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Lanaroflavone

Family: Plantae - Iridaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Isoflavone

Canonical Smiles	Oc1ccc(cc1)c1cc(=O)c2c(o1)c(Oc1ccc(cc1)c1cc(=O)c3c(o1)cc(cc3O)O)c(cc2O)O
InChI	InChI=1S/C30H18O10/c31-16-5-1-14(2-6-16)25-13-22(36)28-20(34)11-23(37)29(30(28)40-25)38-18-7-3-15(4-8-18)24-12-21(35)27-19(33)9-17(32)10-26(27)39-24/h1-13,31-34,37H
InChIKey	DLWAHHFLQNUOIA-UHFFFAOYSA-N
Formula	C₃₀H₁₈O₁₀
HBA	10
HBD	5
MW	538.46
Rotatable Bonds	4
TPSA	170.8
LogP	5.55
Number Rings	6
Number Aromatic Rings	6
Heavy Atom Count	40
Formal Charge	0
Fraction CSP3	0.0
Exact Mass	538.09
Number of Lipinski Rule Violations	2

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Dietes bicolor	Iridaceae	Plantae	93015

Showing of synonyms

Ayoub I.M, Korinek M, et al. (2018). Probing the antiallergic and anti-inflammatory activity of biflavonoids and dihydroflavonols from dietes bicolor. Journal of natural products, 2018, 81(2), 243-253. [View] [PubMed]

Pubchem: 11272651

Cas: 521-50-6

Zinc: ZINC000085995102

Nmrshiftdb2: 60079085

Chembl: CHEMBL2172395

No compound-protein relationship available.

SMILES: c1ccccc1-c(cc2=O)oc(c23)c(ccc3)Oc(cc4)ccc4-c(cc5=O)oc(c56)cccc6

Level: 3

Mol. Weight: 538.46 g/mol

SMILES: O=c1ccoc(c12)c(ccc2)Oc(cc3)ccc3-c(cc4=O)oc(c45)cccc5

Level: 2

Mol. Weight: 538.46 g/mol

SMILES: c1ccccc1Oc(ccc2)c(c23)oc(cc3=O)-c4ccccc4

Level: 2

Mol. Weight: 538.46 g/mol

SMILES: O=c1ccoc(c12)c(ccc2)Oc3ccccc3

Level: 1

Mol. Weight: 538.46 g/mol

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 538.46 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 538.46 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 538.46 g/mol

Anti-inflammatory

Antiallergic

Absorption

Caco-2 (logPapp): -5.89
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.030
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: 4.53

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.610
Plasma Protein Binding: 99.77
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.320
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.470
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.420
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.900
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -5874.250
Rat (Acute): 2.450
Rat (Chronic Oral): 2.790
Fathead Minnow: 20.580
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 609.610
Hydration Free Energy: -3.040
Log(D) at pH=7.4: 4.080
Log(P): 5.86
Log S: -7.61
Log(Vapor Pressure): -9.61
Melting Point: 431.91
pKa Acid: 9.99
pKa Basic: 4.59

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9761
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.9485
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.9280
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9265
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9252
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	5	0.9217
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.9147
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.9124
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	3	0.9105
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9076
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.9003
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8980
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8969
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8916
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.8845
Geranylgeranyl transferase type-2 subunit alpha	Q08602	PGTA_RAT	Rattus norvegicus	3	0.8841
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8809
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8791
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.8789
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	3	0.8763
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.8737
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8696
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.8673
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.8664
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.8569
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8503
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8499
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.8497
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	4	0.8489
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8449
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8447
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8411
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	3	0.8394
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8347
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8318
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8303
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.8280
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.8275
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.8273
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.8267
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.8255
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	4	0.8239
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8222
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.8198
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.8192
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8179
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8170
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.8102
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8082
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	5	0.8054
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	3	0.8046
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8042
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8042
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.8037
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8002
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.7988
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.7987
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7955
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	4	0.7934
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	3	0.7917
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7895
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7892
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7890
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7839
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7835
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.7832
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7821
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7779
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7778
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7761
Succinyl-CoA:acetate CoA-transferase	B3EY95	SCACT_ACEAC	Acetobacter aceti	3	0.7756
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7738
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7727
Botulinum neurotoxin type A	P0DPI0	BXA1_CLOBO	Clostridium botulinum	3	0.7711
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.7705
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.7705
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7690
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	4	0.7687
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7687
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.7675
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	3	0.7672
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.7662
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	3	0.7661
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.7613
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7591
Single-strand selective monofunctional uracil DNA glycosylase	Q9YGN6	SMUG1_XENLA	Xenopus laevis	4	0.7582
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7574
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7554
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	3	0.7547
Bromodomain-containing protein 9	Q9H8M2	BRD9_HUMAN	Homo sapiens	3	0.7545
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	2	0.7537
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7535
Caspase-6	P55212	CASP6_HUMAN	Homo sapiens	3	0.7535
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7525
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7489
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7482
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7470
Renin	P00797	RENI_HUMAN	Homo sapiens	4	0.7463
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7462
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7456
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7453
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7451
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7436
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	4	0.7419
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7414
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	5	0.7388
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7386
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7382
RAC-alpha serine/threonine-protein kinase	P31749	AKT1_HUMAN	Homo sapiens	3	0.7381
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7378
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7372
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7372
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7362
Major strawberry allergen Fra a 1-3	D0E0C7	FRA13_FRAAN	Fragaria ananassa	4	0.7352
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7352
O-methyltransferase family 2	D5STZ7	D5STZ7_PLAL2	Planctopirus limnophila	4	0.7345
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7332
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7322
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7321
Cytochrome P450 130	P9WPN5	CP130_MYCTU	Mycobacterium tuberculosis	3	0.7316
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.7313
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7306
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7298
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.7292
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7288
Genome polyprotein	C0LMU0	C0LMU0_9FLAV	dengue virus type 3	3	0.7282
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7268
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7268
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7256
Nitric oxide synthase 3	P29474	NOS3_HUMAN	Homo sapiens	3	0.7246
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7230
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.7222
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	3	0.7210
Tissue factor	P13726	TF_HUMAN	Homo sapiens	3	0.7208
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7207
Geranylgeranyl transferase type-2 subunit alpha	Q08602	PGTA_RAT	Rattus norvegicus	4	0.7197
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q4WP27	Q4WP27_ASPFU	Aspergillus fumigatus	3	0.7184
Geranylgeranyl transferase type-2 subunit alpha	Q08602	PGTA_RAT	Rattus norvegicus	3	0.7178
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.7174
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.7172
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7171
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7166
Dihydrofolate reductase	P00381	DYR_LACCA	Lacticaseibacillus casei	4	0.7163
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7119
Methyltransferase	D0VX01	D0VX01_WSLV	Wesselsbron virus	4	0.7100
Nucleoside permease	Q9KPL5	Q9KPL5_VIBCH	Vibrio cholerae serotype O1	3	0.7094
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7092
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7078
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7076
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7064
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7057
Cyclin-dependent kinase 5	Q00535	CDK5_HUMAN	Homo sapiens	4	0.7048
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7045
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7029
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	4	0.7028
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7025
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.7017
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7015
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7015
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	4	0.7014

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