Stagonosporyne D - Compound Card

Stagonosporyne D

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Stagonosporyne D

Structure
Zoomed Structure
  • Family: Fungi - Pleosporomycetidae
  • Kingdom: Fungi
  • Class: Cyclohexanoid
    • Subclass: Oxygenated Cyclohexanoid
Canonical Smiles Oc1ccc(cc1CNC(=O)c1cc(nc2c1c(C)no2)c1ccccc1)N(=O)=O
InChI InChI=1S/C21H16N4O5/c1-12-19-16(10-17(23-21(19)30-24-12)13-5-3-2-4-6-13)20(27)22-11-14-9-15(25(28)29)7-8-18(14)26/h2-10,26H,11H2,1H3,(H,22,27)
InChIKey NSEWPMAHTNCVMI-UHFFFAOYSA-N
Formula C21H16N4O5
HBA 7
HBD 2
MW 404.38
Rotatable Bonds 5
TPSA 131.39
LogP 3.74
Number Rings 4
Number Aromatic Rings 4
Heavy Atom Count 30
Formal Charge 0
Fraction CSP3 0.1
Exact Mass 404.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Parastagonospora nodorum Pleosporomycetidae Fungi 13684

Showing of synonyms

  • El-Demerdash A, Genta-Jouve G, et al. (2019). Highly oxygenated isoprenylated cyclohexanoids from the fungus Parastagonospora nodorum SN15. Phytochemistry, 2019, 166, 112056. [View] [PubMed]
Pubchem: 46682445

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CNC(=O)c2cc(nc(c23)onc3)-c4ccccc4

Level: 2

Mol. Weight: 404.38 g/mol

Structure

SMILES: c1ccccc1CNC(=O)c2ccnc(c23)onc3

Level: 1

Mol. Weight: 404.38 g/mol

Structure

SMILES: c1noc(c12)nc(cc2)-c3ccccc3

Level: 1

Mol. Weight: 404.38 g/mol

Structure

SMILES: c1noc(c12)nccc2

Level: 0

Mol. Weight: 404.38 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 404.38 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.76
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.170
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.03

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.880
Plasma Protein Binding
100.3
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.830
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.990
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.120
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
4.630
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Toxic
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-42.280
Rat (Acute)
2.690
Rat (Chronic Oral)
2.210
Fathead Minnow
5.180
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
528.550
Hydration Free Energy
-4.180
Log(D) at pH=7.4
3.490
Log(P)
3.53
Log S
-5.43
Log(Vapor Pressure)
-11.43
Melting Point
211.56
pKa Acid
6.61
pKa Basic
4.86
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9722
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9681
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9613
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 3 0.9447
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9418
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9349
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.9337
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9322
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9257
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 3 0.9247
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9235
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.9153
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9121
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.9046
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.9039
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 3 0.9038
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q4WP27 Q4WP27_ASPFU Aspergillus fumigatus 3 0.8997
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8936
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8930
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 3 0.8923
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8916
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8884
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8879
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8870
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8865
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.8842
L-lactate dehydrogenase (cytochrome) P00175 CYB2_YEAST Saccharomyces cerevisiae 3 0.8839
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8836
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8828
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8786
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8718
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 3 0.8690
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8678
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.8654
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.8583
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.8577
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8537
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8520
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8514
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.8383
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8362
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8351
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8337
Geranylgeranyl transferase type-2 subunit alpha Q08602 PGTA_RAT Rattus norvegicus 3 0.8329
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8329
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8327
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8317
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8287
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8265
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 2 0.8257
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 3 0.8252
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 3 0.8246
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8225
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.8215
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.8179
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8162
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8157
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8154
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8152
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 3 0.8133
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8099
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8076
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.8060
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8032
Fatty acid-binding protein, adipocyte P04117 FABP4_MOUSE Mus musculus 3 0.8001
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8001
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7977
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7973
Renin P00797 RENI_HUMAN Homo sapiens 3 0.7972
Putative choline kinase Q5CUP2 Q5CUP2_CRYPI Cryptosporidium parvum 3 0.7961
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7959
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 3 0.7929
Cytochrome P450 107B1 A0R5U2 A0R5U2_MYCS2 Mycolicibacterium smegmatis155) 3 0.7920
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7919
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7917
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7903
Aminotransferase A8R0K5 A8R0K5_9ACTN Streptomyces pactum 3 0.7900
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7888
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7880
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7830
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 3 0.7824
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7820
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7811
Thymidylate synthase P04818 TYSY_HUMAN Homo sapiens 3 0.7792
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7777
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7773
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7773
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7772
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7755
Metallo-beta-lactamase type 2 P25910 BLAB_BACFG Bacteroides fragilis 3 0.7746
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7746
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 3 0.7743
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.7741
Ketohexokinase P50053 KHK_HUMAN Homo sapiens 3 0.7735
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7726
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7715
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7710
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7699
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7694
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7685
F420H(2)-dependent reductase Rv1155 O06553 F420R_MYCTU Mycobacterium tuberculosis 3 0.7670
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7670
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7665
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7664
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7662
Inorganic pyrophosphatase Q3JUV5 Q3JUV5_BURP1 Burkholderia pseudomallei 3 0.7644
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7635
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7631
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7619
Coagulation factor V P12259 FA5_HUMAN Homo sapiens 3 0.7619
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7614
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 4 0.7608
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7605
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7599
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 FNTA_HUMAN Homo sapiens 3 0.7598
Thymidylate synthase P45352 TYSY_RAT Rattus norvegicus 3 0.7592
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 3 0.7573
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 2 0.7563
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7556
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.7542
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7537
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7536
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7536
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 2 0.7535
Dual specificity protein kinase TTK P33981 TTK_HUMAN Homo sapiens 3 0.7529
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7529
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7520
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7517
Protocatechuate 3,4-dioxygenase alpha chain P00436 PCXA_PSEPU Pseudomonas putida 3 0.7513
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7510
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7500
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7494
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7491
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.7491
Serine/threonine-protein kinase receptor R3 P37023 ACVL1_HUMAN Homo sapiens 4 0.7487
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7485
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7483
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7473
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7473
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7469
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7465
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7464
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7461
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7456
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7449
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7437
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7415
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7399
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7398
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7368
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7367
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7365
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7365
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7361
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7361
UDP-N-acetylglucosamine 1-carboxyvinyltransferase P33038 MURA_ENTCC Enterobacter cloacae subsp. cloacae 3 0.7359
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7358
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 4 0.7345
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7343
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7341
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7337
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7336
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 3 0.7335
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7329
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7327
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7327
Hydroxymethylglutaryl-CoA synthase Q9FD71 HMGCS_ENTFL Enterococcus faecalis 2 0.7323
Orf1ab polyprotein Q6T1E9 Q6T1E9_CVHSA SARS coronavirus CUHK-L2 3 0.7322
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 3 0.7320
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7318
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7316
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 3 0.7315
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7309
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7305
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7298
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7296
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7294
Renin P00797 RENI_HUMAN Homo sapiens 3 0.7293
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7289
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7287
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.7286
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 3 0.7282
Retinoic acid receptor RXR-alpha P28700 RXRA_MOUSE Mus musculus 4 0.7277
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7275
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7270
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7254
Prothrombin P00734 THRB_HUMAN Homo sapiens 4 0.7254
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7252
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7246
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 3 0.7246
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7245
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7236
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7235
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7232
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7231
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 4 0.7231
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7224
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7222
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7219
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7217
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7212
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7208
Serine/threonine-protein kinase TBK1 Q9UHD2 TBK1_HUMAN Homo sapiens 3 0.7205
Protein UshA P07024 USHA_ECOLI Escherichia coli 3 0.7204
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7196
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7193
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7188
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7179
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7172
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7169
Serine protease 1 P00760 TRY1_BOVIN Bos taurus 3 0.7164
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7162
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7161
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7153
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7144
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7139
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 3 0.7139
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7132
Capsid scaffolding protein P88911 P88911_HHV8 Human herpesvirus 8 type M 3 0.7127
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7126
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7119
Carbonic anhydrase 5A, mitochondrial P23589 CAH5A_MOUSE Mus musculus 3 0.7117
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 2 0.7116
Heat shock cognate 71 kDa protein P11142 HSP7C_HUMAN Homo sapiens 3 0.7112
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 2 0.7110
dTDP-fucosamine acetyltransferase Q8FBQ3 WECD_ECOL6 Escherichia coli O6:H1 3 0.7102
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7102
Angiotensin-converting enzyme Q10714 ACE_DROME Drosophila melanogaster 2 0.7093
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7087
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 3 0.7083
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7080
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7079
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7075
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7075
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7073
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7071
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7066
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 2 0.7066
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7061
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7057
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7051
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7047
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.7044
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7030
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7027
Adenylate cyclase type 10 Q96PN6 ADCYA_HUMAN Homo sapiens 3 0.7027
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7027
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7026
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7025
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7021
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7016
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7010
Nitrogen regulatory protein P-II O66513 GLNB_AQUAE Aquifex aeolicus 2 0.7003
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7002

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