0.7156
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7153
NAD(P) transhydrogenase subunit alpha part 1	Q2RSB2	PNTAA_RHORT	Rhodospirillum rubrum	3	0.7150
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7149
Nucleoside phosphorylase, putative	Q57VZ2	Q57VZ2_TRYB2	Trypanosoma brucei brucei	3	0.7146
Alpha-aminoadipic semialdehyde dehydrogenase	P49419	AL7A1_HUMAN	Homo sapiens	2	0.7145
Reductase homolog	Q9ZGC1	Q9ZGC1_STRCY	Streptomyces cyanogenus	4	0.7142
Feruloyl esterase A	O42807	FAEA_ASPNG	Aspergillus niger	2	0.7142
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7141
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.7140
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7135
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	2	0.7132
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	2	0.7132
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7131
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	3	0.7129
Diamine acetyltransferase 1	P21673	SAT1_HUMAN	Homo sapiens	2	0.7127
Abscisic acid receptor PYL1	Q8VZS8	PYL1_ARATH	Arabidopsis thaliana	2	0.7126
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7124
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	2	0.7118
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	2	0.7116
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7108
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7104
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7104
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7103
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	2	0.7101
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7099
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7098
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7091
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7091
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7088
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	2	0.7084
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.7082
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7078
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7078
Alanine racemase	Q180W0	Q180W0_CLOD6	Clostridioides difficile	2	0.7077
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7074
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7073
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7072
Metallo-beta-lactamase type 2	P25910	BLAB_BACFG	Bacteroides fragilis	3	0.7070
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7067
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7064
Glutamate receptor ionotropic, kainate 1	P22756	GRIK1_RAT	Rattus norvegicus	2	0.7062
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7055
Perakine reductase	Q3L181	PERR_RAUSE	Rauvolfia serpentina	2	0.7053
Copper-transporting ATPase 1	Q04656	ATP7A_HUMAN	Homo sapiens	3	0.7052
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7051
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7047
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	Q46381	BPHB_COMTE	Comamonas testosteroni	3	0.7045
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7043
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7043
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	3	0.7041
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7041
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7040
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7039
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7039
Regulatory protein SdiA	P07026	SDIA_ECOLI	Escherichia coli	3	0.7039
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7039
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7036
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7036
Protein mono-ADP-ribosyltransferase PARP15	Q460N3	PAR15_HUMAN	Homo sapiens	3	0.7030
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7030
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	2	0.7025
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7023
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.7023
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7023
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7022
Anthranilate phosphoribosyltransferase	P9WFX5	TRPD_MYCTU	Mycobacterium tuberculosis	3	0.7022
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	4	0.7021
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.7021
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7017
Raucaffricine-O-beta-D-glucosidase	Q9SPP9	RG1_RAUSE	Rauvolfia serpentina	3	0.7014
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.7014
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7010
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7010
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7010
Cell division cycle 7-related protein kinase	O00311	CDC7_HUMAN	Homo sapiens	3	0.7009
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7008
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	2	0.7007
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7006
Metabotropic glutamate receptor 7	Q14831	GRM7_HUMAN	Homo sapiens	3	0.7003
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	4	0.7001
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7001

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