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Phenylmethyl anthranilate

Family: Fungi - Montagnulaceae
Kingdom: Fungi
Class: Phenolic
- Subclass: Phenolic Ester

Canonical Smiles	O=C(c1ccccc1N)OCc1ccccc1
InChI	InChI=1S/C14H13NO2/c15-13-9-5-4-8-12(13)14(16)17-10-11-6-2-1-3-7-11/h1-9H,10,15H2
InChIKey	ZHZPDMZPDWXVMJ-UHFFFAOYSA-N
Formula	C₁₄H₁₃NO₂
HBA	3
HBD	1
MW	227.26
Rotatable Bonds	3
TPSA	52.32
LogP	2.63
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	17
Formal Charge	0
Fraction CSP3	0.07
Exact Mass	227.09
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Dendrothyrium variisporum	Montagnulaceae	Fungi	1985348

Showing of synonyms

Teponno RB, Noumeur SR, et al. (2017). Furanones and anthranilic acid derivatives from the endophytic fungus Dendrothyrium variisporum. Molecules 2017, 22(10), 1674. [View] [PubMed]

Pubchem: 522771

Cas: 82185-41-9

Zinc: ZINC000002169730

Comptox: DTXSID10231606

No compound-protein relationship available.

SMILES: c1ccccc1C(=O)OCc2ccccc2

Level: 1

Mol. Weight: 227.26 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 227.26 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.69
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.26
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.82

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.92
Plasma Protein Binding: 51.73
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.77
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.95
Biodegradation: Safe
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 0.55
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.31
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.97
Rat (Acute): 1.92
Rat (Chronic Oral): 1.69
Fathead Minnow: 4.38
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 346.44
Hydration Free Energy: -9.72
Log(D) at pH=7.4: 3.79
Log(P): 3.64
Log S: -3.51
Log(Vapor Pressure): -5.0
Melting Point: 58.64
pKa Acid: 11.59
pKa Basic: 3.04

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9870
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.9839
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9828
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.9792
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9775
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.9699
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9677
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.9670
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.9626
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.9607
Acetolactate synthase catalytic subunit, mitochondrial	P07342	ILVB_YEAST	Saccharomyces cerevisiae	3	0.9589
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.9584
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.9570
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9569
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9551
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.9513
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.9492
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9454
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.9420
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9408
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.9397
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.9370
Calmodulin-like domain protein kinase isoenzyme gamma, related	F0V9W9	F0V9W9_NEOCL	Neospora caninum	3	0.9344
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.9341
Flavonoid 3-O-glucosyltransferase	A6XNC6	UGFGT_MEDTR	Medicago truncatula	3	0.9329
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.9324
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9322
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.9315
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.9309
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9302
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.9300
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.9288
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9271
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.9270
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.9259
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.9254
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.9226
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.9220
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9188
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	4	0.9173
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.9145
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9145
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.9123
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.9109
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9103
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.9070
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9049
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	4	0.9027
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.9020
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.8979
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8971
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8929
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8924
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8914
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8879
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.8857
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.8840
Calmodulin-domain protein kinase 1, putative	A3FQ16	A3FQ16_CRYPI	Cryptosporidium parvum	3	0.8838
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8835
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8796
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8794
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	3	0.8744
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8720
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8704
Dihydroorotate dehydrogenase (quinone), mitochondrial	Q08210	PYRD_PLAF7	Plasmodium falciparum	3	0.8700
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8692
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.8683
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8615
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8615
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8608
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	3	0.8594
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8587
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8537
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8526
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.8522
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8516
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8498
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	Q15750	TAB1_HUMAN	Homo sapiens	3	0.8496
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8487
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.8440
Epoxide hydrolase B	P95276	EPHB_MYCTO	Mycobacterium tuberculosis	4	0.8434
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	3	0.8350
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.8336
cytokinin dehydrogenase	E3T1W8	E3T1W8_MAIZE	Zea mays	3	0.8332
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8308
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8297
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8254
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8246
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.8220
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8184
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.8163
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.8159
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8145
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8142
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.8124
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.8074
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8049
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.8041
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8032
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8029
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8029
Nitric oxide synthase 3	P29474	NOS3_HUMAN	Homo sapiens	3	0.8017
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	3	0.7968
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7968
Class 10 plant pathogenesis-related protein 2B	Q9LLQ2	P102B_LUPLU	Lupinus luteus	2	0.7967
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7945
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7917
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7906
Subunit alpha of sarocosine oxidase	Q50LF0	Q50LF0_9CORY	Corynebacterium sp. U-96	3	0.7899
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7886
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7884
Bifunctional dihydrofolate reductase-thymidylate synthase	Q27793	DRTS_TRYCR	Trypanosoma cruzi	3	0.7874
Mitogen-activated protein kinase 1	P63086	MK01_RAT	Rattus norvegicus	3	0.7862
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7853
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7823
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7819
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7814
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7811
Serine hydroxymethyltransferase	Q7SIB6	Q7SIB6_GEOSE	Geobacillus stearothermophilus	4	0.7803
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7786
Serine endoprotease DegS	P0AEE3	DEGS_ECOLI	Escherichia coli	4	0.7779
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.7743
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	2	0.7727
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7721
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7716
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.7713
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7706
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7700
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	2	0.7686
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7681
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7673
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7673
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7665
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7660
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7659
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	3	0.7657
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7657
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7656
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7654
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7654
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7653
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7652
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7651
Probable flavin-dependent thymidylate synthase	O41156	THYX_PBCV1	Paramecium bursaria Chlorella virus 1	3	0.7646
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7638
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.7636
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7635
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7619
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7616
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	3	0.7612
Serine protease 1	P00760	TRY1_BOVIN	Bos taurus	3	0.7611
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7610
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	2	0.7604
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7601
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7598
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	2	0.7598
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7594
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7592
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7586
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7582
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7570
Fumarate reductase subunit D	P0A8Q3	FRDD_ECOLI	Escherichia coli	2	0.7568
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.7563
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7557
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	2	0.7550
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7548
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7539
Caspase-6	P55212	CASP6_HUMAN	Homo sapiens	3	0.7538
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	3	0.7535
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7529
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7529
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7529
Beta-lactamase	P00811	AMPC_ECOLI	Escherichia coli	3	0.7525
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7521
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	3	0.7513
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7506
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7500
Prostaglandin F2a synthase	Q8I6L9	Q8I6L9_TRYCR	Trypanosoma cruzi	2	0.7499
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	2	0.7493
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7492
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7492
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7487
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7486
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7484
Beta-adrenergic receptor kinase 1	P25098	ARBK1_HUMAN	Homo sapiens	2	0.7483
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	2	0.7482
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7478
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7477
Calmodulin-domain protein kinase 1, putative	A3FQ16	A3FQ16_CRYPI	Cryptosporidium parvum	3	0.7472
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	2	0.7469
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7468
Glutathione S-transferase A1	P08263	GSTA1_HUMAN	Homo sapiens	3	0.7468
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	2	0.7467
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7466
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7461
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7461
Carboxypeptidase A1	P00730	CBPA1_BOVIN	Bos taurus	3	0.7461
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	2	0.7454
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	2	0.7452
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7452
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7450
Cyclin-dependent kinase 6	Q00534	CDK6_HUMAN	Homo sapiens	4	0.7449
Macrophage colony-stimulating factor 1 receptor	P07333	CSF1R_HUMAN	Homo sapiens	3	0.7448
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7443
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	3	0.7435
Pyruvate kinase PKM	P14618	KPYM_HUMAN	Homo sapiens	2	0.7426
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7425
Amine oxidase [flavin-containing] B	P27338	AOFB_HUMAN	Homo sapiens	3	0.7425
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7418
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7416
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7416
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7414
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7413
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7412
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7411
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7410
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7407
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7405
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7404
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7403
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7402
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7401
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	2	0.7400
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7396
Heat shock protein 75 kDa, mitochondrial	Q12931	TRAP1_HUMAN	Homo sapiens	3	0.7393
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7383
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7382
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7376
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7371
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	2	0.7370
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7369
Putative cysteine ligase BshC	P55342	BSHC_BACSU	Bacillus subtilis	3	0.7365
Transcriptional activator, LuxR/UhpA family of regulators	Q7NQP7	Q7NQP7_CHRVO	Chromobacterium violaceum	3	0.7361
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	2	0.7355
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7353
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7352
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7351
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7351
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.7348
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7347
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7345
Peroxisome proliferator-activated receptor alpha	Q07869	PPARA_HUMAN	Homo sapiens	2	0.7343
Adenosine 5'-monophosphoramidase HINT1	P80912	HINT1_RABIT	Oryctolagus cuniculus	2	0.7341
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7340
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.7336
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7334
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7332
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7331
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7329
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7329
Cytochrome P450 2C9	P11712	CP2C9_HUMAN	Homo sapiens	2	0.7324
Poly [ADP-ribose] polymerase tankyrase-1	O95271	TNKS1_HUMAN	Homo sapiens	2	0.7312
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7309
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7300
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7300
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7299
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7294
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7293
Cyclin-G-associated kinase	O14976	GAK_HUMAN	Homo sapiens	4	0.7292
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7291
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7291
Pantothenate kinase	P9WPA7	COAA_MYCTU	Mycobacterium tuberculosis	2	0.7291
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	3	0.7289
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7282
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7280
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7279
Adenosine kinase	Q9TVW2	ADK_TOXGO	Toxoplasma gondii	3	0.7273
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.7271
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7270
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7267
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7265
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7264
Polymerase acidic protein	Q5EP34	Q5EP34_9INFA	Influenza A virus	2	0.7264
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7258
Mandelate racemase	P11444	MANR_PSEPU	Pseudomonas putida	2	0.7257
Endoplasmic reticulum aminopeptidase 2	Q6P179	ERAP2_HUMAN	Homo sapiens	2	0.7254
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7243
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	2	0.7243
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	3	0.7241
Transcriptional activator, LuxR/UhpA family of regulators	Q7NQP7	Q7NQP7_CHRVO	Chromobacterium violaceum	3	0.7240
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	2	0.7238
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7236
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7236
Class B acid phosphatase	P0AE22	APHA_ECOLI	Escherichia coli	2	0.7227
Cellular tumor antigen p53	P04637	P53_HUMAN	Homo sapiens	3	0.7224
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7224
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	3	0.7222
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7221
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7220
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	2	0.7220
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7215
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	2	0.7214
Beta-lactamase	P00811	AMPC_ECOLI	Escherichia coli	3	0.7203
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7199
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7199
Thymidylate synthase	Q9Y052	Q9Y052_CAEEL	Caenorhabditis elegans	3	0.7196
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	2	0.7196
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7193
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7191
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.7191
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7191
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.7188
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	2	0.7188
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7188
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7187
Quercetin 2,3-dioxygenase	Q7SIC2	QDOI_ASPJA	Aspergillus japonicus	4	0.7186
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7186
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	P33038	MURA_ENTCC	Enterobacter cloacae subsp. cloacae	2	0.7182
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	P12995	BIOA_ECOLI	Escherichia coli	2	0.7180
Sphingosine 1-phosphate receptor 1	P21453	S1PR1_HUMAN	Homo sapiens	3	0.7178
Phosphoribosylformylglycinamidine synthase subunit PurL	Q9X0X3	PURL_THEMA	Thermotoga maritima	3	0.7175
Putative snRNP Sm-like protein	Q8ZYG5	Q8ZYG5_PYRAE	Pyrobaculum aerophilum	2	0.7174
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7172
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7171
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7169
3-oxoacyl-[acyl-carrier-protein] synthase 2	P0AAI5	FABF_ECOLI	Escherichia coli	3	0.7168
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7168
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7165
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7163
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7163
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7156
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7155
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7151
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7149
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	2	0.7149
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7148
Genome polyprotein	P27395	POLG_JAEV1	Japanese encephalitis virus	2	0.7146
Feruloyl esterase A	O42807	FAEA_ASPNG	Aspergillus niger	2	0.7146
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7145
Epothilone C/D epoxidase	Q9KIZ4	C167_SORCE	Sorangium cellulosum	2	0.7142
Protein polybromo-1	Q86U86	PB1_HUMAN	Homo sapiens	4	0.7137
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7137
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7133
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7129
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	2	0.7123
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7120
Alanine racemase	Q180W0	Q180W0_CLOD6	Clostridioides difficile	2	0.7118
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	2	0.7117
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7116
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7114
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	2	0.7108
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	2	0.7106
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7100
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic	Q1XH05	HGL1B_WHEAT	Triticum aestivum	3	0.7099
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7098
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7096
3-dehydroquinate dehydratase	P9WPX7	AROQ_MYCTU	Mycobacterium tuberculosis	2	0.7096
Muconolactone Delta-isomerase	Q8G9L0	Q8G9L0_RHOOP	Rhodococcus opacus	2	0.7093
Nitrate reductase [NADH] 1	P17571	NIA1_MAIZE	Zea mays	2	0.7093
Alcohol dehydrogenase E chain	P00327	ADH1E_HORSE	Equus caballus	2	0.7093
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7090
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7083
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7082
Unconventional myosin-Va	Q02440	MYO5A_CHICK	Gallus gallus	2	0.7081
Anthranilate phosphoribosyltransferase	P00500	TRPD_ACIAD	Acinetobacter baylyi	2	0.7080
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7077
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	2	0.7076
Troponin C, slow skeletal and cardiac muscles	P09860	TNNC1_CHICK	Gallus gallus	2	0.7073
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7069
Pantothenate kinase	P9WPA7	COAA_MYCTU	Mycobacterium tuberculosis	2	0.7067
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7056
Acidic phospholipase A2 3	P60045	PA2A3_NAJSG	Naja sagittifera	2	0.7056
Beta-secretase 2	Q9Y5Z0	BACE2_HUMAN	Homo sapiens	2	0.7055
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7050
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7049
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7048
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7048
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7046
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7045
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7044
2-keto-3-deoxy-gluconate kinase	Q96XN9	Q96XN9_SULTO	Sulfolobus tokodaii	3	0.7041
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7039
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7039
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7039
Alpha/beta hydrolase fold	A5VAT9	A5VAT9_SPHWW	Sphingomonas wittichii	2	0.7036
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7034
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7032
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7031
Chromosome-associated kinesin KIF4	P33174	KIF4_MOUSE	Mus musculus	2	0.7029
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7028
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7026
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7019
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	3	0.7012
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7012
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	2	0.7012
Thymidylate synthase	P04818	TYSY_HUMAN	Homo sapiens	4	0.7004
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7003
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7002
Adenosine 5'-monophosphoramidase HINT1	P49773	HINT1_HUMAN	Homo sapiens	2	0.7002

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