2-heptyl-4-hydroxyquinolone - Compound Card

2-heptyl-4-hydroxyquinolone

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2-heptyl-4-hydroxyquinolone

Structure
Zoomed Structure
  • Family: Fungi - Nectriaceae
  • Kingdom: Fungi
  • Class: Alkaloid
    • Subclass: Quinoline Alkaloid
Canonical Smiles CCCCCCCc1cc(O)c2c(n1)cccc2
InChI InChI=1S/C16H21NO/c1-2-3-4-5-6-9-13-12-16(18)14-10-7-8-11-15(14)17-13/h7-8,10-12H,2-6,9H2,1H3,(H,17,18)
InChIKey UYRHHBXYXSYGHA-UHFFFAOYSA-N
Formula C16H21NO
HBA 2
HBD 1
MW 243.35
Rotatable Bonds 6
TPSA 33.12
LogP 4.45
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 18
Formal Charge 0
Fraction CSP3 0.44
Exact Mass 243.16
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Fusarium tricinctum Nectriaceae Fungi 61284

Showing of synonyms

  • Moussa M, Ebrahim W, et al. (2020). Co-culture of the bacterium Pseudomonas aeruginosa with the fungus Fusarium tricinctum induces bacterial antifungal and quorum sensing signaling molecules. Phytochemistry Letters, 2020, 36, 37-41. [View]
Pubchem: 164974
Chebi: 62219
Nmrshiftdb2: 70008219
Metabolights: MTBLC62219
Pdb Ligand: HLH
CPRiL: 189420
Structure

SMILES: c1ccnc(c12)cccc2

Level: 0

Mol. Weight: 243.35 g/mol

Antifungal

Absorption

Caco-2 (logPapp)
-4.91
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.17
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-3.24

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.33
Plasma Protein Binding
71.29
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.41
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
2.1
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.53
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
4.59
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.92
Rat (Acute)
2.11
Rat (Chronic Oral)
2.05
Fathead Minnow
4.06
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
349.1
Hydration Free Energy
-8.5
Log(D) at pH=7.4
4.23
Log(P)
4.91
Log S
-3.9
Log(Vapor Pressure)
-6.0
Melting Point
89.37
pKa Acid
8.86
pKa Basic
6.91
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9567
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 3 0.9406
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9387
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.9351
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9206
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9161
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9108
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9097
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.9021
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9018
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8896
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8867
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8858
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8852
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8844
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8765
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8734
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8698
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8659
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.8645
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8623
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8543
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.8512
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8505
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8484
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.8365
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.8174
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8167
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.8138
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8133
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8115
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8111
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8103
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.8098
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.8084
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8046
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7995
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7985
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7982
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7972
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 2 0.7933
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7932
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7912
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7903
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7901
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7881
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7873
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7859
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7849
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7842
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7839
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7839
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7836
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7835
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 2 0.7826
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7821
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7815
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7811
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR0 INHA_MYCTO Mycobacterium tuberculosis 3 0.7809
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7806
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7804
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7797
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7793
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7788
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7783
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7780
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7777
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7766
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7764
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 2 0.7759
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7754
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 2 0.7741
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7737
LL-diaminopimelate aminotransferase, chloroplastic Q93ZN9 DAPAT_ARATH Arabidopsis thaliana 2 0.7725
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7721
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7719
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7718
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7711
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7692
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7679
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7675
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7665
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.7662
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7662
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 2 0.7656
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7654
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 2 0.7651
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7649
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7645
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7637
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7635
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 2 0.7632
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7631
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7628
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 2 0.7621
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 2 0.7619
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7610
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7607
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7601
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7595
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 2 0.7594
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7594
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7594
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7590
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 2 0.7589
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7586
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7584
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7580
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7575
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7574
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7564
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7564
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7564
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7557
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 2 0.7552
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 2 0.7547
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7546
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7539
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 2 0.7536
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7534
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7530
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7529
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7528
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7524
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7520
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 2 0.7520
Death-associated protein kinase 3 O43293 DAPK3_HUMAN Homo sapiens 2 0.7519
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7518
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7515
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7513
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7508
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7507
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7504
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7503
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7500
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7495
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7494
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7493
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 2 0.7491
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7488
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7486
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7485
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7485
Tryptophan synthase beta chain 2 Q97TX6 TRPB2_SACS2 Saccharolobus solfataricus 2 0.7484
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7483
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7483
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7478
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7475
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7474
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7474
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7473
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7469
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7468
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7467
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 2 0.7466
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7465
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7461
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7459
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7458
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7449
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7448
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7446
Envelope glycoprotein gp160 Q0ED31 Q0ED31_9HIV1 Human immunodeficiency virus 1 2 0.7443
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7443
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7443
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7437
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7436
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7436
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7436
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7433
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7431
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7430
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7430
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 2 0.7426
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7423
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7421
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7418
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7417
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7417
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7416
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7415
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7409
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7407
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7404
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7402
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 2 0.7401
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 2 0.7401
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7398
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7397
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7394
Oxysterols receptor LXR-beta P55055 NR1H2_HUMAN Homo sapiens 3 0.7392
Ribosomal protein S6 kinase beta-1 P23443 KS6B1_HUMAN Homo sapiens 3 0.7390
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7389
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7389
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7388
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7384
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7383
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7380
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7376
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7375
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7374
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7372
Lactoylglutathione lyase Q04760 LGUL_HUMAN Homo sapiens 2 0.7371
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.7367
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7366
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 2 0.7365
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7364
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 2 0.7359
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7359
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7359
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7358
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7355
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7355
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7353
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7352
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7351
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7351
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 2 0.7350
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7350
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7349
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7349
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7348
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7347
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7345
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 2 0.7345
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.7338
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7332
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 2 0.7331
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7328
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7317
Envelope glycoprotein gp160 C6G099 C6G099_9HIV1 Human immunodeficiency virus 1 2 0.7315
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7314
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7314
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7314
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7308
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7305
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7304
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7302
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7301
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7299
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7298
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 2 0.7298
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7297
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7295
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7294
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7294
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7294
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 2 0.7294
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7293
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7293
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7292
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7292
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7291
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7291
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7290
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7286
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7283
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7282
Lethal factor P15917 LEF_BACAN Bacillus anthracis 2 0.7281
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7279
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.7278
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7277
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 2 0.7276
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7276
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7274
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7274
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7272
Albumin P14639 ALBU_SHEEP Ovis aries 2 0.7270
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7268
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7268
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 2 0.7266
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7265
Phenylpyruvate C(3)-methyltransferase Q643C8 MPPJ_STRHY Streptomyces hygroscopicus 2 0.7265
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7263
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7262
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7260
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7257
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7254
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 2 0.7253
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7252
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7251
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7249
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7247
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7247
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7247
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7246
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7239
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7238
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7237
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7236
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7233
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7228
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7228
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7226
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 2 0.7223
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7222
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7220
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 2 0.7220
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7218
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7215
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7210
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 2 0.7209
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 2 0.7207
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7205
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7204
Chorismate pyruvate-lyase P26602 UBIC_ECOLI Escherichia coli 2 0.7203
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7201
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7199
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 2 0.7198
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7198
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7196
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7195
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7194
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7193
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7191
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 2 0.7190
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7188
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7188
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7187
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7184
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7181
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7181
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7181
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7178
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7178
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7176
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7174
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7174
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 2 0.7171
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7167
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 2 0.7167
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7164
VioE domain-containing protein Q7NSZ5 Q7NSZ5_CHRVO Chromobacterium violaceum 2 0.7163
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7162
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 2 0.7161
Putative FAD-dependent oxygenase EncM Q9KHK2 Q9KHK2_9ACTN Streptomyces maritimus 2 0.7160
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7159
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7159
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7159
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 2 0.7157
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7153
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7153
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7152
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7151
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7149
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7140
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7140
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7136
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7135
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7135
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7134
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7134
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7132
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7131
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7130
L-lactate dehydrogenase (cytochrome) P00175 CYB2_YEAST Saccharomyces cerevisiae 2 0.7130
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7129
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7125
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7124
Peroxisome proliferator-activated receptor delta Q03181 PPARD_HUMAN Homo sapiens 3 0.7123
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7123
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7123
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7121
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7118
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7117
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 2 0.7117
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7117
D-alanine--D-alanine ligase Q5HEB7 DDL_STAAC Staphylococcus aureus 2 0.7115
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 2 0.7113
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7113
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7110
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7110
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7109
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7108
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7107
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 2 0.7106
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7106
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 2 0.7105
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7104
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase P12995 BIOA_ECOLI Escherichia coli 2 0.7102
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7100
Aspartate aminotransferase P00509 AAT_ECOLI Escherichia coli 2 0.7096
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7095
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7095
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7094
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7094
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7094
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7092
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7091
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7090
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 2 0.7090
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7086
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7086
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 2 0.7086
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7084
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7081
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 2 0.7081
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7080
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 2 0.7080
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7080
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7080
Aminoglycoside 3'-phosphotransferase P0A3Y5 KKA3_ENTFL Enterococcus faecalis 2 0.7076
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7076
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 2 0.7074
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7070
Genome polyprotein P27395 POLG_JAEV1 Japanese encephalitis virus 2 0.7070
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7069
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7068
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7066
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 2 0.7064
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 2 0.7061
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7058
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7055
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7055
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 2 0.7052
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7041
Repressor protein Q7X0D9 Q7X0D9_ACIAD Acinetobacter baylyi 2 0.7040
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7038
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7037
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7035
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase O58523 TYW2_PYRHO Pyrococcus horikoshii 2 0.7030
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7025
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7024
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 2 0.7024
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7023
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7020
Kallikrein-4 Q9Y5K2 KLK4_HUMAN Homo sapiens 2 0.7018
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 2 0.7015
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 2 0.7014
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7014
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 2 0.7014
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7013
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7013
Feruloyl esterase A O42807 FAEA_ASPNG Aspergillus niger 2 0.7010
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7009
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7009
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7008
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7007
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7006
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7005
5-aminolevulinate synthase P18079 HEM1_RHOCB Rhodobacter capsulatus 2 0.7005
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7004
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 2 0.7002
Candida glabrata strain CBS138 chromosome E complete sequence Q6FV03 Q6FV03_CANGA Candida glabrata 2 0.7000

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