5,7,3’,4’-tetrahydroxy-7-0-lactoylflavone - Compound Card

5,7,3’,4’-tetrahydroxy-7-0-lactoylflavone

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5,7,3’,4’-tetrahydroxy-7-0-lactoylflavone

Structure
Zoomed Structure
  • Family: Plantae - Labiateae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Lactoyl Flavonoid
Canonical Smiles O=C(C(O)C)Oc1cc(O)c2c(c1)oc(cc2=O)c1ccc(c(c1)O)O
InChI InChI=1S/C18H14O8/c1-8(19)18(24)25-10-5-13(22)17-14(23)7-15(26-16(17)6-10)9-2-3-11(20)12(21)4-9/h2-8,19-22H,1H3
InChIKey RWLCWWWLTRAVKI-UHFFFAOYSA-N
Formula C18H14O8
HBA 8
HBD 4
MW 358.3
Rotatable Bonds 3
TPSA 137.43
LogP 1.86
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.11
Exact Mass 358.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Marrubium vulgare Lamiaceae Plantae 41230
2 Marrubium vulgare Labiateae Plantae 41230

Showing of synonyms

  • Nawwar M, El-Mousallamy A, et al. (1989). Flavonoid Lactates from Leaves of Marrubium Vulgare. Phytochemistry, 1989, 28(11), 3201-3206.. [View]
Pubchem: 44258150

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 358.3 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 358.3 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 358.3 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.74
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.9
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.84

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.36
Plasma Protein Binding
78.23
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.51
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.16
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.1
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.58
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.31
Rat (Acute)
2.48
Rat (Chronic Oral)
2.95
Fathead Minnow
4.52
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
495.44
Hydration Free Energy
-10.42
Log(D) at pH=7.4
2.75
Log(P)
2.21
Log S
-4.4
Log(Vapor Pressure)
-8.89
Melting Point
245.01
pKa Acid
8.91
pKa Basic
4.65
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9560
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9381
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9334
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9246
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9230
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.9184
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9179
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9054
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9027
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.9001
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.8989
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8981
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8957
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8922
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8922
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8913
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8863
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8794
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8779
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8764
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8756
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8722
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8717
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8708
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8667
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8661
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8660
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8659
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8658
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8641
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8640
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8638
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8624
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8564
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8547
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8532
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8527
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8514
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8513
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8500
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8487
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8457
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.8420
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8413
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.8371
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8363
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8359
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8346
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8345
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8316
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8305
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8303
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8293
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8291
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8275
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8269
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8269
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8268
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8237
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8222
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8195
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8175
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8173
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8137
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8135
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8124
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8120
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8118
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8061
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8059
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8051
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8030
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8028
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.8018
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8004
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7986
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7953
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7943
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7912
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7871
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7849
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7805
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7795
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7788
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7773
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7770
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7766
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 4 0.7762
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7753
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7748
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7737
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7732
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7720
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7697
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7694
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7693
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7685
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7673
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 4 0.7658
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7655
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7649
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7623
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7594
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.7590
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7589
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7577
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7574
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7574
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7572
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7570
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7557
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7553
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7546
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7541
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 3 0.7540
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7527
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7511
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7508
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7506
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7498
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7490
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7477
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7472
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7464
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7460
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7451
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7447
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7439
Maltose/maltodextrin-binding periplasmic protein P0AEX9 MALE_ECOLI Escherichia coli 3 0.7438
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7432
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7412
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7374
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 4 0.7358
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7354
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7349
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7347
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7332
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7326
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7326
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7320
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7316
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7314
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7313
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7311
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 3 0.7287
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7286
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7285
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7283
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7281
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7280
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7269
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7266
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7263
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7253
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7252
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7248
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7237
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7237
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7227
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7226
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7213
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7212
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7208
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7207
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7195
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 5 0.7192
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7185
CRP-like cAMP-activated global transcriptional regulator P9WMH3 CRPL_MYCTU Mycobacterium tuberculosis 3 0.7180
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7180
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7169
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7166
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7143
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7140
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7138
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7120
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7117
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7116
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7115
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7111
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7110
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7109
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7108
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7105
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7105
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7102
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7098
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7094
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7089
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7083
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7082
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7081
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7080
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7080
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7079
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7077
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7077
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7066
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7065
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7059
DNA-(apurinic or apyrimidinic site) lyase Q97FM4 Q97FM4_CLOAB Clostridium acetobutylicum 4 0.7057
Methyltransferase domain-containing protein O57965 O57965_PYRHO Pyrococcus horikoshii 4 0.7057
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7056
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7050
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7041
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7034
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7034
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 3 0.7030
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7028
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7023
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7018
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7017
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7015
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7005
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7000

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