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Ganomycine A

Family: Plantae - Ganodermataceae
Kingdom: Plantae
Class: Terpenoid
- Subclass: Triterpene

Canonical Smiles	OC/C(=C/CC/C(=C/CC/C(=C/Cc1cc(O)ccc1O)/C(=O)O)/C)/C
InChI	InChI=1S/C21H28O5/c1-15(5-3-7-16(2)14-22)6-4-8-17(21(25)26)9-10-18-13-19(23)11-12-20(18)24/h6-7,9,11-13,22-24H,3-5,8,10,14H2,1-2H3,(H,25,26)/b15-6+,16-7+,17-9-
InChIKey	YMBZMWGZXRRFEN-KPJMVHGFSA-N
Formula	C₂₁H₂₈O₅
HBA	4
HBD	4
MW	360.45
Rotatable Bonds	10
TPSA	97.99
LogP	4.1
Number Rings	1
Number Aromatic Rings	1
Heavy Atom Count	26
Formal Charge	0
Fraction CSP3	0.38
Exact Mass	360.19
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Ganoderma sp	Ganodermataceae	Plantae	1869158

Showing of synonyms

Kojom Foko L.P, Jakhan J, et al. (2024). New antimalarial lanostane triterpenes from a new isolate of Egyptian Ganoderma species. Journal of parasitic diseases : official organ of the Indian Society for Parasitology, 2024, 48(3), 610-623. [View] [PubMed]

Pubchem: 9841824

Cas: 267418-82-6

Zinc: ZINC000015251935

Nmrshiftdb2: 70012244

Chembl: CHEMBL496059

No compound-protein relationship available.

SMILES: c1ccccc1

Level: 0

Mol. Weight: 360.45 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.31
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.02
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -4.46

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.23
Plasma Protein Binding: 56.77
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.97
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.04
Biodegradation: Toxic
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.5
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 3.32
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 2.27
Rat (Acute): 2.02
Rat (Chronic Oral): 2.07
Fathead Minnow: 4.66
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 452.8
Hydration Free Energy: -9.5
Log(D) at pH=7.4: 1.38
Log(P): 3.03
Log S: -3.42
Log(Vapor Pressure): -11.03
Melting Point: 166.55
pKa Acid: 6.87
pKa Basic: 6.41

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Epoxide hydrolase	Q41415	Q41415_SOLTU	Solanum tuberosum	3	0.9573
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9498
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.9479
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.9392
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9335
Anthranilate phosphoribosyltransferase	P9WFX5	TRPD_MYCTU	Mycobacterium tuberculosis	3	0.9308
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.9279
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.9272
Aspartate aminotransferase	P00509	AAT_ECOLI	Escherichia coli	3	0.9266
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	3	0.9264
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.9204
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.9160
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.9156
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.9141
Anthranilate phosphoribosyltransferase	P9WFX5	TRPD_MYCTU	Mycobacterium tuberculosis	3	0.9116
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8970
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.8932
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8896
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	3	0.8883
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8872
Cysteine desulfurase IscS 2	O29689	ISCS2_ARCFU	Archaeoglobus fulgidus	3	0.8869
Nitric oxide synthase, inducible	P35228	NOS2_HUMAN	Homo sapiens	3	0.8865
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8850
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8845
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8835
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.8827
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8811
SKP1-like protein 1A	Q39255	SKP1A_ARATH	Arabidopsis thaliana	3	0.8780
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8754
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8741
Thiazole tautomerase	P25053	TENI_BACSU	Bacillus subtilis	3	0.8733
Glycogen phosphorylase, liver form	P06737	PYGL_HUMAN	Homo sapiens	3	0.8726
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8708
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	3	0.8697
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	3	0.8683
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8669
L-lactate dehydrogenase (cytochrome)	P00175	CYB2_YEAST	Saccharomyces cerevisiae	3	0.8666
11-beta-hydroxysteroid dehydrogenase 1	P50172	DHI1_MOUSE	Mus musculus	3	0.8661
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.8650
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8650
Pyridoxal kinase	O00764	PDXK_HUMAN	Homo sapiens	3	0.8636
Polymerase acidic protein	Q5EP34	Q5EP34_9INFA	Influenza A virus	3	0.8634
Vitamin D-binding protein	P02774	VTDB_HUMAN	Homo sapiens	3	0.8613
Alcohol dehydrogenase 1C	P00326	ADH1G_HUMAN	Homo sapiens	3	0.8609
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	3	0.8608
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.8604
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	4	0.8594
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	3	0.8582
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8570
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8565
Major NAD(P)H-flavin oxidoreductase	P46072	FRA1_ALIFS	Aliivibrio fischeri	3	0.8549
Cysteine desulfurase IscS 2	O29689	ISCS2_ARCFU	Archaeoglobus fulgidus	3	0.8548
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.8532
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8529
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8502
2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase	Q988D3	Q988D3_RHILO	Mesorhizobium japonicum)	3	0.8488
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	3	0.8481
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8477
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8475
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.8471
Pyridoxal kinase, putative	C4LVZ4	C4LVZ4_ENTHI	Entamoeba histolytica	3	0.8467
Integrin alpha-L	P20701	ITAL_HUMAN	Homo sapiens	3	0.8459
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	3	0.8437
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.8433
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8391
SKP1-like protein 1A	Q39255	SKP1A_ARATH	Arabidopsis thaliana	3	0.8391
Anthranilate phosphoribosyltransferase	P50384	TRPD_SACS2	Saccharolobus solfataricus	3	0.8387
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8361
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8336
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.8321
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.8312
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8311
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.8302
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	3	0.8287
Phenylpyruvate C(3)-methyltransferase	Q643C8	MPPJ_STRHY	Streptomyces hygroscopicus	3	0.8276
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8267
Mandelate racemase	P11444	MANR_PSEPU	Pseudomonas putida	3	0.8264
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.8260
Pyrrolysine--tRNA ligase	Q8PWY1	PYLS_METMA	Methanosarcina mazei	3	0.8254
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8245
Xanthine dehydrogenase/oxidase	P22985	XDH_RAT	Rattus norvegicus	3	0.8243
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8241
Kynurenine--oxoglutarate transaminase 1	Q16773	KAT1_HUMAN	Homo sapiens	3	0.8238
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8234
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8217
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8196
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.8194
Protein mono-ADP-ribosyltransferase PARP14	Q460N5	PAR14_HUMAN	Homo sapiens	3	0.8187
L-methionine gamma-lyase	P13254	MEGL_PSEPU	Pseudomonas putida	4	0.8185
Trifunctional purine biosynthetic protein adenosine-3	P22102	PUR2_HUMAN	Homo sapiens	3	0.8183
Virulence sensor histidine kinase PhoQ	P0DM80	PHOQ_SALTY	Salmonella typhimurium	4	0.8167
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8155
SKP1-like protein 1A	Q39255	SKP1A_ARATH	Arabidopsis thaliana	3	0.8142
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8138
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	3	0.8138
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	4	0.8136
Acetylornithine/succinyldiaminopimelate aminotransferase	P40732	ARGD_SALTY	Salmonella typhimurium	3	0.8128
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8105
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8103
Glycogen synthase	P0A6U8	GLGA_ECOLI	Escherichia coli	3	0.8103
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.8102
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	3	0.8093
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.8091
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	P12995	BIOA_ECOLI	Escherichia coli	3	0.8088
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	3	0.8068
Aspartate aminotransferase, mitochondrial	P00508	AATM_CHICK	Gallus gallus	3	0.8068
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.8054
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	3	0.8044
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8043
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	4	0.8039
Threonine synthase 1, chloroplastic	Q9S7B5	THRC1_ARATH	Arabidopsis thaliana	3	0.8038
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.8028
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	3	0.8025
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8019
DNA ligase	P43813	DNLJ_HAEIN	Haemophilus influenzae	4	0.8017
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8002
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase	P9WNH5	HSAD_MYCTU	Mycobacterium tuberculosis	3	0.7990
Chaperone protein HtpG	P0A6Z3	HTPG_ECOLI	Escherichia coli	3	0.7983
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.7971
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7966
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7946
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.7938
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7937
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7928
Mandelate racemase	P11444	MANR_PSEPU	Pseudomonas putida	3	0.7917
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7911
Chorismate mutase AroH	P19080	AROH_BACSU	Bacillus subtilis	3	0.7911
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7910
VioE domain-containing protein	Q7NSZ5	Q7NSZ5_CHRVO	Chromobacterium violaceum	3	0.7898
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7896
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7893
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7888
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.7881
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7866
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7860
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.7852
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7831
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.7830
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.7828
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.7808
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	P12995	BIOA_ECOLI	Escherichia coli	3	0.7798
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7798
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.7786
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7785
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	3	0.7782
LysR-type regulatory protein	Q7WT50	Q7WT50_9BURK	Burkholderia sp. DNT	3	0.7776
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7774
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7770
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7768
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7762
Anthranilate phosphoribosyltransferase	P00500	TRPD_ACIAD	Acinetobacter baylyi	3	0.7755
Deacetoxycephalosporin C synthase	P18548	CEFE_STRCL	Streptomyces clavuligerus	3	0.7738
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7733
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7722
Fatty acid-binding protein 10-A, liver basic	Q9I8L5	FA10A_DANRE	Danio rerio	3	0.7712
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7706
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7699
DNA polymerase III subunit epsilon	P03007	DPO3E_ECOLI	Escherichia coli	3	0.7686
Prenyltransferase	Q4R2T2	Q4R2T2_STRC1	Streptomyces sp	2	0.7683
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7679
Poly(A) polymerase, putative	Q381M1	Q381M1_TRYB2	Trypanosoma brucei brucei	4	0.7673
Nucleoside diphosphate kinase A 2	P52175	NDKA2_BOVIN	Bos taurus	3	0.7673
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7667
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7662
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7654
5-aminolevulinate synthase	P18079	HEM1_RHOCB	Rhodobacter capsulatus	3	0.7654
Peroxisome proliferator-activated receptor alpha	Q07869	PPARA_HUMAN	Homo sapiens	3	0.7651
Beta-galactoside-specific lectin 1	P81446	ML1_VISAL	Viscum album	3	0.7649
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.7645
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7637
Succinyl-CoA:acetate CoA-transferase	B3EY95	SCACT_ACEAC	Acetobacter aceti	3	0.7635
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7627
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.7624
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7621
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7621
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7617
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7614
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7614
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.7613
Eukaryotic translation initiation factor 4E type 3	Q9DBB5	IF4E3_MOUSE	Mus musculus	3	0.7610
Copper-transporting ATPase 1	Q04656	ATP7A_HUMAN	Homo sapiens	3	0.7609
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7606
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7601
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.7586
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7565
Mitochondrial dynamics protein MIEF1	Q9NQG6	MID51_HUMAN	Homo sapiens	3	0.7565
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7560
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7547
Fatty acid-binding protein, intestinal	P02693	FABPI_RAT	Rattus norvegicus	3	0.7537
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7536
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7535
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7531
Class 10 plant pathogenesis-related protein 2B	Q9LLQ2	P102B_LUPLU	Lupinus luteus	2	0.7524
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	4	0.7523
Beta-1,4-galactosyltransferase 1	P08037	B4GT1_BOVIN	Bos taurus	3	0.7520
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	2	0.7517
Elongation factor Tu 1	P0CE47	EFTU1_ECOLI	Escherichia coli	3	0.7509
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7508
Anthranilate phosphoribosyltransferase	P50384	TRPD_SACS2	Saccharolobus solfataricus	3	0.7504
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	4	0.7503
Trichodiene synthase	P13513	TRI5_FUSSP	Fusarium sporotrichioides	2	0.7503
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7500
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7487
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7483
Ribosomal RNA large subunit methyltransferase H	P0C1V0	RLMH_STAAU	Staphylococcus aureus	3	0.7482
3-hydroxy-3-methylglutaryl-coenzyme A reductase	P04035	HMDH_HUMAN	Homo sapiens	3	0.7481
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	3	0.7476
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7470
Orotidine 5'-phosphate decarboxylase	O26232	PYRF_METTH	Methanothermobacter thermautotrophicus	3	0.7466
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7454
Guanylate kinase	P15454	KGUA_YEAST	Saccharomyces cerevisiae	3	0.7449
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase	Q8U0R7	PURP_PYRFU	Pyrococcus furiosus	3	0.7445
Cytochrome b6	P83791	CYB6_MASLA	Mastigocladus laminosus	3	0.7440
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7439
Ethanolamine-phosphate cytidylyltransferase	Q99447	PCY2_HUMAN	Homo sapiens	3	0.7436
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7428
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7418
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7415
Tryptophan synthase beta chain 2	Q97TX6	TRPB2_SACS2	Saccharolobus solfataricus	3	0.7413
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7412
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7409
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7403
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7403
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.7403
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7384
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	3	0.7377
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7373
Toluene-4-monooxygenase system, hydroxylase component subunit alpha	Q00456	TMOA_PSEME	Pseudomonas mendocina	2	0.7373
Orotidine 5'-phosphate decarboxylase	Q5L0U0	PYRF_GEOKA	Geobacillus kaustophilus	3	0.7370
Chorismate mutase AroH	P19080	AROH_BACSU	Bacillus subtilis	2	0.7367
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7362
4-hydroxyphenylacetate 3-monooxygenase, reductase component	Q5SJP7	HPAC_THET8	Thermus thermophilus	3	0.7358
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7357
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	3	0.7352
Aminotransferase homolog	Q9S5Y7	Q9S5Y7_CAMJU	Campylobacter jejuni	3	0.7350
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7350
Sphingosine 1-phosphate receptor 1	P21453	S1PR1_HUMAN	Homo sapiens	3	0.7349
Aminotransferase class I/classII domain-containing protein	O57946	O57946_PYRHO	Pyrococcus horikoshii	3	0.7349
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7348
MutT/nudix family protein	O33199	O33199_MYCTO	Mycobacterium tuberculosis	3	0.7347
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7347
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7346
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7343
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7340
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	3	0.7336
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7334
Acyl-CoA:acyl-CoA alkyltransferase	Q8PDX2	OLEA_XANCP	Xanthomonas campestris pv. campestris	3	0.7332
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	2	0.7331
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.7318
Probable nicotinate-nucleotide adenylyltransferase	Q9HX21	NADD_PSEAE	Pseudomonas aeruginosa	3	0.7318
Aldo-keto reductase family 1 member C1	Q04828	AK1C1_HUMAN	Homo sapiens	2	0.7316
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7316
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7312
CalS13	Q8KND8	Q8KND8_MICEC	Micromonospora echinospora	3	0.7309
Fatty acid-binding protein 10-A, liver basic	Q9I8L5	FA10A_DANRE	Danio rerio	3	0.7304
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7302
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.7291
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7289
Cyclic nucleotide-binding domain-containing protein	E0RR11	E0RR11_SPITD	Spirochaeta thermophila	2	0.7286
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7285
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7278
Uncharacterized protein	Q46E79	Q46E79_METBF	Methanosarcina barkeri	3	0.7269
Cytosolic IMP-GMP specific 5'-nucleotidase	Q5ZZB6	Q5ZZB6_LEGPH	Legionella pneumophila subsp. pneumophila	3	0.7267
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7266
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7263
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7262
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7260
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7255
Probable enoyl-CoA hydratase EchA8	P9WNN9	ECHA8_MYCTU	Mycobacterium tuberculosis	3	0.7253
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	2	0.7250
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7247
Formylmethanofuran--tetrahydromethanopterin formyltransferase	Q49610	FTR_METKA	Methanopyrus kandleri	3	0.7243
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7243
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7238
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7234
tRNA (adenine(9)-N1)-methyltransferase	Q4J894	TRM10_SULAC	Sulfolobus acidocaldarius	3	0.7229
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7229
Methionine aminopeptidase 1	P53582	MAP11_HUMAN	Homo sapiens	2	0.7224
Ethylene receptor 1	P49333	ETR1_ARATH	Arabidopsis thaliana	3	0.7218
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7210
Ferrichrome outer membrane transporter/phage receptor	P06971	FHUA_ECOLI	Escherichia coli	3	0.7208
Muconolactone Delta-isomerase	Q8G9L0	Q8G9L0_RHOOP	Rhodococcus opacus	2	0.7208
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7207
Translation initiation factor 2 subunit gamma	Q980A5	IF2G_SACS2	Saccharolobus solfataricus	3	0.7204
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7204
Benzoylformate decarboxylase	P20906	MDLC_PSEPU	Pseudomonas putida	3	0.7201
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7198
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7186
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7180
AcsD	Q93AT8	Q93AT8_DICCH	Dickeya chrysanthemi	3	0.7179
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	2	0.7177
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7174
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7173
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7171
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7169
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7167
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7164
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7164
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.7161
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	3	0.7161
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7158
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7156
Lipoprotein E	P26093	HEL_HAEIN	Haemophilus influenzae	3	0.7152
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7152
HD domain protein	Q836G9	Q836G9_ENTFA	Enterococcus faecalis	3	0.7148
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7139
Glutamate receptor ionotropic, kainate 1	P22756	GRIK1_RAT	Rattus norvegicus	2	0.7136
4-substituted benzoates-glutamate ligase GH3.12	Q9LYU4	GH312_ARATH	Arabidopsis thaliana	3	0.7134
RNA 2',3'-cyclic phosphodiesterase	P37025	THPR_ECOLI	Escherichia coli	3	0.7130
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.7130
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7127
Hydroxymethylglutaryl-CoA synthase	Q9FD71	HMGCS_ENTFL	Enterococcus faecalis	2	0.7127
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.7123
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7123
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7120
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7120
Catabolite activator protein	C3SQJ7	C3SQJ7_ECOLX	Escherichia coli	3	0.7118
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7118
Aspartate aminotransferase, mitochondrial	P00508	AATM_CHICK	Gallus gallus	3	0.7117
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7115
Branched-chain-amino-acid aminotransferase, mitochondrial	O15382	BCAT2_HUMAN	Homo sapiens	3	0.7114
Flavin reductase like domain-containing protein	Q4UKE8	Q4UKE8_RICFE	Rickettsia felis	3	0.7109
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7109
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7107
NTPase P4	Q94M05	Q94M05_9VIRU	Pseudomonas phage phi12	3	0.7105
Biotin carboxylase	P43873	ACCC_HAEIN	Haemophilus influenzae	3	0.7102
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7102
Glutamate--cysteine ligase	P32477	GSH1_YEAST	Saccharomyces cerevisiae	3	0.7099
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7099
orotidine-5'-phosphate decarboxylase	Q8T6J6	Q8T6J6_PLAFA	Plasmodium falciparum	4	0.7098
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7098
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7095
Tyrosine-protein kinase ABL1	P00519	ABL1_HUMAN	Homo sapiens	3	0.7094
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7090
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7088
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7086
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	2	0.7084
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7081
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7080
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7077
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7076
RIO-type serine/threonine-protein kinase Rio1	O28471	RIO1_ARCFU	Archaeoglobus fulgidus	2	0.7076
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7074
dTDP-4-dehydrorhamnose 3,5-epimerase	A0A6L7H6N0	A0A1S0QLH9_BACAN	Bacillus anthracis	3	0.7068
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7068
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7066
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.7065
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7060
tRNA-guanine(15) transglycosylase	O58843	ATGT_PYRHO	Pyrococcus horikoshii	3	0.7059
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	2	0.7057
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	2	0.7054
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7054
Beta-hexosaminidase	Q9KU37	NAGZ_VIBCH	Vibrio cholerae serotype O1	3	0.7053
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7046
SKP1-like protein 1A	Q39255	SKP1A_ARATH	Arabidopsis thaliana	3	0.7045
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7044
Holliday junction branch migration complex subunit RuvB	Q9PMT7	RUVB_CAMJE	Campylobacter jejuni subsp. jejuni serotype O:2	2	0.7042
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	3	0.7042
Tyrosine 3-monooxygenase	P04177	TY3H_RAT	Rattus norvegicus	3	0.7041
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7040
histidine kinase	Q9WZV7	Q9WZV7_THEMA	Thermotoga maritima	3	0.7039
Cytosol aminopeptidase	P00727	AMPL_BOVIN	Bos taurus	2	0.7035
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	2	0.7035
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7034
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7032
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	2	0.7032
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	2	0.7031
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	2	0.7030
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	Q9Y3Z3	SAMH1_HUMAN	Homo sapiens	3	0.7029
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	3	0.7027
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7026
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7025
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7024
3',5'-cyclic-AMP phosphodiesterase 4B	Q07343	PDE4B_HUMAN	Homo sapiens	3	0.7017
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7014
Malate dehydrogenase	P10584	MDH_THETH	Thermus thermophilus	3	0.7008
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7006
Glycogenin-1	P46976	GLYG_HUMAN	Homo sapiens	3	0.7006
Orotidine 5'-phosphate decarboxylase	O58462	PYRF_PYRHO	Pyrococcus horikoshii	3	0.7005
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7005
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7004
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7004
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	2	0.7003

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