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Dichlorodiaportin

Family: Fungi - Trichocomaceae
Kingdom: Fungi
Class: Coumarin
- Subclass: Isocoumarin

Canonical Smiles	COc1cc2cc(C[C@H](C(Cl)Cl)O)oc(=O)c2c(c1)O
InChI	InChI=1S/C13H12Cl2O5/c1-19-7-2-6-3-8(5-10(17)12(14)15)20-13(18)11(6)9(16)4-7/h2-4,10,12,16-17H,5H2,1H3/t10-/m1/s1
InChIKey	RCUFLECOBNVNRE-SNVBAGLBSA-N
Formula	C₁₃H₁₂Cl₂O₅
HBA	5
HBD	2
MW	319.14
Rotatable Bonds	4
TPSA	79.9
LogP	2.21
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	20
Formal Charge	0
Fraction CSP3	0.31
Exact Mass	318.01
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Aspergillus falconensis	Trichocomaceae	Fungi	1810910

Showing of synonyms

El-Kashef D.H, Youssef F.S, et al. (2021). Polyketides from the marine-derived fungus Aspergillus falconensis: In silico and in vitro cytotoxicity studies. Bioorg Med Chem,2021,29,115883. [View] [PubMed]

Pubchem: 5324333

Zinc: ZINC000067910584

Nmrshiftdb2: 70087643

Chembl: CHEMBL4165254

CPRiL: 57618

SMILES: c1cccc(c12)ccoc2=O

Level: 0

Mol. Weight: 319.14 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.55
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.740
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.18

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.140
Plasma Protein Binding: 50.57
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.980
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 1.090
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.350
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.850
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 1.630
Rat (Acute): 2.150
Rat (Chronic Oral): 1.990
Fathead Minnow: 4.350
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 393.240
Hydration Free Energy: -11.910
Log(D) at pH=7.4: 2.230
Log(P): 2.43
Log S: -3.72
Log(Vapor Pressure): -7.24
Melting Point: 132.77
pKa Acid: 7.45
pKa Basic: 2.85

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.9737
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9704
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9501
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.9436
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9407
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9270
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.9255
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9243
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9229
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9202
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.9177
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.9170
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9164
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9161
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9134
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.9114
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.9088
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9076
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9018
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.9000
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8997
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8992
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8990
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8970
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8965
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8941
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	3	0.8901
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8901
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.8901
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8876
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8854
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8844
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8801
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8790
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.8777
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.8767
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8728
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.8724
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8693
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8691
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8686
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8618
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	4	0.8603
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8601
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8534
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8492
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	3	0.8487
tRNA (adenine(9)-N1)-methyltransferase	Q4J894	TRM10_SULAC	Sulfolobus acidocaldarius	4	0.8485
Ribosomal RNA small subunit methyltransferase E	Q5SKI6	Q5SKI6_THET8	Thermus thermophilus	4	0.8453
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8453
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8431
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.8405
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	3	0.8402
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8397
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	4	0.8395
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8386
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8374
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.8372
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.8369
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	4	0.8338
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	3	0.8304
DNA polymerase III subunit epsilon	P03007	DPO3E_ECOLI	Escherichia coli	3	0.8299
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8285
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.8280
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8271
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.8262
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8261
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	4	0.8248
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	3	0.8240
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	4	0.8201
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.8166
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8153
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.8142
Cytochrome P450 2A6	P11509	CP2A6_HUMAN	Homo sapiens	3	0.8104
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	3	0.8070
Laminarinase	Q9WXN1	Q9WXN1_THEMA	Thermotoga maritima	3	0.8069
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	4	0.8047
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.8025
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8022
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	3	0.8016
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8013
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7998
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.7986
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7975
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	3	0.7963
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.7942
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	3	0.7921
Aspartokinase 1, chloroplastic	Q9LYU8	AK1_ARATH	Arabidopsis thaliana	4	0.7918
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7908
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7887
Coniferyl alcohol 9-O-methyltransferase	A6XNE6	A6XNE6_9ROSI	Linum nodiflorum	3	0.7865
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7862
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7856
D(3) dopamine receptor	P35462	DRD3_HUMAN	Homo sapiens	3	0.7844
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7828
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7805
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7768
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7760
Sepiapterin reductase	Q64105	SPRE_MOUSE	Mus musculus	4	0.7742
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7730
16S rRNA (guanine(1405)-N(7))-methyltransferase	Q763K9	Q763K9_ECOLX	Escherichia coli	3	0.7722
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7695
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	3	0.7685
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7655
Spermidine synthase	P19623	SPEE_HUMAN	Homo sapiens	4	0.7651
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7621
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	3	0.7617
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7603
Methyltransferase	D0VX01	D0VX01_WSLV	Wesselsbron virus	4	0.7601
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	3	0.7579
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7571
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7551
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7549
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7543
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7536
Threonine synthase 1, chloroplastic	Q9S7B5	THRC1_ARATH	Arabidopsis thaliana	3	0.7517
Nucleoside diphosphate kinase A 2	P52175	NDKA2_BOVIN	Bos taurus	3	0.7506
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7504
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	3	0.7504
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7490
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7475
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7467
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7466
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7465
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7460
Ras-related protein Rab-27A	Q9ERI2	RB27A_MOUSE	Mus musculus	4	0.7457
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7456
Rifampin ADP-ribosyl transferase	A0QRS5	A0QRS5_MYCS2	Mycolicibacterium smegmatis155)	3	0.7451
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7451
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7437
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7434
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7431
16S rRNA (adenine(1408)-N(1))-methyltransferase	A8C927	NPMA_ECOLX	Escherichia coli	4	0.7425
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7420
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7418
Glucose-1-phosphate thymidylyltransferase	Q9AGY4	Q9AGY4_ANETH	Aneurinibacillus thermoaerophilus	4	0.7411
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.7408
Methyltransferase	O26771	O26771_METTH	Methanothermobacter thermautotrophicus	4	0.7407
Inosine-5'-monophosphate dehydrogenase	Q756Z6	Q756Z6_ASHGO	Ashbya gossypii	3	0.7407
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	3	0.7394
tRNA U34 carboxymethyltransferase	A1AC32	CMOB_ECOK1	Escherichia coli O1:K1 / APEC	4	0.7393
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7391
DNA mismatch repair protein Msh2	P43246	MSH2_HUMAN	Homo sapiens	3	0.7385
AGAP003309-PA	A0A1U7F4W2	A0A1U7F4W2_ANOGA	Anopheles gambiae	3	0.7382
Prenyltransferase	Q4R2T2	Q4R2T2_STRC1	Streptomyces sp	3	0.7379
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7373
Eugenol synthase 1	Q15GI4	EGS1_OCIBA	Ocimum basilicum	3	0.7370
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7365
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	3	0.7361
Orotidine 5'-phosphate decarboxylase	O26232	PYRF_METTH	Methanothermobacter thermautotrophicus	3	0.7358
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7353
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7347
SRSF protein kinase 1	Q96SB4	SRPK1_HUMAN	Homo sapiens	3	0.7345
uroporphyrinogen-III C-methyltransferase	P95417	P95417_PSEAI	Pseudomonas aeruginosa	4	0.7343
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	2	0.7342
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7339
Polyamine aminopropyltransferase	Q5SK28	SPEE_THET8	Thermus thermophilus	3	0.7335
Thymidylate kinase	Q9KQI2	KTHY_VIBCH	Vibrio cholerae serotype O1	3	0.7332
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7330
Nucleoside permease	Q9KPL5	Q9KPL5_VIBCH	Vibrio cholerae serotype O1	3	0.7322
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.7318
tRNA (guanine-N(7)-)-methyltransferase	Q12009	TRMB_YEAST	Saccharomyces cerevisiae	4	0.7312
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	O88704	HCN1_MOUSE	Mus musculus	3	0.7299
Cytochrome b-c1 complex subunit 1, mitochondrial	P31800	QCR1_BOVIN	Bos taurus	3	0.7297
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7297
Class 10 plant pathogenesis-related protein 2B	Q9LLQ2	P102B_LUPLU	Lupinus luteus	2	0.7295
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7291
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7290
Ribonuclease TTHA0252	Q5SLP1	RNSE_THET8	Thermus thermophilus	3	0.7288
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	2	0.7285
DNA mismatch repair protein MutS	P23909	MUTS_ECOLI	Escherichia coli	3	0.7280
uroporphyrinogen-III C-methyltransferase	Q5SKH6	Q5SKH6_THET8	Thermus thermophilus	4	0.7274
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7270
cAMP-dependent protein kinase regulatory subunit	P07278	KAPR_YEAST	Saccharomyces cerevisiae	3	0.7265
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	2	0.7264
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7259
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	4	0.7258
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7256
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	4	0.7250
Cyclic nucleotide-gated potassium channel mll3241	Q98GN8	CNGK1_RHILO	Mesorhizobium japonicum)	3	0.7249
Ribosomal protein L11 methyltransferase, putative	C3MWA1	C3MWA1_SULIM	Sulfolobus islandicus	4	0.7246
BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1	Q94F62	BAK1_ARATH	Arabidopsis thaliana	4	0.7245
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.7238
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.7238
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7237
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7232
Single-strand selective monofunctional uracil DNA glycosylase	Q9YGN6	SMUG1_XENLA	Xenopus laevis	4	0.7231
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7230
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.7228
Nitroreductase domain-containing protein	Q8DW21	Q8DW21_STRMU	Streptococcus mutans serotype c	3	0.7227
Histone-arginine methyltransferase CARM1	Q4AE70	CARM1_RAT	Rattus norvegicus	4	0.7219
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7210
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7209
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7208
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7208
Nitric oxide synthase 3	P29474	NOS3_HUMAN	Homo sapiens	3	0.7205
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7204
Orotidine 5'-phosphate decarboxylase	O58462	PYRF_PYRHO	Pyrococcus horikoshii	3	0.7203
Ras-related protein M-Ras	O08989	RASM_MOUSE	Mus musculus	4	0.7202
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	2	0.7199
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7196
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7195
DNA topoisomerase 1	P06612	TOP1_ECOLI	Escherichia coli	3	0.7192
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7192
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7186
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7182
DNA mismatch repair protein MutS	P23909	MUTS_ECOLI	Escherichia coli	3	0.7182
Trimethylamine dehydrogenase	P16099	DHTM_METME	Methylophilus methylotrophus	4	0.7181
Oxygenase	Q194P4	Q194P4_STRAA	Streptomyces argillaceus	3	0.7181
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7178
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7173
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7167
Activated CDC42 kinase 1	Q07912	ACK1_HUMAN	Homo sapiens	3	0.7162
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7162
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7161
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7159
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7158
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7157
Ribosomal RNA small subunit methyltransferase B	P36929	RSMB_ECOLI	Escherichia coli	4	0.7152
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	3	0.7152
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7145
Tyrosine-protein kinase ABL1	P00519	ABL1_HUMAN	Homo sapiens	3	0.7143
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7143
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7135
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7132
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	4	0.7131
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7127
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	Q9UL51	HCN2_HUMAN	Homo sapiens	3	0.7121
Uncharacterized protein	A6L5C0	A6L5C0_BACV8	Bacteroides vulgatus	4	0.7120
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7120
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	3	0.7119
Type II methyltransferase M.HhaI	P05102	MTH1_HAEPH	Haemophilus parahaemolyticus	3	0.7119
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7113
rRNA adenine N-6-methyltransferase	P13956	ERM_BACIU	Bacillus subtilis	4	0.7107
Methyltransferase protein	Q5LFK0	Q5LFK0_BACFN	Bacteroides fragilis	4	0.7101
N-terminal acetyltransferase A complex subunit NAT1	P12945	NAT1_YEAST	Saccharomyces cerevisiae	2	0.7099
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	2	0.7098
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7097
GTPase IMAP family member 2	Q9UG22	GIMA2_HUMAN	Homo sapiens	3	0.7097
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7093
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7092
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7092
CTP synthase	P0A7E5	PYRG_ECOLI	Escherichia coli	4	0.7082
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7081
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	2	0.7081
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7079
Protein mono-ADP-ribosyltransferase PARP10	Q53GL7	PAR10_HUMAN	Homo sapiens	3	0.7074
Purine nucleoside phosphorylase DeoD-type 1	Q9KPM0	DEOD1_VIBCH	Vibrio cholerae serotype O1	3	0.7073
Genome polyprotein	C0LMU5	C0LMU5_9FLAV	dengue virus type 3	4	0.7068
tRNA wybutosine-synthesizing protein 4	Q08282	TYW4_YEAST	Saccharomyces cerevisiae	4	0.7067
DUF574 domain-containing protein	Q47KX2	Q47KX2_THEFY	Thermobifida fusca	4	0.7064
Maltokinase	A1TH50	MAK_MYCVP	Mycolicibacterium vanbaalenii	3	0.7063
Leucine carboxyl methyltransferase 1	Q04081	LCMT1_YEAST	Saccharomyces cerevisiae	4	0.7062
Release factor glutamine methyltransferase	Q9WYV8	PRMC_THEMA	Thermotoga maritima	3	0.7061
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7061
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7060
DNA (cytosine-5)-methyltransferase 3A	Q9Y6K1	DNM3A_HUMAN	Homo sapiens	4	0.7057
43.2 kDa salivary protein	Q5WPU9	Q5WPU9_LUTLO	Lutzomyia longipalpis	3	0.7053
Precorrin-3 methylase	O68097	O68097_RHOCA	Rhodobacter capsulatus	3	0.7052
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7048
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.7048
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7046
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7038
Riboflavin synthase	Q58584	RISC_METJA	Methanocaldococcus jannaschii	4	0.7034
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7034
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.7034
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7032
mRNA cap guanine-N7 methyltransferase	O43148	MCES_HUMAN	Homo sapiens	4	0.7031
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7030
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7030
Ribosomal RNA small subunit methyltransferase E	Q5SKI6	Q5SKI6_THET8	Thermus thermophilus	4	0.7018
Dimethylglycine dehydrogenase, mitochondrial	Q63342	M2GD_RAT	Rattus norvegicus	3	0.7014
Bacteriochlorophyllide d C-20 methyltransferase	Q8KGE0	BCHU_CHLTE	Chlorobaculum tepidum	4	0.7013
orotidine-5'-phosphate decarboxylase	Q8T6J6	Q8T6J6_PLAFA	Plasmodium falciparum	4	0.7011
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7011
cAMP-activated global transcriptional regulator Vfr	P55222	VFR_PSEAE	Pseudomonas aeruginosa	3	0.7005
GTP 3',8-cyclase	P69848	MOAA_STAA8	Staphylococcus aureus	3	0.7003

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