6'-hydroxydaphnoretin - Compound Card

6'-hydroxydaphnoretin

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6'-hydroxydaphnoretin

Structure
Zoomed Structure
  • Family: Plantae - Thymelaeaceae
  • Kingdom: Plantae
  • Class: Coumarin
    • Subclass: Biscoumarin
Canonical Smiles COc1cc2cc(Oc3cc4oc(=O)ccc4cc3O)c(=O)oc2cc1O
InChI InChI=1S/C19H12O8/c1-24-15-5-10-6-17(19(23)27-13(10)7-12(15)21)25-16-8-14-9(4-11(16)20)2-3-18(22)26-14/h2-8,20-21H,1H3
InChIKey RIBGUNLTZKCEGB-UHFFFAOYSA-N
Formula C19H12O8
HBA 8
HBD 2
MW 368.3
Rotatable Bonds 3
TPSA 119.34
LogP 3.11
Number Rings 4
Number Aromatic Rings 4
Heavy Atom Count 27
Formal Charge 0
Fraction CSP3 0.05
Exact Mass 368.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Thymelaea hirsuta Thymelaeaceae Plantae 69845

Showing of synonyms

  • Badawy A, Hassanean H, et al. (2011). Isolates From Thymelaea Hirsuta Inhibit Progression Of Hepatocellular Carcinoma In Vitro And In Vivo. Natural Product Research, 2011,35(11),1799–1798. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(=O)c(c2)Oc(cc3)cc(c34)oc(=O)cc4

Level: 1

Mol. Weight: 368.3 g/mol

Structure

SMILES: c1cccc(c12)oc(=O)cc2

Level: 0

Mol. Weight: 368.3 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.83
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.830
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.2

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.870
Plasma Protein Binding
95.61
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.560
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.620
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.670
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.580
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-2.720
Rat (Acute)
2.210
Rat (Chronic Oral)
2.010
Fathead Minnow
5.080
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
523.150
Hydration Free Energy
-8.400
Log(D) at pH=7.4
2.790
Log(P)
2.01
Log S
-6.17
Log(Vapor Pressure)
-9.53
Melting Point
309.53
pKa Acid
7.42
pKa Basic
3.69
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9555
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9416
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9315
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.9252
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9198
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9150
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9138
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9131
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9090
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9042
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.9019
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8973
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8944
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8933
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8918
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8913
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8866
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8859
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8856
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8806
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8786
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.8696
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8690
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8666
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8615
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.8614
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8581
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8556
Aldehyde dehydrogenase, dimeric NADP-preferring P30838 AL3A1_HUMAN Homo sapiens 3 0.8551
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.8534
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8492
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 4 0.8481
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8423
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8409
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8391
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8367
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.8349
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 4 0.8343
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8341
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8340
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.8332
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8327
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8310
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8307
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.8279
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8279
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8274
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8265
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8222
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 4 0.8200
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8132
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8078
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8078
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 3 0.8074
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 4 0.8063
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8060
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8054
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8036
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8034
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 3 0.7992
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7990
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7978
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 4 0.7959
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7957
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7942
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7933
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7918
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7913
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7904
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7892
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7873
CRP-like cAMP-activated global transcriptional regulator P9WMH3 CRPL_MYCTU Mycobacterium tuberculosis 3 0.7869
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.7867
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7846
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7825
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7820
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7819
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7808
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7805
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7793
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7757
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7750
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7747
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7719
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7711
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7704
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7703
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7700
Mu-type opioid receptor P42866 OPRM_MOUSE Mus musculus 3 0.7671
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7661
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7661
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.7648
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 4 0.7644
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7642
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7640
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7639
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7623
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.7622
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7613
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7611
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7609
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7605
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7602
Poly [ADP-ribose] polymerase 1 P26446 PARP1_CHICK Gallus gallus 3 0.7587
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7583
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 4 0.7581
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7557
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7555
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7544
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7540
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7535
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7526
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7512
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7511
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7511
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 SIR3_HUMAN Homo sapiens 4 0.7510
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7507
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7503
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7487
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7464
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7462
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7454
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 4 0.7445
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7441
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7438
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7435
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7434
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7415
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7414
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7413
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7405
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7390
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7378
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7377
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7376
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7371
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7368
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7359
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7359
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7346
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7343
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7329
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7325
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7319
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7318
Enterochelin uptake periplasmic binding protein Q0P8Q4 Q0P8Q4_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 4 0.7314
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7307
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7304
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7301
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7296
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7293
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7290
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7288
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7273
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7272
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7270
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7268
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.7266
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7266
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7265
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7262
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 FNTA_HUMAN Homo sapiens 3 0.7259
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7250
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7242
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7241
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7240
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7227
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7225
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7225
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7225
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7225
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7222
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7222
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7217
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7211
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7199
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7189
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7189
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7185
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7185
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7185
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7185
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7172
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7172
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7171
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7164
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7162
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7157
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7156
Retinoic acid receptor gamma P13631 RARG_HUMAN Homo sapiens 3 0.7155
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7144
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7134
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7131
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7128
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7120
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7108
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7108
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7104
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7100
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7099
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7092
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7092
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7091
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7085
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7083
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7077
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7077
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7076
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7066
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7062
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7061
Interstitial collagenase P03956 MMP1_HUMAN Homo sapiens 3 0.7053
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7051
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7048
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7045
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7043
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 4 0.7038
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7037
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.7033
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7033
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7029
Uncharacterized protein C7YVL8 C7YVL8_NECH7 Nectria haematococca 3 0.7026
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7022
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7022
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7015
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7008
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7006
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7002
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7000

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