2-phenylethyl 3-hydroxyanthranilate - Compound Card

2-phenylethyl 3-hydroxyanthranilate

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2-phenylethyl 3-hydroxyanthranilate

Structure
Zoomed Structure
  • Family: Fungi - Montagnulaceae
  • Kingdom: Fungi
  • Class: Phenolic
    • Subclass: Phenolic Ester
Canonical Smiles O=C(c1cccc(c1N)O)OCCc1ccccc1
InChI InChI=1S/C15H15NO3/c16-14-12(7-4-8-13(14)17)15(18)19-10-9-11-5-2-1-3-6-11/h1-8,17H,9-10,16H2
InChIKey ZRQXUMMXFUTNSQ-UHFFFAOYSA-N
Formula C15H15NO3
HBA 4
HBD 2
MW 257.29
Rotatable Bonds 4
TPSA 72.55
LogP 2.37
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.13
Exact Mass 257.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Dendrothyrium variisporum Montagnulaceae Fungi 1985348

Showing of synonyms

  • Teponno RB, Noumeur SR, et al. (2017). Furanones and anthranilic acid derivatives from the endophytic fungus Dendrothyrium variisporum. Molecules 2017, 22(10), 1674. [View] [PubMed]
Pubchem: 139593738

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)OCCc2ccccc2

Level: 1

Mol. Weight: 257.29 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 257.29 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.78
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.37
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.96

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.73
Plasma Protein Binding
38.3
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.23
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.67
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.21
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.65
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.18
Rat (Acute)
1.87
Rat (Chronic Oral)
2.03
Fathead Minnow
4.31
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
368.17
Hydration Free Energy
-10.62
Log(D) at pH=7.4
2.73
Log(P)
3.3
Log S
-3.76
Log(Vapor Pressure)
-6.94
Melting Point
87.83
pKa Acid
8.23
pKa Basic
5.47
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 1.0100
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9812
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9779
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9737
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.9649
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9534
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9533
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.9518
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9515
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9513
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9485
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9443
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9418
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9416
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9393
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9391
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.9369
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9354
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.9352
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9341
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9311
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9299
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9276
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9264
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.9256
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9245
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9217
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9190
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9182
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9181
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.9172
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9138
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.9126
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9110
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9100
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9098
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.9096
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.9061
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.9025
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9015
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9014
Ribosomal protein S6 kinase beta-1 P23443 KS6B1_HUMAN Homo sapiens 3 0.8994
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8975
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8973
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8934
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8924
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8921
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8918
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8915
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8901
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8890
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8871
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8850
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8841
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8832
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8811
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8808
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8797
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.8788
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8785
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.8751
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8750
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8747
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8722
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8717
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8716
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 4 0.8706
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8704
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8704
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8697
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8689
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8682
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8672
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8667
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8665
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8660
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8660
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8657
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8656
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8652
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8649
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8644
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.8636
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8630
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8622
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8614
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8595
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8589
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.8583
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8579
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.8570
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.8568
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8548
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8539
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.8531
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8528
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8524
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8521
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.8491
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.8461
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8454
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8454
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8448
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.8445
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.8444
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8441
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8437
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8435
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8431
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8418
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 3 0.8378
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8374
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8371
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8371
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8362
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8359
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.8357
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8357
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8344
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8341
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8335
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 4 0.8332
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8312
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8304
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8296
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.8295
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8290
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8280
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8280
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8270
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8265
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8262
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8254
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8246
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.8231
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8227
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.8223
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.8223
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8218
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8215
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8193
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8188
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8182
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8181
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.8155
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.8136
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8133
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8133
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8126
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8113
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8107
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8101
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8093
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8087
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.8085
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8075
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.8073
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 4 0.8073
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8066
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8064
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8055
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8034
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 3 0.8014
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8010
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8005
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8002
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7998
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7993
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7969
Inorganic pyrophosphatase Q3JUV5 Q3JUV5_BURP1 Burkholderia pseudomallei 3 0.7963
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7950
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7949
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7948
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7944
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7941
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7930
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7925
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7919
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7912
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7908
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7901
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7896
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7891
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7887
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7880
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7873
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7851
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7850
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7846
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7843
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7837
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7833
Precorrin-3 methylase O68097 O68097_RHOCA Rhodobacter capsulatus 3 0.7827
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7816
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7814
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7803
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7802
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7781
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7780
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7777
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7758
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7750
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7745
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7745
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7737
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7732
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7728
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7727
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7722
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7713
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7711
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7704
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7697
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7697
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7691
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7689
Orf1ab polyprotein Q6T1E9 Q6T1E9_CVHSA SARS coronavirus CUHK-L2 3 0.7688
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7686
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7685
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7680
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7679
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7675
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7675
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7672
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7671
Interleukin-1 receptor-associated kinase 4 Q9NWZ3 IRAK4_HUMAN Homo sapiens 3 0.7663
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.7663
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7663
Mitogen-activated protein kinase 14 P47811 MK14_MOUSE Mus musculus 3 0.7661
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7657
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7656
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7653
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7648
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7647
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7645
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7643
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7640
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7637
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7632
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7629
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.7623
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7621
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 4 0.7619
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.7618
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7618
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7616
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7612
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7611
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7611
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7604
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 4 0.7604
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7602
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7599
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7596
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7594
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7590
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7590
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7589
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7579
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7577
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7577
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7574
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7574
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7572
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7569
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7564
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7561
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7559
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7559
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7557
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7556
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7550
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7547
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7546
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7542
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7538
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7536
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7534
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7532
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7531
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7530
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7529
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7528
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7522
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7522
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7521
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7515
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7512
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7510
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7503
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7502
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7502
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7499
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7499
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7497
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7496
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7493
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7492
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 3 0.7489
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7488
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7480
Protein-tyrosine kinase 2-beta Q14289 FAK2_HUMAN Homo sapiens 3 0.7479
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7478
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7477
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7476
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7471
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7468
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7464
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7458
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.7457
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7455
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7453
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7450
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7449
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7448
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 2 0.7446
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7445
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7442
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7437
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7436
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7434
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7433
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7427
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.7423
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7422
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7420
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7419
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7419
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7418
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7412
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7411
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7406
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7405
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7404
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7402
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7399
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7398
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7396
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7396
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7395
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7393
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7391
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7389
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7384
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.7384
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7383
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7377
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7376
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7375
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7375
N-glycosylase/DNA lyase O15527 OGG1_HUMAN Homo sapiens 3 0.7372
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7371
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7369
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7367
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7366
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7366
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7364
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7363
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7362
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7360
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7359
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7359
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7357
Cyclin-dependent kinase 2 homolog Q07785 CDC2H_PLAFK Plasmodium falciparum 4 0.7354
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7351
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7348
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7347
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7346
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7346
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7345
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7344
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7343
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7343
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7342
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7340
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7338
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7337
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7335
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7333
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7333
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7331
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7329
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.7329
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7328
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7327
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7324
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7322
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7320
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7320
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7318
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7318
Cell division protein FtsZ P0A029 FTSZ_STAAM Staphylococcus aureus 3 0.7314
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7313
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7310
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.7309
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7307
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7306
Phosphoribosylformylglycinamidine synthase subunit PurL Q9X0X3 PURL_THEMA Thermotoga maritima 3 0.7304
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7302
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7302
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7301
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7297
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 4 0.7295
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7295
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7291
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7284
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7283
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7280
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7280
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7279
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7279
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7276
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7276
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7275
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7274
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7272
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7272
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7272
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7272
Methionine--tRNA ligase P00959 SYM_ECOLI Escherichia coli 3 0.7271
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7270
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7268
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7264
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7263
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7261
Sphingosine 1-phosphate receptor 1 P21453 S1PR1_HUMAN Homo sapiens 3 0.7260
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7259
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7258
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7258
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7257
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7249
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7249
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7246
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7243
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7243
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7238
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7236
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7236
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7234
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 2 0.7232
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7231
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7230
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7227
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7223
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7222
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7222
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7221
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7220
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7220
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7219
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7218
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7217
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7216
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7215
Purine nucleoside phosphorylase 2 P45563 XAPA_ECOLI Escherichia coli 3 0.7213
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7212
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7211
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7209
Ephrin type-A receptor 4 Q03137 EPHA4_MOUSE Mus musculus 3 0.7206
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7206
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7206
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7203
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7203
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7200
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7197
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7190
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7189
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7188
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7188
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7188
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7186
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7180
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7175
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7175
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7175
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7174
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7173
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7171
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7170
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7167
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7166
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7161
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7159
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7157
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7154
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7150
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7149
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7146
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7145
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7145
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7144
Botulinum neurotoxin type A P0DPI0 BXA1_CLOBO Clostridium botulinum 2 0.7144
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7143
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7141
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7140
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7140
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7138
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7138
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7137
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 2 0.7136
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7135
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7134
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7133
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7130
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7129
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7128
Transthyretin P02766 TTHY_HUMAN Homo sapiens 3 0.7126
Kelch-like ECH-associated protein 1 Q14145 KEAP1_HUMAN Homo sapiens 3 0.7124
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7122
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7121
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7118
3-oxoacyl-[acyl-carrier-protein] synthase 2 P0AAI5 FABF_ECOLI Escherichia coli 3 0.7118
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7117
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7116
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7114
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7114
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7112
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7112
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7110
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7109
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7108
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7101
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7100
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7099
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7097
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7096
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7095
Feruloyl esterase A O42807 FAEA_ASPNG Aspergillus niger 2 0.7093
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7092
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7092
Uridine phosphorylase 2 O95045 UPP2_HUMAN Homo sapiens 4 0.7089
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7088
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7087
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7087
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7086
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7085
Thymidylate synthase P04818 TYSY_HUMAN Homo sapiens 4 0.7085
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7084
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7082
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7082
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7080
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7078
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7078
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7077
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7074
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7074
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7074
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7073
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7073
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7073
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7073
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 4 0.7072
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7068
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7068
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7067
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7067
Cell division protein FtsZ P0A031 FTSZ_STAAU Staphylococcus aureus 3 0.7065
Genome polyprotein C0LMU0 C0LMU0_9FLAV dengue virus type 3 3 0.7063
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7062
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7058
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7057
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7057
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7057
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 2 0.7057
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7056
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 2 0.7056
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7053
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7052
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7051
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7048
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7048
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7043
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7042
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.7041
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7041
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7039
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7035
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7035
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7035
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7034
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7033
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7032
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7032
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7031
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7029
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7029
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7028
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7027
Cyclin-G-associated kinase O14976 GAK_HUMAN Homo sapiens 4 0.7025
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7023
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7023
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7021
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7018
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7017
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7015
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7015
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.7012
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7011
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 3 0.7010
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7010
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7009
Thymidylate kinase Q9KQI2 KTHY_VIBCH Vibrio cholerae serotype O1 4 0.7008
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7006
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7005
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7003
Beta-glucosidase Q8T0W7 Q8T0W7_9NEOP Neotermes koshunensis 3 0.7001

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