1-methyl-2-n-nonyl-4-(1H)-quinolone - Compound Card

1-methyl-2-n-nonyl-4-(1H)-quinolone

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1-methyl-2-n-nonyl-4-(1H)-quinolone

Structure
Zoomed Structure
  • Family: Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Quinoline Alkaloid
Canonical Smiles CCCCCCCCCc1cc(=O)c2c(n1C)cccc2
InChI InChI=1S/C19H27NO/c1-3-4-5-6-7-8-9-12-16-15-19(21)17-13-10-11-14-18(17)20(16)2/h10-11,13-15H,3-9,12H2,1-2H3
InChIKey XIGBBPQAXHSVSN-UHFFFAOYSA-N
Formula C19H27NO
HBA 2
HBD 0
MW 285.43
Rotatable Bonds 8
TPSA 22.0
LogP 4.83
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.53
Exact Mass 285.21
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Haplophyllum tuberculatum Rutaceae Plantae 452784

Showing of synonyms

  • M. Sheriha G, Abouamer K, et al. (1987). Quinoline alkaloids and cytotoxic lignans from Haplophyllum tuberculatum. Phytochemistry, 1987, 26(12), 3339-3341. [View]
Pubchem: 13967189
Chebi: 174025
Nmrshiftdb2: 60072585

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)[nH]ccc2=O

Level: 0

Mol. Weight: 145.16 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.05
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-3.98
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-3.09

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.82
Plasma Protein Binding
70.28
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.21
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
2.45
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.86
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
4.59
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
5.74
Rat (Acute)
2.33
Rat (Chronic Oral)
1.94
Fathead Minnow
4.31
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
396.44
Hydration Free Energy
-7.41
Log(D) at pH=7.4
4.76
Log(P)
5.02
Log S
-3.73
Log(Vapor Pressure)
-6.31
Melting Point
95.74
pKa Acid
8.75
pKa Basic
6.16
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.9629
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9506
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9352
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9345
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.9264
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8996
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.8982
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.8950
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8937
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8870
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8862
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8778
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8746
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8696
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8630
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8574
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8543
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8507
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8474
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.8439
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR0 INHA_MYCTO Mycobacterium tuberculosis 3 0.8414
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8410
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.8344
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8297
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.8268
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 2 0.8262
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8260
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.8259
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.8243
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8165
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.8154
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.8149
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8137
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8120
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8101
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8097
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.8094
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.8082
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8072
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.8070
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8048
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.8036
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.8026
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8017
Beta-elicitin cinnamomin P15569 ELIB_PHYCI Phytophthora cinnamomi 3 0.8005
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7995
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7993
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7990
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7984
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7983
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7977
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7955
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7954
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7946
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7944
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.7934
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7926
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7922
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7918
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7909
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7902
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 3 0.7901
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7899
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7896
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7890
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7887
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7886
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7883
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.7881
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7880
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7873
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7869
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 3 0.7861
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7857
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7845
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 2 0.7843
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7842
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7840
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7838
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7836
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7832
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7832
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 2 0.7828
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7827
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7825
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7823
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7822
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7820
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7820
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 2 0.7817
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7815
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7812
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7811
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7808
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7800
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7798
Aromatase P11511 CP19A_HUMAN Homo sapiens 2 0.7794
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7792
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 2 0.7790
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7789
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7786
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7785
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7785
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7784
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7783
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7782
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7779
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 2 0.7771
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7766
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.7763
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7762
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 2 0.7762
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7759
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7758
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7757
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7756
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7755
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7751
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7744
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7743
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7741
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7741
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7734
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7720
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7715
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7714
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7708
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7707
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7706
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7702
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7701
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7701
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7700
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7693
Trichodiene synthase P13513 TRI5_FUSSP Fusarium sporotrichioides 2 0.7685
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7682
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7679
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 3 0.7673
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7672
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7669
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.7667
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7662
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7661
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 2 0.7660
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7659
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.7654
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.7645
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7643
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7639
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7636
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7636
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7633
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7632
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7630
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7627
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 2 0.7624
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7621
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7621
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7620
Aromatase P11511 CP19A_HUMAN Homo sapiens 2 0.7619
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7618
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7616
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7611
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7611
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7610
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 2 0.7607
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7606
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7606
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7603
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7587
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7585
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7583
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7583
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7580
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7577
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7574
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7569
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7567
Bifunctional epoxide hydrolase 2 P34914 HYES_MOUSE Mus musculus 3 0.7564
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7564
D-alanine--D-alanine ligase Q5HEB7 DDL_STAAC Staphylococcus aureus 2 0.7563
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7563
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7562
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 2 0.7562
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7554
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7553
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7553
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7553
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7552
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7549
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7547
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7546
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7544
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7543
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7539
Putative cytochrome P450 120 Q59990 CP120_SYNY3 Synechocystis sp 3 0.7535
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7533
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7532
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7532
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 2 0.7530
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7528
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7527
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7526
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7526
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7523
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7523
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7523
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7521
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7519
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7514
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 2 0.7511
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7511
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7510
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7508
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7507
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7500
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7498
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7497
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 3 0.7496
Lactoylglutathione lyase Q04760 LGUL_HUMAN Homo sapiens 2 0.7495
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7494
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7491
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7488
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7486
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7484
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7482
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7480
Aminoglycoside 3'-phosphotransferase P0A3Y5 KKA3_ENTFL Enterococcus faecalis 2 0.7478
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 2 0.7474
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7473
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7473
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7470
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 2 0.7470
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7470
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7469
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7466
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7466
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7461
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7456
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7455
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7453
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7451
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7450
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7449
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7449
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7448
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 2 0.7446
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7440
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7440
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7438
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7438
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7429
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7429
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7428
Envelope glycoprotein gp160 C6G099 C6G099_9HIV1 Human immunodeficiency virus 1 2 0.7427
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7426
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7426
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7425
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 2 0.7421
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7413
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7407
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7405
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7404
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7399
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7397
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7396
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7393
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7387
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7386
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.7383
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7382
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7372
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7371
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.7367
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7364
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7361
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7361
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.7358
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7353
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7353
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 2 0.7347
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 2 0.7347
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7342
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7341
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7339
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7338
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7332
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7328
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 2 0.7327
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7323
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7322
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.7322
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7321
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7315
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7313
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7311
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 2 0.7311
Putative FAD-dependent oxygenase EncM Q9KHK2 Q9KHK2_9ACTN Streptomyces maritimus 2 0.7306
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7306
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7301
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7296
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7296
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7294
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7294
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 3 0.7293
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 2 0.7290
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7285
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7284
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7284
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7283
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7283
Death-associated protein kinase 3 O43293 DAPK3_HUMAN Homo sapiens 2 0.7282
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7282
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7281
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7281
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7279
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7271
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7270
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7269
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7267
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7266
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7264
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7261
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7260
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7258
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7256
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.7256
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7255
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7252
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7251
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 2 0.7251
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7249
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 2 0.7243
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7238
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7238
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7237
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7236
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7234
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7234
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7232
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 2 0.7232
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7230
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7229
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7228
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7228
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7225
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7224
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7221
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 2 0.7219
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7218
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7216
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7212
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 3 0.7209
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7205
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7203
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7196
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7195
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 2 0.7192
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 2 0.7188
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7188
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7174
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 2 0.7173
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 2 0.7172
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 2 0.7170
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 2 0.7165
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7165
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7165
Ribosomal protein S6 kinase beta-1 P23443 KS6B1_HUMAN Homo sapiens 3 0.7157
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7156
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7155
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7154
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7152
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7149
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 2 0.7145
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7145
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7144
C-C chemokine receptor type 5 P51681 CCR5_HUMAN Homo sapiens 3 0.7141
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7140
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7139
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7136
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7135
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 2 0.7127
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7121
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7120
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 2 0.7120
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7119
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7119
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7118
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7113
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7109
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7108
Bifunctional dihydrofolate reductase-thymidylate synthase Q27783 DRTS_TRYBB Trypanosoma brucei brucei 3 0.7104
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7102
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7102
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7100
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7099
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7098
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 2 0.7096
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 2 0.7092
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7092
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7091
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7090
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 2 0.7090
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7089
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 2 0.7084
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7079
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7075
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7069
L-lactate dehydrogenase (cytochrome) P00175 CYB2_YEAST Saccharomyces cerevisiae 2 0.7065
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7064
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7063
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7061
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7059
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7059
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 2 0.7055
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 2 0.7055
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7054
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7047
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7043
Phospholipase A2 P00593 PA21B_BOVIN Bos taurus 2 0.7042
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7040
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 2 0.7038
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7037
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 2 0.7037
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7036
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7033
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 2 0.7032
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7030
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7030
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7026
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7024
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 2 0.7023
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7023
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7018
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7015
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7014
Calmodulin-1 P0DP29 CALM1_RAT Rattus norvegicus 2 0.7013
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7012
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7011
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7005
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7003

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