2,3,6-dibenzofurantriol - Compound Card

2,3,6-dibenzofurantriol

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2,3,6-dibenzofurantriol

Structure
Zoomed Structure
  • Family: Plantae - Salicaceae
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles Oc1cc2c(cc1O)oc1c2cccc1O
InChI InChI=1S/C12H8O4/c13-8-3-1-2-6-7-4-9(14)10(15)5-11(7)16-12(6)8/h1-5,13-15H
InChIKey GRRLSAHUZCWJAU-UHFFFAOYSA-N
Formula C12H8O4
HBA 4
HBD 3
MW 216.19
Rotatable Bonds 0
TPSA 73.83
LogP 2.7
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 16
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 216.04
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Flacourtia rukam Salicaceae Plantae 1085434

Showing of synonyms

  • Afifi N.I, Moawad A.S, et al. (2022). Four new phenolics and antiparasitic secondary metabolites from Flacourtia rukam Zoll. & Mortizi. Natural product research, 2022, 36(14), 3626-3637. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1cccc(c1c23)oc2cccc3

Level: 0

Mol. Weight: 216.19 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.86
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.550
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.46

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.850
Plasma Protein Binding
66.44
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.320
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.450
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.590
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.390
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.830
Rat (Acute)
1.600
Rat (Chronic Oral)
2.450
Fathead Minnow
4.530
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Toxic
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
402.080
Hydration Free Energy
-10.620
Log(D) at pH=7.4
2.560
Log(P)
2.69
Log S
-3.02
Log(Vapor Pressure)
-8.9
Melting Point
286.75
pKa Acid
6.06
pKa Basic
6.95
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9437
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9426
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9230
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9220
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9205
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9135
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9103
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9090
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9063
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9052
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9032
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9028
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.9007
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 4 0.8988
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.8969
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8962
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.8935
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8919
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8892
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8863
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8860
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8840
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8814
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8808
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8755
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8711
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.8709
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8707
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8705
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8702
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8697
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8692
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8684
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8561
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8531
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8526
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8515
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.8496
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8479
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8478
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8474
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8436
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8434
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8428
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8408
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8400
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.8389
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8377
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.8370
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8364
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8351
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.8332
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8304
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8260
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8249
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8210
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8206
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8202
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8184
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8176
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8162
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8143
Phytohormone-binding protein G7J032 PHBP_MEDTR Medicago truncatula 4 0.8123
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8122
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8105
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8102
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8099
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.8074
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8063
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8028
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8026
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8012
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8008
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8003
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7995
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7974
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7973
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7968
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7967
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7959
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7935
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7924
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.7918
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7900
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.7887
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7867
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 4 0.7859
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7857
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7855
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7855
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7851
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7846
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7832
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7789
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7788
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7787
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7778
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7776
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7739
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 4 0.7713
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 3 0.7707
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7697
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7692
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7671
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7671
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7671
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7667
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7664
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7661
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 4 0.7653
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7647
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 4 0.7643
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7633
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7623
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 4 0.7617
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7599
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7595
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7593
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7592
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7572
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7571
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7561
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7557
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7551
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7542
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7538
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7523
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7522
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7511
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7501
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7498
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7492
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7479
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7472
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7459
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7459
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7457
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7455
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7448
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7430
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7425
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7418
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7415
N-acetylhexosamine 1-kinase E8MF12 NAHK_BIFL2 Bifidobacterium longum subsp. longum 3 0.7415
Diguanylate phosphodiesterase A6T8V8 A6T8V8_KLEP7 Klebsiella pneumoniae subsp. pneumoniae 4 0.7413
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7412
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7412
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 3 0.7412
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7408
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7402
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7396
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7395
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7386
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7383
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7383
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7382
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7378
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7376
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7347
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7334
Farnesyl pyrophosphate synthase P14324 FPPS_HUMAN Homo sapiens 2 0.7333
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7329
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7328
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7327
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7320
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7315
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 3 0.7313
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7300
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7294
Histone-lysine N-methyltransferase ASH1L Q9NR48 ASH1L_HUMAN Homo sapiens 4 0.7291
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7290
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7289
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7279
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7277
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 2 0.7275
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7275
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7272
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7265
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7263
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7262
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7257
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7257
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7256
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7253
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.7252
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7244
Adenosine receptor A2a P29274 AA2AR_HUMAN Homo sapiens 4 0.7243
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7232
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7227
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.7224
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7222
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7221
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7217
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7213
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7212
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7210
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7207
Androgen receptor P19091 ANDR_MOUSE Mus musculus 3 0.7195
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7194
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7193
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7190
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7188
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7185
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7184
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7180
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 3 0.7169
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7167
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7165
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7159
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 3 0.7155
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 3 0.7155
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7154
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 4 0.7148
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 4 0.7144
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7141
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7133
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7129
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7122
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7116
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.7116
Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 Q8GZB6 SUVH4_ARATH Arabidopsis thaliana 3 0.7107
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7103
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.7100
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7099
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7098
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7097
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7096
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7096
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7093
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7090
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7089
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7087
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7083
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7082
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 4 0.7077
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7074
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7072
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7072
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7070
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7065
Ribosomal RNA small subunit methyltransferase E Q5SKI6 Q5SKI6_THET8 Thermus thermophilus 3 0.7063
Bifunctional dihydrofolate reductase-thymidylate synthase D9N170 D9N170_PLAFA Plasmodium falciparum 3 0.7051
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7047
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 2 0.7040
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7039
Glutathione S-transferase Q8ILQ7 GST_PLAFA Plasmodium falciparum 3 0.7038
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7034
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7033
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 3 0.7030
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7029
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7027
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7019
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7016
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7007
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7007
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7005
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7000

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