ANPDB

Select a section from the left sidebar

Norjuziphine

Family: Plantae - Papaveraceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Isoquinoline Alkaloid

Canonical Smiles	COc1ccc2c(c1O)[C@H](NCC2)Cc1ccc(cc1)O
InChI	InChI=1S/C17H19NO3/c1-21-15-7-4-12-8-9-18-14(16(12)17(15)20)10-11-2-5-13(19)6-3-11/h2-7,14,18-20H,8-10H2,1H3/t14-/m1/s1
InChIKey	BXWMZVREXWPYKF-CQSZACIVSA-N
Formula	C₁₇H₁₉NO₃
HBA	4
HBD	3
MW	285.34
Rotatable Bonds	3
TPSA	61.72
LogP	2.54
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	21
Formal Charge	0
Fraction CSP3	0.29
Exact Mass	285.14
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Fumaria parviflora	Fumariaceae	Plantae	1464625
2	Fumaria parviflora	Papaveraceae	Plantae	1464625

Showing of synonyms

Elsaid M.B, Elnaggar D.M, et al. (2022). Production of isoquinoline alkaloids from the in vitro conserved Fumaria parviflora and their in vitro wound healing activity. Natural product research, 2022, 36(10), 2575-2579. [View] [PubMed]

Pubchem: 15690955

Cas: 74119-87-2

Gnps: CCMSLIB00008851345

Nmrshiftdb2: 70127874

No compound-protein relationship available.

SMILES: c1ccccc1CC2NCCc(c23)cccc3

Level: 1

Mol. Weight: 285.34 g/mol

SMILES: C1CNCc(c12)cccc2

Level: 0

Mol. Weight: 285.34 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 285.34 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.97
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.880
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.82

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.790
Plasma Protein Binding: 66.88
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 12.100
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.220
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.010
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 9.200
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -1.790
Rat (Acute): 2.410
Rat (Chronic Oral): 2.300
Fathead Minnow: 4.130
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 385.100
Hydration Free Energy: -8.860
Log(D) at pH=7.4: 2.280
Log(P): 1.34
Log S: -2.77
Log(Vapor Pressure): -6.79
Melting Point: 196.17
pKa Acid: 9.61
pKa Basic: 7.71

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9491
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.9475
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.9470
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9301
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9256
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.9200
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.9185
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9175
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.9169
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.9162
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9144
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9107
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9062
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9024
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8982
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8968
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.8953
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8952
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.8930
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.8907
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8903
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8815
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8814
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.8800
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8764
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.8756
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8741
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8733
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8650
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.8647
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8629
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.8607
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8572
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8537
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.8526
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8514
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.8497
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8492
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8484
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.8479
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.8461
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.8453
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8443
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8441
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8440
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8421
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8414
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8411
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.8373
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.8360
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.8335
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8329
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8286
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.8250
Cyclin-dependent kinase 6	Q00534	CDK6_HUMAN	Homo sapiens	3	0.8230
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.8150
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.8132
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8092
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.8063
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8055
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	3	0.8043
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.7974
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7968
Abscisic acid receptor PYL1	Q8VZS8	PYL1_ARATH	Arabidopsis thaliana	3	0.7948
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7946
Odorant binding protein ASP1	Q8WRW5	Q8WRW5_APIME	Apis mellifera	3	0.7941
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.7928
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	4	0.7914
Dihydroorotate dehydrogenase (quinone), mitochondrial	Q08210	PYRD_PLAF7	Plasmodium falciparum	3	0.7864
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.7858
Cytochrome P450 2C5	P00179	CP2C5_RABIT	Oryctolagus cuniculus	3	0.7849
Enoyl-ACP reductase	Q9BJJ9	Q9BJJ9_PLAFA	Plasmodium falciparum	3	0.7843
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7829
Renin	P00797	RENI_HUMAN	Homo sapiens	3	0.7817
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.7812
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7796
Poly [ADP-ribose] polymerase tankyrase-1	O95271	TNKS1_HUMAN	Homo sapiens	3	0.7770
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.7741
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7740
Dihydrofolate reductase	P00374	DYR_HUMAN	Homo sapiens	3	0.7717
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7709
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7708
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7707
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7700
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7693
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7692
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7690
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7675
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7643
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7641
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7628
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7624
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	3	0.7624
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7618
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7612
Isoflavone-7-O-methyltransferase 8	O24529	7OMT8_MEDSA	Medicago sativa	4	0.7599
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7597
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	4	0.7593
Putative HMP/thiamine-binding protein YkoF	O34911	YKOF_BACSU	Bacillus subtilis	3	0.7578
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7564
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7563
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.7562
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7553
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7553
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.7538
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7535
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7517
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.7513
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7509
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7505
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7498
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7493
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7482
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7467
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	4	0.7455
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7449
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7427
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7425
Thymidylate synthase ThyA	P9WFR9	TYSY_MYCTU	Mycobacterium tuberculosis	3	0.7419
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.7404
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	3	0.7404
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	4	0.7397
Dihydrofolate reductase	P00374	DYR_HUMAN	Homo sapiens	3	0.7392
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7392
Methionine adenosyltransferase 2 subunit beta	Q9NZL9	MAT2B_HUMAN	Homo sapiens	4	0.7386
Threonine synthase 1, chloroplastic	Q9S7B5	THRC1_ARATH	Arabidopsis thaliana	3	0.7384
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7373
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7368
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7367
Transthyretin	P02766	TTHY_HUMAN	Homo sapiens	3	0.7366
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7364
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7362
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	3	0.7345
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7335
Calmodulin-like domain protein kinase isoenzyme gamma, related	F0V9W9	F0V9W9_NEOCL	Neospora caninum	3	0.7330
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7325
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7319
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7318
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7309
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7302
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7297
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7292
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7290
Acyl-CoA:acyl-CoA alkyltransferase	Q8PDX2	OLEA_XANCP	Xanthomonas campestris pv. campestris	3	0.7272
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	2	0.7272
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7266
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7261
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7260
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.7256
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7249
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7243
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.7242
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7226
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7210
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7199
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7194
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	3	0.7190
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7187
Capsid protein VP1	O56137	O56137_9VIRU	Adeno-associated virus - 6	3	0.7187
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7185
Beta-lactamase	P00811	AMPC_ECOLI	Escherichia coli	3	0.7184
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7182
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7181
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7173
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7172
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7163
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7162
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7162
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7145
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	2	0.7143
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	P08559	ODPA_HUMAN	Homo sapiens	3	0.7138
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7137
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7136
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	3	0.7130
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7129
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7128
Protein mono-ADP-ribosyltransferase PARP15	Q460N3	PAR15_HUMAN	Homo sapiens	3	0.7120
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7115
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7108
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7108
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7091
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7090
Inorganic pyrophosphatase	Q3JUV5	Q3JUV5_BURP1	Burkholderia pseudomallei	3	0.7090
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7089
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7087
Serine/threonine-protein kinase Nek2	P51955	NEK2_HUMAN	Homo sapiens	3	0.7082
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7082
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7078
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7077
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7071
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7069
Petrobactin biosynthesis protein AsbB	Q81RQ8	Q81RQ8_BACAN	Bacillus anthracis	3	0.7064
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7053
dTDP-4-dehydrorhamnose 3,5-epimerase	A0A6L7H6N0	A0A1S0QLH9_BACAN	Bacillus anthracis	3	0.7051
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7050
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7048
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	3	0.7047
Glutathione S-transferase	Q8ILQ7	GST_PLAFA	Plasmodium falciparum	3	0.7045
Beta-lactamase	P00811	AMPC_ECOLI	Escherichia coli	3	0.7038
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7036
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7029
Pyruvate dehydrogenase [ubiquinone]	P07003	POXB_ECOLI	Escherichia coli	3	0.7025
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	3	0.7025
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	3	0.7022
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7012
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7010

Download SDF