1,6 dihydroxy-3 methyl 6 [2′-methyl(heptoxy)] anthraquinone - Compound Card

1,6 dihydroxy-3 methyl 6 [2′-methyl(heptoxy)] anthraquinone

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1,6 dihydroxy-3 methyl 6 [2′-methyl(heptoxy)] anthraquinone

Structure
Zoomed Structure
  • Family: Plantae - Rhamnaceae
  • Kingdom: Plantae
  • Class: Anthaquinone
    • Subclass: Anthraquinone Glycoside
Canonical Smiles CCCCCC(COc1ccc2c(c1)C(=O)c1c(C2=O)c(O)cc(c1)C)C
InChI InChI=1S/C23H26O4/c1-4-5-6-7-14(2)13-27-16-8-9-17-18(12-16)22(25)19-10-15(3)11-20(24)21(19)23(17)26/h8-12,14,24H,4-7,13H2,1-3H3
InChIKey WLPOJYQDCDGDMJ-UHFFFAOYSA-N
Formula C23H26O4
HBA 4
HBD 1
MW 366.46
Rotatable Bonds 7
TPSA 63.6
LogP 5.07
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 27
Formal Charge 0
Fraction CSP3 0.39
Exact Mass 366.18
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Rhamnus alaternus Rhamnaceae Plantae 280017

Showing of synonyms

  • Ben Ammar R, Miyamoto T, et al. (2019). Isolation and identification of new anthraquinones from Rhamnus alaternus L and evaluation of their free radical scavenging activity. Natural product research,2019, 33(2), 280-286. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)C(=O)c3c(C2=O)cccc3

Level: 0

Mol. Weight: 366.46 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.96
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.6
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.18

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.23
Plasma Protein Binding
78.84
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.84
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.13
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.98
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.9
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
0.86
Rat (Acute)
2.13
Rat (Chronic Oral)
2.26
Fathead Minnow
4.73
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
459.78
Hydration Free Energy
-6.35
Log(D) at pH=7.4
5.03
Log(P)
7.37
Log S
-6.94
Log(Vapor Pressure)
-8.26
Melting Point
112.65
pKa Acid
7.41
pKa Basic
4.92
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.9668
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9639
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.9481
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9404
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.9074
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8974
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8939
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.8909
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8901
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8889
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8856
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8792
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8756
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8738
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.8723
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8615
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8582
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8579
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8567
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8517
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8509
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 4 0.8508
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8486
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8480
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8455
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8451
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8443
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8351
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8328
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8316
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8220
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.8205
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.8205
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8195
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8185
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8179
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.8173
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8151
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8139
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8129
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8120
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8116
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.8106
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8087
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8082
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.8074
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8074
Enoyl-acyl carrier reductase Q6UCJ9 Q6UCJ9_TOXGO Toxoplasma gondii 4 0.8071
Cytochrome b6 P83791 CYB6_MASLA Mastigocladus laminosus 3 0.8071
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8028
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8024
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7959
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7954
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7946
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7938
Squalene--hopene cyclase P33247 SQHC_ALIAD Alicyclobacillus acidocaldarius subsp. acidocaldarius 4 0.7925
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7915
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7886
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7850
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7850
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7843
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 4 0.7832
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7820
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7807
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7790
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.7746
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7744
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7703
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7699
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7678
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7673
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7670
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7665
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7664
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7663
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7663
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7661
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7660
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7650
Fructose-1,6-bisphosphatase 1 P00636 F16P1_PIG Sus scrofa 3 0.7649
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7628
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7621
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7614
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7609
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7606
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7604
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7600
Squalene--hopene cyclase P33247 SQHC_ALIAD Alicyclobacillus acidocaldarius subsp. acidocaldarius 4 0.7596
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7592
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7581
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7574
Myosin light chain kinase family member 4 Q86YV6 MYLK4_HUMAN Homo sapiens 3 0.7561
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7552
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7548
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7533
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7525
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 2 0.7521
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7516
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7512
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7511
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7508
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7503
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7498
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7496
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7489
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7485
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7483
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7481
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7480
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7480
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7467
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7454
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7445
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7438
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7436
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7429
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7426
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7425
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7424
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7421
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7414
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7411
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7406
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7406
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7405
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7400
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7395
Cartilage oligomeric matrix protein P35444 COMP_RAT Rattus norvegicus 3 0.7392
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7383
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7381
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7381
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7380
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7380
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7376
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7374
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7374
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7373
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7370
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7368
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7363
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7363
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7351
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7330
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7322
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7320
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7320
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7307
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7307
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7303
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7298
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7297
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7295
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7292
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7285
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7284
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7279
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7279
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7276
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7274
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7273
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7269
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7264
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7250
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7250
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7250
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7249
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7248
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7247
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7245
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7237
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7236
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7235
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7235
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7227
Oxysterols receptor LXR-beta P55055 NR1H2_HUMAN Homo sapiens 3 0.7217
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7215
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 2 0.7215
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7213
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7210
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7208
Transketolase 1 P23254 TKT1_YEAST Saccharomyces cerevisiae 4 0.7198
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7190
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 3 0.7189
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7187
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7178
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7164
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7162
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7155
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7153
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7151
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 4 0.7150
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7147
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7144
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7140
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7136
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7127
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7123
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7120
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7120
Thymidine phosphorylase P07650 TYPH_ECOLI Escherichia coli 4 0.7107
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7101
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 2 0.7095
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7094
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7090
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7089
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7086
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7085
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 4 0.7080
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7077
Tyrosine-protein kinase Lyn P25911 LYN_MOUSE Mus musculus 3 0.7075
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7075
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7063
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7049
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 2 0.7048
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7031
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7030
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7027
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7023
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7021
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7020
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7020
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7019
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7015
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7009
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7007
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7005
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7004

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