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Aegelbine B

Family: Plantae - Rutaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Furoquinoline Alkaloid

Canonical Smiles	CC(=CCOc1c(O)ccc2c1nc1occc1c2)C
InChI	InChI=1S/C16H15NO3/c1-10(2)5-7-19-15-13(18)4-3-11-9-12-6-8-20-16(12)17-14(11)15/h3-6,8-9,18H,7H2,1-2H3
InChIKey	RNRPNLPTGRZVRC-UHFFFAOYSA-N
Formula	C₁₆H₁₅NO₃
HBA	4
HBD	1
MW	269.3
Rotatable Bonds	3
TPSA	55.49
LogP	4.03
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	20
Formal Charge	0
Fraction CSP3	0.19
Exact Mass	269.11
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Aegle marmelos	Rutaceae	Plantae	68527

Showing of synonyms

Mohammed M.M.D, Ibrahim N.A, et al. (2016). Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn) Correa. Natural product research, 2016, 30(22), 2559-2566. [View] [PubMed]

No compound-protein relationship available.

SMILES: c1coc(c12)nc3c(c2)cccc3

Level: 0

Mol. Weight: 269.3 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp): -4.82
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.42
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.16

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.09
Plasma Protein Binding: 79.43
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 12.35
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.64
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.41
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.2
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.63
Rat (Acute): 2.51
Rat (Chronic Oral): 2.3
Fathead Minnow: 4.77
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 406.26
Hydration Free Energy: -11.32
Log(D) at pH=7.4: 3.0
Log(P): 3.37
Log S: -4.0
Log(Vapor Pressure): -7.09
Melting Point: 143.85
pKa Acid: 7.97
pKa Basic: 6.54

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9339
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9278
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.9250
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.9237
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.9237
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.9228
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.9160
Calmodulin-2	P0DP24	CALM2_HUMAN	Homo sapiens	3	0.9130
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9091
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9091
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	4	0.9000
Cyclin-dependent kinase 6	Q00534	CDK6_HUMAN	Homo sapiens	3	0.8976
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.8928
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8911
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8890
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.8865
Actin, alpha skeletal muscle	P68135	ACTS_RABIT	Oryctolagus cuniculus	4	0.8852
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8799
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8791
Odorant-binding protein	P81245	OBP_PIG	Sus scrofa	3	0.8738
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	3	0.8699
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.8698
EbrA repressor	Q79SH7	Q79SH7_STRLI	Streptomyces lividans	3	0.8685
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8681
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8639
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8627
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8485
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.8483
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.8480
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8428
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8424
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.8424
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8402
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.8396
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8390
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	3	0.8386
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8337
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.8333
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8275
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.8267
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	4	0.8224
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8206
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	4	0.8200
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8182
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.8154
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.8149
Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UDY8	MALT1_HUMAN	Homo sapiens	3	0.8143
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8115
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8115
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8112
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8108
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8106
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8104
Chloramphenicol acetyltransferase	P62577	CAT_ECOLX	Escherichia coli	3	0.8087
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	3	0.8077
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8075
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8061
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8014
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8014
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8005
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7998
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7994
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	3	0.7976
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7975
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7969
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7931
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7897
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	3	0.7879
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7875
Biphenyl-2,3-diol 1,2-dioxygenase	P47228	BPHC_PARXL	Paraburkholderia xenovorans	3	0.7868
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7867
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7866
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7860
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.7860
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7859
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	4	0.7855
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.7855
Endoplasmin	P14625	ENPL_HUMAN	Homo sapiens	3	0.7844
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.7833
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7815
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7806
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7799
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7788
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7779
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7749
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7747
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7728
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7722
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7720
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7702
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7698
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7691
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7689
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7686
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7685
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7683
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7677
Dual specificity protein kinase TTK	P33981	TTK_HUMAN	Homo sapiens	3	0.7666
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7658
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7654
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7648
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7637
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7632
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7630
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7628
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7617
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7610
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7608
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	3	0.7604
Phosphodiesterase	Q53I60	Q53I60_TRYCR	Trypanosoma cruzi	3	0.7594
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7594
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7591
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7585
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7572
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7569
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7545
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7545
F420-dependent NADP reductase	O29370	FNO_ARCFU	Archaeoglobus fulgidus	3	0.7543
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7537
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7517
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	4	0.7509
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7493
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7489
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.7486
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7477
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7474
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7460
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7459
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7459
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7456
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7455
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	4	0.7453
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7449
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	3	0.7434
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7406
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7402
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7398
V-1 PROTEASE protein	Q9Q288	Q9Q288_9HIV1	Human immunodeficiency virus 1	3	0.7396
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7392
Scytalone dehydratase	P56221	SCYD_MAGO7	Pyricularia oryzae	3	0.7386
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7386
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7379
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7375
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7372
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	2	0.7363
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7362
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7351
Caspase-7	P55210	CASP7_HUMAN	Homo sapiens	3	0.7351
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7338
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7338
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7337
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.7336
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7333
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7331
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7329
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7321
Biphenyl dioxygenase subunit alpha	P37333	BPHA_PARXL	Paraburkholderia xenovorans	3	0.7321
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	2	0.7319
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7313
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7286
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7285
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7281
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7281
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7280
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7278
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7271
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	2	0.7257
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.7254
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7251
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7242
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	2	0.7237
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7234
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7232
Cytochrome P450 130	P9WPN5	CP130_MYCTU	Mycobacterium tuberculosis	2	0.7232
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7231
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	2	0.7226
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.7224
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	3	0.7224
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7212
Jasmonoyl--L-amino acid synthetase JAR1	Q9SKE2	JAR1_ARATH	Arabidopsis thaliana	3	0.7206
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7199
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7198
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7197
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7171
Cytochrome P450 3A4	P08684	CP3A4_HUMAN	Homo sapiens	3	0.7169
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7166
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7164
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7160
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7159
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	3	0.7156
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	2	0.7156
Protoporphyrinogen oxidase, mitochondrial	O24164	PPOM_TOBAC	Nicotiana tabacum	2	0.7150
Renin	P00797	RENI_HUMAN	Homo sapiens	2	0.7148
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	2	0.7139
DNA ligase	P43813	DNLJ_HAEIN	Haemophilus influenzae	2	0.7138
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7125
Oxygen-insensitive NAD(P)H nitroreductase	P38489	NFSB_ECOLI	Escherichia coli	3	0.7124
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7121
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	Q46381	BPHB_COMTE	Comamonas testosteroni	3	0.7120
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7120
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7116
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7115
Fumarate reductase subunit D	P0A8Q3	FRDD_ECOLI	Escherichia coli	3	0.7115
Vitamin D-binding protein	P02774	VTDB_HUMAN	Homo sapiens	2	0.7113
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7110
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7109
Dihydrofolate reductase	P00381	DYR_LACCA	Lacticaseibacillus casei	3	0.7108
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7103
Acetylcholine-binding protein	P58154	ACHP_LYMST	Lymnaea stagnalis	3	0.7101
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7095
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7092
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7091
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7090
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7089
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	3	0.7083
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7082
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7082
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7080
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7079
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7076
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7070
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7062
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7061
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7055
Enoyl-ACP reductase	Q9BJJ9	Q9BJJ9_PLAFA	Plasmodium falciparum	2	0.7053
Bifunctional dihydrofolate reductase-thymidylate synthase	A7UD81	A7UD81_PLAFA	Plasmodium falciparum	3	0.7049
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7046
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	3	0.7041
Glutamate receptor 2	P42262	GRIA2_HUMAN	Homo sapiens	2	0.7041
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7035
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7032
Uncharacterized protein	Q3F0V8	Q3F0V8_BACTI	Bacillus thuringiensis serovar israelensis ATCC 35646	3	0.7031
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	3	0.7027
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7026
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	4	0.7022
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7018
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7012
Carbonic anhydrase 4	P22748	CAH4_HUMAN	Homo sapiens	3	0.7010
Beta sliding clamp	P0A988	DPO3B_ECOLI	Escherichia coli	2	0.7009
Putative HMP/thiamine-binding protein YkoF	O34911	YKOF_BACSU	Bacillus subtilis	2	0.7007
Cell division cycle 7-related protein kinase	O00311	CDC7_HUMAN	Homo sapiens	3	0.7006

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