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Myricetin-3,5,3'-trimethyl ether

Family: Plantae - Myrtaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Polyoxygenated Flavonoid

Canonical Smiles	COc1cc(cc(c1O)O)c1oc2cc(O)cc(c2c(=O)c1OC)OC
InChI	InChI=1S/C18H16O8/c1-23-11-6-9(19)7-12-14(11)16(22)18(25-3)17(26-12)8-4-10(20)15(21)13(5-8)24-2/h4-7,19-21H,1-3H3
InChIKey	ODRBLEJSVVCENJ-UHFFFAOYSA-N
Formula	C₁₈H₁₆O₈
HBA	8
HBD	3
MW	360.32
Rotatable Bonds	4
TPSA	118.59
LogP	2.6
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	26
Formal Charge	0
Fraction CSP3	0.17
Exact Mass	360.08
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Eugenia edulis	Myrtaceae	Plantae	2729927

Showing of synonyms

Hussein S.A, Hashem A.N, et al. (2003). Polyoxygenated flavonoids from Eugenia edulis. Phytochemistry, 2003, 64(4), 883-9. [View] [PubMed]

Pubchem: 44259711

Cas: 637774-71-1

Zinc: ZINC000014436782

Nmrshiftdb2: 60028474

No compound-protein relationship available.

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 360.32 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 360.32 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 360.32 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.35
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.030
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -0.23

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.190
Plasma Protein Binding: 78.44
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 9.740
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.680
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.700
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.400
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 1.270
Rat (Acute): 2.270
Rat (Chronic Oral): 2.920
Fathead Minnow: 4.700
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 496.690
Hydration Free Energy: -10.480
Log(D) at pH=7.4: 2.120
Log(P): 1.76
Log S: -5.24
Log(Vapor Pressure): -7.66
Melting Point: 215.88
pKa Acid: 7.18
pKa Basic: 3.81

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9262
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	4	0.9213
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9196
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.9180
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9086
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.9066
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9056
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	5	0.9054
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9024
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8977
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	4	0.8962
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8940
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	4	0.8938
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8915
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.8895
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8872
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8850
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	4	0.8828
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.8827
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.8812
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.8794
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8784
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8779
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8765
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	4	0.8743
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.8737
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.8733
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8726
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.8709
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.8703
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8699
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8676
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8659
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8635
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8612
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8609
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8595
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8592
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	6	0.8575
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8550
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8549
Ribosomal protein S6 kinase alpha-3	P18654	KS6A3_MOUSE	Mus musculus	6	0.8546
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8534
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8516
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8514
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8462
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8453
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8445
Protein polybromo-1	Q86U86	PB1_HUMAN	Homo sapiens	5	0.8360
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8344
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8339
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8337
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	4	0.8327
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8288
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8287
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8286
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8284
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8249
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8244
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.8243
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8236
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.8236
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8229
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8223
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8207
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.8202
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	4	0.8200
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.8192
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	4	0.8175
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.8158
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	4	0.8144
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8141
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8140
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.8133
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.8123
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8113
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8108
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.8106
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8101
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8101
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8100
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8097
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8088
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.8086
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8074
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	6	0.8072
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	3	0.8070
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8065
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.8036
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8027
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8013
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8005
Histamine N-methyltransferase	P50135	HNMT_HUMAN	Homo sapiens	4	0.7999
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7982
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7970
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7941
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7911
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7900
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.7879
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7835
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7776
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7751
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7734
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.7724
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	7	0.7717
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7711
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	4	0.7699
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7694
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7687
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7686
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7681
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7678
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	4	0.7671
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.7668
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7667
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	6	0.7657
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7653
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7650
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7648
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7645
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	3	0.7632
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7631
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7631
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7590
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7582
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7579
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	5	0.7578
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	5	0.7578
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7568
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7547
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7538
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7519
Eukaryotic translation initiation factor 4E-1	P29557	IF4E1_WHEAT	Triticum aestivum	4	0.7495
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	4	0.7486
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7483
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7474
EbrA repressor	Q79SH7	Q79SH7_STRLI	Streptomyces lividans	3	0.7468
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7454
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7454
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7453
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7430
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	4	0.7370
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7365
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	4	0.7362
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	5	0.7361
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	5	0.7353
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7349
Major strawberry allergen Fra a 1-3	D0E0C7	FRA13_FRAAN	Fragaria ananassa	4	0.7345
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7314
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	5	0.7303
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.7293
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7285
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7280
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7272
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7269
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	4	0.7265
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7255
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	4	0.7250
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.7247
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7229
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7226
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7216
Beta-glucosidase 12	B8AVF0	BGL12_ORYSI	Oryza sativa subsp. indica	3	0.7216
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7210
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7204
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7200
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7188
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	4	0.7186
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7184
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	3	0.7179
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.7178
Beta-galactosidase	P00722	BGAL_ECOLI	Escherichia coli	3	0.7176
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.7173
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7173
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7165
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7162
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7159
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.7157
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7155
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7150
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7144
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	3	0.7142
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7137
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7133
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7130
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	4	0.7128
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7121
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7120
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7112
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7109
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7108
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7102
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7093
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7091
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7074
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7073
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7057
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	Q46381	BPHB_COMTE	Comamonas testosteroni	3	0.7051
dTDP-4-dehydrorhamnose 3,5-epimerase	A0A6L7H6N0	A0A1S0QLH9_BACAN	Bacillus anthracis	3	0.7050
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7045
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7042
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	4	0.7042
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	3	0.7037
DNA ligase	P43813	DNLJ_HAEIN	Haemophilus influenzae	3	0.7019
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.7012
Deoxynucleoside kinase	Q9XZT6	DNK_DROME	Drosophila melanogaster	4	0.7007
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7002

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