19-hydroxyceratinamide A - Compound Card

19-hydroxyceratinamide A

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19-hydroxyceratinamide A

Structure
Zoomed Structure
  • Family: Pseudoceratinidae
  • Kingdom: Animalia
  • Class: Alkaloid
Canonical Smiles O=CNCC(c1cc(Br)c(c(c1)Br)OCCCNC(=O)C1=NO[C@@]2([C@H]1O)OC=C(C(=C(C2)Br)OC)Br)O
InChI InChI=1S/C22H23Br4N3O8/c1-34-18-14(25)7-22(36-9-15(18)26)20(32)17(29-37-22)21(33)28-3-2-4-35-19-12(23)5-11(6-13(19)24)16(31)8-27-10-30/h5-6,9-10,16,20,31-32H,2-4,7-8H2,1H3,(H,27,30)(H,28,33)/t16?,20-,22-/m0/s1
InChIKey ACLQABYEWNXQAA-OIGSQQCRSA-N
Formula C22H23Br4N3O8
HBA 9
HBD 4
MW 777.06
Rotatable Bonds 11
TPSA 147.94
LogP 3.23
Number Rings 3
Number Aromatic Rings 1
Heavy Atom Count 37
Formal Charge 0
Fraction CSP3 0.41
Exact Mass 772.82
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Pseudoceratina arabica Pseudoceratinidae Animalia 375148

Showing of synonyms

  • Shaala L, Youssef D, et al. (2015). Bioactive alkaloids from the Red Sea marine Verongid sponge Pseudoceratina arabica. Tetrahedron, 2015, 71(41), 7837-7841. [View]
Pubchem: 102227803

No compound-protein relationship available.

Structure

SMILES: O1C=CC=CCC12CC(=NO2)C(=O)NCCCOc3ccccc3

Level: 1

Mol. Weight: 328.37 g/mol

Structure

SMILES: O1N=CCC12CC=CC=CO2

Level: 0

Mol. Weight: 151.16 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.16
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.11
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
-1.81

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.88
Plasma Protein Binding
73.85
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
1.68
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
-1.13
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.74
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
7.38
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-635.41
Rat (Acute)
2.42
Rat (Chronic Oral)
1.89
Fathead Minnow
6.16
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
584.48
Hydration Free Energy
-2.96
Log(D) at pH=7.4
3.67
Log(P)
2.93
Log S
-3.37
Log(Vapor Pressure)
-11.8
Melting Point
186.55
pKa Acid
6.84
pKa Basic
4.09
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.9780
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9741
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9723
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9704
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.9703
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.9640
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.9638
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9621
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.9615
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9608
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.9537
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9531
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9512
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.9493
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.9383
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9335
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.9322
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.9299
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.9275
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.9266
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9260
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.9259
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.9247
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9237
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.9228
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9220
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9195
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.9154
Glucosidase II subunit alpha Q9STC1 Q9STC1_GRALE Gracilariopsis lemaneiformis 3 0.9153
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.9045
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 4 0.9002
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8981
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8975
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8961
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8925
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.8925
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.8921
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8854
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8854
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8848
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8831
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8828
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8817
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8800
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.8780
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8779
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8712
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8699
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8626
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8597
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8544
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.8530
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8490
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 4 0.8481
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8453
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 4 0.8427
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 4 0.8414
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8402
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8347
Phenolphthiocerol/phthiocerol polyketide synthase subunit C P96202 PPSC_MYCTU Mycobacterium tuberculosis 3 0.8332
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8319
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8309
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8305
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8283
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.8232
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.8223
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8220
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8204
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8199
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8197
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8187
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8181
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8174
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.8164
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.8132
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 4 0.8130
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 3 0.8127
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8114
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8113
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 3 0.8086
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8083
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8083
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 3 0.8082
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8082
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.8065
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8043
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 3 0.8033
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8033
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.8030
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.8028
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.8013
Mitogen-activated protein kinase kinase kinase 7 O43318 M3K7_HUMAN Homo sapiens 4 0.8005
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7987
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7978
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7962
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7955
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7948
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.7928
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 4 0.7924
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7913
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7911
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7892
Ficolin-2 Q15485 FCN2_HUMAN Homo sapiens 3 0.7890
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7877
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7861
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7860
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 4 0.7856
Dihydroneopterin aldolase P9WNC5 FOLB_MYCTU Mycobacterium tuberculosis 5 0.7834
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 3 0.7829
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7810
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7806
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7779
adenine phosphoribosyltransferase Q967M2 Q967M2_GIAIN Giardia intestinalis 3 0.7778
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7764
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7763
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 3 0.7741
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 3 0.7739
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7739
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 4 0.7733
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7730
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7723
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7717
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7712
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7704
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7690
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 4 0.7685
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7682
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7675
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7673
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7667
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7654
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7646
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7643
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7642
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 4 0.7633
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7630
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7629
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7628
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7624
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7615
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7601
Malate synthase G P9WK17 MASZ_MYCTU Mycobacterium tuberculosis 3 0.7597
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 4 0.7593
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7589
Genome polyprotein P29991 POLG_DEN27 Dengue virus type 2 4 0.7584
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7583
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7577
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7574
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7573
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7566
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 3 0.7551
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7540
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7538
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7536
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7532
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7532
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7528
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7527
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7525
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7522
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7519
DNA topoisomerase 1 P06612 TOP1_ECOLI Escherichia coli 3 0.7516
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7512
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7508
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7507
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7492
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7488
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7485
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7462
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7447
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7439
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic Q9FYS3 HGGL_SECCE Secale cereale 4 0.7432
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 2 0.7428
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7423
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7420
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7417
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7416
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7403
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7401
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7396
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7390
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7389
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7389
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7387
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7383
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 2 0.7380
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7378
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7371
Tubulin--tyrosine ligase F6Z895 A9ULH4_XENTR Xenopus tropicalis 4 0.7370
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7368
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7363
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7360
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7355
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7354
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7353
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7351
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7349
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7349
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7340
Flagellum-specific ATP synthase P26465 FLII_SALTY Salmonella typhimurium 2 0.7340
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7339
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7337
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7337
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7334
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7334
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7331
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7328
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7318
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7316
Ribosomal protein S6 kinase alpha-1 Q15418 KS6A1_HUMAN Homo sapiens 3 0.7308
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7302
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7296
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7288
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7283
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 2 0.7282
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7281
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7279
Ornithine transcarbamylase, mitochondrial P00480 OTC_HUMAN Homo sapiens 3 0.7278
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7274
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 4 0.7273
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7271
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7268
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7264
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7262
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 2 0.7258
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7255
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7251
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7242
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7237
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7235
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7223
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7223
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7222
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7218
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7211
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7210
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.7207
Adenine DNA glycosylase P83847 MUTY_GEOSE Geobacillus stearothermophilus 3 0.7206
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7205
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7204
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 3 0.7203
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7203
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7203
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7201
Transitional endoplasmic reticulum ATPase Q01853 TERA_MOUSE Mus musculus 3 0.7199
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7199
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7193
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7192
Mitogen-activated protein kinase FUS3 P16892 FUS3_YEAST Saccharomyces cerevisiae 4 0.7190
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7189
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7188
Morphinone reductase Q51990 Q51990_PSEPU Pseudomonas putida 2 0.7184
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7180
Protein kinase, putative Q4YRR5 Q4YRR5_PLABA Plasmodium berghei 4 0.7177
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7176
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7165
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7164
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7164
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7162
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7159
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7150
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7146
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7145
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7145
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7144
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7143
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 2 0.7139
Metallophosphoesterase MPPED2 B1WBP0 MPPD2_RAT Rattus norvegicus 3 0.7138
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 4 0.7123
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7119
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7115
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7112
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.7111
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7107
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 2 0.7106
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7105
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7105
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 2 0.7103
Activated CDC42 kinase 1 Q07912 ACK1_HUMAN Homo sapiens 3 0.7097
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7095
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7094
Mitogen-activated protein kinase kinase kinase 21 Q5TCX8 M3K21_HUMAN Homo sapiens 3 0.7093
Cystathionine gamma-synthase P56069 METB_HELPY Helicobacter pylori 3 0.7086
Lactoperoxidase A5JUY8 PERL_BUBBU Bubalus bubalis 3 0.7083
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7080
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7078
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7077
Actin, alpha skeletal muscle P68135 ACTS_RABIT Oryctolagus cuniculus 3 0.7058
Angiotensin-converting enzyme Q10714 ACE_DROME Drosophila melanogaster 2 0.7057
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7056
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.7046
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7043
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7039
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7034
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7033
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7030
Three-prime repair exonuclease 1 Q91XB0 TREX1_MOUSE Mus musculus 2 0.7029
Plasmid partition protein A P07620 PARA_ECOLX Escherichia coli 3 0.7028
Purine nucleoside phosphorylase DeoD-type 1 Q9KPM0 DEOD1_VIBCH Vibrio cholerae serotype O1 3 0.7027
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 2 0.7026
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7025
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 2 0.7020
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7019
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 3 0.7017
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7016
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7012
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7003
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7001
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 3 0.7000

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