Trans-cinnamoyl tyramine - Compound Card

Trans-cinnamoyl tyramine

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Trans-cinnamoyl tyramine

Structure
Zoomed Structure
  • Family: Plantae - Solanaceae
  • Kingdom: Plantae
  • Class: Cinnamide
Canonical Smiles O=C(/C=C/c1ccccc1)NCCc1ccc(cc1)O
InChI InChI=1S/C17H17NO2/c19-16-9-6-15(7-10-16)12-13-18-17(20)11-8-14-4-2-1-3-5-14/h1-11,19H,12-13H2,(H,18,20)/b11-8+
InChIKey KGOYCHSKGXJDND-DHZHZOJOSA-N
Formula C17H17NO2
HBA 2
HBD 2
MW 267.33
Rotatable Bonds 5
TPSA 49.33
LogP 2.76
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 267.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Lycium schweinfurthii Solanaceae Plantae 416539

Showing of synonyms

  • Elbermawi A, Halim A.F, et al. (2022). Lycium schweinfurthii: new secondary metabolites and their cytotoxic activities. Natural product research,2022, 36(20), 5134-5141. [View] [PubMed]
Pubchem: 5315911
Chebi: 177872
Nmrshiftdb2: 60021860
Metabolights: MTBLC177872
Bindingdb: 50069771
CPRiL: 293641
Structure

SMILES: c1ccccc1C=CC(=O)NCCc2ccccc2

Level: 1

Mol. Weight: 267.33 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 267.33 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.83
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.31
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.41

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.72
Plasma Protein Binding
68.21
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.36
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.2
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.85
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.33
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.96
Rat (Acute)
1.61
Rat (Chronic Oral)
2.15
Fathead Minnow
4.43
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
398.6
Hydration Free Energy
-11.52
Log(D) at pH=7.4
3.3
Log(P)
2.62
Log S
-3.36
Log(Vapor Pressure)
-8.11
Melting Point
165.56
pKa Acid
10.25
pKa Basic
5.02
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9639
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.9638
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9613
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9594
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.9574
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9571
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9562
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9557
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9555
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9534
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9491
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9478
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9472
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.9433
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.9427
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.9417
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9417
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9411
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9411
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.9403
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9383
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.9364
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.9352
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.9346
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9324
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9311
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9300
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9222
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9209
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.9180
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 3 0.9176
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.9172
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9152
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.9143
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.9119
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.9109
Matrilysin P09237 MMP7_HUMAN Homo sapiens 4 0.9106
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.9098
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.9065
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.9037
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9012
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8997
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.8971
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 4 0.8941
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8931
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8915
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8904
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8895
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8893
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8870
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.8867
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8865
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8861
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8858
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8854
Laminarinase Q9WXN1 Q9WXN1_THEMA Thermotoga maritima 3 0.8844
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.8842
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8833
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.8819
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8811
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8797
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8790
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.8781
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.8779
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8771
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8767
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.8754
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 3 0.8747
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8744
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.8742
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8693
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8692
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8690
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8687
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8686
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8684
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8684
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8675
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8660
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8658
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8654
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8620
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8605
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8568
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.8563
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8555
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8548
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8525
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.8523
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 4 0.8490
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8477
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8426
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.8425
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8418
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.8417
Repressor protein Q7X0D9 Q7X0D9_ACIAD Acinetobacter baylyi 3 0.8392
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8364
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.8364
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8361
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 3 0.8351
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8349
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8325
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8321
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8317
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8308
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8301
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8299
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8294
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8290
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.8281
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8271
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8253
Purine nucleoside phosphorylase Q9BMI9 Q9BMI9_SCHMA Schistosoma mansoni 3 0.8251
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8242
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.8225
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8206
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8204
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.8200
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 3 0.8192
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8180
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8159
Pol protein Q000H7 Q000H7_9HIV1 Human immunodeficiency virus 1 3 0.8136
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8128
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8116
Heat shock cognate 71 kDa protein P11142 HSP7C_HUMAN Homo sapiens 3 0.8114
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8109
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8107
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8085
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8083
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8076
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8073
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8068
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.8060
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8058
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.8049
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8044
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8033
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8030
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.8005
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7992
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 3 0.7985
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 4 0.7979
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7978
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 3 0.7974
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 2 0.7971
S-methyl-5'-thioadenosine phosphorylase Q97W94 MTAP_SACS2 Saccharolobus solfataricus 3 0.7970
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7966
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7956
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7945
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7939
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7927
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7924
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7920
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7920
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7913
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7910
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7897
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7897
Genome polyprotein C0LMU0 C0LMU0_9FLAV dengue virus type 3 3 0.7893
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7891
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7881
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7877
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7872
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7871
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7853
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7847
cytokinin dehydrogenase E3T1W8 E3T1W8_MAIZE Zea mays 3 0.7839
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7839
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7832
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7825
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7821
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7812
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7810
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7807
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7804
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7796
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7796
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7789
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7785
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7785
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7780
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7771
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 2 0.7766
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7764
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7761
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7747
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7747
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7741
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7741
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7738
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7733
Gag-Pol polyprotein P04587 POL_HV1B5 Human immunodeficiency virus type 1 group M subtype B 3 0.7731
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7729
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7725
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7721
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7718
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7711
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7710
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7709
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7703
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7699
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7692
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.7691
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7689
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7683
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7682
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7674
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7672
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7665
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7660
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7655
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7653
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7651
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7650
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7650
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7645
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7639
Interstitial collagenase P03956 MMP1_HUMAN Homo sapiens 3 0.7633
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7632
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 2 0.7627
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7623
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7618
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7611
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7610
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7610
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7610
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 2 0.7605
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7598
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7597
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7591
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7590
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7590
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7589
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7588
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7584
Chaperone protein ClpB Q9RA63 CLPB_THET8 Thermus thermophilus 3 0.7584
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7582
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7582
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7578
Neprilysin P08473 NEP_HUMAN Homo sapiens 4 0.7577
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7574
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7574
Vanillyl-alcohol oxidase P56216 VAOX_PENSI Penicillium simplicissimum 3 0.7566
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7560
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7550
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7548
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7537
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7536
Precorrin-3 methylase O68097 O68097_RHOCA Rhodobacter capsulatus 3 0.7535
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7531
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 3 0.7530
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7528
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7527
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7525
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7524
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7519
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7517
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7517
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7517
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 2 0.7515
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7512
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7510
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7510
Cystathionine beta-lyase MetC P06721 METC_ECOLI Escherichia coli 3 0.7502
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7500
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7495
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7491
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7486
Dihydroorotate dehydrogenase (quinone), mitochondrial Q63707 PYRD_RAT Rattus norvegicus 2 0.7482
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7480
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7476
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7476
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7475
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7475
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7474
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7473
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7467
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7467
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7465
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7463
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7460
Genome polyprotein P29991 POLG_DEN27 Dengue virus type 2 3 0.7459
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7457
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7451
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7451
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7451
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7444
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7443
Mismatch repair endonuclease PMS2 P54278 PMS2_HUMAN Homo sapiens 3 0.7443
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7441
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7441
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 3 0.7438
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7436
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7435
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7435
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein Q5SHN1 Q5SHN1_THET8 Thermus thermophilus 3 0.7433
Cell division protein FtsZ P0A029 FTSZ_STAAM Staphylococcus aureus 3 0.7428
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7425
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7424
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7420
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7418
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7416
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7412
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7411
Signaling protein P83820 P83820_THETH Thermus thermophilus 3 0.7410
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7409
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7408
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7403
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7403
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7402
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7394
Mitogen-activated protein kinase kinase kinase 7 O43318 M3K7_HUMAN Homo sapiens 3 0.7390
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7389
Indole-3-glycerol phosphate synthase P9WFX7 TRPC_MYCTU Mycobacterium tuberculosis 2 0.7383
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7381
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7380
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7380
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7379
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7377
Genome polyprotein Q8QL64 Q8QL64_9FLAV Modoc virus 3 0.7374
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7374
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7367
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7367
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7364
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7359
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7355
Serine/threonine-protein kinase CtkA Q9ZKJ5 CTKA_HELPJ Helicobacter pylori 3 0.7351
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7349
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7349
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7347
Plasmid partition protein A P07620 PARA_ECOLX Escherichia coli 3 0.7345
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 2 0.7344
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7343
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7340
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7333
AcsD Q93AT8 Q93AT8_DICCH Dickeya chrysanthemi 3 0.7332
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7332
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 4 0.7331
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7326
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7325
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7320
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7318
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7317
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.7317
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7316
LD-carboxypeptidase A0A6L8PVW7 A0A1Q4LWC0_BACAN Bacillus anthracis 3 0.7315
Probable enoyl-CoA hydratase EchA8 P9WNN9 ECHA8_MYCTU Mycobacterium tuberculosis 3 0.7314
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7313
N-glycosylase/DNA lyase O15527 OGG1_HUMAN Homo sapiens 4 0.7313
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7310
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7310
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7310
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7306
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7303
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7302
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 2 0.7302
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7301
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7300
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7296
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7296
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7295
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7295
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7294
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 2 0.7293
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7293
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7293
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7291
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7289
Metallophosphoesterase MPPED2 B1WBP0 MPPD2_RAT Rattus norvegicus 3 0.7288
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7285
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7285
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7284
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7283
Alanine racemase Q180W0 Q180W0_CLOD6 Clostridioides difficile 2 0.7282
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7281
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7280
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7279
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7279
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7279
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7278
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7277
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 2 0.7275
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7273
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7272
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7270
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7258
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7258
Adenine DNA glycosylase P83847 MUTY_GEOSE Geobacillus stearothermophilus 3 0.7257
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7256
DNA adenine methylase P0AEE8 DMA_ECOLI Escherichia coli 3 0.7249
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7247
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7245
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7245
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7243
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7241
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7239
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7234
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7231
Botulinum neurotoxin type A P0DPI0 BXA1_CLOBO Clostridium botulinum 2 0.7226
ATP-dependent protease ATPase subunit HslU P43773 HSLU_HAEIN Haemophilus influenzae 3 0.7225
Genome polyprotein A9LIE0 A9LIE0_9FLAV dengue virus type 3 3 0.7225
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7224
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 2 0.7224
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7221
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7218
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7216
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7215
Nuclear receptor subfamily 5 group A member 2 O00482 NR5A2_HUMAN Homo sapiens 3 0.7215
Ras-related protein Rap-1b P61224 RAP1B_HUMAN Homo sapiens 3 0.7214
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7212
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 2 0.7211
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7211
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7210
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7210
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7209
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7208
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7208
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7207
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7206
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7206
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7206
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7202
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7202
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7199
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 2 0.7197
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7189
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7188
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7187
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7187
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7187
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7186
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7183
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7182
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7180
eIF-2-alpha kinase GCN2 P15442 GCN2_YEAST Saccharomyces cerevisiae 3 0.7179
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7178
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7178
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7171
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7171
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7170
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7170
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7169
tRNA (cytidine-2'-O-)-methyltransferase TrmJ Q4JB16 TRMJ_SULAC Sulfolobus acidocaldarius 3 0.7169
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7169
5'-methylthioadenosine nucleosidase / s-adenosylhomocysteine nucleosidase Q8YBL1 Q8YBL1_BRUME Brucella melitensis biotype 1 3 0.7166
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7164
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7163
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7163
Adenosine 5'-monophosphoramidase HINT1 P80912 HINT1_RABIT Oryctolagus cuniculus 2 0.7163
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7162
Purine nucleoside phosphorylase 2 P45563 XAPA_ECOLI Escherichia coli 4 0.7160
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7159
Chaperone protein ClpB Q9RA63 CLPB_THET8 Thermus thermophilus 3 0.7157
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7157
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7155
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7153
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7149
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7148
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7148
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7146
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7145
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7142
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7140
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7140
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7139
Genome polyprotein Q6YMS4 POLG_DEN3S Dengue virus type 3 3 0.7136
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7136
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7134
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7133
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7133
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7132
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7131
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7130
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7128
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.7125
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7124
Ribosomal protein S6 kinase alpha-1 Q15418 KS6A1_HUMAN Homo sapiens 3 0.7118
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7113
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7112
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7112
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 2 0.7110
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7109
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7107
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7102
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7102
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7100
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7099
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7099
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7098
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7097
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7095
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7095
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7094
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7091
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 3 0.7091
Genome polyprotein P26664 POLG_HCV1 Hepatitis C virus genotype 1a 3 0.7090
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 2 0.7090
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7089
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7087
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7086
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7084
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7084
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7081
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7080
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7078
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7074
Holliday junction branch migration complex subunit RuvB Q9PMT7 RUVB_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.7074
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 2 0.7074
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7073
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 2 0.7073
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7071
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7065
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7065
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7065
Thymidylate synthase Q9Y052 Q9Y052_CAEEL Caenorhabditis elegans 3 0.7064
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7064
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7064
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7064
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7064
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7062
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 3 0.7062
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7062
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7061
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7060
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7059
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7058
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7057
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7056
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7056
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7056
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7054
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7052
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7051
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7050
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7050
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7050
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase Q8U0R7 PURP_PYRFU Pyrococcus furiosus 3 0.7049
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7048
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7048
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7047
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7046
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7045
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7045
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7044
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7044
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7042
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7040
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7038
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7038
Serine/threonine-protein kinase PLK Q4KMI8 Q4KMI8_DANRE Danio rerio 3 0.7038
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7038
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7036
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7034
Putative aminoglycoside phosphotransferase P9WI99 Y3168_MYCTU Mycobacterium tuberculosis 3 0.7034
Seed lectin subunit I P05045 LEC1_VIGUC Vigna unguiculata subsp. cylindrica 2 0.7033
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7032
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7031
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7030
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7030
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7029
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7027
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7026
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 2 0.7026
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7024
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7023
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7022
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7021
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7019
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7016
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7015
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7014
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7014
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7013
Cellular tumor antigen p53 P04637 P53_HUMAN Homo sapiens 3 0.7011
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7011
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7010
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7010
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 2 0.7010
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7009
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7008
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7007
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7005
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7005
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7005
Phosphodiesterase Q53I60 Q53I60_TRYCR Trypanosoma cruzi 3 0.7004
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7003
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7002
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 2 0.7002
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7001
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7000

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