[9]-shogaol - Compound Card

[9]-shogaol

Select a section from the left sidebar

[9]-shogaol

Structure
Zoomed Structure
  • Family: Plantae - Lamiaceae
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles CCCCCCCC/C=C/C(=O)CCc1ccc(c(c1)OC)O
InChI InChI=1S/C20H30O3/c1-3-4-5-6-7-8-9-10-11-18(21)14-12-17-13-15-19(22)20(16-17)23-2/h10-11,13,15-16,22H,3-9,12,14H2,1-2H3/b11-10+
InChIKey MUGMBXUYWJEPBH-ZHACJKMWSA-N
Formula C20H30O3
HBA 3
HBD 1
MW 318.46
Rotatable Bonds 12
TPSA 46.53
LogP 5.21
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.55
Exact Mass 318.22
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Rosmarinuseriocalyx Lamiaceae Plantae —

Showing of synonyms

  • Boudiar T, Lozano-Sánchez J, et al. (2019). Phytochemical characterization of bioactive compounds composition of Rosmarinus eriocalyx by RP–HPLC–ESI–QTOF–MS. Natural product research, 2019, 33(15), 2208-2214. [View] [PubMed]
Pubchem: 44459459

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 318.46 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.04
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.14
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-3.14

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.15
Plasma Protein Binding
56.49
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.47
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.62
Biodegradation
Toxic
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.03
Liver Injury II
Safe
hERG Blockers
Toxic
Daphnia Maga
6.38
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
6.05
Rat (Acute)
1.95
Rat (Chronic Oral)
2.19
Fathead Minnow
4.5
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
379.84
Hydration Free Energy
-6.53
Log(D) at pH=7.4
4.58
Log(P)
4.67
Log S
-4.8
Log(Vapor Pressure)
-6.3
Melting Point
38.44
pKa Acid
10.38
pKa Basic
5.7
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9583
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9579
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9578
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9543
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9503
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.9501
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9480
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9442
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9387
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9383
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9383
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9345
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9327
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9307
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9272
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.9262
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.9246
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9230
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.9226
Glycogenin-1 P46976 GLYG_HUMAN Homo sapiens 3 0.9222
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9167
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9113
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9026
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8997
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8956
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8938
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8922
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8902
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8887
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8871
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8871
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.8857
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 3 0.8834
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8820
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8771
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8760
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8755
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8708
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8694
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.8690
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8571
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8541
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8528
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.8515
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8510
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8496
Peridinin-chlorophyll a protein, high-salt form O76183 O76183_AMPCA Amphidinium carterae 3 0.8464
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8368
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8356
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8347
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8335
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8281
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.8272
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8223
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.8174
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.8170
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8158
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8145
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8131
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8109
Glycogen synthase P0A6U8 GLGA_ECOLI Escherichia coli 3 0.8090
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8037
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 4 0.8008
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7985
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7976
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7958
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7947
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7926
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7908
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7898
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7884
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7883
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7852
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7852
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7837
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7813
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7801
Ras-related protein Rap-1b P61224 RAP1B_HUMAN Homo sapiens 4 0.7791
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 2 0.7783
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7767
S-methyl-5'-thioadenosine phosphorylase Q97W94 MTAP_SACS2 Saccharolobus solfataricus 3 0.7750
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7743
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7740
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7734
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7733
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7728
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 2 0.7713
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7711
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 3 0.7708
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7694
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7682
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7681
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7677
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 3 0.7675
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7675
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7674
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 2 0.7672
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7671
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7667
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7661
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.7661
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7658
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7657
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7648
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7643
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7639
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7636
5'-methylthioadenosine nucleosidase Q9T0I8 MTN1_ARATH Arabidopsis thaliana 3 0.7634
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7626
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7620
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7617
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7613
Mevalonate kinase P17256 KIME_RAT Rattus norvegicus 3 0.7612
cAMP-activated global transcriptional regulator Vfr P55222 VFR_PSEAE Pseudomonas aeruginosa 3 0.7611
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7608
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 4 0.7607
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7607
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7606
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7604
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7603
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7603
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7603
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7599
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7595
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7595
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7593
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7578
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7576
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 3 0.7574
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7569
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7564
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7560
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7560
Petrobactin biosynthesis protein AsbB Q81RQ8 Q81RQ8_BACAN Bacillus anthracis 3 0.7553
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7552
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7551
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7551
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7548
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7542
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7533
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7529
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7527
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7521
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7518
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7517
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7511
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7511
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7511
Uroporphyrinogen-III C-methyltransferase P21631 SUMT_SINSX Sinorhizobium sp 4 0.7510
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7510
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7510
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7503
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7503
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7503
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7488
Ribosomal RNA small subunit methyltransferase E Q5SKI6 Q5SKI6_THET8 Thermus thermophilus 3 0.7483
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7483
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7481
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7474
Argininosuccinate synthase P59846 ASSY_THET8 Thermus thermophilus 3 0.7473
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7472
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7468
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7467
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7467
L-methionine gamma-lyase Q84AR1 Q84AR1_CITFR Citrobacter freundii 3 0.7462
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7462
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 3 0.7460
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7459
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7456
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7454
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7453
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7450
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7450
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7449
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7447
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7443
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7441
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7439
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7439
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7436
ADP-ribosylation factor 1 P11076 ARF1_YEAST Saccharomyces cerevisiae 4 0.7434
Genome polyprotein A9LIE0 A9LIE0_9FLAV dengue virus type 3 3 0.7434
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7434
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7433
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7431
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7429
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7426
dTDP-epi-vancosaminyltransferase P96558 GTFA_AMYOR Amycolatopsis orientalis 4 0.7424
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7420
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7418
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7415
Argininosuccinate synthase P59846 ASSY_THET8 Thermus thermophilus 3 0.7413
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7411
Ribosomal RNA small subunit methyltransferase E Q5SKI6 Q5SKI6_THET8 Thermus thermophilus 3 0.7402
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7401
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 3 0.7401
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7401
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7400
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7392
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7391
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7391
Ribosomal RNA large subunit methyltransferase H P0C1V0 RLMH_STAAU Staphylococcus aureus 3 0.7389
Deoxyuridine 5'-triphosphate nucleotidohydrolase P9WNS5 DUT_MYCTU Mycobacterium tuberculosis 4 0.7388
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7386
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7383
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7380
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7379
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7379
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7374
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7373
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7373
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7369
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7364
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 3 0.7361
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7360
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7360
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7359
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7358
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7358
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7357
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7356
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7356
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7355
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7355
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7354
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7354
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7352
N-glycosylase/DNA lyase O15527 OGG1_HUMAN Homo sapiens 3 0.7352
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7352
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7350
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7350
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7349
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Q9UL51 HCN2_HUMAN Homo sapiens 3 0.7347
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7346
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7345
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7342
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7337
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7335
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 2 0.7334
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7333
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7332
RNA 2'-O ribose methyltransferase Q5SLL8 Q5SLL8_THET8 Thermus thermophilus 3 0.7331
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7330
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7328
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7326
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 2 0.7324
Adenylosuccinate synthetase isozyme 1 P28650 PURA1_MOUSE Mus musculus 4 0.7323
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7323
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7319
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7315
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7314
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7313
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7312
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7311
Precorrin-3 methylase O68097 O68097_RHOCA Rhodobacter capsulatus 3 0.7308
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7307
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7305
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7303
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7302
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7301
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7300
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7298
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 3 0.7297
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7295
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 Q9HAN9 NMNA1_HUMAN Homo sapiens 4 0.7294
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7292
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7292
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7292
tRNA (guanine-N(1)-)-methyltransferase Q2GIL5 TRMD_ANAPZ Anaplasma phagocytophilum 3 0.7291
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7290
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7287
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 2 0.7284
dCTP deaminase P28248 DCD_ECOLI Escherichia coli 4 0.7282
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7282
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7277
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7276
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7276
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7276
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7275
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7275
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7273
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7272
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7272
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7271
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7270
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7269
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7269
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7265
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7261
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7261
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7261
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7260
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7258
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7256
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7255
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7253
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7253
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7253
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7252
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7252
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7247
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7247
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7247
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7247
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7246
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 3 0.7243
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7242
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7241
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7238
histidine kinase Q9WZV7 Q9WZV7_THEMA Thermotoga maritima 3 0.7237
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7237
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7236
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7235
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7234
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7233
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7230
Thymidylate kinase P9WKE1 KTHY_MYCTU Mycobacterium tuberculosis 4 0.7229
Cobalamin synthesis related protein Q6NIF5 Q6NIF5_CORDI Corynebacterium diphtheriae 3 0.7229
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7225
tRNA (cytidine-2'-O-)-methyltransferase TrmJ Q4JB16 TRMJ_SULAC Sulfolobus acidocaldarius 3 0.7224
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7222
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7221
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7217
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 2 0.7211
Major histocompatibility complex class I-related gene protein Q95460 HMR1_HUMAN Homo sapiens 4 0.7210
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7207
LD-carboxypeptidase A0A6L8PVW7 A0A1Q4LWC0_BACAN Bacillus anthracis 3 0.7206
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7206
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7205
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7204
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7204
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7204
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7204
Rho family GTPase C4M4W4 C4M4W4_ENTHI Entamoeba histolytica 4 0.7202
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7200
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7200
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 2 0.7198
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7196
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7196
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7195
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7187
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7185
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7178
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7178
Carboxyethyl-arginine beta-lactam-synthase P0DJQ7 BLS_STRCL Streptomyces clavuligerus 3 0.7176
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7176
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7175
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7175
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7173
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7173
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7171
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7170
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7167
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7167
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7165
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 2 0.7163
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7162
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7160
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7156
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7156
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7155
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7154
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7154
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 2 0.7154
Sodium/potassium-transporting ATPase subunit alpha Q4H132 Q4H132_SQUAC Squalus acanthias 2 0.7152
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7148
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7148
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7144
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7144
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7143
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7143
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7143
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 2 0.7141
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7140
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 3 0.7140
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7137
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7136
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7135
tRNA (guanine-N(1)-)-methyltransferase B2JF31 TRMD_PARP8 Paraburkholderia phymatum 4 0.7131
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7128
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7125
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7125
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7123
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.7121
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7120
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7120
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7119
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7117
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7115
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7110
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7110
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7110
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7109
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7108
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7108
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7105
LL-diaminopimelate aminotransferase, chloroplastic Q93ZN9 DAPAT_ARATH Arabidopsis thaliana 2 0.7104
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7102
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.7102
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7097
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7097
Ferrichrome outer membrane transporter/phage receptor P06971 FHUA_ECOLI Escherichia coli 3 0.7095
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7092
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.7092
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7092
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7092
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.7091
Three-prime repair exonuclease 1 Q91XB0 TREX1_MOUSE Mus musculus 2 0.7089
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7088
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7087
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7082
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7080
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7078
Purine nucleoside phosphorylase 2 P45563 XAPA_ECOLI Escherichia coli 3 0.7076
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7069
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7069
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7068
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7063
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7062
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7061
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 2 0.7057
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7056
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7051
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7051
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7051
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7051
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 4 0.7050
Uracil-DNA glycosylase P20536 UNG_VACCC Vaccinia virus 3 0.7049
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7047
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7047
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7047
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7045
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7041
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7041
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7040
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7039
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7039
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7038
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7038
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7035
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 2 0.7035
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7034
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7033
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7029
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7027
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 3 0.7026
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 2 0.7026
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 2 0.7025
tRNA-specific 2-thiouridylase MnmA Q97T38 MNMA_STRPN Streptococcus pneumoniae serotype 4 3 0.7024
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7024
Branched-chain-amino-acid aminotransferase, mitochondrial O15382 BCAT2_HUMAN Homo sapiens 2 0.7023
Genome polyprotein Q6YMS4 POLG_DEN3S Dengue virus type 3 3 0.7022
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7021
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7020
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7016
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7016
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7012
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7011
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7009
Uracil-DNA glycosylase P13051 UNG_HUMAN Homo sapiens 3 0.7008
Coniferyl alcohol 9-O-methyltransferase A6XNE6 A6XNE6_9ROSI Linum nodiflorum 2 0.7008
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7007
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7007
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7006
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7005
Peptide deformylase 1B, chloroplastic/mitochondrial Q9FUZ2 DEF1B_ARATH Arabidopsis thaliana 2 0.7004
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7004
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7003
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 2 0.7003
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7002

Download SDF