Orobol-7,3′-di-O-methyl ether - Compound Card

Orobol-7,3′-di-O-methyl ether

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Orobol-7,3′-di-O-methyl ether

Structure
Zoomed Structure
  • Family: Plantae - Iridaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavone
Canonical Smiles COc1cc(O)c2c(c1)occ(c2=O)c1ccc(c(c1)OC)O
InChI InChI=1S/C17H14O6/c1-21-10-6-13(19)16-15(7-10)23-8-11(17(16)20)9-3-4-12(18)14(5-9)22-2/h3-8,18-19H,1-2H3
InChIKey NMQZMHHAWZDJOJ-UHFFFAOYSA-N
Formula C17H14O6
HBA 6
HBD 2
MW 314.29
Rotatable Bonds 3
TPSA 89.13
LogP 2.89
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 314.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Dietes bicolor Iridaceae Plantae 93015

Showing of synonyms

  • Ayoub I.M, Korinek M, et al. (2018). Probing the antiallergic and anti-inflammatory activity of biflavonoids and dihydroflavonols from dietes bicolor. Journal of natural products, 2018, 81(2), 243-253. [View] [PubMed]
Pubchem: 13845970
Chebi: 175017
Nmrshiftdb2: 60024545

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 314.29 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 314.29 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 314.29 g/mol

Anti-inflammatory
Antiallergic

Absorption

Caco-2 (logPapp)
-4.6
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.720
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.46

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.510
Plasma Protein Binding
78.53
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.580
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.630
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.160
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.810
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.410
Rat (Acute)
2.330
Rat (Chronic Oral)
2.580
Fathead Minnow
4.890
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
440.170
Hydration Free Energy
-10.170
Log(D) at pH=7.4
3.230
Log(P)
3.01
Log S
-5.75
Log(Vapor Pressure)
-7.86
Melting Point
210.64
pKa Acid
8.46
pKa Basic
3.5
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9652
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9548
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9506
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9493
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9455
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9397
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9394
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9345
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9332
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9240
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9149
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9130
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9128
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9123
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.9120
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.9115
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9084
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9082
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.9051
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8994
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8983
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8969
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8923
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8915
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8878
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8876
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8870
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8861
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8830
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8805
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8793
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8793
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8788
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8771
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8770
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8770
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8769
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8752
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8731
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8730
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8712
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8675
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8669
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8653
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.8614
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8596
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8544
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8537
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8501
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.8489
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8487
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8482
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8473
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8472
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8452
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8442
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8419
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8411
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8393
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8389
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8375
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8366
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8359
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8352
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8350
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8345
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8344
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8323
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8311
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8302
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8288
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.8287
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8254
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8253
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8219
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8186
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8149
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8111
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8099
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.8096
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8093
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8050
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.8049
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8045
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8045
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8040
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8019
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.8002
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7989
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7980
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7975
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7957
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7944
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7938
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7934
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7931
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7927
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7893
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7892
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7888
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7881
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7871
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7869
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7857
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7851
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7834
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7830
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7826
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7809
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7772
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7765
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7754
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7721
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7719
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7716
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7714
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7678
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7677
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7670
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7662
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7662
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7661
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7648
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.7648
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7639
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7601
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7589
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7584
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7581
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7580
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7577
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7570
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7570
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7555
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7550
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7530
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7527
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7520
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7511
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7494
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7489
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7485
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7485
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7483
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7480
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7478
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7477
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7473
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7472
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7462
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7459
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7457
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7455
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 4 0.7447
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7442
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7437
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7430
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7429
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7428
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7408
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7405
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7405
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7403
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 4 0.7400
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7393
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7380
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7375
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7371
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7370
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7369
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7356
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7350
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7349
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7343
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7340
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7338
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7337
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7331
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7328
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 3 0.7322
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7320
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7319
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7290
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7288
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7285
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7273
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7272
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7271
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7269
Bifunctional dihydrofolate reductase-thymidylate synthase Q27783 DRTS_TRYBB Trypanosoma brucei brucei 4 0.7267
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7266
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7265
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7262
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7249
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7248
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7246
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7242
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7231
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7229
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7228
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7223
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7223
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7219
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7217
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7214
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 4 0.7209
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7208
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7208
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7200
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7198
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7183
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7183
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7183
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7182
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7172
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7171
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7158
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7157
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7156
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7155
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7153
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7152
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7149
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7148
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7134
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7132
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.7119
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7116
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7116
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7115
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7112
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7110
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7094
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7091
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7090
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7088
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7087
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7083
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7083
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7083
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7079
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7078
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7070
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7064
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7063
Beta-ketoacyl-[acyl-carrier-protein] synthase III Q820T1 FABH_ENTFA Enterococcus faecalis 2 0.7059
GTPase IMAP family member 2 Q9UG22 GIMA2_HUMAN Homo sapiens 3 0.7058
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7058
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7055
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7053
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 4 0.7034
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7023
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7023
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7016
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7015
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7014
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7013
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7011
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7010
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7001
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 2 0.7001
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7001
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7000
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7000

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