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Lariciresinol 4’-monomethylether

Family: Plantae - Meliaceae
Kingdom: Plantae
Class: Lignan
- Subclass: Enterolignan

Canonical Smiles	OC[C@H]1[C@H](CO[C@@H]1c1ccc(c(c1)OC)OC)Cc1ccc(c(c1)OC)O
InChI	InChI=1S/C21H26O6/c1-24-18-7-5-14(10-20(18)26-3)21-16(11-22)15(12-27-21)8-13-4-6-17(23)19(9-13)25-2/h4-7,9-10,15-16,21-23H,8,11-12H2,1-3H3/t15-,16-,21+/m0/s1
InChIKey	VVKJZDWKHOGKOG-CKJXQJPGSA-N
Formula	C₂₁H₂₆O₆
HBA	6
HBD	2
MW	374.43
Rotatable Bonds	7
TPSA	77.38
LogP	2.96
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	27
Formal Charge	0
Fraction CSP3	0.43
Exact Mass	374.17
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Turrea nilotica	Meliaceae	Plantae	992803

Showing of synonyms

Ayoub S.M, Kingston D.G. (1984). Lariciresinol Derivatives from Turrea nilotica and Monechma ciliatum. Journal of natural products, 1984, 47(5), 875-6. [View] [PubMed]

Pubchem: 155977

Cas: 73354-13-9

Nmrshiftdb2: 60064809

Chembl: CHEMBL483422

Comptox: DTXSID40223599

No compound-protein relationship available.

SMILES: c1ccccc1CC2CC(OC2)c3ccccc3

Level: 2

Mol. Weight: 374.43 g/mol

SMILES: C1OCCC1Cc2ccccc2

Level: 1

Mol. Weight: 374.43 g/mol

SMILES: O1CCCC1c2ccccc2

Level: 1

Mol. Weight: 374.43 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 374.43 g/mol

SMILES: C1CCOC1

Level: 0

Mol. Weight: 374.43 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.66
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.800
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.25

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.090
Plasma Protein Binding: 77.53
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 12.270
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.640
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.820
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 5.500
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -7.280
Rat (Acute): 2.110
Rat (Chronic Oral): 2.500
Fathead Minnow: 4.230
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 435.430
Hydration Free Energy: -6.690
Log(D) at pH=7.4: 2.510
Log(P): 1.9
Log S: -3.54
Log(Vapor Pressure): -7.93
Melting Point: 132.34
pKa Acid: 9.11
pKa Basic: 4.58

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9456
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.9456
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9392
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.9349
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9281
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9246
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.9242
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.9218
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.9188
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9140
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.9137
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.9118
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9079
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9061
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9007
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.9003
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8976
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8974
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8929
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.8914
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8891
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.8883
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8882
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8870
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.8863
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8818
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8806
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8794
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8714
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8688
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8618
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.8599
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8581
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.8540
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8502
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8495
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.8494
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.8489
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8468
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8453
tRNA (guanine-N(1)-)-methyltransferase	Q2GIL5	TRMD_ANAPZ	Anaplasma phagocytophilum	4	0.8430
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8426
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.8398
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	3	0.8373
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8369
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8362
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8332
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.8328
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8314
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.8302
2-aminohexano-6-lactam racemase	Q7M181	ACLR_ACHOB	Achromobacter obae	3	0.8298
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.8284
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8245
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8224
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8168
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8154
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.8140
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	4	0.8112
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8107
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.8100
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	4	0.8082
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.8074
16S rRNA (adenine(1408)-N(1))-methyltransferase	A8C927	NPMA_ECOLX	Escherichia coli	4	0.8067
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8060
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8048
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7977
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7959
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7955
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.7947
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7885
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	5	0.7879
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.7878
beta-glucosidase	Q92AS9	Q92AS9_LISIN	Listeria innocua serovar 6a	3	0.7875
Decaprenylphosphoryl-beta-D-ribose oxidase	I6X8C4	I6X8C4_MYCTU	Mycobacterium tuberculosis	3	0.7861
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7853
Fumarate reductase subunit D	P0A8Q3	FRDD_ECOLI	Escherichia coli	3	0.7842
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7840
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7837
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7835
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7829
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	4	0.7802
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7763
Ceramide transfer protein	Q9Y5P4	CERT_HUMAN	Homo sapiens	3	0.7753
Flavin reductase like domain-containing protein	Q4UKE8	Q4UKE8_RICFE	Rickettsia felis	3	0.7746
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.7724
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7695
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7664
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7662
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	4	0.7659
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7655
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	3	0.7652
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7644
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7634
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7628
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7620
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7613
L-lactate dehydrogenase	Q5SJA1	LDH_THET8	Thermus thermophilus	3	0.7609
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7606
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7602
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7583
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7570
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7567
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7563
Disks large homolog 1	Q12959	DLG1_HUMAN	Homo sapiens	3	0.7552
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7548
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7548
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7545
Glycogen phosphorylase, liver form	P06737	PYGL_HUMAN	Homo sapiens	4	0.7540
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7535
Glycogen phosphorylase, liver form	P06737	PYGL_HUMAN	Homo sapiens	3	0.7529
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7526
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	4	0.7518
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7517
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7513
TamL	D3Y1I2	D3Y1I2_9ACTN	Streptomyces sp. 307-9	3	0.7500
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7499
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7479
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7472
GTP 3',8-cyclase	P69848	MOAA_STAA8	Staphylococcus aureus	3	0.7471
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7471
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7453
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.7450
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.7425
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7420
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7400
S-methyl-5'-thioadenosine phosphorylase	Q13126	MTAP_HUMAN	Homo sapiens	4	0.7396
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	3	0.7394
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7394
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7385
Oxygen-insensitive NAD(P)H nitroreductase	P38489	NFSB_ECOLI	Escherichia coli	3	0.7381
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7375
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7361
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7359
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7359
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.7359
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7354
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7353
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7347
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7342
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7341
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7341
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.7336
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7331
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7330
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7330
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	3	0.7326
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7326
Tubulin--tyrosine ligase	F6Z895	A9ULH4_XENTR	Xenopus tropicalis	4	0.7322
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7320
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7318
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7317
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7316
Uncharacterized protein	Q3F0V8	Q3F0V8_BACTI	Bacillus thuringiensis serovar israelensis ATCC 35646	3	0.7315
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7312
Myosin heavy chain, striated muscle	P24733	MYS_ARGIR	Argopecten irradians	3	0.7304
[LysW]-aminoadipate kinase	O50147	LYSZ_THET2	Thermus thermophilus	3	0.7303
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7303
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7301
Acyl-CoA:acyl-CoA alkyltransferase	Q8PDX2	OLEA_XANCP	Xanthomonas campestris pv. campestris	3	0.7289
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7289
Aspartokinase 1, chloroplastic	Q9LYU8	AK1_ARATH	Arabidopsis thaliana	3	0.7286
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7283
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7281
Genome polyprotein	C0LMU0	C0LMU0_9FLAV	dengue virus type 3	3	0.7275
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7274
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7265
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7263
Phosphoglycerate kinase	Q83AU6	PGK_COXBU	Coxiella burnetii	3	0.7259
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7240
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7238
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7235
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7231
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7230
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.7221
Histone-lysine N-methyltransferase 2A	Q03164	KMT2A_HUMAN	Homo sapiens	3	0.7220
Chorismate mutase AroH	P19080	AROH_BACSU	Bacillus subtilis	2	0.7218
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7213
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	2	0.7210
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7204
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	2	0.7197
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7193
Histone-lysine N-methyltransferase EHMT2	Q96KQ7	EHMT2_HUMAN	Homo sapiens	3	0.7188
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7186
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7184
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.7184
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	3	0.7174
Bifunctional protein GAL10	P04397	GAL10_YEAST	Saccharomyces cerevisiae	4	0.7172
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7171
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7169
Mitogen-activated protein kinase kinase kinase 5	Q99683	M3K5_HUMAN	Homo sapiens	3	0.7161
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.7156
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7154
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7153
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7151
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7146
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	5	0.7142
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7138
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7132
Peptide deformylase	Q9I7A8	DEF_PSEAE	Pseudomonas aeruginosa	4	0.7132
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7130
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7129
Heat shock protein 75 kDa, mitochondrial	Q12931	TRAP1_HUMAN	Homo sapiens	3	0.7128
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7126
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7126
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7123
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7117
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7117
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	3	0.7115
Cystathionine gamma-synthase	P56069	METB_HELPY	Helicobacter pylori	3	0.7113
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7113
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7109
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	4	0.7107
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7106
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7099
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7096
Probable flavin-dependent thymidylate synthase	O41156	THYX_PBCV1	Paramecium bursaria Chlorella virus 1	4	0.7094
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7087
tRNA (cytidine(56)-2'-O)-methyltransferase	O58214	TRM56_PYRHO	Pyrococcus horikoshii	4	0.7086
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7082
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7081
Beta-adrenergic receptor kinase 1	P25098	ARBK1_HUMAN	Homo sapiens	3	0.7080
Hypoxanthine-guanine phosphoribosyltransferase	P00492	HPRT_HUMAN	Homo sapiens	3	0.7077
Petrobactin biosynthesis protein AsbB	Q81RQ8	Q81RQ8_BACAN	Bacillus anthracis	3	0.7076
Capsid protein VP1	O56137	O56137_9VIRU	Adeno-associated virus - 6	3	0.7075
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7072
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7071
Coniferyl alcohol 9-O-methyltransferase	A6XNE6	A6XNE6_9ROSI	Linum nodiflorum	3	0.7071
Anthranilate phosphoribosyltransferase	P00500	TRPD_ACIAD	Acinetobacter baylyi	2	0.7065
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7064
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7061
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7061
Ferric enterobactin-binding periplasmic protein FepB	P0AEL6	FEPB_ECOLI	Escherichia coli	3	0.7060
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7058
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7058
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7056
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7056
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7051
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7043
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7034
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7034
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7031
Cell division protein FtsZ	P0A029	FTSZ_STAAM	Staphylococcus aureus	3	0.7030
Histone-lysine N-methyltransferase 2C	Q8NEZ4	KMT2C_HUMAN	Homo sapiens	3	0.7026
Pol protein	Q000H7	Q000H7_9HIV1	Human immunodeficiency virus 1	3	0.7021
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7021
Uracil-DNA glycosylase	P20536	UNG_VACCC	Vaccinia virus	3	0.7020
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7016
Beta-lactamase	Q79MP6	Q79MP6_PSEAI	Pseudomonas aeruginosa	2	0.7013
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7012
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7010
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	3	0.7010
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	4	0.7006
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7005
tRNA (guanine-N(1)-)-methyltransferase	P43912	TRMD_HAEIN	Haemophilus influenzae	5	0.7002
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7002
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7000

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