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Diapigenin, 7-O- (6"-trans, 6"-cis-p,p'-dihydroxy-mu-truxinyl) glucoside

Family: Plantae - Labiateae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Flavone

Canonical Smiles	O=C([C@H]1[C@H](C(=O)OC[C@H]2O[C@@H](Oc3cc(O)c4c(c3)oc(cc4=O)c3ccc(cc3)O)[C@@H]([C@H]([C@@H]2O)O)O)[C@@H]([C@H]1c1ccc(cc1)O)c1ccc(cc1)O)OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)c2ccc(cc2)O)[C@@H]([C@H]([C@@H]1O)O)O
InChI	InChI=1S/C60H52O24/c61-29-9-1-25(2-10-29)39-21-37(67)47-35(65)17-33(19-41(47)81-39)79-59-55(73)53(71)51(69)43(83-59)23-77-57(75)49-45(27-5-13-31(63)14-6-27)46(28-7-15-32(64)16-8-28)50(49)58(76)78-24-44-52(70)54(72)56(74)60(84-44)80-34-18-36(66)48-38(68)22-40(82-42(48)20-34)26-3-11-30(62)12-4-26/h1-22,43-46,49-56,59-66,69-74H,23-24H2/t43-,44-,45-,46-,49-,50-,51-,52-,53+,54+,55-,56-,59-,60-/m1/s1
InChIKey	VLKZMOAGAREVTL-YDXYIZPWSA-N
Formula	C₆₀H₅₂O₂₄
HBA	24
HBD	12
MW	1157.05
Rotatable Bonds	14
TPSA	392.7
LogP	3.44
Number Rings	11
Number Aromatic Rings	8
Heavy Atom Count	84
Formal Charge	0
Fraction CSP3	0.27
Exact Mass	1156.28
Number of Lipinski Rule Violations	3

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Stachys aegyptiaca	Lamiaceae	Plantae	1391947
2	Stachys aegyptiaca	Labiateae	Plantae	1391947

Showing of synonyms

El-Ansari M, Nawwar M, et al. (1995). Stachysetin, A Diapigenin-7-Glucoside-p,p'-Dihydroxytruxinate from Stachys Aegyptiaca. Phytochemistry, 1995, 40(5),1543-1548.. [View]

Pubchem: 101682257

Nmrshiftdb2: 70020322

No compound-protein relationship available.

SMILES: c1ccccc1-c(cc2=O)oc(c23)cc(cc3)OC(O4)CCCC4COC(=O)C5C(C(c6ccccc6)C5c7ccccc7)C(=O)OCC8CCCC(O8)Oc(cc9)cc(c19)oc(cc1=O)-c1ccccc1

Level: 8

Mol. Weight: 1157.05 g/mol

SMILES: c1ccccc1-c(cc2=O)oc(c23)cc(cc3)OC(O4)CCCC4COC(=O)C5C(CC5c6ccccc6)C(=O)OCC7CCCC(O7)Oc(cc8)cc(c89)oc(cc9=O)-c1ccccc1

Level: 7

Mol. Weight: 1157.05 g/mol

SMILES: O=c1ccoc(c12)cc(cc2)OC(O3)CCCC3COC(=O)C(C(c4ccccc4)C5c6ccccc6)C5C(=O)OCC7CCCC(O7)Oc(cc8)cc(c89)oc(cc9=O)-c1ccccc1

Level: 7

Mol. Weight: 1157.05 g/mol

SMILES: c1ccccc1-c(cc2=O)oc(c23)cc(cc3)OC(O4)CCCC4COC(=O)C5C(CC5)C(=O)OCC6CCCC(O6)Oc(cc7)cc(c78)oc(cc8=O)-c9ccccc9

Level: 6

Mol. Weight: 1157.05 g/mol

SMILES: O=c1ccoc(c12)cc(cc2)OC(O3)CCCC3COC(=O)C4C(CC4c5ccccc5)C(=O)OCC6CCCC(O6)Oc(cc7)cc(c78)oc(cc8=O)-c9ccccc9

Level: 6

Mol. Weight: 1157.05 g/mol

SMILES: O=c1ccoc(c12)cc(cc2)OC(O3)CCCC3COC(=O)C4C(C(c5ccccc5)C4c6ccccc6)C(=O)OCC7CCCC(O7)Oc(cc8)cc(c89)occc9=O

Level: 6

Mol. Weight: 1157.05 g/mol

SMILES: O=c1ccoc(c12)cc(cc2)OC(O3)CCCC3COC(=O)C(CC4c5ccccc5)C4C(=O)OCC6CCCC(O6)Oc(cc7)cc(c78)oc(cc8=O)-c9ccccc9

Level: 6

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C(C(c2ccccc2)C3c4ccccc4)C3C(=O)OCC5CCCC(O5)Oc(cc6)cc(c67)oc(cc7=O)-c8ccccc8

Level: 6

Mol. Weight: 1157.05 g/mol

SMILES: O=c1ccoc(c12)cc(cc2)OC(O3)CCCC3COC(=O)C4C(CC4c5ccccc5)C(=O)OCC6CCCC(O6)Oc(cc7)cc(c78)occc8=O

Level: 5

Mol. Weight: 1157.05 g/mol

SMILES: O=c1ccoc(c12)cc(cc2)OC(O3)CCCC3COC(=O)C(CC4)C4C(=O)OCC5CCCC(O5)Oc(cc6)cc(c67)oc(cc7=O)-c8ccccc8

Level: 5

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C2C(CC2c3ccccc3)C(=O)OCC4CCCC(O4)Oc(cc5)cc(c56)oc(cc6=O)-c7ccccc7

Level: 5

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C(CC2c3ccccc3)C2C(=O)OCC4CCCC(O4)Oc(cc5)cc(c56)oc(cc6=O)-c7ccccc7

Level: 5

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C(C(c2ccccc2)C3c4ccccc4)C3C(=O)OCC5CCCC(O5)Oc(cc6)cc(c67)occc7=O

Level: 5

Mol. Weight: 1157.05 g/mol

SMILES: c1ccccc1C(C2)C(c3ccccc3)C2C(=O)OCC4CCCC(O4)Oc(cc5)cc(c56)oc(cc6=O)-c7ccccc7

Level: 5

Mol. Weight: 1157.05 g/mol

SMILES: O=c1ccoc(c12)cc(cc2)OC(O3)CCCC3COC(=O)C4C(CC4)C(=O)OCC5CCCC(O5)Oc(cc6)cc(c67)occc7=O

Level: 4

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C2C(CC2c3ccccc3)C(=O)OCC4CCCC(O4)Oc(cc5)cc(c56)occc6=O

Level: 4

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C(CC2c3ccccc3)C2C(=O)OCC4CCCC(O4)Oc(cc5)cc(c56)occc6=O

Level: 4

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C(CC2)C2C(=O)OCC3CCCC(O3)Oc(cc4)cc(c45)oc(cc5=O)-c6ccccc6

Level: 4

Mol. Weight: 1157.05 g/mol

SMILES: c1ccccc1C(CC2)C2C(=O)OCC3CCCC(O3)Oc(cc4)cc(c45)oc(cc5=O)-c6ccccc6

Level: 4

Mol. Weight: 1157.05 g/mol

SMILES: c1ccccc1C(C2)CC2C(=O)OCC3CCCC(O3)Oc(cc4)cc(c45)oc(cc5=O)-c6ccccc6

Level: 4

Mol. Weight: 1157.05 g/mol

SMILES: c1ccccc1C(C2)C(c3ccccc3)C2C(=O)OCC4CCCC(O4)Oc(cc5)cc(c56)occc6=O

Level: 4

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C2C(C(=O)OCC3CCCCO3)C(c4ccccc4)C2c5ccccc5

Level: 4

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C(CC2)C2C(=O)OCC3CCCC(O3)Oc(cc4)cc(c45)occc5=O

Level: 3

Mol. Weight: 1157.05 g/mol

SMILES: c1ccccc1C(CC2)C2C(=O)OCC3CCCC(O3)Oc(cc4)cc(c45)occc5=O

Level: 3

Mol. Weight: 1157.05 g/mol

SMILES: c1ccccc1C(C2)CC2C(=O)OCC3CCCC(O3)Oc(cc4)cc(c45)occc5=O

Level: 3

Mol. Weight: 1157.05 g/mol

SMILES: C1CCC1C(=O)OCC2CCCC(O2)Oc(cc3)cc(c34)oc(cc4=O)-c5ccccc5

Level: 3

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C2C(C(=O)OCC3CCCCO3)CC2c4ccccc4

Level: 3

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C2C(c3ccccc3)C(C2)c4ccccc4

Level: 3

Mol. Weight: 1157.05 g/mol

SMILES: C1CCC1C(=O)OCC2CCCC(O2)Oc(cc3)cc(c34)occc4=O

Level: 2

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C2C(CC2)C(=O)OCC3CCCCO3

Level: 2

Mol. Weight: 1157.05 g/mol

SMILES: c1ccccc1-c(cc2=O)oc(c23)cc(cc3)OC4CCCCO4

Level: 2

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C2CC(C2)c3ccccc3

Level: 2

Mol. Weight: 1157.05 g/mol

SMILES: O1CCCCC1COC(=O)C2C(CC2)c3ccccc3

Level: 2

Mol. Weight: 1157.05 g/mol

SMILES: c1ccccc1C2C(CC2)c3ccccc3

Level: 2

Mol. Weight: 1157.05 g/mol

SMILES: O=c1ccoc(c12)cc(cc2)OC3CCCCO3

Level: 1

Mol. Weight: 1157.05 g/mol

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 1157.05 g/mol

SMILES: C1CCC1C(=O)OCC2CCCCO2

Level: 1

Mol. Weight: 1157.05 g/mol

SMILES: C1CCC1c2ccccc2

Level: 1

Mol. Weight: 1157.05 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 1157.05 g/mol

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 1157.05 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 1157.05 g/mol

SMILES: C1CCC1

Level: 0

Mol. Weight: 1157.05 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -6.31
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Non-Absorbed
Madin-Darby Canine Kidney: 1089905944.920
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: 142437755374.25

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.790
Plasma Protein Binding: 78.54
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Inhibitor

Excretion

Clearance: 6.370
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Toxic
Bee: Safe
Bioconcentration Factor: -3312779731.700
Biodegradation: Toxic
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -1353.700
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 4.050
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Toxic
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -258517680667348.469
Rat (Acute): 2.660
Rat (Chronic Oral): 554499.200
Fathead Minnow: 326323336406.550
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Toxic

General Properties

Boiling Point: 29076070838355.570
Hydration Free Energy: -2.920
Log(D) at pH=7.4: -16163376.000
Log(P): -1876.88
Log S: -7.57
Log(Vapor Pressure): -957460464613.7
Melting Point: -286693.96
pKa Acid: -6976606989.09
pKa Basic: -56126577.28

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9583
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.9505
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.9305
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.9129
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	5	0.9097
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.9056
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9011
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8994
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8917
Putative protease I	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron	3	0.8916
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	4	0.8898
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8869
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8840
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8827
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8811
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8770
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8766
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.8729
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8600
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.8548
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8484
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.8473
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8458
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	3	0.8433
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8405
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8327
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8324
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8312
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8264
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8263
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8236
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8135
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.8117
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8113
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	4	0.8094
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8033
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.8014
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	3	0.8012
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7999
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7908
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7864
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	3	0.7862
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7817
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7797
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7793
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.7790
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.7786
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7779
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7758
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7748
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7713
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7712
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7700
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	3	0.7686
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	3	0.7670
Sterol 14alpha-demethylase	P9WPP9	CP51_MYCTU	Mycobacterium tuberculosis	4	0.7669
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7639
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7633
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7610
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	4	0.7605
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7604
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7596
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7593
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7586
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.7577
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7538
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	3	0.7525
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7514
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	4	0.7504
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.7501
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	2	0.7500
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7494
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7467
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7455
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	3	0.7445
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7419
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7384
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7358
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	3	0.7350
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7334
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7302
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7295
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7292
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7281
Acyl-coenzyme A synthetase ACSM2A, mitochondrial	Q08AH3	ACS2A_HUMAN	Homo sapiens	2	0.7277
Methyltransferase	D0VX01	D0VX01_WSLV	Wesselsbron virus	3	0.7277
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7276
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7269
Beta-secretase 2	Q9Y5Z0	BACE2_HUMAN	Homo sapiens	3	0.7266
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	3	0.7263
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7253
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7248
DNA mismatch repair protein Msh2	P43246	MSH2_HUMAN	Homo sapiens	3	0.7235
EbrA repressor	Q79SH7	Q79SH7_STRLI	Streptomyces lividans	3	0.7233
Methyltransferase	D0VX01	D0VX01_WSLV	Wesselsbron virus	4	0.7213
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7198
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7197
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7195
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7177
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7156
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	4	0.7156
Threonine--tRNA ligase	P0A8M3	SYT_ECOLI	Escherichia coli	3	0.7144
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7140
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7131
DNA mismatch repair protein MutS	P23909	MUTS_ECOLI	Escherichia coli	3	0.7127
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7114
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7110
Histone deacetylase 7	Q8WUI4	HDAC7_HUMAN	Homo sapiens	3	0.7086
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7086
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	3	0.7085
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	2	0.7083
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7071
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	3	0.7066
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7063
Genome polyprotein	A0EKU1	A0EKU1_9FLAV	Meaban virus	3	0.7059
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	3	0.7058
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	5	0.7050
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7038
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7037
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7029
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7027
DNA mismatch repair protein MutS	P23909	MUTS_ECOLI	Escherichia coli	3	0.7018
Beta sliding clamp	P0A988	DPO3B_ECOLI	Escherichia coli	3	0.7000

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