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Nepetoidin

Family: Plantae - Lamiaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Bis-Catechol Derivative

Canonical Smiles	O=C(/C=C/c1ccc(c(c1)O)O)O/C=C\c1ccc(c(c1)O)O
InChI	InChI=1S/C17H14O6/c18-13-4-1-11(9-15(13)20)3-6-17(22)23-8-7-12-2-5-14(19)16(21)10-12/h1-10,18-21H/b6-3+,8-7-
InChIKey	GFZFUVWXGQWUGX-DGEKEWMVSA-N
Formula	C₁₇H₁₄O₆
HBA	6
HBD	4
MW	314.29
Rotatable Bonds	4
TPSA	107.22
LogP	2.74
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	23
Formal Charge	0
Fraction CSP3	0.0
Exact Mass	314.08
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Salvia buchananii	Lamiaceae	Plantae	2026467

Showing of synonyms

Beladjila K.A, Cotugno R, et al. (2018). Cytotoxic triterpenes from Salvia buchananii roots. Natural product research, 2018, 32(17), 2025-2030. [View] [PubMed]

Pubchem: 5316819

Cas: 55486-06-1

Zinc: ZINC000033830800

Nmrshiftdb2: 60066684

Chembl: CHEMBL2335274

CPRiL: 156627

SMILES: c1ccccc1C=CC(=O)OC=Cc2ccccc2

Level: 1

Mol. Weight: 314.29 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 314.29 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.73
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.76
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.92

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.99
Plasma Protein Binding: 38.56
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 9.16
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.01
Biodegradation: Toxic
Carcinogenesis: Toxic
Crustacean: Safe
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.31
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 4.49
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.95
Rat (Acute): 2.18
Rat (Chronic Oral): 3.14
Fathead Minnow: 4.54
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 472.93
Hydration Free Energy: -10.85
Log(D) at pH=7.4: 1.48
Log(P): 2.63
Log S: -3.14
Log(Vapor Pressure): -8.66
Melting Point: 238.48
pKa Acid: 7.23
pKa Basic: 6.44

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.9356
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9345
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9253
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.9189
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	3	0.9177
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9120
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.9114
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.9104
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8966
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8943
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8898
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.8883
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8842
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8840
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8793
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.8761
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8699
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.8680
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.8665
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	4	0.8634
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8616
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.8549
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8548
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.8531
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.8522
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8480
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8408
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8386
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8365
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	3	0.8333
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8316
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	4	0.8309
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8276
Caffeic acid O-methyltransferase	Q9ZTU2	Q9ZTU2_LOLPR	Lolium perenne	4	0.8251
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.8245
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8240
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.8216
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8093
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8048
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	3	0.8047
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.8043
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8040
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.8037
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.8007
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8005
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8000
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.7998
RAC-alpha serine/threonine-protein kinase	P31749	AKT1_HUMAN	Homo sapiens	3	0.7939
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7936
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	4	0.7935
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7894
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7886
2-aminohexano-6-lactam racemase	Q7M181	ACLR_ACHOB	Achromobacter obae	3	0.7876
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.7838
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7837
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.7819
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7791
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7780
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7770
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.7761
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7722
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7720
Nucleoside diphosphate kinase A 2	P52175	NDKA2_BOVIN	Bos taurus	3	0.7714
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7699
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7681
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7674
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7673
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.7669
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7658
Cyclic GMP-AMP synthase	Q8C6L5	CGAS_MOUSE	Mus musculus	3	0.7648
Pol protein	Q000H7	Q000H7_9HIV1	Human immunodeficiency virus 1	3	0.7643
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7639
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7629
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7616
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7614
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7607
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7592
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7589
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.7581
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7579
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7578
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7577
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7573
Major strawberry allergen Fra a 1-3	D0E0C7	FRA13_FRAAN	Fragaria ananassa	4	0.7572
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7562
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7560
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7559
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7556
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7547
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7533
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	4	0.7527
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7524
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7509
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7507
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.7497
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7495
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7495
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7491
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7486
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7483
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7480
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7470
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7468
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7454
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7442
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.7427
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7426
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7412
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7409
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	3	0.7399
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7392
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7386
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.7382
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7364
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7336
Guanylate kinase	P15454	KGUA_YEAST	Saccharomyces cerevisiae	3	0.7332
Elongation factor Tu 1	P0CE47	EFTU1_ECOLI	Escherichia coli	3	0.7330
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7316
Uncharacterized protein	Q3F0V8	Q3F0V8_BACTI	Bacillus thuringiensis serovar israelensis ATCC 35646	3	0.7310
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7306
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7303
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7293
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	3	0.7289
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7284
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7272
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7260
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7257
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7255
Ribosomal RNA small subunit methyltransferase Nep1	Q57977	NEP1_METJA	Methanocaldococcus jannaschii	3	0.7253
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7248
Class 10 plant pathogenesis-related protein 2B	Q9LLQ2	P102B_LUPLU	Lupinus luteus	2	0.7246
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7241
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7241
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7238
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7233
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.7233
Aminopeptidase N	P15145	AMPN_PIG	Sus scrofa	2	0.7223
Tryptophan--tRNA ligase	Q9PIB4	SYW_CAMJE	Campylobacter jejuni subsp. jejuni serotype O:2	4	0.7218
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7215
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	4	0.7211
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7211
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7207
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7204
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7203
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	2	0.7198
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7195
Orotidine 5'-phosphate decarboxylase	O26232	PYRF_METTH	Methanothermobacter thermautotrophicus	3	0.7194
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7187
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7185
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7184
Aspartokinase 1, chloroplastic	Q9LYU8	AK1_ARATH	Arabidopsis thaliana	3	0.7183
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7183
Adenosine receptor A2a	P29274	AA2AR_HUMAN	Homo sapiens	4	0.7181
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7177
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7168
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	4	0.7167
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7166
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7164
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	3	0.7160
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7158
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7157
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7152
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7146
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7146
Eukaryotic translation initiation factor 4E type 3	Q9DBB5	IF4E3_MOUSE	Mus musculus	3	0.7145
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7144
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7143
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7143
Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	RET_HUMAN	Homo sapiens	3	0.7143
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7142
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	3	0.7140
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7139
Threonine--tRNA ligase	P0A8M3	SYT_ECOLI	Escherichia coli	3	0.7137
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7135
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7130
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7127
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7126
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	3	0.7124
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7123
Disks large homolog 1	Q12959	DLG1_HUMAN	Homo sapiens	3	0.7122
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7116
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	2	0.7116
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7113
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7111
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7110
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7107
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7104
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.7104
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7101
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7095
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	4	0.7094
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7092
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7092
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7089
Beta-hexosaminidase	Q9KU37	NAGZ_VIBCH	Vibrio cholerae serotype O1	3	0.7088
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7086
Protein RecA	Q59560	RECA_MYCS2	Mycolicibacterium smegmatis155)	3	0.7084
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7067
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7062
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4	Q8GZB6	SUVH4_ARATH	Arabidopsis thaliana	3	0.7061
Anthranilate phosphoribosyltransferase	P00500	TRPD_ACIAD	Acinetobacter baylyi	2	0.7061
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	4	0.7057
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7053
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	2	0.7053
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7051
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7047
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7046
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7045
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7044
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7042
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7040
16S rRNA (adenine(1408)-N(1))-methyltransferase	A8C927	NPMA_ECOLX	Escherichia coli	3	0.7035
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	3	0.7033
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7033
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7030
L-seryl-tRNA(Sec) kinase	Q58933	PSTK_METJA	Methanocaldococcus jannaschii	2	0.7029
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7027
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7027
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	3	0.7026
NTPase P4	Q94M05	Q94M05_9VIRU	Pseudomonas phage phi12	3	0.7026
Beta-galactoside alpha-2,6-sialyltransferase 1	P15907	SIAT1_HUMAN	Homo sapiens	3	0.7017
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7015
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7014
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7010
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	2	0.7010
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7005
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7004
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	4	0.7002

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