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Verguansin

Family: Plantae - Magnoliaceae
Kingdom: Plantae
Class: Lignan

Canonical Smiles	COc1cc(ccc1OC)CC1OC([C@H]([C@H]1C)C)Cc1ccc(c(c1)OC)OC
InChI	InChI=1S/C24H32O5/c1-15-16(2)22(12-18-8-10-20(26-4)24(14-18)28-6)29-21(15)11-17-7-9-19(25-3)23(13-17)27-5/h7-10,13-16,21-22H,11-12H2,1-6H3/t15-,16+,21?,22?
InChIKey	HZKZOZYRGRLGDF-MBWAJUJLSA-N
Formula	C₂₄H₃₂O₅
HBA	5
HBD	0
MW	400.52
Rotatable Bonds	8
TPSA	46.15
LogP	4.55
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	29
Formal Charge	0
Fraction CSP3	0.5
Exact Mass	400.22
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Magnolia saulangiana	Magnoliaceae	Plantae	3402

Showing of synonyms

Abdallah O. (1993). Lignans in flower buds of Magnolia saulangiana. Phytochemistry, 1993, 34(4), 1185-1187. [View]

No compound-protein relationship available.

SMILES: c1ccccc1CC2CCC(O2)Cc3ccccc3

Level: 2

Mol. Weight: 400.52 g/mol

SMILES: O1CCCC1Cc2ccccc2

Level: 1

Mol. Weight: 400.52 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 400.52 g/mol

SMILES: C1CCOC1

Level: 0

Mol. Weight: 400.52 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.89
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.580
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.83

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.180
Plasma Protein Binding: 68.21
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 11.020
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 2.530
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.840
Liver Injury II: Safe
hERG Blockers: Toxic
Daphnia Maga: 7.250
Micronucleos: Safe
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -17.710
Rat (Acute): 2.620
Rat (Chronic Oral): 1.950
Fathead Minnow: 4.950
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 436.330
Hydration Free Energy: -5.180
Log(D) at pH=7.4: 3.770
Log(P): 4.7
Log S: -4.98
Log(Vapor Pressure): -6.45
Melting Point: 80.26
pKa Acid: 10.99
pKa Basic: 5.33

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.9455
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.9391
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9345
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9276
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.9180
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.9129
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.9092
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9056
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8998
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.8977
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.8964
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8885
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8873
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8857
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8851
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8830
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8781
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8765
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.8763
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8687
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8681
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.8644
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8602
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8570
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.8550
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8523
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8516
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.8466
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8440
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8427
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8396
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8355
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	3	0.8342
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8332
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8316
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8303
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8284
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8256
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.8245
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8203
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8198
AGAP003309-PA	A0A1U7F4W2	A0A1U7F4W2_ANOGA	Anopheles gambiae	3	0.8172
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.8142
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.8139
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8135
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.8104
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8090
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8065
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.8062
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8004
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	3	0.7982
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7973
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7955
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.7954
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7953
Diamine oxidase [copper-containing]	P19801	AOC1_HUMAN	Homo sapiens	3	0.7920
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	3	0.7917
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7915
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7911
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7900
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.7880
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7878
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7865
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7840
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7837
Aldo-keto reductase family 1 member C1	Q04828	AK1C1_HUMAN	Homo sapiens	2	0.7835
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7821
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7820
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7818
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7818
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7814
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7790
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7783
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7776
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7774
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7768
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	3	0.7759
Retinol-binding protein 2	P50120	RET2_HUMAN	Homo sapiens	3	0.7750
Sterol 14alpha-demethylase	P9WPP9	CP51_MYCTU	Mycobacterium tuberculosis	3	0.7743
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7724
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7719
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.7719
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7708
Cellular retinol-binding protein type II	Q8UVG6	Q8UVG6_DANRE	Danio rerio	3	0.7696
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	4	0.7667
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7659
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7658
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7655
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7652
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7643
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7642
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7641
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7636
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7634
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7631
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7629
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7620
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.7618
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7614
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7607
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7602
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7595
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7583
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7581
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7567
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7564
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7563
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7537
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	2	0.7537
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7537
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7536
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.7527
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7521
Caspase-6	P55212	CASP6_HUMAN	Homo sapiens	3	0.7511
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7507
Lanosterol synthase	P48449	ERG7_HUMAN	Homo sapiens	3	0.7503
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7501
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7499
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7499
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7479
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	2	0.7474
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	3	0.7472
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7459
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7457
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.7456
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7446
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7432
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7421
Lanosterol 14-alpha-demethylase	Q385E8	Q385E8_TRYB2	Trypanosoma brucei brucei	3	0.7416
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7405
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7404
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	3	0.7394
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7393
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7388
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7371
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7368
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7368
Uncharacterized protein	Q3F0V8	Q3F0V8_BACTI	Bacillus thuringiensis serovar israelensis ATCC 35646	3	0.7363
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7356
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.7353
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7340
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7336
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7334
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7332
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7329
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7329
Mitochondrial ubiquinol-cytochrome-c reductase complex core protein i	D0VX31	D0VX31_CHICK	Gallus gallus	3	0.7322
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.7295
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7284
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7282
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7281
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7280
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7278
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.7278
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7273
Ceramide transfer protein	Q9Y5P4	CERT_HUMAN	Homo sapiens	4	0.7272
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7267
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7264
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7242
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	4	0.7234
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	4	0.7232
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7230
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7223
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	2	0.7223
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7220
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7217
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7216
Acetolactate synthase catalytic subunit, mitochondrial	P07342	ILVB_YEAST	Saccharomyces cerevisiae	4	0.7205
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7204
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7173
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7171
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7163
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7162
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.7159
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7149
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7145
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.7145
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7144
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7143
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7141
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7139
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7138
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.7128
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	2	0.7127
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7127
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7122
Beta-elicitin cryptogein	P15570	ELIB_PHYCR	Phytophthora cryptogea	3	0.7103
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7103
Cytochrome P450 3A4	P08684	CP3A4_HUMAN	Homo sapiens	3	0.7098
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7096
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.7093
Integrin alpha-L	P20701	ITAL_HUMAN	Homo sapiens	3	0.7089
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7088
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7081
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	2	0.7080
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7071
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7071
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7059
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7056
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7056
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7054
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7052
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7047
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7039
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7039
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7037
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	2	0.7037
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7036
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7035
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.7026
Ribosome-inactivating protein 3	P25891	RIP3_MAIZE	Zea mays	2	0.7024
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7024
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7021
17-beta-hydroxysteroid dehydrogenase 14	Q9BPX1	DHB14_HUMAN	Homo sapiens	2	0.7018
Gene 2 protein	Q716H3	Q716H3_BPSFV	Shigella phage Sf6	3	0.7011
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7009
Pol polyprotein	Q90K99	Q90K99_9HIV1	Human immunodeficiency virus 1	3	0.7006
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7003
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7002

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