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1beta,3beta,11alpha,15alpha-tetrahydroxy-urs-12-ene
- Family: Plantae - Lamiaceae
- Kingdom: Plantae
-
Class: Terpenoid
- Subclass: Ursene Triterpene
Canonical Smiles | C[C@@H]1CC[C@]2([C@@H]([C@H]1C)C1=C[C@@H](O)[C@H]3[C@@]([C@@]1([C@H](C2)O)C)(C)CC[C@@H]1[C@]3(C)[C@H](O)C[C@@H](C1(C)C)O)C |
---|---|
InChI | InChI=1S/C30H50O4/c1-16-9-11-27(5)15-23(34)30(8)18(24(27)17(16)2)13-19(31)25-28(30,6)12-10-20-26(3,4)21(32)14-22(33)29(20,25)7/h13,16-17,19-25,31-34H,9-12,14-15H2,1-8H3/t16-,17+,19-,20+,21+,22-,23+,24+,25+,27-,28-,29-,30+/m1/s1 |
InChIKey | ODYWNFJAWDOSSM-SNELVHNSSA-N |
Formula | C30H50O4 |
HBA | 4 |
HBD | 4 |
MW | 474.73 |
Rotatable Bonds | 0 |
TPSA | 80.92 |
LogP | 4.94 |
Number Rings | 5 |
Number Aromatic Rings | 0 |
Heavy Atom Count | 34 |
Formal Charge | 0 |
Fraction CSP3 | 0.93 |
Exact Mass | 474.37 |
Number of Lipinski Rule Violations | 0 |
# | Species | Family | Kingdom | NCBI Taxonomy ID |
---|---|---|---|---|
1 | Salvia argentea | Lamiaceae | Plantae | 49208 |
Showing of synonyms
1beta,3beta,11alpha,15alpha-tetrahydroxy-urs-12-ene
No compound-protein relationship available.
SMILES: C1CCCC2C1CCC(C2=3)C4C(CC3)C5C(CC4)CCCC5
Level: 0
Mol. Weight: 474.73 g/mol
Anti-inflammatory
Antibacterial
Anticancer
Anticholinesterase
Antioxidant
Cytotoxic
Absorption
- Caco-2 (logPapp)
- -4.84
- Human Oral Bioavailability 20%
- Bioavailable
- Human Intestinal Absorption
- Absorbed
- Madin-Darby Canine Kidney
- -4.86
- Human Oral Bioavailability 50%
- Bioavailable
- P-Glycoprotein Inhibitor
- Inhibitor
- P-Glycoprotein Substrate
- Substrate
- Skin Permeability
- -2.56
Distribution
- Blood-Brain Barrier (CNS)
- -
- Blood-Brain Barrier
- Penetrable
- Fraction Unbound (Human)
- 1.03
- Plasma Protein Binding
- 85.79
- Steady State Volume of Distribution
- -
Metabolism
- Breast Cancer Resistance Protein
- Non-Inhibitor
- CYP 1A2 Inhibitor
- Non-Inhibitor
- CYP 1A2 Substrate
- Non-Substrate
- CYP 2C19 Inhibitor
- Non-Inhibitor
- CYP 2C19 Substrate
- Substrate
- CYP 2C9 Inhibitor
- Non-Inhibitor
- CYP 2C9 Substrate
- Non-Substrate
- CYP 2D6 Inhibitor
- Non-Inhibitor
- CYP 2D6 Substrate
- Non-Substrate
- CYP 3A4 Inhibitor
- Non-Inhibitor
- CYP 3A4 Substrate
- Substrate
- OATP1B1
- Non-Inhibitor
- OATP1B3
- Non-Inhibitor
Excretion
- Clearance
- 10.16
- Organic Cation Transporter 2
- Non-Inhibitor
- Half-Life of Drug
- -
Toxicity
- AMES Mutagenesis
- Safe
- Avian
- Safe
- Bee
- Toxic
- Bioconcentration Factor
- -1.2
- Biodegradation
- Safe
- Carcinogenesis
- Safe
- Crustacean
- Safe
- Liver Injury I (DILI)
- Safe
- Eye Corrosion
- Safe
- Eye Irritation
- Safe
- Maximum Tolerated Dose
- 0.87
- Liver Injury II
- Safe
- hERG Blockers
- Toxic
- Daphnia Maga
- 5.55
- Micronucleos
- Safe
- NR-AhR
- Safe
- NR-AR
- Toxic
- NR-AR-LBD
- Safe
- NR-Aromatase
- Safe
- NR-ER
- Safe
- NR-ER-LBD
- Safe
- NR-GR
- Safe
- NR-PPAR-gamma
- Safe
- NR-TR
- Toxic
- T. Pyriformis
- -117.82
- Rat (Acute)
- 3.96
- Rat (Chronic Oral)
- 2.33
- Fathead Minnow
- 3.72
- Respiratory Disease
- Toxic
- Skin Sensitisation
- Safe
- SR-ARE
- Safe
- SR-ATAD5
- Safe
- SR-HSE
- Safe
- SR-MMP
- Safe
- SR-p53
- Safe
General Properties
- Boiling Point
- 417.36
- Hydration Free Energy
- -2.52
- Log(D) at pH=7.4
- 5.14
- Log(P)
- 5.3
- Log S
- -4.86
- Log(Vapor Pressure)
- -9.07
- Melting Point
- 218.87
- pKa Acid
- 9.26
- pKa Basic
- 7.02
Protein Name | UniProt ID | Entry Name | Species | #Pharmacophore Points | Probability (0.7 ≤ Tversky Score ≤ 1.0) |
---|---|---|---|---|---|
Lactoylglutathione lyase | Q9CPU0 | LGUL_MOUSE | Mus musculus | 2 | 0.7374 |